Details of the Target

General Information of Target

Target ID LDTP09054
Target Name Golgi membrane protein 1 (GOLM1)
Gene Name GOLM1
Gene ID 51280
Synonyms
C9orf155; GOLPH2; Golgi membrane protein 1; Golgi membrane protein GP73; Golgi phosphoprotein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIMELEGRVRRAAAER
GAVELKKNEFQGELEKQREQLDKIQSSHNFQLESVNKLYQDEKAVLVNNITTGERLIRVL
QDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEERIEEVTKK
GNEAVASRDLSENNDQRQQLQALSEPQPRLQAAGLPHTEVPQGKGNVLGNSKSQTPAPSS
EVVLDSKRQVEKEETNEIQVVNEEPQRDRLPQEPGREQVVEDRPVGGRGFGGAGELGQTP
QVQAALSVSQENPEMEGPERDQLVIPDGQEEEQEAAGEGRNQQKLRGEDDYNMDENEAES
ETDKQAALAGNDRNIDVFNVEDQKRDTINLLDQREKRNHTL
Target Bioclass
Other
Family
GOLM family
Subcellular location
Golgi apparatus, cis-Golgi network membrane
Function Unknown. Cellular response protein to viral infection.
Uniprot ID
Q8NBJ4
Ensemble ID
ENST00000388711.7
HGNC ID
HGNC:15451

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.M163R DBIA    Probe Info 
FTC133 SNV: p.C170R .
HL60 SNV: p.L42V .
ICC3 SNV: p.L401H .
MEWO SNV: p.P271A .
MFE319 SNV: p.M1? .
NCIH1155 SNV: p.G61S .
NCIH1793 SNV: p.A62S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		36.55  LDD0318  [1]
STPyne
 Probe Info  		K125(7.65); K67(7.67)  LDD0277  [2]
ONAyne
 Probe Info  		K66(7.14)  LDD0275  [2]
DBIA
 Probe Info  		C159(2.13)  LDD3310  [3]
N1
 Probe Info  		N.A.  LDD0245  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C073
 Probe Info  		4.96  LDD1769  [8]
C170
 Probe Info  		16.56  LDD1850  [8]
C221
 Probe Info  		6.19  LDD1895  [8]
C237
 Probe Info  		7.84  LDD1910  [8]
C310
 Probe Info  		19.97  LDD1977  [8]
C346
 Probe Info  		10.48  LDD2007  [8]
C376
 Probe Info  		7.67  LDD2036  [8]
C425
 Probe Info  		5.98  LDD2080  [8]
FFF probe12
 Probe Info  		20.00  LDD0473  [9]
FFF probe9
 Probe Info  		20.00  LDD0470  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C159(1.34)  LDD1509  [10]
 LDCM0278  AC19 HEK-293T C159(2.18)  LDD1517  [10]
 LDCM0281  AC21 HEK-293T C159(1.03)  LDD1520  [10]
 LDCM0284  AC24 HEK-293T C159(1.08)  LDD1523  [10]
 LDCM0287  AC27 HEK-293T C159(1.08)  LDD1526  [10]
 LDCM0289  AC29 HEK-293T C159(0.96)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C159(1.24)  LDD1529  [10]
 LDCM0293  AC32 HEK-293T C159(0.78)  LDD1532  [10]
 LDCM0296  AC35 HEK-293T C159(1.07)  LDD1535  [10]
 LDCM0298  AC37 HEK-293T C159(0.93)  LDD1537  [10]
 LDCM0302  AC40 HEK-293T C159(1.07)  LDD1541  [10]
 LDCM0305  AC43 HEK-293T C159(1.05)  LDD1544  [10]
 LDCM0307  AC45 HEK-293T C159(1.14)  LDD1546  [10]
 LDCM0310  AC48 HEK-293T C159(1.00)  LDD1549  [10]
 LDCM0312  AC5 HEK-293T C159(1.02)  LDD1551  [10]
 LDCM0314  AC51 HEK-293T C159(1.39)  LDD1553  [10]
 LDCM0316  AC53 HEK-293T C159(1.13)  LDD1555  [10]
 LDCM0319  AC56 HEK-293T C159(1.00)  LDD1558  [10]
 LDCM0322  AC59 HEK-293T C159(1.10)  LDD1561  [10]
 LDCM0325  AC61 HEK-293T C159(0.97)  LDD1564  [10]
 LDCM0328  AC64 HEK-293T C159(0.89)  LDD1567  [10]
 LDCM0345  AC8 HEK-293T C159(1.06)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C159(1.16)  LDD1511  [10]
 LDCM0275  AKOS034007705 HEK-293T C159(1.14)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C159(0.97)  LDD1571  [10]
 LDCM0370  CL101 HEK-293T C159(1.13)  LDD1574  [10]
 LDCM0374  CL105 HEK-293T C159(1.13)  LDD1578  [10]
 LDCM0378  CL109 HEK-293T C159(0.98)  LDD1582  [10]
 LDCM0383  CL113 HEK-293T C159(0.95)  LDD1587  [10]
 LDCM0387  CL117 HEK-293T C159(1.06)  LDD1591  [10]
 LDCM0390  CL12 HEK-293T C159(1.27)  LDD1594  [10]
 LDCM0392  CL121 HEK-293T C159(1.05)  LDD1596  [10]
 LDCM0396  CL125 HEK-293T C159(0.92)  LDD1600  [10]
 LDCM0400  CL13 HEK-293T C159(1.18)  LDD1604  [10]
 LDCM0406  CL19 HEK-293T C159(1.16)  LDD1610  [10]
 LDCM0409  CL21 HEK-293T C159(0.86)  LDD1613  [10]
 LDCM0412  CL24 HEK-293T C159(0.95)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C159(0.94)  LDD1617  [10]
 LDCM0420  CL31 HEK-293T C159(1.04)  LDD1624  [10]
 LDCM0422  CL33 HEK-293T C159(1.37)  LDD1626  [10]
 LDCM0425  CL36 HEK-293T C159(1.11)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C159(1.07)  LDD1630  [10]
 LDCM0433  CL43 HEK-293T C159(1.02)  LDD1637  [10]
 LDCM0435  CL45 HEK-293T C159(1.37)  LDD1639  [10]
 LDCM0438  CL48 HEK-293T C159(1.14)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C159(1.00)  LDD1643  [10]
 LDCM0446  CL55 HEK-293T C159(1.06)  LDD1649  [10]
 LDCM0448  CL57 HEK-293T C159(1.18)  LDD1651  [10]
 LDCM0452  CL60 HEK-293T C159(1.21)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C159(1.03)  LDD1656  [10]
 LDCM0459  CL67 HEK-293T C159(1.01)  LDD1662  [10]
 LDCM0461  CL69 HEK-293T C159(1.08)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C159(1.26)  LDD1665  [10]
 LDCM0465  CL72 HEK-293T C159(1.37)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C159(1.01)  LDD1669  [10]
 LDCM0472  CL79 HEK-293T C159(1.38)  LDD1675  [10]
 LDCM0475  CL81 HEK-293T C159(0.99)  LDD1678  [10]
 LDCM0478  CL84 HEK-293T C159(1.21)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C159(1.02)  LDD1682  [10]
 LDCM0484  CL9 HEK-293T C159(0.88)  LDD1687  [10]
 LDCM0486  CL91 HEK-293T C159(1.32)  LDD1689  [10]
 LDCM0488  CL93 HEK-293T C159(1.20)  LDD1691  [10]
 LDCM0491  CL96 HEK-293T C159(1.38)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C159(1.00)  LDD1695  [10]
 LDCM0022  KB02 HEK-293T C159(0.97)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C159(1.09)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C159(2.13)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase GET3 (GET3) ArsA ATPase family O43681
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Desumoylating isopeptidase 1 (DESI1) DeSI family Q6ICB0
Sialidase-1 (NEU1) Glycosyl hydrolase 33 family Q99519
Beta-galactosidase (GLB1) Glycosyl hydrolase 35 family P16278
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9) Glycosyltransferase 10 family Q9Y231
Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15) Glycosyltransferase 2 family Q8N3T1
Hepatocyte growth factor activator (HGFAC) Peptidase S1 family Q04756
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 1 (BCL2L1) Bcl-2 family Q07817
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q99726
Claudin-4 (CLDN4) Claudin family O14493
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264
Insulin-induced gene 2 protein (INSIG2) INSIG family Q9Y5U4
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Ninjurin-1 (NINJ1) Ninjurin family Q92982
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) Nucleotide-sugar transporter family Q8TB61
Na(+)/citrate cotransporter (SLC13A5) SLC13A/DASS transporter family Q86YT5
Probable glucose sensor protein SLC5A4 (SLC5A4) Sodium:solute symporter (SSF) (TC 2.A.21) family Q9NY91
BOS complex subunit TMEM147 (TMEM147) TMEM147 family Q9BVK8
Transmembrane protein 176A (TMEM176A) TMEM176 family Q96HP8
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) . Q9BVT8
Voltage-gated monoatomic cation channel TMEM109 (TMEM109) . Q9BVC6
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Protein canopy homolog 3 (CNPY3) Canopy family Q9BT09
Dymeclin (DYM) Dymeclin family Q7RTS9
Gastrin (GAST) Gastrin/cholecystokinin family P01350
Guanylin (GUCA2A) Guanylin family Q02747
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) LEM family P42167
Claudin domain-containing protein 2 (CLDND2) PMP-22/EMP/MP20 family Q8NHS1
Protein ripply2 (RIPPLY2) Ripply family Q5TAB7
Transmembrane protein 98 (TMEM98) TMEM98 family Q9Y2Y6
Serotransferrin (TF) Transferrin family P02787
Complement C1q-like protein 4 (C1QL4) . Q86Z23
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Pulmonary surfactant-associated protein C (SFTPC) . P11686
Thrombospondin type-1 domain-containing protein 7A (THSD7A) . Q9UPZ6
Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) . Q71RG4
Transmembrane protein 140 (TMEM140) . Q9NV12

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402