Details of the Target

General Information of Target

Target ID LDTP05538
Target Name Prolow-density lipoprotein receptor-related protein 1 (LRP1)
Gene Name LRP1
Gene ID 4035
Synonyms
A2MR; APR; Prolow-density lipoprotein receptor-related protein 1; LRP-1; Alpha-2-macroglobulin receptor; A2MR; Apolipoprotein E receptor; APOER; CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit; LRP-85; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; LRP-515; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRPICD)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA
PEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGC
QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANE
TVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDI
DDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK
LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFE
NYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACEN
DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG
MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDG
IHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNG
WMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFY
DRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVT
LLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGV
TCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRF
KCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD
CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF
KCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRW
RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC
ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAP
GEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES
CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK
IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT
LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLT
VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNT
LAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT
VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL
DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTN
KKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSG
QKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW
WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQL
CLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG
TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIY
WTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDG
TERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFS
VSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCA
VANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNL
NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVE
NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLD
ECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK
IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI
PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAV
NSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVS
NMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS
ATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY
FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG
DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDD
REFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDG
ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH
INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH
GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV
ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD
KGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSR
SVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLF
EDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGG
CSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCG
DHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC
TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV
DGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ
FRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDC
ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ
CNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTD
NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP
KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN
TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESV
RIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMP
RGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW
GNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI
VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH
QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC
NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPT
GFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM
AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH
CSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGV
VFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPT
NFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
LDLR family
Subcellular location
Cytoplasm; Golgi outpost; Cell membrane; Extracellular side; Peripheral membrane protein
Function
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.; (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
TTD ID
T91130
Uniprot ID
Q07954
DrugMap ID
TT9JAGO
Ensemble ID
ENST00000243077.8
HGNC ID
HGNC:6692
ChEMBL ID
CHEMBL4630884

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P3318H DBIA    Probe Info 
AGS SNV: p.C4222S DBIA    Probe Info 
AN3CA SNV: p.C519Y; p.Q1804H DBIA    Probe Info 
CAL148 SNV: p.E2323K .
CAL27 SNV: p.W3974C .
CCLP1 SNV: p.E2196A DBIA    Probe Info 
CHL1 SNV: p.P1029L DBIA    Probe Info 
CORL88 SNV: p.Q255E DBIA    Probe Info 
DU145 SNV: p.N4110T; p.S4251F DBIA    Probe Info 
EFO27 SNV: p.R3274Q; p.R3714C DBIA    Probe Info 
FTC133 SNV: p.W383R DBIA    Probe Info 
G415 SNV: p.P3655T DBIA    Probe Info 
HCT116 Deletion: p.R3612AfsTer171;p.G4514AfsTer26
Insertion: p.D1163Ter
SNV: p.E594Q;p.H3598N		 .
HCT15 SNV: p.Y530H; p.V1619L .
HEC1 SNV: p.F566L; p.R1880W; p.R3797C DBIA    Probe Info 
HEC1B SNV: p.R2509Ter .
HGC27 SNV: p.S2705N DBIA    Probe Info 
HS936T SNV: p.A1642V DBIA    Probe Info 
HT Deletion: p.E1490RfsTer80 DBIA    Probe Info 
HT115 SNV: p.A1228T .
IM95 SNV: p.D3824Y DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.W2027C DBIA    Probe Info 
JHH7 SNV: p.I2278V .
JURKAT SNV: p.G1356S; p.C2342Y; p.G4514A .
KARPAS422 SNV: p.L4202P; p.F4205L DBIA    Probe Info 
KMS27 SNV: p.A2128G DBIA    Probe Info 
LN229 SNV: p.T3950I DBIA    Probe Info 
LNCaP clone FGC SNV: p.E2196K DBIA    Probe Info 
MFE296 SNV: p.P2548T DBIA    Probe Info 
MFE319 SNV: p.D2797E; p.A2801V; p.S4386F DBIA    Probe Info 
MOLT4 SNV: p.D298N; p.R350H; p.R712C; p.G1819D; p.A4064T; p.R4533W IA-alkyne    Probe Info 
NALM6 SNV: p.V1244M; p.A3873T .
NCIH1666 SNV: p.R808Q DBIA    Probe Info 
NCIH2291 SNV: p.D717N .
NCIH716 SNV: p.Y2200Ter; p.L2945P; p.R3753P .
OVCAR4 SNV: p.V2520G DBIA    Probe Info 
OVK18 SNV: p.M1809T DBIA    Probe Info 
OVTOKO SNV: p.V1852F DBIA    Probe Info 
PF382 SNV: p.R3547H .
RKO SNV: p.R1880W; p.A2240V DBIA    Probe Info 
SKMEL5 SNV: p.P1029L DBIA    Probe Info 
SNU1 Insertion: p.E1490GfsTer6
SNV: p.L320P		 DBIA    Probe Info 
SUPT1 SNV: p.R1297C; p.R2841C .
SW1271 SNV: p.G4439V .
SW948 SNV: p.E3250Ter DBIA    Probe Info 
TE4 SNV: p.G3523V DBIA    Probe Info 
TGBC1TKB SNV: p.Y1487H DBIA    Probe Info 
TGBC52TKB SNV: p.Q2463R DBIA    Probe Info 
TOV21G SNV: p.A1416T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.55  LDD0318  [1]
OPA-S-S-alkyne
 Probe Info  		K3910(1.43); K2653(1.54); K806(1.57); K587(1.62)  LDD3494  [2]
IPM
 Probe Info  		C3754(4.18)  LDD1701  [3]
DBIA
 Probe Info  		C2939(0.94); C2944(0.94); C3822(0.94); C3828(0.94)  LDD0078  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
IA-alkyne
 Probe Info  		C4330(0.00); C3709(0.00); C4294(0.00); C1075(0.00)  LDD0162  [6]
TFBX
 Probe Info  		C3860(0.00); C2660(0.00); C3021(0.00)  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C115
 Probe Info  		7.21  LDD1802  [9]
C149
 Probe Info  		8.34  LDD1830  [9]
C170
 Probe Info  		15.14  LDD1850  [9]
C221
 Probe Info  		6.87  LDD1895  [9]
C223
 Probe Info  		7.62  LDD1897  [9]
C237
 Probe Info  		10.70  LDD1910  [9]
C302
 Probe Info  		11.31  LDD1971  [9]
C310
 Probe Info  		18.90  LDD1977  [9]
C425
 Probe Info  		10.93  LDD2080  [9]
C433
 Probe Info  		6.63  LDD2088  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C3119(1.28)  LDD0812  [4]
 LDCM0215  AC10 HEK-293T C3119(0.98)  LDD0813  [4]
 LDCM0226  AC11 HEK-293T C3119(1.09)  LDD0824  [4]
 LDCM0230  AC113 HEK-293T C3119(0.72)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C3119(0.73)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C3119(1.74)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C3119(0.98)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C3119(0.93)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C3119(1.14)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C3119(1.01)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C3119(1.08)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C3119(0.99)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C3119(2.82)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C3119(1.58)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C3119(1.05)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C3119(1.94)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C3119(2.84)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C3119(0.95)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C3119(0.57)  LDD0843  [4]
 LDCM0259  AC14 HEK-293T C3119(1.30)  LDD0857  [4]
 LDCM0270  AC15 HEK-293T C3119(1.26)  LDD0868  [4]
 LDCM0276  AC17 HEK-293T C4151(0.98); C4330(1.15); C1578(1.05); C2660(0.99)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C3294(1.03); C4151(1.01); C2605(0.86); C2660(1.05)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C3294(1.83); C4151(1.27); C2605(1.36); C1578(1.39)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C3119(1.33)  LDD0877  [4]
 LDCM0280  AC20 HEK-293T C3294(0.99); C2605(1.21); C1578(1.05); C2660(1.02)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C3294(0.99); C4151(0.99); C2605(1.09); C1578(1.03)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C4151(0.98); C2605(1.04); C1578(0.95); C2660(0.98)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C3294(0.95); C4151(1.25); C1578(1.04); C2660(0.94)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C3294(0.97); C4151(0.86); C2605(0.97); C1578(1.00)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C4151(1.18); C4330(1.31); C1578(1.09); C2660(0.97)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C3294(1.08); C4151(0.88); C2605(1.15); C2660(1.01)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C3294(1.05); C4151(0.95); C2605(1.17); C1578(1.05)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C3294(1.04); C2605(1.03); C1578(1.01); C2660(1.02)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C3294(1.05); C4151(0.98); C2605(1.03); C1578(1.04)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C3119(1.23)  LDD0888  [4]
 LDCM0291  AC30 HEK-293T C4151(1.00); C2605(1.05); C1578(0.93); C2660(1.02)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C3294(1.02); C4151(1.18); C1578(1.02); C2660(0.98)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C3294(0.98); C4151(0.86); C2605(1.04); C1578(0.98)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C4151(1.07); C4330(1.25); C1578(1.01); C2660(1.06)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C3294(1.08); C4151(0.95); C2605(0.91); C2660(1.04)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C3294(1.09); C4151(1.01); C2605(1.14); C1578(0.91)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C3294(1.02); C2605(1.03); C1578(1.06); C2660(1.09)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C3294(0.99); C4151(0.96); C2605(0.98); C1578(1.01)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C4151(0.93); C2605(1.03); C1578(0.93); C2660(0.97)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C3294(1.03); C4151(0.84); C1578(1.01); C2660(1.00)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C3119(1.17)  LDD0899  [4]
 LDCM0302  AC40 HEK-293T C3294(0.99); C4151(0.80); C2605(1.03); C1578(1.03)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C4151(0.75); C4330(1.15); C1578(1.00); C2660(0.99)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C3294(1.09); C4151(1.52); C2605(0.91); C2660(1.07)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C3294(1.05); C4151(0.97); C2605(1.21); C1578(0.91)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C3294(1.09); C2605(1.20); C1578(1.09); C2660(1.09)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C3294(1.06); C4151(1.08); C2605(1.12); C1578(1.02)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C4151(1.03); C2605(1.07); C1578(0.95); C2660(0.99)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C3294(1.12); C4151(0.89); C1578(1.05); C2660(0.94)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C3294(0.98); C4151(1.03); C2605(0.99); C1578(0.94)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C4151(1.01); C4330(1.02); C1578(1.01); C2660(1.03)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C3119(1.19)  LDD0910  [4]
 LDCM0313  AC50 HEK-293T C3294(1.04); C4151(0.85); C2605(0.82); C2660(1.08)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C3294(1.01); C4151(1.26); C2605(1.10); C1578(0.97)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C3294(1.07); C2605(1.30); C1578(1.11); C2660(1.02)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C3294(1.02); C4151(0.97); C2605(1.06); C1578(0.99)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C4151(1.14); C2605(1.04); C1578(0.97); C2660(1.05)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C3294(1.00); C4151(0.98); C1578(1.01); C2660(0.94)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C3294(1.00); C4151(0.97); C2605(0.94); C1578(0.99)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C4151(0.84); C4330(1.14); C1578(1.05); C2660(1.07)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C3294(1.13); C4151(0.88); C2605(0.93); C2660(1.09)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C3294(1.05); C4151(0.96); C2605(1.12); C1578(1.02)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C3119(0.87)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C3294(1.12); C2605(1.00); C1578(1.04); C2660(1.07)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C3294(1.12); C4151(1.05); C2605(1.06); C1578(1.02)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C4151(0.88); C2605(0.98); C1578(0.94); C2660(1.02)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C3294(1.07); C4151(0.83); C1578(1.04); C2660(0.99)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C3294(1.01); C4151(1.19); C2605(0.92); C1578(1.01)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C3119(0.86)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C3119(1.46)  LDD0943  [4]
 LDCM0248  AKOS034007472 HEK-293T C3119(1.02)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C3119(1.38)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C3119(1.24)  LDD0873  [4]
 LDCM0020  ARS-1620 HCC44 C2939(0.94); C2944(0.94); C3822(0.94); C3828(0.94)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C3294(1.01); C4151(1.09); C4330(0.86); C2605(1.08)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C4151(1.20); C2605(1.16); C1578(1.41); C2660(1.09)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C3119(1.52)  LDD0967  [4]
 LDCM0370  CL101 HEK-293T C3119(1.37)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C3119(1.23)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C3119(1.18)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C3119(1.30)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C3294(1.02); C4151(1.28); C4330(0.80); C2605(0.94)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C3294(1.01); C4151(0.75); C2605(0.97); C1578(0.91)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C3294(0.99); C4151(0.98); C2605(1.07); C1578(0.87)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C3294(1.18); C4151(1.51); C2605(1.11); C1578(0.94)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C3294(1.01); C4151(0.98); C4330(0.99); C2605(0.94)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C3294(1.18); C4151(0.94); C1578(1.40); C2660(0.96)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C3294(0.98); C4151(0.79); C2605(0.98); C1578(0.88)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C3294(1.06); C4151(0.88); C2605(1.05); C1578(0.98)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C3294(1.21); C4151(1.05); C2605(1.01); C1578(0.92)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C3294(1.15); C4151(1.26); C4330(1.06); C2605(1.07)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C3294(1.04); C4151(0.95); C2605(1.10); C1578(0.93)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C3294(1.10); C4151(1.01); C2605(1.09); C1578(1.04)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C3294(1.08); C4151(1.39); C2605(1.08); C1578(0.91)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C3294(0.98); C4151(1.52); C4330(0.86); C2605(0.93)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C3294(1.26); C4151(1.00); C2605(1.07); C1578(1.11)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C3294(1.11); C4151(0.96); C2605(1.08); C1578(1.02)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C3294(1.14); C4151(1.42); C2605(1.22); C1578(1.33)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C3294(1.16); C4151(0.92); C2605(1.13); C1578(1.11)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C3294(1.02); C4151(1.35); C4330(0.77); C2605(0.94)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C3294(1.03); C4151(0.70); C2605(1.02); C1578(1.01)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C3294(1.08); C4151(0.84); C2605(1.05); C1578(0.92)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C3294(1.03); C4151(0.87); C2605(1.12); C1578(0.99)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C3294(1.01); C4151(1.03); C4330(0.88); C2605(0.92)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C3294(1.08); C4151(0.85); C2605(1.01); C1578(0.99)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C3294(1.12); C4151(0.94); C2605(0.95); C1578(0.97)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C3294(1.22); C4151(1.27); C2605(1.06); C1578(1.01)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C3294(1.13); C4151(1.24); C4330(1.03); C2605(1.00)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C3294(1.14); C4151(0.77); C2605(1.00); C1578(0.96)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C3294(1.25); C4151(1.02); C2605(1.14); C1578(1.05)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C3294(1.25); C4151(1.39); C2605(1.06); C1578(1.04)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C4151(1.37); C4330(1.02); C1578(1.07); C2660(1.06)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C3294(1.11); C4151(1.06); C2605(1.09); C2660(1.01)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C3294(1.06); C4151(1.10); C2605(1.50); C1578(1.05)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C3294(1.11); C4151(0.94); C2605(1.08); C1578(1.04)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C3294(1.05); C2605(1.17); C1578(1.39); C2660(1.06)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C3294(1.16); C4151(0.93); C2605(1.09); C1578(1.45)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C4151(1.05); C2605(1.23); C1578(1.32); C2660(1.01)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C3294(1.00); C4151(1.06); C1578(1.42); C2660(0.95)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C3294(1.04); C4151(1.02); C2605(1.21); C1578(1.29)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C3294(0.95); C4151(1.04); C4330(0.82); C2605(0.92)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C3294(0.99); C4151(0.90); C2605(0.93); C1578(0.96)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C3294(1.08); C4151(0.77); C2605(1.13); C1578(1.01)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C3294(1.03); C4151(1.45); C2605(1.20); C1578(1.06)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C4151(1.08); C4330(1.07); C1578(1.10); C2660(1.01)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C3294(1.14); C4151(1.00); C2605(1.14); C1578(0.96)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C3294(1.03); C4151(0.89); C2605(1.04); C2660(1.08)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C3119(1.03)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C3119(1.11)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C3119(0.82)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C3119(0.89)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C3119(0.90)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C3119(1.08)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C3119(1.27)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C3119(2.02)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C3294(1.14); C4151(1.17); C2605(1.02); C1578(1.10)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C3119(1.42)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C3119(1.07)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C3119(1.90)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C3119(1.41)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C3119(0.93)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C3119(1.41)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C4151(1.09); C2605(1.29); C1578(1.31); C2660(1.05)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C3294(0.97); C4151(1.30); C1578(1.51); C2660(1.04)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C3294(0.99); C4151(0.97); C2605(1.21); C1578(1.36)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C3294(1.07); C4151(1.23); C4330(0.92); C2605(1.03)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C4151(1.07); C4330(1.40); C1578(1.04); C2660(1.12)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C3294(1.07); C4151(0.77); C2605(1.12); C1578(0.97)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C3294(1.17); C4151(0.95); C2605(1.05); C1578(1.07)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C4151(0.78); C4330(1.42); C1578(1.10); C2660(1.01)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C3294(1.02); C4151(1.13); C2605(0.94); C2660(1.05)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C3294(1.08); C4151(1.40); C2605(1.22); C1578(1.19)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C3294(1.03); C2605(1.33); C1578(1.36); C2660(1.00)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C3294(1.32); C4151(1.07); C2605(1.28); C1578(1.39)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C4151(1.04); C2605(1.24); C1578(1.21); C2660(0.99)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C3294(1.09); C4151(1.11); C1578(1.58); C2660(1.05)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C3294(1.12); C4151(1.26); C2605(0.95); C2660(1.03)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C3294(1.06); C4151(1.06); C2605(1.35); C1578(1.42)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C3294(1.02); C4151(1.22); C4330(0.99); C2605(0.95)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C3294(0.96); C4151(0.73); C2605(1.07); C1578(1.09)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C3294(1.04); C4151(0.82); C2605(1.11); C1578(0.94)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C3294(0.95); C4151(1.31); C2605(1.06); C1578(1.01)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C4151(1.13); C4330(1.08); C1578(1.10); C2660(1.06)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C3294(1.01); C4151(1.29); C2605(1.09); C2660(0.99)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C3294(1.07); C4151(1.11); C2605(1.10); C1578(1.08)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C3294(1.02); C2605(1.14); C1578(1.30); C2660(1.09)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C3294(1.08); C4151(1.11); C2605(1.16); C1578(1.20)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C3294(1.09); C4151(1.00); C2605(1.26); C1578(1.20)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C4151(0.97); C2605(1.24); C1578(1.25); C2660(0.99)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C3294(1.04); C4151(1.35); C1578(1.38); C2660(0.98)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C3294(0.97); C4151(0.83); C2605(1.24); C1578(1.39)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C3294(1.05); C4151(1.48); C4330(0.76); C2605(0.90)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C3294(1.04); C4151(0.92); C2605(1.00); C1578(0.95)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C3294(0.92); C4151(0.98); C2605(1.08); C1578(0.96)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C4151(1.14); C4330(1.10); C1578(1.08); C2660(1.07)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C3294(1.05); C4151(1.08); C2605(0.94); C2660(1.06)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C3294(1.03); C4151(1.17); C2605(1.20); C1578(1.00)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C3294(1.08); C2605(1.25); C1578(1.48); C2660(1.01)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C3294(1.06); C2605(1.14); C1578(1.22); C2660(1.02)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C3294(1.09); C4151(1.02); C2605(1.25); C1578(1.27)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C4151(1.06); C2605(1.17); C1578(1.11); C2660(1.00)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C3294(1.00); C4151(1.30); C1578(1.38); C2660(0.99)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C3294(1.01); C4151(1.47); C2605(1.14); C1578(1.20)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C3294(1.02); C4151(1.38); C4330(0.74); C2605(0.96)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C3294(1.14); C4151(0.96); C2605(1.02); C1578(0.95)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C3294(1.14); C4151(0.92); C2605(1.01); C1578(0.94)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C3294(1.06); C4151(1.28); C2605(1.21); C1578(1.00)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C4151(1.02); C4330(1.19); C1578(1.02); C2660(0.95)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C3294(1.14); C4151(1.01); C2605(1.12); C1578(1.33)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C3294(1.20); C4151(1.14); C2605(0.93); C2660(1.05)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C3119(1.13)  LDD1084  [4]
 LDCM0487  CL92 HEK-293T C3119(1.03)  LDD1085  [4]
 LDCM0488  CL93 HEK-293T C3119(1.25)  LDD1086  [4]
 LDCM0489  CL94 HEK-293T C3119(1.48)  LDD1087  [4]
 LDCM0490  CL95 HEK-293T C3119(1.39)  LDD1088  [4]
 LDCM0491  CL96 HEK-293T C3119(1.18)  LDD1089  [4]
 LDCM0492  CL97 HEK-293T C3119(1.34)  LDD1090  [4]
 LDCM0493  CL98 HEK-293T C3119(1.39)  LDD1091  [4]
 LDCM0494  CL99 HEK-293T C3119(1.21)  LDD1092  [4]
 LDCM0495  E2913 HEK-293T C3294(1.14); C4151(1.02); C2605(1.12); C1578(0.92)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C3294(1.07); C4151(0.89); C2605(1.14); C1578(0.96)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C3119(0.91)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C3353(20.00); C3369(20.00); C3359(20.00); C2696(9.49)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C3353(8.63); C3369(8.63); C3359(8.63); C2696(5.89)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C3353(9.48); C3369(9.48); C3359(9.48); C2696(4.21)  LDD0082  [4]
 LDCM0109  NEM HeLa H1388(0.00); H2310(0.00); H1705(0.00)  LDD0227  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) Glycosyltransferase 58 family Q92685
Bleomycin hydrolase (BLMH) Peptidase C1 family Q13867
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Amyloid-beta precursor protein (APP) APP family P05067
Glutamate receptor ionotropic, NMDA 2A (GRIN2A) Glutamate-gated ion channel family Q12879
Disks large homolog 4 (DLG4) MAGUK family P78352
Protein S100-B (S100B) S-100 family P04271
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2-macroglobulin receptor-associated protein (LRPAP1) Alpha-2-MRAP family P30533
Ficolin-2 (FCN2) Ficolin lectin family Q15485
Amyloid beta precursor protein binding family B member 1 (APBB1) . O00213
Mannose-binding protein C (MBL2) . P11226

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Coagulation Factor Ix (Recombinant) BiotechDrug DB00100
Tenecteplase BiotechDrug DB00031
Coagulation Factor Ix Human . DB13152
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999
Von Willebrand Factor Human . DB13133
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lanoteplase . DB06245

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402