Details of the Target

General Information of Target

Target ID LDTP15115
Target Name Protein GOLM2 (GOLM2)
Gene Name GOLM2
Gene ID 113201
Synonyms
CASC4; Protein GOLM2; Cancer susceptibility candidate gene 4 protein; CASC4; Golgi membrane protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQEKMKLGFKSLPSSTTADGNILRRVNSAPLINGLGFNSQVLQADMLRIRTNRTTFRNR
RSLLLPPPPFHGSISRLHQIKQEEAMDLINRETMSEWKLQSEIQISHSWEEGLKLVKWHF
NINQKRFSKAQPTCFLLILPNCQKIMCIYFQLLLMETTAMLDLLVIRQLKSALSQTLLCH
LLILVLICSSRQTFN
Target Bioclass
Other
Family
GOLM family
Subcellular location
Membrane
Uniprot ID
Q6P4E1
Ensemble ID
ENST00000299957.11
HGNC ID
HGNC:24892

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		38.12  LDD0318  [1]
STPyne
 Probe Info  		K78(6.88)  LDD0277  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C223
 Probe Info  		12.64  LDD1897  [5]
C281
 Probe Info  		15.56  LDD1951  [5]
C284
 Probe Info  		35.51  LDD1954  [5]
C310
 Probe Info  		27.86  LDD1977  [5]
C407
 Probe Info  		16.11  LDD2064  [5]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587