Details of the Target

General Information of Target

Target ID LDTP00541
Target Name NPC intracellular cholesterol transporter 1 (NPC1)
Gene Name NPC1
Gene ID 4864
Synonyms
NPC intracellular cholesterol transporter 1; Niemann-Pick C1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQ
ELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQF
LNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKD
ADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSC
QDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVS
EYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVF
ITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIY
QPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCT
ILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGP
VFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT
ISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAG
ILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETL
DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFV
SLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIA
IFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYT
SSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVD
NITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYS
SAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFP
YSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFG
VMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFS
GITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKS
CATEERYKGTERERLLNF
Target Bioclass
Transporter and channel
Family
Patched family
Subcellular location
Late endosome membrane
Function
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment . Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9.; (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Uniprot ID
O15118
Ensemble ID
ENST00000269228.10
HGNC ID
HGNC:7897
ChEMBL ID
CHEMBL1293277

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V20L DBIA    Probe Info 
HCT116 SNV: p.S72N DBIA    Probe Info 
HCT15 SNV: p.R1059Ter; p.L1234S .
HEC1 SNV: p.P249H DBIA    Probe Info 
HT115 SNV: p.F311C DBIA    Probe Info 
LS180 SNV: p.A186T; p.F1224L DBIA    Probe Info 
MCC13 Substitution: p.G765R DBIA    Probe Info 
NCIH1793 SNV: p.G500E DBIA    Probe Info 
NCIH2172 SNV: p.V757L DBIA    Probe Info 
SW480 SNV: p.P48Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.68  LDD0197  [2]
ILS-1
 Probe Info  		2.15  LDD0415  [3]
FBPP2
 Probe Info  		20.65  LDD0318  [4]
CHEMBL5175495
 Probe Info  		11.70  LDD0196  [5]
FBP2
 Probe Info  		4.19  LDD0323  [4]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
IPM
 Probe Info  		N.A.  LDD0241  [7]
P11
 Probe Info  		11.78  LDD0201  [8]
BTD
 Probe Info  		C1261(2.11)  LDD1700  [9]
AHL-Pu-1
 Probe Info  		C177(20.00)  LDD0170  [10]
Acrolein
 Probe Info  		C177(0.00); C42(0.00)  LDD0222  [11]
DBIA
 Probe Info  		C1261(1.08)  LDD0078  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
PAL-AfBPP Probe
Click To Hide/Show 121 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		4.16  LDD0417  [3]
C004
 Probe Info  		8.63  LDD1714  [16]
C010
 Probe Info  		5.24  LDD1719  [16]
C011
 Probe Info  		5.66  LDD1720  [16]
C052
 Probe Info  		5.28  LDD1750  [16]
C063
 Probe Info  		12.55  LDD1760  [16]
C064
 Probe Info  		10.48  LDD1761  [16]
C067
 Probe Info  		5.24  LDD1763  [16]
C070
 Probe Info  		11.96  LDD1766  [16]
C072
 Probe Info  		8.11  LDD1768  [16]
C082
 Probe Info  		10.56  LDD1774  [16]
C085
 Probe Info  		7.11  LDD1777  [16]
C087
 Probe Info  		8.34  LDD1779  [16]
C091
 Probe Info  		15.78  LDD1782  [16]
C092
 Probe Info  		19.56  LDD1783  [16]
C106
 Probe Info  		19.84  LDD1793  [16]
C107
 Probe Info  		11.71  LDD1794  [16]
C108
 Probe Info  		13.27  LDD1795  [16]
C130
 Probe Info  		9.78  LDD1812  [16]
C135
 Probe Info  		9.65  LDD1817  [16]
C141
 Probe Info  		9.38  LDD1823  [16]
C143
 Probe Info  		14.12  LDD1825  [16]
C149
 Probe Info  		5.58  LDD1830  [16]
C153
 Probe Info  		19.03  LDD1834  [16]
C163
 Probe Info  		9.65  LDD1843  [16]
C166
 Probe Info  		7.31  LDD1846  [16]
C169
 Probe Info  		22.94  LDD1849  [16]
C170
 Probe Info  		15.03  LDD1850  [16]
C174
 Probe Info  		6.41  LDD1854  [16]
C177
 Probe Info  		12.30  LDD1856  [16]
C178
 Probe Info  		20.97  LDD1857  [16]
C183
 Probe Info  		7.62  LDD1861  [16]
C186
 Probe Info  		18.13  LDD1864  [16]
C187
 Probe Info  		19.16  LDD1865  [16]
C194
 Probe Info  		12.30  LDD1870  [16]
C197
 Probe Info  		6.63  LDD1873  [16]
C198
 Probe Info  		16.11  LDD1874  [16]
C201
 Probe Info  		81.01  LDD1877  [16]
C203
 Probe Info  		5.90  LDD1878  [16]
C205
 Probe Info  		9.25  LDD1880  [16]
C206
 Probe Info  		43.41  LDD1881  [16]
C207
 Probe Info  		26.54  LDD1882  [16]
C208
 Probe Info  		6.96  LDD1883  [16]
C211
 Probe Info  		9.45  LDD1885  [16]
C215
 Probe Info  		5.03  LDD1889  [16]
C218
 Probe Info  		11.39  LDD1892  [16]
C219
 Probe Info  		10.85  LDD1893  [16]
C220
 Probe Info  		18.64  LDD1894  [16]
C221
 Probe Info  		5.21  LDD1895  [16]
C222
 Probe Info  		5.06  LDD1896  [16]
C223
 Probe Info  		9.45  LDD1897  [16]
C225
 Probe Info  		10.34  LDD1898  [16]
C226
 Probe Info  		9.51  LDD1899  [16]
C228
 Probe Info  		18.00  LDD1901  [16]
C229
 Probe Info  		11.16  LDD1902  [16]
C231
 Probe Info  		18.38  LDD1904  [16]
C233
 Probe Info  		13.93  LDD1906  [16]
C235
 Probe Info  		16.91  LDD1908  [16]
C237
 Probe Info  		5.35  LDD1910  [16]
C239
 Probe Info  		6.41  LDD1912  [16]
C240
 Probe Info  		14.03  LDD1913  [16]
C243
 Probe Info  		16.22  LDD1916  [16]
C245
 Probe Info  		4.92  LDD1918  [16]
C246
 Probe Info  		16.68  LDD1919  [16]
C249
 Probe Info  		12.82  LDD1922  [16]
C258
 Probe Info  		8.28  LDD1931  [16]
C270
 Probe Info  		6.45  LDD1940  [16]
C277
 Probe Info  		7.67  LDD1947  [16]
C280
 Probe Info  		9.85  LDD1950  [16]
C286
 Probe Info  		5.17  LDD1956  [16]
C287
 Probe Info  		15.67  LDD1957  [16]
C288
 Probe Info  		10.41  LDD1958  [16]
C290
 Probe Info  		6.06  LDD1960  [16]
C293
 Probe Info  		20.39  LDD1963  [16]
C296
 Probe Info  		14.22  LDD1966  [16]
C307
 Probe Info  		7.94  LDD1975  [16]
C310
 Probe Info  		14.72  LDD1977  [16]
C314
 Probe Info  		11.63  LDD1981  [16]
C326
 Probe Info  		10.85  LDD1990  [16]
C339
 Probe Info  		8.34  LDD2002  [16]
C343
 Probe Info  		12.21  LDD2005  [16]
C346
 Probe Info  		10.20  LDD2007  [16]
C348
 Probe Info  		21.86  LDD2009  [16]
C349
 Probe Info  		17.88  LDD2010  [16]
C350
 Probe Info  		43.71  LDD2011  [16]
C353
 Probe Info  		7.67  LDD2014  [16]
C355
 Probe Info  		30.27  LDD2016  [16]
C356
 Probe Info  		10.93  LDD2017  [16]
C357
 Probe Info  		6.50  LDD2018  [16]
C362
 Probe Info  		36.00  LDD2023  [16]
C363
 Probe Info  		21.71  LDD2024  [16]
C364
 Probe Info  		22.63  LDD2025  [16]
C373
 Probe Info  		4.99  LDD2033  [16]
C376
 Probe Info  		9.25  LDD2036  [16]
C378
 Probe Info  		7.26  LDD2037  [16]
C380
 Probe Info  		7.41  LDD2039  [16]
C382
 Probe Info  		12.73  LDD2041  [16]
C383
 Probe Info  		12.04  LDD2042  [16]
C386
 Probe Info  		9.32  LDD2045  [16]
C390
 Probe Info  		43.11  LDD2049  [16]
C399
 Probe Info  		8.28  LDD2058  [16]
C407
 Probe Info  		11.79  LDD2064  [16]
C419
 Probe Info  		17.27  LDD2074  [16]
C420
 Probe Info  		20.39  LDD2075  [16]
C425
 Probe Info  		8.46  LDD2080  [16]
C426
 Probe Info  		25.11  LDD2081  [16]
C429
 Probe Info  		22.94  LDD2084  [16]
C431
 Probe Info  		18.25  LDD2086  [16]
C433
 Probe Info  		6.23  LDD2088  [16]
FFF probe11
 Probe Info  		20.00  LDD0471  [17]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		20.00  LDD0478  [17]
FFF probe3
 Probe Info  		20.00  LDD0480  [17]
FFF probe7
 Probe Info  		20.00  LDD0483  [17]
JN0003
 Probe Info  		20.00  LDD0469  [17]
STS-1
 Probe Info  		N.A.  LDD0136  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [18]
A-DA
 Probe Info  		2.76  LDD0144  [19]
Alk-rapa
 Probe Info  		4.18  LDD0213  [20]
OEA-DA
 Probe Info  		20.00  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1261(0.99)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1261(1.00)  LDD2112  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1261(0.88)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1261(1.26); C177(0.52)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1261(2.22)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C979(0.62)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1261(0.51)  LDD2131  [9]
 LDCM0025  4SU-RNA DM93 C177(20.00)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA DM93 C816(3.10); C1261(2.21)  LDD0171  [10]
 LDCM0214  AC1 HCT 116 C816(1.30); C1261(1.31); C799(1.20); C800(1.30)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C816(1.13); C1261(0.91); C324(0.47); C334(0.47)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C816(0.93); C323(0.87); C334(0.87); C799(1.02)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C816(0.84); C323(0.91); C334(0.91); C799(0.73)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C816(0.77); C323(0.89); C334(0.89); C799(1.80)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C816(0.96); C323(0.96); C334(0.96); C799(1.98)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C816(0.94); C323(0.86); C334(0.86); C799(0.96)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C816(0.90); C323(0.88); C334(0.88); C799(1.18)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C816(0.78); C323(0.96); C334(0.96); C799(1.35)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C816(0.83); C323(1.07); C334(1.07); C799(1.19)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C816(0.76); C323(0.71); C334(0.92); C799(1.11)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C816(0.84); C323(0.80); C334(0.77); C799(0.83)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C816(1.09); C1261(0.86); C324(0.74); C334(0.74)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C816(0.82); C323(0.90); C334(0.86); C799(1.07)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C816(0.83); C323(0.80); C334(0.78); C799(0.92)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C816(0.96); C323(1.07); C334(0.83); C799(1.14)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C816(1.01); C1261(1.06); C323(0.98); C334(0.98)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C816(1.03); C1261(0.97); C323(0.91); C334(1.06)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C816(1.26); C1261(1.22); C323(0.87); C334(0.84)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C816(1.21); C1261(1.12); C323(0.89); C334(1.10)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C816(0.97); C1261(1.11); C323(1.00); C334(1.05)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C816(0.87); C1261(1.03); C323(1.05); C334(1.32)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C816(1.00); C1261(1.20); C323(0.85); C334(0.98)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C816(1.12); C1261(0.99); C324(0.52); C334(0.52)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C816(0.89); C1261(0.89); C323(1.02); C334(1.09)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C816(0.70); C1261(0.92); C323(1.13); C334(1.05)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C816(0.90); C1261(1.13); C323(0.98); C334(1.35)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C816(0.81); C1261(1.03); C323(0.97); C334(1.16)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C816(0.98); C1261(0.96); C323(0.95); C334(1.29)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C816(0.96); C1261(0.94); C323(0.93); C334(1.27)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C816(1.01); C1261(1.21); C323(1.01); C334(1.14)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C816(1.04); C1261(1.06); C323(1.15); C334(1.20)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C1261(0.86); C323(1.32); C334(1.32); C956(0.85)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C1261(1.05); C323(1.43); C334(1.43); C956(0.90)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C1261(0.92); C323(1.26); C334(1.26); C956(1.67)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C1261(0.96); C323(1.50); C334(1.50); C956(1.06)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C1261(1.14); C323(1.56); C334(1.56); C956(1.01)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C1261(1.29); C323(1.35); C334(1.35); C956(1.10)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C1261(1.13); C323(1.90); C334(1.90); C956(1.60)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C1261(0.94); C323(1.11); C334(1.11); C956(0.99)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C1261(1.09); C323(1.52); C334(1.52); C956(0.85)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C1261(1.06); C323(1.38); C334(1.38); C956(1.28)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C1261(1.43); C323(1.40); C334(1.40); C956(1.47)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C1261(1.08); C323(1.79); C334(1.79); C956(1.15)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C816(1.02); C1261(0.79); C324(0.55); C334(0.55)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C1261(1.48); C323(1.93); C334(1.93); C956(1.01)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C1261(1.38); C323(1.84); C334(1.84); C956(1.12)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C1261(1.20); C323(1.35); C334(1.35); C956(0.86)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C816(1.19); C799(0.83); C800(0.83); C956(1.04)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C957(0.89); C956(0.94); C816(1.13); C1261(1.16)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C957(0.90); C956(1.00); C800(1.10); C1261(1.14)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C957(0.93); C956(0.94); C800(0.95); C816(1.03)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C956(0.72); C799(0.80); C957(0.83); C816(1.01)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C957(0.76); C956(0.82); C800(1.08); C799(1.52)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C957(0.84); C956(1.06); C799(1.32); C816(1.41)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C324(0.52); C334(0.52); C799(0.79); C800(0.79)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C800(0.98); C957(1.00); C956(1.10); C799(1.11)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C800(0.86); C816(0.86); C957(0.94); C956(0.95)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C956(0.86); C800(0.86); C957(0.89); C816(0.93)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C957(0.70); C956(0.76); C800(0.89); C799(1.53)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C816(1.40); C1261(1.25); C799(1.34); C800(1.79)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C816(1.01); C1261(1.36); C799(1.29); C800(1.32)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C816(1.52); C1261(1.04); C799(1.49); C800(1.12)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C816(0.89); C1261(1.26); C799(1.32); C800(1.05)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C1261(0.95); C816(1.24); C800(1.55)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C816(1.29); C800(1.30); C1261(1.61)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C1261(1.03); C816(1.24); C800(1.24)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C956(0.94); C816(1.24); C799(1.29); C1261(1.38)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C1261(0.96); C800(1.19); C816(1.49)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C1261(0.97); C800(1.25); C816(1.46)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C1261(0.98); C816(1.29); C800(1.45)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C1261(0.96); C800(1.48); C816(1.95)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C1261(1.00); C800(1.17); C816(1.27)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C1261(0.91); C323(0.91); C334(0.91); C816(0.92)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C816(0.81); C1261(0.85); C800(0.93); C799(1.10)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C1261(0.82); C816(1.01); C799(1.20); C800(1.22)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C1261(1.07); C800(1.09); C323(1.19); C334(1.19)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C816(0.97); C1261(1.02); C323(1.16); C334(1.16)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C956(0.86); C1261(1.03); C816(1.13); C799(1.40)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C816(1.02); C1261(1.09); C323(1.18); C334(1.18)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C1261(0.86); C323(0.98); C334(0.98); C816(1.00)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C1261(0.89); C816(1.07); C800(1.26); C323(1.30)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C1261(0.92); C323(1.04); C334(1.04); C799(1.19)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C1261(0.93); C323(0.97); C334(0.97); C799(1.05)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C816(0.81); C1261(0.81); C956(1.03); C324(1.06)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C816(0.94); C799(1.05); C800(1.05); C324(1.13)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C1261(0.82); C816(0.86); C324(1.02); C334(1.02)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C799(0.95); C800(0.95); C816(0.99); C324(1.08)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C324(0.88); C334(0.88); C816(0.92); C799(0.96)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C956(1.04); C816(1.11); C1261(1.15); C799(1.50)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C799(1.03); C800(1.03); C1261(1.06); C324(1.06)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C816(0.91); C1261(0.92); C799(1.03); C800(1.03)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C816(0.97); C799(1.04); C800(1.04); C1261(1.15)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C799(1.03); C800(1.03); C1261(1.22); C324(1.29)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C816(0.69); C956(0.98); C799(1.01); C800(1.01)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C1261(0.73); C816(0.74); C324(0.94); C334(0.94)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C323(0.85); C334(0.85); C1261(0.91); C816(1.07)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C323(0.74); C334(0.74); C1261(0.93); C816(1.05)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C323(0.83); C334(0.83); C1261(1.02); C816(1.13)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C323(0.83); C334(0.83); C816(1.08); C1261(1.29)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C956(1.00); C816(1.07); C1261(1.30); C799(1.41)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C323(0.93); C334(0.93); C1261(1.10); C816(1.12)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C323(0.74); C334(0.74); C1261(0.83); C816(0.89)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C1261(0.92); C816(0.97); C323(1.03); C334(1.03)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C1261(1.13); C323(1.15); C334(1.15); C816(1.30)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C816(0.91); C323(1.00); C334(1.00); C1261(1.22)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C1261(1.08); C816(1.12); C323(1.26); C334(1.26)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C816(1.21); C1261(1.34); C323(1.79); C334(1.79)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C1261(1.02); C816(1.09); C323(1.20); C334(1.28)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C816(0.97); C323(1.18); C1261(1.20); C334(1.31)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C1261(1.19); C323(1.32); C334(1.44); C324(1.63)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C324(0.62); C334(0.62); C1261(0.94); C799(1.07)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C1261(1.05); C799(1.25); C800(1.25); C323(1.35)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C816(0.87); C1261(0.98); C324(1.34); C323(1.35)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C323(1.33); C1261(1.37); C334(1.46); C324(1.64)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C1261(1.17); C334(1.47); C323(1.50); C324(1.56)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C1261(1.16); C324(1.50); C323(1.67); C334(1.68)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C323(1.24); C334(1.39); C799(1.47); C800(1.47)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C324(1.21); C1261(1.41); C323(1.51); C334(1.55)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C323(1.16); C334(1.18); C324(1.25); C1261(1.45)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C1261(0.98); C346(1.01); C323(1.04); C334(1.04)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C346(0.95); C323(0.96); C334(0.96); C816(1.15)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C324(0.46); C334(0.46); C1261(0.85); C799(0.93)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C323(0.82); C334(0.82); C346(0.90); C1261(0.98)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C1261(0.80); C346(0.99); C323(1.00); C334(1.00)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C323(0.87); C334(0.87); C346(1.02); C1261(1.03)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C323(0.76); C334(0.76); C346(0.89); C1261(1.23)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C323(0.85); C334(0.85); C1261(1.04); C346(1.06)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C346(0.80); C323(1.14); C334(1.14); C1261(1.50)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C323(0.89); C334(0.89); C346(0.96); C1261(1.09)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C346(0.94); C323(0.97); C334(0.97); C1261(1.12)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C323(0.99); C334(0.99); C1261(1.05); C816(1.12)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C323(0.97); C334(0.97); C346(1.08); C816(1.20)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C324(0.48); C334(0.48); C799(0.95); C800(0.95)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C323(0.92); C334(0.92); C346(0.95); C1261(0.97)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C323(0.90); C334(0.90); C1261(0.92); C346(1.05)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C346(0.97); C323(1.07); C334(1.07); C1261(1.48)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C799(1.04); C800(1.04); C323(1.20); C816(1.32)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C799(0.99); C800(0.99); C323(1.00); C816(1.02)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C323(0.99); C1261(1.17); C334(1.26); C816(1.43)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C1261(1.17); C323(1.20); C799(1.21); C800(1.21)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C323(0.89); C1261(0.97); C799(1.02); C800(1.02)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C323(0.88); C956(0.98); C957(0.98); C799(1.17)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C956(1.04); C957(1.04); C799(1.06); C800(1.06)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C323(0.82); C334(1.03); C1261(1.06); C956(1.22)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C816(0.89); C323(1.03); C956(1.24); C957(1.24)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C323(0.91); C816(1.05); C1261(1.38); C956(1.43)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C323(0.95); C816(1.02); C799(1.18); C800(1.18)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C1261(1.01); C816(1.18); C323(1.27); C334(1.50)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C323(0.89); C956(1.01); C957(1.01); C816(1.08)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C816(0.82); C323(1.17); C956(1.23); C957(1.23)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C323(1.10); C816(1.12); C956(1.48); C957(1.48)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C323(1.03); C334(1.03); C816(1.18); C957(1.39)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C816(0.74); C323(0.86); C334(0.86); C800(0.98)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C816(1.02); C1261(0.93); C324(0.52); C334(0.52)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C324(0.61); C334(0.61); C1261(1.17); C816(1.18)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C799(0.86); C800(0.86); C324(0.91); C334(0.91)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C1261(1.08)  LDD0078  [12]
 LDCM0199  BPK-21 T cell C816(6.18)  LDD0517  [22]
 LDCM0088  C45 HEK-293T 11.78  LDD0201  [8]
 LDCM0108  Chloroacetamide HeLa C177(0.00); C42(0.00)  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C956(0.74); C1261(1.02); C816(1.15); C799(1.29)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C956(0.72); C816(1.20); C1261(1.25); C799(1.59)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C956(0.87); C816(1.12); C799(1.17); C1261(1.29)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C324(0.57); C334(0.57); C799(0.82); C800(0.82)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C324(0.46); C334(0.46); C1261(0.81); C799(0.85)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C799(0.62); C800(0.62); C1261(0.80); C324(0.81)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C799(0.68); C800(0.68); C324(0.75); C334(0.75)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C1261(1.01); C800(1.39); C816(1.55)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C1261(1.21); C800(1.61); C816(1.63)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C1261(1.09); C800(1.50); C816(1.52)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C1261(1.27); C816(1.34); C800(2.05)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C1261(1.06); C800(2.15); C816(2.41)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C956(0.65); C1261(1.31); C799(1.89); C800(1.89)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C1261(1.19); C800(1.44); C816(1.65)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C1261(1.12); C800(1.30); C816(1.65)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C1261(0.80); C800(1.01); C799(1.09); C816(1.12)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C816(1.00); C1261(1.09); C800(1.19); C799(1.24)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C1261(1.15); C800(1.18); C799(1.20); C323(1.35)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C1261(0.95); C816(0.96); C799(1.17); C800(1.18)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C1261(0.92); C816(1.09); C799(1.09); C800(1.12)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C324(0.90); C334(0.90); C799(0.98); C800(0.98)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C956(0.87); C816(0.95); C1261(0.96); C324(1.03)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C324(1.02); C334(1.02); C956(1.07); C816(1.07)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C956(0.82); C1261(0.96); C816(1.18); C799(2.33)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C816(1.12); C324(1.22); C334(1.22); C1261(1.23)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C323(1.03); C334(1.03); C816(1.09); C1261(1.20)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C1261(0.99); C323(1.12); C334(1.12); C816(1.99)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C1261(1.00); C323(1.46); C334(1.46); C816(8.13)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C1261(1.09); C816(1.34); C323(1.38); C334(1.38)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C816(0.76); C1261(0.96); C324(1.20); C323(1.21)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C816(0.89); C1261(0.90); C799(1.16); C800(1.16)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C816(1.06); C1261(1.11); C799(1.13); C800(1.13)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C1261(1.17); C323(1.48); C324(1.50); C799(1.52)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C956(0.90); C799(0.93); C800(0.93); C1261(0.94)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C1261(0.89); C956(1.18); C799(1.22); C800(1.22)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C956(0.89); C1261(1.02); C799(1.47); C800(1.47)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C816(0.92); C1261(1.04); C799(1.38); C800(1.38)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C1261(0.90); C956(1.07); C957(1.07); C799(1.74)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C816(0.94); C1261(1.01); C956(1.17); C957(1.17)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C956(0.98); C957(0.98); C799(1.24); C800(1.24)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C956(0.80); C1261(0.97); C816(1.14); C799(1.18)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C956(1.06); C957(1.06); C1261(1.07); C816(1.35)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C956(1.09); C957(1.09); C1261(1.60); C799(1.92)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C956(0.83); C957(0.83); C799(0.96); C800(0.96)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C816(0.95); C956(0.99); C957(0.99); C1261(1.01)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C956(0.97); C957(0.97); C816(1.11); C799(1.30)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C816(3.45); C1261(1.51); C799(2.01); C800(2.01)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C816(1.18); C1261(0.96); C799(1.46); C800(1.46)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C816(1.01); C1261(1.16); C799(1.47); C800(1.47)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C816(1.40); C1261(1.12); C799(1.74); C800(1.74)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C816(1.27); C1261(1.06); C799(1.38); C800(1.38)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C816(1.34); C1261(0.88); C799(1.20); C800(1.20)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C816(1.00); C1261(1.02); C799(1.63); C800(1.63)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C816(1.13); C1261(1.03); C799(1.54); C800(1.39)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C816(1.36); C1261(1.09); C799(1.05); C800(1.05)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C816(2.93); C1261(1.38); C799(2.21); C800(1.73)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C816(1.52); C1261(1.10); C799(0.95); C800(1.25)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C816(1.32); C1261(1.15); C799(1.19); C800(1.15)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C816(1.55); C1261(1.18); C799(0.96); C800(1.15)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C816(1.64); C1261(1.14); C799(0.92); C800(1.08)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C816(1.52); C1261(1.01); C799(1.02); C800(1.13)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C816(7.80); C1261(1.17); C799(1.03); C800(1.03)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C816(1.15); C1261(1.39); C799(1.18); C800(1.32)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C816(1.52); C1261(1.32); C799(0.98); C800(1.12)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C816(1.99); C1261(1.02); C799(0.93); C800(1.04)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C816(1.43); C1261(0.96); C799(0.94); C800(1.16)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C816(1.51); C1261(0.93); C799(1.08); C800(1.20)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C816(1.40); C1261(1.07); C799(1.01); C800(1.43)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C816(1.63); C1261(1.27); C346(0.79); C799(0.89)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C816(1.47); C1261(1.62); C346(0.73); C799(0.85)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C816(1.83); C1261(1.35); C346(0.64); C799(0.75)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C816(1.84); C1261(1.37); C346(0.87); C799(0.91)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C816(1.02); C1261(0.85); C799(0.94); C800(0.94)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C816(1.66); C1261(1.43); C346(0.77); C799(0.75)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C816(2.37); C1261(1.22); C346(0.80); C799(0.82)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C816(1.67); C1261(1.53); C346(0.69); C799(0.93)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C816(3.27); C1261(1.29); C346(0.84); C799(0.78)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C816(2.98); C1261(2.08); C346(0.76); C799(0.87)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C816(1.26); C1261(1.33); C346(0.76); C799(0.81)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C816(1.18); C1261(1.43); C346(0.89); C799(0.80)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C816(1.78); C1261(1.31); C346(0.89); C799(0.78)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C816(1.43); C1261(1.22); C346(0.87); C799(0.96)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C816(1.45); C1261(1.42); C346(0.80); C799(0.85)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C816(1.54); C1261(0.97); C799(1.30); C800(1.30)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C816(1.68); C1261(1.18); C346(0.72); C799(0.81)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C1261(0.99); C799(1.13); C800(1.12)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C1261(0.90); C799(1.27); C800(1.23)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C1261(0.64); C799(1.43); C800(1.36)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C1261(0.84); C799(1.87); C800(1.77)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C1261(0.87); C799(1.23); C800(1.24)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C1261(0.83); C799(2.24); C800(1.99)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C1261(0.72); C799(1.74); C800(1.66)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C1261(0.83); C799(1.53); C800(1.46)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C1261(0.96); C799(1.17); C800(1.13)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C816(1.33); C1261(1.11); C799(1.34); C800(1.34)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C1261(0.78); C799(1.33); C800(1.33)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C1261(1.08); C799(1.51); C800(1.45)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C1261(0.96); C799(1.18); C800(1.17)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C1261(0.84); C799(1.61); C800(1.54)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C1261(0.96); C799(1.48); C800(1.41)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C816(1.11); C1261(1.05); C323(1.08); C334(1.08)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C816(0.93); C1261(1.26); C323(1.21); C334(1.21)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C816(1.69); C1261(1.14); C323(1.15); C334(1.15)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C816(0.84); C1261(0.85); C323(1.10); C334(1.10)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C816(1.33); C1261(1.08); C799(2.64); C800(2.64)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C816(0.77); C1261(1.14); C323(1.09); C334(1.09)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C816(1.00); C1261(1.10); C323(0.95); C334(0.95)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C816(0.92); C1261(0.90); C323(1.25); C334(1.25)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C816(1.48); C1261(0.74); C323(2.08); C334(2.08)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C816(1.32); C1261(1.03); C323(1.23); C334(1.23)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C816(0.84); C1261(1.00); C323(0.87); C334(0.87)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C816(0.98); C1261(0.93); C323(0.96); C334(0.96)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C816(1.07); C1261(0.94); C323(0.83); C334(0.83)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C816(1.00); C1261(0.85); C323(0.98); C334(0.98)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C816(1.15); C1261(0.97); C323(0.87); C334(0.87)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C816(1.18); C1261(1.01); C799(1.10); C800(1.10)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C816(3.53); C1261(1.02); C323(2.38); C334(2.38)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C816(1.31); C1261(1.48); C799(1.19); C800(1.04)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C816(0.78); C1261(1.54); C799(0.98); C800(0.97)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C816(0.80); C1261(1.48); C799(0.98); C800(1.64)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C816(0.71); C1261(1.49); C799(1.15); C800(1.22)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C816(0.75); C1261(1.45); C799(1.12); C800(1.37)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C816(0.91); C1261(1.35); C799(1.04); C800(1.19)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C816(1.18); C1261(1.78); C799(1.18); C800(1.30)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C816(1.14); C1261(1.17); C799(1.41); C800(1.33)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C816(1.06); C1261(1.16); C799(1.43); C800(1.39)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C1261(0.97); C979(1.06); C177(0.57)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C957(1.76); C956(1.22); C979(0.89)  LDD1702  [9]
 LDCM0468  Fragment33 HCT 116 C1261(0.90); C799(1.52); C800(1.43)  LDD0785  [12]
 LDCM0427  Fragment51 HCT 116 C816(1.70); C1261(2.49); C799(0.98); C800(1.76)  LDD0744  [12]
 LDCM0022  KB02 HCT 116 C1261(1.52)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C1261(1.30)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C1261(1.84)  LDD0082  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1261(0.52)  LDD2121  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1261(0.80)  LDD2089  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1261(0.68)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1261(0.87)  LDD2093  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1261(0.81)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1261(0.78)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1261(1.13); C177(1.02)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1261(1.05)  LDD2100  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1261(0.90)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1261(1.19)  LDD2106  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1261(1.03)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C177(0.58)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1261(1.92)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1261(1.22); C177(0.53)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1261(0.80)  LDD2114  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1261(1.11); C177(0.55)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1261(1.69)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1261(1.12)  LDD2127  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C177(0.50)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1261(0.87)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1261(1.24); C177(0.49)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1261(2.11)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1261(0.94); C177(0.50)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1261(0.92)  LDD2141  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1261(2.98)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C177(0.39)  LDD2146  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1261(0.78)  LDD2150  [9]
 LDCM0090  Rapamycin JHH-7 4.18  LDD0213  [20]
 LDCM0084  Ro 48-8071 A-549 2.76  LDD0144  [19]
 LDCM0021  THZ1 HCT 116 C799(1.12); C800(1.12); C1261(1.29)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
NPC intracellular cholesterol transporter 2 (NPC2) NPC2 family P61916

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
20 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402