Details of the Target

General Information of Target

Target ID	LDTP00592
Target Name	Surfeit locus protein 4 (SURF4)
Gene Name	SURF4
Gene ID	6836
Synonyms	SURF-4; Surfeit locus protein 4
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWN CGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRN LALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFF SIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFF QTMSVIGGLLLVVALGPGGVSMDEKKKEW
Target Bioclass	Transporter and channel
Family	SURF4 family
Subcellular location	Endoplasmic reticulum membrane
Function	Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
Uniprot ID	O15260
Ensemble ID	ENST00000371989.8
HGNC ID	HGNC:11476

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
JURKAT	SNV: p.H232Y			.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 23 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	7.47	LDD0402	[1]
HDSF-alk Probe Info	1.94	LDD0197	[2]
CY4 Probe Info	100.00	LDD0244	[3]
TH211 Probe Info	Y24(20.00)	LDD0260	[4]
C-Sul Probe Info	3.47	LDD0066	[5]
TH214 Probe Info	Y24(9.93)	LDD0258	[4]
ONAyne Probe Info	K139(6.92); K22(0.88)	LDD0274	[6]
OPA-S-S-alkyne Probe Info	K139(3.69); K22(3.81); K154(4.16)	LDD3494	[7]
Jackson_14 Probe Info	4.55	LDD0123	[8]
EA-probe Probe Info	C32(1.20); C32(1.26)	LDD2210	[9]
Acrolein Probe Info	N.A.	LDD0221	[10]
DBIA Probe Info	C32(1.16)	LDD0531	[11]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[12]
IA-alkyne Probe Info	N.A.	LDD0032	[13]
IPIAA_L Probe Info	N.A.	LDD0031	[14]
Lodoacetamide azide Probe Info	N.A.	LDD0037	[12]
IPM Probe Info	N.A.	LDD0005	[15]
STPyne Probe Info	N.A.	LDD0009	[15]
TFBX Probe Info	N.A.	LDD0148	[16]
Crotonaldehyde Probe Info	N.A.	LDD0219	[10]
W1 Probe Info	N.A.	LDD0236	[17]
AOyne Probe Info	15.00	LDD0443	[18]
NAIA_5 Probe Info	N.A.	LDD2223	[19]

PAL-AfBPP Probe

Click To Hide/Show 114 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C004 Probe Info	8.88	LDD1714	[20]
C010 Probe Info	6.41	LDD1719	[20]
C011 Probe Info	11.39	LDD1720	[20]
C017 Probe Info	10.13	LDD1725	[20]
C022 Probe Info	8.46	LDD1728	[20]
C049 Probe Info	5.82	LDD1747	[20]
C055 Probe Info	15.24	LDD1752	[20]
C056 Probe Info	22.94	LDD1753	[20]
C063 Probe Info	14.22	LDD1760	[20]
C064 Probe Info	6.45	LDD1761	[20]
C070 Probe Info	10.56	LDD1766	[20]
C087 Probe Info	12.64	LDD1779	[20]
C091 Probe Info	11.16	LDD1782	[20]
C092 Probe Info	17.03	LDD1783	[20]
C094 Probe Info	25.28	LDD1785	[20]
C106 Probe Info	21.26	LDD1793	[20]
C107 Probe Info	6.82	LDD1794	[20]
C108 Probe Info	12.13	LDD1795	[20]
C112 Probe Info	23.10	LDD1799	[20]
C129 Probe Info	6.92	LDD1811	[20]
C130 Probe Info	8.06	LDD1812	[20]
C134 Probe Info	22.94	LDD1816	[20]
C138 Probe Info	5.13	LDD1820	[20]
C141 Probe Info	13.74	LDD1823	[20]
C143 Probe Info	15.56	LDD1825	[20]
C145 Probe Info	9.58	LDD1827	[20]
C153 Probe Info	15.45	LDD1834	[20]
C163 Probe Info	6.06	LDD1843	[20]
C169 Probe Info	35.75	LDD1849	[20]
C170 Probe Info	10.06	LDD1850	[20]
C174 Probe Info	5.35	LDD1854	[20]
C186 Probe Info	10.20	LDD1864	[20]
C197 Probe Info	5.46	LDD1873	[20]
C198 Probe Info	13.36	LDD1874	[20]
C208 Probe Info	6.63	LDD1883	[20]
C210 Probe Info	88.65	LDD1884	[20]
C211 Probe Info	10.85	LDD1885	[20]
C212 Probe Info	6.36	LDD1886	[20]
C213 Probe Info	24.25	LDD1887	[20]
C214 Probe Info	7.67	LDD1888	[20]
C217 Probe Info	7.26	LDD1891	[20]
C218 Probe Info	15.35	LDD1892	[20]
C219 Probe Info	8.40	LDD1893	[20]
C220 Probe Info	23.10	LDD1894	[20]
C221 Probe Info	9.78	LDD1895	[20]
C222 Probe Info	5.35	LDD1896	[20]
C223 Probe Info	5.74	LDD1897	[20]
C225 Probe Info	8.75	LDD1898	[20]
C226 Probe Info	7.89	LDD1899	[20]
C228 Probe Info	33.36	LDD1901	[20]
C229 Probe Info	17.75	LDD1902	[20]
C231 Probe Info	44.63	LDD1904	[20]
C232 Probe Info	99.73	LDD1905	[20]
C233 Probe Info	18.38	LDD1906	[20]
C234 Probe Info	14.83	LDD1907	[20]
C235 Probe Info	71.51	LDD1908	[20]
C243 Probe Info	14.03	LDD1916	[20]
C249 Probe Info	13.45	LDD1922	[20]
C260 Probe Info	5.39	LDD1932	[20]
C264 Probe Info	24.08	LDD1935	[20]
C265 Probe Info	16.80	LDD1936	[20]
C269 Probe Info	7.36	LDD1939	[20]
C270 Probe Info	7.52	LDD1940	[20]
C280 Probe Info	9.65	LDD1950	[20]
C282 Probe Info	18.13	LDD1952	[20]
C284 Probe Info	39.95	LDD1954	[20]
C288 Probe Info	6.68	LDD1958	[20]
C289 Probe Info	28.05	LDD1959	[20]
C296 Probe Info	20.39	LDD1966	[20]
C299 Probe Info	7.26	LDD1968	[20]
C302 Probe Info	6.77	LDD1971	[20]
C305 Probe Info	19.43	LDD1974	[20]
C307 Probe Info	5.43	LDD1975	[20]
C310 Probe Info	12.04	LDD1977	[20]
C313 Probe Info	12.30	LDD1980	[20]
C314 Probe Info	35.75	LDD1981	[20]
C317 Probe Info	5.74	LDD1983	[20]
C322 Probe Info	5.82	LDD1988	[20]
C326 Probe Info	10.78	LDD1990	[20]
C349 Probe Info	9.38	LDD2010	[20]
C354 Probe Info	7.94	LDD2015	[20]
C376 Probe Info	24.59	LDD2036	[20]
C378 Probe Info	12.64	LDD2037	[20]
C380 Probe Info	14.72	LDD2039	[20]
C382 Probe Info	21.11	LDD2041	[20]
C383 Probe Info	17.51	LDD2042	[20]
C386 Probe Info	9.25	LDD2045	[20]
C388 Probe Info	50.21	LDD2047	[20]
C390 Probe Info	25.99	LDD2049	[20]
C399 Probe Info	17.75	LDD2058	[20]
C400 Probe Info	5.17	LDD2059	[20]
C403 Probe Info	30.27	LDD2061	[20]
C407 Probe Info	22.01	LDD2064	[20]
C409 Probe Info	5.98	LDD2066	[20]
C420 Probe Info	15.67	LDD2075	[20]
C426 Probe Info	14.22	LDD2081	[20]
C430 Probe Info	5.62	LDD2085	[20]
C431 Probe Info	17.63	LDD2086	[20]
FFF probe11 Probe Info	16.96	LDD0471	[21]
FFF probe12 Probe Info	11.34	LDD0473	[21]
FFF probe13 Probe Info	20.00	LDD0475	[21]
FFF probe14 Probe Info	15.35	LDD0477	[21]
FFF probe15 Probe Info	7.80	LDD0478	[21]
FFF probe2 Probe Info	20.00	LDD0463	[21]
FFF probe3 Probe Info	19.95	LDD0464	[21]
FFF probe4 Probe Info	14.09	LDD0466	[21]
FFF probe6 Probe Info	7.45	LDD0467	[21]
FFF probe7 Probe Info	5.53	LDD0483	[21]
FFF probe9 Probe Info	20.00	LDD0470	[21]
JN0003 Probe Info	17.90	LDD0469	[21]
STS-2 Probe Info	N.A.	LDD0139	[22]
DA-2 Probe Info	N.A.	LDD0072	[23]
OEA-DA Probe Info	10.82	LDD0046	[24]
STS-1 Probe Info	N.A.	LDD0068	[25]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HCT 116	C32(1.16)	LDD0531	[11]
LDCM0215	AC10	HCT 116	C32(0.69)	LDD0532	[11]
LDCM0216	AC100	HCT 116	C32(1.08)	LDD0533	[11]
LDCM0217	AC101	HCT 116	C32(1.16)	LDD0534	[11]
LDCM0218	AC102	HCT 116	C32(0.75)	LDD0535	[11]
LDCM0219	AC103	HCT 116	C32(0.94)	LDD0536	[11]
LDCM0220	AC104	HCT 116	C32(0.87)	LDD0537	[11]
LDCM0221	AC105	HCT 116	C32(0.75)	LDD0538	[11]
LDCM0222	AC106	HCT 116	C32(0.88)	LDD0539	[11]
LDCM0223	AC107	HCT 116	C32(0.91)	LDD0540	[11]
LDCM0224	AC108	HCT 116	C32(0.73)	LDD0541	[11]
LDCM0225	AC109	HCT 116	C32(0.72)	LDD0542	[11]
LDCM0226	AC11	HCT 116	C32(0.77)	LDD0543	[11]
LDCM0227	AC110	HCT 116	C32(0.91)	LDD0544	[11]
LDCM0228	AC111	HCT 116	C32(0.96)	LDD0545	[11]
LDCM0229	AC112	HCT 116	C32(0.92)	LDD0546	[11]
LDCM0230	AC113	HCT 116	C32(1.16)	LDD0547	[11]
LDCM0231	AC114	HCT 116	C32(0.84)	LDD0548	[11]
LDCM0232	AC115	HCT 116	C32(0.80)	LDD0549	[11]
LDCM0233	AC116	HCT 116	C32(0.90)	LDD0550	[11]
LDCM0234	AC117	HCT 116	C32(1.11)	LDD0551	[11]
LDCM0235	AC118	HCT 116	C32(0.96)	LDD0552	[11]
LDCM0236	AC119	HCT 116	C32(1.31)	LDD0553	[11]
LDCM0237	AC12	HCT 116	C32(0.81)	LDD0554	[11]
LDCM0238	AC120	HCT 116	C32(1.10)	LDD0555	[11]
LDCM0239	AC121	HCT 116	C32(1.29)	LDD0556	[11]
LDCM0240	AC122	HCT 116	C32(0.84)	LDD0557	[11]
LDCM0241	AC123	HCT 116	C32(0.80)	LDD0558	[11]
LDCM0242	AC124	HCT 116	C32(1.02)	LDD0559	[11]
LDCM0243	AC125	HCT 116	C32(0.90)	LDD0560	[11]
LDCM0244	AC126	HCT 116	C32(0.92)	LDD0561	[11]
LDCM0245	AC127	HCT 116	C32(0.82)	LDD0562	[11]
LDCM0246	AC128	HCT 116	C32(1.13)	LDD0563	[11]
LDCM0247	AC129	HCT 116	C32(0.98)	LDD0564	[11]
LDCM0249	AC130	HCT 116	C32(0.93)	LDD0566	[11]
LDCM0250	AC131	HCT 116	C32(1.03)	LDD0567	[11]
LDCM0251	AC132	HCT 116	C32(1.09)	LDD0568	[11]
LDCM0252	AC133	HCT 116	C32(0.99)	LDD0569	[11]
LDCM0253	AC134	HCT 116	C32(0.95)	LDD0570	[11]
LDCM0254	AC135	HCT 116	C32(0.98)	LDD0571	[11]
LDCM0255	AC136	HCT 116	C32(0.99)	LDD0572	[11]
LDCM0256	AC137	HCT 116	C32(1.05)	LDD0573	[11]
LDCM0257	AC138	HCT 116	C32(1.03)	LDD0574	[11]
LDCM0258	AC139	HCT 116	C32(1.04)	LDD0575	[11]
LDCM0259	AC14	HCT 116	C32(0.87)	LDD0576	[11]
LDCM0260	AC140	HCT 116	C32(1.05)	LDD0577	[11]
LDCM0261	AC141	HCT 116	C32(1.02)	LDD0578	[11]
LDCM0262	AC142	HCT 116	C32(1.08)	LDD0579	[11]
LDCM0263	AC143	HCT 116	C32(0.88)	LDD0580	[11]
LDCM0264	AC144	HCT 116	C32(0.56)	LDD0581	[11]
LDCM0265	AC145	HCT 116	C32(0.74)	LDD0582	[11]
LDCM0266	AC146	HCT 116	C32(0.79)	LDD0583	[11]
LDCM0267	AC147	HCT 116	C32(0.69)	LDD0584	[11]
LDCM0268	AC148	HCT 116	C32(0.80)	LDD0585	[11]
LDCM0269	AC149	HCT 116	C32(0.66)	LDD0586	[11]
LDCM0270	AC15	HCT 116	C32(0.70)	LDD0587	[11]
LDCM0271	AC150	HCT 116	C32(0.88)	LDD0588	[11]
LDCM0272	AC151	HCT 116	C32(0.69)	LDD0589	[11]
LDCM0273	AC152	HCT 116	C32(0.59)	LDD0590	[11]
LDCM0274	AC153	HCT 116	C32(0.81)	LDD0591	[11]
LDCM0621	AC154	HCT 116	C32(0.68)	LDD2158	[11]
LDCM0622	AC155	HCT 116	C32(0.76)	LDD2159	[11]
LDCM0623	AC156	HCT 116	C32(0.79)	LDD2160	[11]
LDCM0624	AC157	HCT 116	C32(0.64)	LDD2161	[11]
LDCM0276	AC17	PaTu 8988t	C32(0.88)	LDD1155	[11]
LDCM0277	AC18	PaTu 8988t	C32(0.78)	LDD1156	[11]
LDCM0278	AC19	PaTu 8988t	C32(0.82)	LDD1157	[11]
LDCM0279	AC2	HCT 116	C32(1.29)	LDD0596	[11]
LDCM0280	AC20	PaTu 8988t	C32(0.79)	LDD1159	[11]
LDCM0281	AC21	PaTu 8988t	C32(0.81)	LDD1160	[11]
LDCM0282	AC22	PaTu 8988t	C32(0.91)	LDD1161	[11]
LDCM0283	AC23	PaTu 8988t	C32(0.81)	LDD1162	[11]
LDCM0284	AC24	PaTu 8988t	C32(0.76)	LDD1163	[11]
LDCM0285	AC25	PaTu 8988t	C32(1.25)	LDD1164	[11]
LDCM0286	AC26	PaTu 8988t	C32(1.22)	LDD1165	[11]
LDCM0287	AC27	PaTu 8988t	C32(1.18)	LDD1166	[11]
LDCM0288	AC28	PaTu 8988t	C32(1.15)	LDD1167	[11]
LDCM0289	AC29	PaTu 8988t	C32(1.21)	LDD1168	[11]
LDCM0290	AC3	HCT 116	C32(1.31)	LDD0607	[11]
LDCM0291	AC30	PaTu 8988t	C32(1.27)	LDD1170	[11]
LDCM0292	AC31	PaTu 8988t	C32(1.17)	LDD1171	[11]
LDCM0293	AC32	PaTu 8988t	C32(1.18)	LDD1172	[11]
LDCM0294	AC33	PaTu 8988t	C32(1.05)	LDD1173	[11]
LDCM0295	AC34	PaTu 8988t	C32(1.21)	LDD1174	[11]
LDCM0296	AC35	HCT 116	C32(1.02)	LDD0613	[11]
LDCM0297	AC36	HCT 116	C32(1.10)	LDD0614	[11]
LDCM0298	AC37	HCT 116	C32(1.00)	LDD0615	[11]
LDCM0299	AC38	HCT 116	C32(0.70)	LDD0616	[11]
LDCM0300	AC39	HCT 116	C32(0.79)	LDD0617	[11]
LDCM0301	AC4	HCT 116	C32(1.09)	LDD0618	[11]
LDCM0302	AC40	HCT 116	C32(1.25)	LDD0619	[11]
LDCM0303	AC41	HCT 116	C32(0.77)	LDD0620	[11]
LDCM0304	AC42	HCT 116	C32(0.93)	LDD0621	[11]
LDCM0305	AC43	HCT 116	C32(0.89)	LDD0622	[11]
LDCM0306	AC44	HCT 116	C32(0.84)	LDD0623	[11]
LDCM0307	AC45	HCT 116	C32(0.84)	LDD0624	[11]
LDCM0308	AC46	HCT 116	C32(1.01)	LDD0625	[11]
LDCM0309	AC47	HCT 116	C32(1.06)	LDD0626	[11]
LDCM0310	AC48	HCT 116	C32(0.93)	LDD0627	[11]
LDCM0311	AC49	HCT 116	C32(1.13)	LDD0628	[11]
LDCM0312	AC5	HCT 116	C32(1.31)	LDD0629	[11]
LDCM0313	AC50	HCT 116	C32(1.17)	LDD0630	[11]
LDCM0314	AC51	HCT 116	C32(1.07)	LDD0631	[11]
LDCM0315	AC52	HCT 116	C32(1.16)	LDD0632	[11]
LDCM0316	AC53	HCT 116	C32(1.09)	LDD0633	[11]
LDCM0317	AC54	HCT 116	C32(1.08)	LDD0634	[11]
LDCM0318	AC55	HCT 116	C32(1.17)	LDD0635	[11]
LDCM0319	AC56	HCT 116	C32(1.31)	LDD0636	[11]
LDCM0320	AC57	HCT 116	C32(1.00)	LDD0637	[11]
LDCM0321	AC58	HCT 116	C32(0.93)	LDD0638	[11]
LDCM0322	AC59	HCT 116	C32(1.05)	LDD0639	[11]
LDCM0323	AC6	HCT 116	C32(0.75)	LDD0640	[11]
LDCM0324	AC60	HCT 116	C32(0.96)	LDD0641	[11]
LDCM0325	AC61	HCT 116	C32(0.95)	LDD0642	[11]
LDCM0326	AC62	HCT 116	C32(1.08)	LDD0643	[11]
LDCM0327	AC63	HCT 116	C32(1.00)	LDD0644	[11]
LDCM0328	AC64	HCT 116	C32(1.09)	LDD0645	[11]
LDCM0329	AC65	HCT 116	C32(1.68)	LDD0646	[11]
LDCM0330	AC66	HCT 116	C32(1.50)	LDD0647	[11]
LDCM0331	AC67	HCT 116	C32(1.28)	LDD0648	[11]
LDCM0332	AC68	PaTu 8988t	C32(0.96)	LDD1211	[11]
LDCM0333	AC69	PaTu 8988t	C32(0.87)	LDD1212	[11]
LDCM0334	AC7	HCT 116	C32(0.98)	LDD0651	[11]
LDCM0335	AC70	PaTu 8988t	C32(0.83)	LDD1214	[11]
LDCM0336	AC71	PaTu 8988t	C32(1.00)	LDD1215	[11]
LDCM0337	AC72	PaTu 8988t	C32(1.23)	LDD1216	[11]
LDCM0338	AC73	PaTu 8988t	C32(0.85)	LDD1217	[11]
LDCM0339	AC74	PaTu 8988t	C32(0.82)	LDD1218	[11]
LDCM0340	AC75	PaTu 8988t	C32(0.78)	LDD1219	[11]
LDCM0341	AC76	PaTu 8988t	C32(0.90)	LDD1220	[11]
LDCM0342	AC77	PaTu 8988t	C32(0.74)	LDD1221	[11]
LDCM0343	AC78	PaTu 8988t	C32(0.81)	LDD1222	[11]
LDCM0344	AC79	PaTu 8988t	C32(0.77)	LDD1223	[11]
LDCM0345	AC8	HCT 116	C32(0.81)	LDD0662	[11]
LDCM0346	AC80	PaTu 8988t	C32(0.72)	LDD1225	[11]
LDCM0347	AC81	PaTu 8988t	C32(0.71)	LDD1226	[11]
LDCM0348	AC82	PaTu 8988t	C32(0.74)	LDD1227	[11]
LDCM0349	AC83	PaTu 8988t	C32(1.01)	LDD1228	[11]
LDCM0350	AC84	PaTu 8988t	C32(1.22)	LDD1229	[11]
LDCM0351	AC85	PaTu 8988t	C32(1.05)	LDD1230	[11]
LDCM0352	AC86	PaTu 8988t	C32(1.13)	LDD1231	[11]
LDCM0353	AC87	PaTu 8988t	C32(1.07)	LDD1232	[11]
LDCM0354	AC88	PaTu 8988t	C32(1.07)	LDD1233	[11]
LDCM0355	AC89	PaTu 8988t	C32(1.15)	LDD1234	[11]
LDCM0357	AC90	PaTu 8988t	C32(1.01)	LDD1236	[11]
LDCM0358	AC91	PaTu 8988t	C32(1.13)	LDD1237	[11]
LDCM0359	AC92	PaTu 8988t	C32(1.17)	LDD1238	[11]
LDCM0360	AC93	PaTu 8988t	C32(1.30)	LDD1239	[11]
LDCM0361	AC94	PaTu 8988t	C32(1.32)	LDD1240	[11]
LDCM0362	AC95	PaTu 8988t	C32(1.12)	LDD1241	[11]
LDCM0363	AC96	PaTu 8988t	C32(1.13)	LDD1242	[11]
LDCM0364	AC97	PaTu 8988t	C32(1.28)	LDD1243	[11]
LDCM0365	AC98	HCT 116	C32(0.75)	LDD0682	[11]
LDCM0366	AC99	HCT 116	C32(0.84)	LDD0683	[11]
LDCM0248	AKOS034007472	HCT 116	C32(0.94)	LDD0565	[11]
LDCM0356	AKOS034007680	HCT 116	C32(0.90)	LDD0673	[11]
LDCM0275	AKOS034007705	HCT 116	C32(0.82)	LDD0592	[11]
LDCM0156	Aniline	NCI-H1299	11.57	LDD0403	[1]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[10]
LDCM0367	CL1	HCT 116	C32(1.06)	LDD0684	[11]
LDCM0368	CL10	HCT 116	C32(0.93)	LDD0685	[11]
LDCM0369	CL100	HCT 116	C32(1.17)	LDD0686	[11]
LDCM0370	CL101	HCT 116	C32(0.95)	LDD0687	[11]
LDCM0371	CL102	HCT 116	C32(1.14)	LDD0688	[11]
LDCM0372	CL103	HCT 116	C32(0.94)	LDD0689	[11]
LDCM0373	CL104	HCT 116	C32(0.73)	LDD0690	[11]
LDCM0374	CL105	PaTu 8988t	C32(0.87)	LDD1253	[11]
LDCM0375	CL106	PaTu 8988t	C32(0.85)	LDD1254	[11]
LDCM0376	CL107	PaTu 8988t	C32(0.76)	LDD1255	[11]
LDCM0377	CL108	PaTu 8988t	C32(0.92)	LDD1256	[11]
LDCM0378	CL109	PaTu 8988t	C32(0.85)	LDD1257	[11]
LDCM0379	CL11	HCT 116	C32(1.05)	LDD0696	[11]
LDCM0380	CL110	PaTu 8988t	C32(0.76)	LDD1259	[11]
LDCM0381	CL111	PaTu 8988t	C32(0.84)	LDD1260	[11]
LDCM0382	CL112	PaTu 8988t	C32(1.20)	LDD1261	[11]
LDCM0383	CL113	PaTu 8988t	C32(1.15)	LDD1262	[11]
LDCM0384	CL114	PaTu 8988t	C32(1.13)	LDD1263	[11]
LDCM0385	CL115	PaTu 8988t	C32(1.21)	LDD1264	[11]
LDCM0386	CL116	PaTu 8988t	C32(1.25)	LDD1265	[11]
LDCM0387	CL117	HCT 116	C32(0.70)	LDD0704	[11]
LDCM0388	CL118	HCT 116	C32(1.27)	LDD0705	[11]
LDCM0389	CL119	HCT 116	C32(1.46)	LDD0706	[11]
LDCM0390	CL12	HCT 116	C32(1.00)	LDD0707	[11]
LDCM0391	CL120	HCT 116	C32(0.98)	LDD0708	[11]
LDCM0392	CL121	HCT 116	C32(0.56)	LDD0709	[11]
LDCM0393	CL122	HCT 116	C32(1.07)	LDD0710	[11]
LDCM0394	CL123	HCT 116	C32(1.04)	LDD0711	[11]
LDCM0395	CL124	HCT 116	C32(1.24)	LDD0712	[11]
LDCM0396	CL125	HCT 116	C32(1.31)	LDD0713	[11]
LDCM0397	CL126	HCT 116	C32(0.97)	LDD0714	[11]
LDCM0398	CL127	HCT 116	C32(0.98)	LDD0715	[11]
LDCM0399	CL128	HCT 116	C32(1.12)	LDD0716	[11]
LDCM0400	CL13	HCT 116	C32(1.00)	LDD0717	[11]
LDCM0401	CL14	HCT 116	C32(0.95)	LDD0718	[11]
LDCM0402	CL15	HCT 116	C32(0.87)	LDD0719	[11]
LDCM0403	CL16	HCT 116	C32(1.01)	LDD0720	[11]
LDCM0404	CL17	HCT 116	C32(0.84)	LDD0721	[11]
LDCM0405	CL18	HCT 116	C32(0.73)	LDD0722	[11]
LDCM0406	CL19	HCT 116	C32(0.80)	LDD0723	[11]
LDCM0407	CL2	HCT 116	C32(1.09)	LDD0724	[11]
LDCM0408	CL20	HCT 116	C32(0.87)	LDD0725	[11]
LDCM0409	CL21	HCT 116	C32(0.78)	LDD0726	[11]
LDCM0410	CL22	HCT 116	C32(1.13)	LDD0727	[11]
LDCM0411	CL23	HCT 116	C32(0.93)	LDD0728	[11]
LDCM0412	CL24	HCT 116	C32(0.96)	LDD0729	[11]
LDCM0413	CL25	HCT 116	C32(0.91)	LDD0730	[11]
LDCM0414	CL26	HCT 116	C32(0.79)	LDD0731	[11]
LDCM0415	CL27	HCT 116	C32(0.80)	LDD0732	[11]
LDCM0416	CL28	HCT 116	C32(0.82)	LDD0733	[11]
LDCM0417	CL29	HCT 116	C32(0.81)	LDD0734	[11]
LDCM0418	CL3	HCT 116	C32(1.07)	LDD0735	[11]
LDCM0419	CL30	HCT 116	C32(0.91)	LDD0736	[11]
LDCM0420	CL31	HCT 116	C32(0.77)	LDD0737	[11]
LDCM0421	CL32	HCT 116	C32(0.67)	LDD0738	[11]
LDCM0422	CL33	HCT 116	C32(0.55)	LDD0739	[11]
LDCM0423	CL34	HCT 116	C32(0.86)	LDD0740	[11]
LDCM0424	CL35	HCT 116	C32(0.79)	LDD0741	[11]
LDCM0425	CL36	HCT 116	C32(0.75)	LDD0742	[11]
LDCM0426	CL37	HCT 116	C32(0.93)	LDD0743	[11]
LDCM0428	CL39	HCT 116	C32(0.81)	LDD0745	[11]
LDCM0429	CL4	HCT 116	C32(1.00)	LDD0746	[11]
LDCM0430	CL40	HCT 116	C32(0.79)	LDD0747	[11]
LDCM0431	CL41	HCT 116	C32(0.78)	LDD0748	[11]
LDCM0432	CL42	HCT 116	C32(0.87)	LDD0749	[11]
LDCM0433	CL43	HCT 116	C32(0.81)	LDD0750	[11]
LDCM0434	CL44	HCT 116	C32(0.69)	LDD0751	[11]
LDCM0435	CL45	HCT 116	C32(0.78)	LDD0752	[11]
LDCM0436	CL46	PaTu 8988t	C32(0.84)	LDD1315	[11]
LDCM0437	CL47	PaTu 8988t	C32(0.88)	LDD1316	[11]
LDCM0438	CL48	PaTu 8988t	C32(0.78)	LDD1317	[11]
LDCM0439	CL49	PaTu 8988t	C32(0.81)	LDD1318	[11]
LDCM0440	CL5	HCT 116	C32(0.91)	LDD0757	[11]
LDCM0441	CL50	PaTu 8988t	C32(0.69)	LDD1320	[11]
LDCM0442	CL51	PaTu 8988t	C32(0.78)	LDD1321	[11]
LDCM0443	CL52	PaTu 8988t	C32(0.76)	LDD1322	[11]
LDCM0444	CL53	PaTu 8988t	C32(0.71)	LDD1323	[11]
LDCM0445	CL54	PaTu 8988t	C32(0.85)	LDD1324	[11]
LDCM0446	CL55	PaTu 8988t	C32(0.74)	LDD1325	[11]
LDCM0447	CL56	PaTu 8988t	C32(0.54)	LDD1326	[11]
LDCM0448	CL57	PaTu 8988t	C32(0.80)	LDD1327	[11]
LDCM0449	CL58	PaTu 8988t	C32(0.78)	LDD1328	[11]
LDCM0450	CL59	PaTu 8988t	C32(0.87)	LDD1329	[11]
LDCM0451	CL6	HCT 116	C32(0.87)	LDD0768	[11]
LDCM0452	CL60	PaTu 8988t	C32(0.84)	LDD1331	[11]
LDCM0453	CL61	HCT 116	C32(0.98)	LDD0770	[11]
LDCM0454	CL62	HCT 116	C32(1.03)	LDD0771	[11]
LDCM0455	CL63	HCT 116	C32(0.93)	LDD0772	[11]
LDCM0456	CL64	HCT 116	C32(0.91)	LDD0773	[11]
LDCM0457	CL65	HCT 116	C32(1.04)	LDD0774	[11]
LDCM0458	CL66	HCT 116	C32(0.96)	LDD0775	[11]
LDCM0459	CL67	HCT 116	C32(0.95)	LDD0776	[11]
LDCM0460	CL68	HCT 116	C32(0.86)	LDD0777	[11]
LDCM0461	CL69	HCT 116	C32(0.90)	LDD0778	[11]
LDCM0462	CL7	HCT 116	C32(1.01)	LDD0779	[11]
LDCM0463	CL70	HCT 116	C32(0.92)	LDD0780	[11]
LDCM0464	CL71	HCT 116	C32(0.88)	LDD0781	[11]
LDCM0465	CL72	HCT 116	C32(1.03)	LDD0782	[11]
LDCM0466	CL73	HCT 116	C32(0.96)	LDD0783	[11]
LDCM0467	CL74	HCT 116	C32(0.93)	LDD0784	[11]
LDCM0469	CL76	PaTu 8988t	C32(1.01)	LDD1348	[11]
LDCM0470	CL77	PaTu 8988t	C32(1.01)	LDD1349	[11]
LDCM0471	CL78	PaTu 8988t	C32(0.80)	LDD1350	[11]
LDCM0472	CL79	PaTu 8988t	C32(0.94)	LDD1351	[11]
LDCM0473	CL8	HCT 116	C32(1.16)	LDD0790	[11]
LDCM0474	CL80	PaTu 8988t	C32(0.79)	LDD1353	[11]
LDCM0475	CL81	PaTu 8988t	C32(0.82)	LDD1354	[11]
LDCM0476	CL82	PaTu 8988t	C32(0.88)	LDD1355	[11]
LDCM0477	CL83	PaTu 8988t	C32(0.77)	LDD1356	[11]
LDCM0478	CL84	PaTu 8988t	C32(0.90)	LDD1357	[11]
LDCM0479	CL85	PaTu 8988t	C32(0.90)	LDD1358	[11]
LDCM0480	CL86	PaTu 8988t	C32(0.85)	LDD1359	[11]
LDCM0481	CL87	PaTu 8988t	C32(0.87)	LDD1360	[11]
LDCM0482	CL88	PaTu 8988t	C32(0.85)	LDD1361	[11]
LDCM0483	CL89	PaTu 8988t	C32(0.89)	LDD1362	[11]
LDCM0484	CL9	HCT 116	C32(0.92)	LDD0801	[11]
LDCM0485	CL90	PaTu 8988t	C32(0.82)	LDD1364	[11]
LDCM0486	CL91	HCT 116	C32(1.17)	LDD0803	[11]
LDCM0487	CL92	HCT 116	C32(1.41)	LDD0804	[11]
LDCM0488	CL93	HCT 116	C32(1.33)	LDD0805	[11]
LDCM0489	CL94	HCT 116	C32(1.09)	LDD0806	[11]
LDCM0490	CL95	HCT 116	C32(1.04)	LDD0807	[11]
LDCM0491	CL96	HCT 116	C32(1.26)	LDD0808	[11]
LDCM0492	CL97	HCT 116	C32(1.18)	LDD0809	[11]
LDCM0493	CL98	HCT 116	C32(1.30)	LDD0810	[11]
LDCM0494	CL99	HCT 116	C32(1.12)	LDD0811	[11]
LDCM0495	E2913	HEK-293T	C32(0.97)	LDD1698	[26]
LDCM0175	Ethacrynic acid	HeLa	C32(1.20); C32(1.26)	LDD2210	[9]
LDCM0625	F8	Ramos	C32(0.78)	LDD2187	[27]
LDCM0572	Fragment10	Ramos	C32(1.11)	LDD2189	[27]
LDCM0573	Fragment11	Ramos	C32(0.18)	LDD2190	[27]
LDCM0574	Fragment12	Ramos	C32(3.58)	LDD2191	[27]
LDCM0575	Fragment13	Ramos	C32(0.45)	LDD2192	[27]
LDCM0576	Fragment14	Ramos	C32(3.74)	LDD2193	[27]
LDCM0580	Fragment21	Ramos	C32(0.85)	LDD2195	[27]
LDCM0582	Fragment23	Ramos	C32(0.63)	LDD2196	[27]
LDCM0578	Fragment27	Ramos	C32(0.71)	LDD2197	[27]
LDCM0586	Fragment28	Ramos	C32(0.74)	LDD2198	[27]
LDCM0588	Fragment30	Ramos	C32(0.57)	LDD2199	[27]
LDCM0589	Fragment31	Ramos	C32(0.71)	LDD2200	[27]
LDCM0468	Fragment33	HCT 116	C32(1.07)	LDD0785	[11]
LDCM0596	Fragment38	Ramos	C32(0.80)	LDD2203	[27]
LDCM0566	Fragment4	Ramos	C32(2.32)	LDD2184	[27]
LDCM0427	Fragment51	HCT 116	C32(0.92)	LDD0744	[11]
LDCM0610	Fragment52	Ramos	C32(0.64)	LDD2204	[27]
LDCM0614	Fragment56	Ramos	C32(0.34)	LDD2205	[27]
LDCM0569	Fragment7	Ramos	C32(2.20)	LDD2186	[27]
LDCM0015	HNE	MDA-MB-231	C32(1.00)	LDD0346	[27]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[10]
LDCM0022	KB02	HEK-293T	C32(1.01)	LDD1492	[26]
LDCM0023	KB03	HEK-293T	C32(0.91)	LDD1497	[26]
LDCM0024	KB05	COLO792	C32(3.89)	LDD3310	[28]
LDCM0109	NEM	HeLa	N.A.	LDD0227	[10]
LDCM0627	NUDT7-COV-1	HEK-293T	C32(1.26)	LDD2206	[29]
LDCM0628	OTUB2-COV-1	HEK-293T	C32(0.62)	LDD2207	[29]
LDCM0131	RA190	MM1.R	C32(1.68)	LDD0304	[30]
LDCM0016	Ranjitkar_cp1	MDA-MB-231	4.55	LDD0123	[8]
LDCM0110	W12	Hep-G2	K22(0.68); Q23(0.68)	LDD0237	[17]
LDCM0113	W17	Hep-G2	K22(1.00); Q23(1.00)	LDD0240	[17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Stimulator of interferon genes protein (STING1)				STING family	Q86WV6
Protein ERGIC-53 (LMAN1)				.	P49257

References

1	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2	Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5	Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
7	A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w. Mass spectrometry data entry: PXD042888
8	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9	Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
13	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
15	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
17	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
20	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
21	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23	Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
25	Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
26	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
27	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
28	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
29	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni