Details of the Target

General Information of Target

Target ID LDTP11826
Target Name Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15)
Gene Name SLC6A15
Gene ID 55117
Synonyms
B0AT2; NTT73; SBAT1; Sodium-dependent neutral amino acid transporter B(0)AT2; Sodium- and chloride-dependent neurotransmitter transporter NTT73; Sodium-coupled branched-chain amino-acid transporter 1; Solute carrier family 6 member 15; Transporter v7-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQDPNADTEWNDILRKKGILPPKESLKELEEEAEEEQRILQQSVVKTYEDMTLEELEDHE
DEFNEEDERAIEMYRRRRLAEWKATKLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLY
KQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIG
PLVFGGMNLTRDELEWKLSESGAIMTDLEENPKKPIEDVLLSSVRRSVLMKRDSDSEGD
Target Bioclass
Transporter and channel
Family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A15 subfamily
Subcellular location
Membrane
Function
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
TTD ID
T01138
Uniprot ID
Q9H2J7
DrugMap ID
TT4LRUE
Ensemble ID
ENST00000266682.10
HGNC ID
HGNC:13621
ChEMBL ID
CHEMBL3351189

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R640C .
COLO678 SNV: p.V436G .
CORL23 Substitution: p.T498K .
HEC1B Deletion: p.N4IfsTer5 .
HT115 SNV: p.Q248P; p.S338P .
LNCaP clone FGC SNV: p.F286L .
NCIH1299 SNV: p.S608Y .
NCIH1793 SNV: p.A653S; p.R711L .
NUGC3 SNV: p.I576N .
PF382 SNV: p.G598D .
RKO SNV: p.R127Ter .
RL952 SNV: p.M560I; p.A707S .
SKMEL24 SNV: p.P454L .
SNU1 SNV: p.R640L .
TE4 SNV: p.A601T .
YSCCC SNV: p.K325N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C91(4.43)  LDD0080  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
AOyne
 Probe Info  		9.20  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.78  LDD1740  [5]
C091
 Probe Info  		14.52  LDD1782  [5]
C092
 Probe Info  		18.77  LDD1783  [5]
C094
 Probe Info  		23.10  LDD1785  [5]
C106
 Probe Info  		31.12  LDD1793  [5]
C107
 Probe Info  		13.18  LDD1794  [5]
C108
 Probe Info  		13.45  LDD1795  [5]
C112
 Probe Info  		17.51  LDD1799  [5]
C130
 Probe Info  		6.96  LDD1812  [5]
C169
 Probe Info  		30.70  LDD1849  [5]
C170
 Probe Info  		16.91  LDD1850  [5]
C171
 Probe Info  		5.13  LDD1851  [5]
C216
 Probe Info  		8.94  LDD1890  [5]
C218
 Probe Info  		19.70  LDD1892  [5]
C219
 Probe Info  		8.40  LDD1893  [5]
C220
 Probe Info  		15.89  LDD1894  [5]
C221
 Probe Info  		7.16  LDD1895  [5]
C237
 Probe Info  		4.96  LDD1910  [5]
C238
 Probe Info  		12.47  LDD1911  [5]
C240
 Probe Info  		8.34  LDD1913  [5]
C278
 Probe Info  		47.84  LDD1948  [5]
C281
 Probe Info  		9.92  LDD1951  [5]
C282
 Probe Info  		17.63  LDD1952  [5]
C287
 Probe Info  		9.78  LDD1957  [5]
C339
 Probe Info  		6.73  LDD2002  [5]
C356
 Probe Info  		8.82  LDD2017  [5]
C380
 Probe Info  		5.78  LDD2039  [5]
C382
 Probe Info  		10.85  LDD2041  [5]
C407
 Probe Info  		15.45  LDD2064  [5]
C429
 Probe Info  		13.18  LDD2084  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C91(1.31)  LDD0812  [1]
 LDCM0215  AC10 HCT 116 C91(0.96)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C91(0.76)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C91(0.85)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C91(0.85)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C91(0.95)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C91(0.79)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C91(0.79)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C91(0.73)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C91(0.84)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C91(0.73)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C91(0.74)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C91(0.95)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C91(0.76)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C91(0.90)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C91(0.92)  LDD0546  [1]
 LDCM0230  AC113 HEK-293T C91(0.90)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C91(0.89)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C91(0.95)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C91(0.93)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C91(0.85)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C91(1.12)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C91(0.89)  LDD0834  [1]
 LDCM0237  AC12 HCT 116 C91(0.97)  LDD0554  [1]
 LDCM0238  AC120 HEK-293T C91(0.94)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C91(0.82)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C91(1.01)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C91(0.86)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C91(0.87)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C91(1.01)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C91(1.02)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C91(0.88)  LDD0843  [1]
 LDCM0259  AC14 HCT 116 C91(1.02)  LDD0576  [1]
 LDCM0263  AC143 HEK-293T C91(1.06)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C91(1.39)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C91(1.16)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C91(1.19)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C91(1.15)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C91(0.97)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C91(0.89)  LDD0867  [1]
 LDCM0270  AC15 HCT 116 C91(1.02)  LDD0587  [1]
 LDCM0271  AC150 HEK-293T C91(0.82)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C91(1.08)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C91(0.92)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C91(0.96)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C91(0.90)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C91(1.14)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C91(1.45)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C91(1.10)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C91(1.02)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C91(0.85)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C91(0.98)  LDD0595  [1]
 LDCM0279  AC2 HEK-293T C91(1.12)  LDD0877  [1]
 LDCM0280  AC20 HCT 116 C91(1.02)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C91(0.92)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C91(0.93)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C91(0.93)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C91(1.02)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C91(0.88)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C91(0.97)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C91(1.08)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C91(0.78)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C91(1.14)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C91(0.99)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C91(1.10)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C91(0.86)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C91(0.84)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C91(1.14)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C91(0.91)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C367(1.10); C426(1.13); C91(0.97)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C367(1.14); C426(0.95); C91(0.94)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C367(1.05); C426(1.16); C91(0.91)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C367(1.01); C426(1.00); C91(0.94)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C367(0.93); C91(0.90)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C91(0.96)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C367(1.08); C426(1.02); C91(0.95)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C367(1.09); C426(0.98); C91(0.91)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C367(1.11); C91(0.95)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C367(1.12); C426(1.02); C91(0.92)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C367(1.01); C426(0.89); C91(0.90)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C367(1.08); C426(1.21); C91(0.96)  LDD1546  [6]
 LDCM0308  AC46 HCT 116 C91(1.13)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C91(1.12)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C91(1.19)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C91(1.23)  LDD0628  [1]
 LDCM0312  AC5 HEK-293T C91(0.70)  LDD0910  [1]
 LDCM0313  AC50 HCT 116 C91(1.13)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C91(1.17)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C91(1.05)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C91(1.14)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C91(1.14)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C91(1.18)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C91(1.23)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C91(0.90)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C91(0.85)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C91(0.89)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C91(0.94)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C91(1.07)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C91(1.79)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C91(1.08)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C91(1.06)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C91(0.95)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C91(1.11)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C91(0.99)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C91(1.05)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C91(1.03)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C91(1.07)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C91(1.02)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C91(1.03)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C91(1.08)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C91(1.19)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C91(1.16)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C91(1.00)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C91(1.17)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C91(1.04)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C91(1.12)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C91(0.94)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C91(0.98)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C91(0.92)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C91(0.92)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C91(0.85)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C91(1.01)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C91(1.03)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C91(0.93)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C91(1.07)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C91(1.12)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C91(0.96)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C91(0.92)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C91(0.98)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C91(0.90)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C91(1.07)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C91(0.92)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C91(0.93)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C91(0.90)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C91(1.07)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C91(0.85)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C91(1.06)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C91(0.67)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C91(0.88)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C91(0.96)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C91(0.97)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C91(1.03)  LDD0592  [1]
 LDCM0367  CL1 HEK-293T C91(1.02)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C91(1.15)  LDD0966  [1]
 LDCM0369  CL100 HEK-293T C91(1.20)  LDD0967  [1]
 LDCM0370  CL101 HCT 116 C91(1.04)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C91(0.99)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C91(0.92)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C91(0.92)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C91(0.94)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C91(0.87)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C91(1.07)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C91(1.06)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C91(0.88)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C91(1.01)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C91(0.91)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C91(0.91)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C91(1.22)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C91(0.99)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C91(1.24)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C91(1.00)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C91(1.13)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C367(1.05); C426(0.98); C91(0.94)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C367(1.13); C426(0.94); C91(0.93)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C367(1.14); C426(0.95); C91(0.91)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C91(0.97)  LDD0988  [1]
 LDCM0391  CL120 HEK-293T C367(1.08); C426(0.99); C91(0.96)  LDD1595  [6]
 LDCM0392  CL121 HCT 116 C91(0.87)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C91(1.15)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C91(1.43)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C91(1.21)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C91(1.07)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C91(1.25)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C91(0.79)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C91(0.92)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C91(0.92)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C91(0.97)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C91(1.20)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C91(0.87)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C91(1.20)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C91(1.00)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C91(1.02)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C91(0.77)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C91(0.99)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C91(1.19)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C91(0.89)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C91(0.88)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C91(0.92)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C91(1.44)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C91(0.99)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C91(1.00)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C91(1.16)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C91(0.97)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C91(0.98)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C91(0.88)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C91(1.08)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C91(0.82)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C91(1.18)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C91(0.93)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C91(0.94)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C91(0.88)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C91(0.92)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C91(0.91)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C91(1.06)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C91(0.88)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C91(1.03)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C91(1.00)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C91(1.00)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C91(1.03)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C91(1.09)  LDD1033  [1]
 LDCM0436  CL46 HEK-293T C367(1.22); C426(1.19); C91(1.15)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C367(0.95); C91(1.06)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C367(1.19); C426(1.07); C91(1.08)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C367(1.01); C426(1.01); C91(1.10)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C91(0.87)  LDD1038  [1]
 LDCM0441  CL50 HEK-293T C367(1.27); C426(0.98); C91(1.24)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C367(1.03); C426(1.02); C91(0.93)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C367(1.88); C426(1.48); C91(1.78)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C367(2.85); C91(2.19)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C367(1.11); C426(1.01); C91(0.97)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C367(1.16); C426(1.00); C91(1.15)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C367(1.52); C426(1.64); C91(1.99)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C367(1.22); C426(1.20); C91(1.35)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C367(1.18); C91(1.05)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C91(1.05)  LDD1049  [1]
 LDCM0452  CL60 HEK-293T C367(1.45); C426(1.13); C91(1.03)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C91(0.95)  LDD1051  [1]
 LDCM0454  CL62 HEK-293T C91(1.14)  LDD1052  [1]
 LDCM0455  CL63 HEK-293T C91(1.05)  LDD1053  [1]
 LDCM0456  CL64 HEK-293T C91(1.23)  LDD1054  [1]
 LDCM0457  CL65 HEK-293T C91(1.21)  LDD1055  [1]
 LDCM0458  CL66 HEK-293T C91(1.35)  LDD1056  [1]
 LDCM0459  CL67 HEK-293T C91(1.29)  LDD1057  [1]
 LDCM0460  CL68 HEK-293T C91(1.48)  LDD1058  [1]
 LDCM0461  CL69 HEK-293T C91(1.20)  LDD1059  [1]
 LDCM0462  CL7 HEK-293T C91(0.96)  LDD1060  [1]
 LDCM0463  CL70 HEK-293T C91(1.02)  LDD1061  [1]
 LDCM0464  CL71 HEK-293T C91(1.50)  LDD1062  [1]
 LDCM0465  CL72 HEK-293T C91(1.06)  LDD1063  [1]
 LDCM0466  CL73 HEK-293T C91(1.42)  LDD1064  [1]
 LDCM0467  CL74 HEK-293T C91(2.07)  LDD1065  [1]
 LDCM0469  CL76 HEK-293T C91(1.14)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C91(1.12)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C91(0.97)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C91(1.10)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C91(1.44)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C91(0.98)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C91(1.02)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C91(1.06)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C91(1.15)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C91(1.07)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C91(1.09)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C91(1.05)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C91(1.17)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C91(0.97)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C91(0.96)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C91(1.41)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C91(1.38)  LDD1083  [1]
 LDCM0486  CL91 HEK-293T C91(0.75)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C91(0.60)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C91(0.84)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C91(1.42)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C91(2.38)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C91(0.70)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C91(0.66)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C91(0.91)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C91(0.88)  LDD1092  [1]
 LDCM0495  E2913 HEK-293T C367(1.08); C426(0.98); C91(1.05)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C91(2.03)  LDD1066  [1]
 LDCM0427  Fragment51 HEK-293T C91(0.91)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C91(4.43)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C91(1.05)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C91(1.41)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Solute carrier family 41 member 2 (SLC41A2) SLC41A transporter family Q96JW4
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nurim (NRM) Nurim family Q8IXM6

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402