Details of the Target

General Information of Target

Target ID LDTP07990
Target Name Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1)
Gene Name HS2ST1
Gene ID 9653
Synonyms
HS2ST; KIAA0448; Heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase; 2OST; EC 2.8.2.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRSKLERAIARHEVREIEQRHTMD
GPRQDATLDEEEDMVIIYNRVPKTASTSFTNIAYDLCAKNKYHVLHINTTKNNPVMSLQD
QVRFVKNITSWKEMKPGFYHGHVSYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFG
DDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQA
KYNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATELYRTGKKSHLRKTTEKKLPTKQT
IAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN
Target Bioclass
Enzyme
Family
Sulfotransferase 3 family
Subcellular location
Golgi apparatus membrane
Function
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues.
Uniprot ID
Q7LGA3
Ensemble ID
ENST00000370550.10
HGNC ID
HGNC:5193

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P219S DBIA    Probe Info 
HCT15 SNV: p.E265D .
SW1271 SNV: p.D69N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K83(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C201(1.26); C209(1.26)  LDD0637  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
SF
 Probe Info  		N.A.  LDD0028  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
PAL-AfBPP Probe
Click To Hide/Show 85 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.00  LDD1714  [6]
C040
 Probe Info  		26.17  LDD1740  [6]
C041
 Probe Info  		7.84  LDD1741  [6]
C056
 Probe Info  		45.89  LDD1753  [6]
C063
 Probe Info  		13.93  LDD1760  [6]
C070
 Probe Info  		11.88  LDD1766  [6]
C087
 Probe Info  		9.85  LDD1779  [6]
C091
 Probe Info  		19.16  LDD1782  [6]
C092
 Probe Info  		29.86  LDD1783  [6]
C094
 Probe Info  		27.47  LDD1785  [6]
C100
 Probe Info  		6.06  LDD1789  [6]
C106
 Probe Info  		33.59  LDD1793  [6]
C107
 Probe Info  		5.98  LDD1794  [6]
C108
 Probe Info  		10.70  LDD1795  [6]
C112
 Probe Info  		39.95  LDD1799  [6]
C130
 Probe Info  		6.36  LDD1812  [6]
C134
 Probe Info  		30.27  LDD1816  [6]
C135
 Probe Info  		11.00  LDD1817  [6]
C143
 Probe Info  		14.12  LDD1825  [6]
C153
 Probe Info  		26.72  LDD1834  [6]
C159
 Probe Info  		12.47  LDD1839  [6]
C160
 Probe Info  		9.06  LDD1840  [6]
C161
 Probe Info  		14.03  LDD1841  [6]
C165
 Probe Info  		12.21  LDD1845  [6]
C169
 Probe Info  		25.99  LDD1849  [6]
C170
 Probe Info  		12.55  LDD1850  [6]
C178
 Probe Info  		15.24  LDD1857  [6]
C186
 Probe Info  		10.70  LDD1864  [6]
C187
 Probe Info  		19.56  LDD1865  [6]
C201
 Probe Info  		42.81  LDD1877  [6]
C206
 Probe Info  		50.21  LDD1881  [6]
C210
 Probe Info  		60.13  LDD1884  [6]
C218
 Probe Info  		20.68  LDD1892  [6]
C220
 Probe Info  		16.11  LDD1894  [6]
C223
 Probe Info  		5.94  LDD1897  [6]
C226
 Probe Info  		5.50  LDD1899  [6]
C228
 Probe Info  		23.92  LDD1901  [6]
C231
 Probe Info  		27.10  LDD1904  [6]
C232
 Probe Info  		40.22  LDD1905  [6]
C233
 Probe Info  		10.63  LDD1906  [6]
C234
 Probe Info  		5.70  LDD1907  [6]
C235
 Probe Info  		32.00  LDD1908  [6]
C238
 Probe Info  		11.88  LDD1911  [6]
C246
 Probe Info  		16.34  LDD1919  [6]
C252
 Probe Info  		9.92  LDD1925  [6]
C264
 Probe Info  		21.71  LDD1935  [6]
C265
 Probe Info  		12.82  LDD1936  [6]
C281
 Probe Info  		6.36  LDD1951  [6]
C287
 Probe Info  		10.78  LDD1957  [6]
C288
 Probe Info  		6.32  LDD1958  [6]
C289
 Probe Info  		44.32  LDD1959  [6]
C293
 Probe Info  		35.02  LDD1963  [6]
C296
 Probe Info  		24.42  LDD1966  [6]
C305
 Probe Info  		9.71  LDD1974  [6]
C310
 Probe Info  		35.02  LDD1977  [6]
C313
 Probe Info  		12.91  LDD1980  [6]
C314
 Probe Info  		13.93  LDD1981  [6]
C317
 Probe Info  		6.02  LDD1983  [6]
C333
 Probe Info  		5.39  LDD1996  [6]
C343
 Probe Info  		13.64  LDD2005  [6]
C349
 Probe Info  		11.79  LDD2010  [6]
C350
 Probe Info  		39.67  LDD2011  [6]
C355
 Probe Info  		26.35  LDD2016  [6]
C362
 Probe Info  		55.33  LDD2023  [6]
C363
 Probe Info  		19.03  LDD2024  [6]
C364
 Probe Info  		16.34  LDD2025  [6]
C366
 Probe Info  		5.54  LDD2027  [6]
C388
 Probe Info  		68.12  LDD2047  [6]
C390
 Probe Info  		99.73  LDD2049  [6]
C391
 Probe Info  		56.10  LDD2050  [6]
C399
 Probe Info  		11.55  LDD2058  [6]
C400
 Probe Info  		6.15  LDD2059  [6]
C403
 Probe Info  		25.81  LDD2061  [6]
C407
 Probe Info  		22.47  LDD2064  [6]
C413
 Probe Info  		14.03  LDD2069  [6]
C429
 Probe Info  		11.39  LDD2084  [6]
C431
 Probe Info  		19.97  LDD2086  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe12
 Probe Info  		20.00  LDD0473  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
FFF probe2
 Probe Info  		20.00  LDD0463  [7]
FFF probe3
 Probe Info  		20.00  LDD0465  [7]
Alk-rapa
 Probe Info  		6.44  LDD0213  [8]
OEA-DA
 Probe Info  		20.00  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C97(0.76)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C97(1.07)  LDD1508  [10]
 LDCM0216  AC100 HEK-293T C97(0.65)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C97(1.08)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C97(0.68)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C97(0.57)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C97(0.81)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C97(1.19)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C97(0.80)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C97(0.63)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C97(0.72)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C97(0.84)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C97(1.06)  LDD1509  [10]
 LDCM0227  AC110 HEK-293T C97(0.48)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C97(0.45)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C97(0.40)  LDD0827  [2]
 LDCM0237  AC12 HEK-293T C97(0.93)  LDD1510  [10]
 LDCM0246  AC128 HEK-293T C97(0.92)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C97(0.82)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C97(0.84)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C97(0.92)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C97(0.93)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C97(0.71)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C97(0.73)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C97(0.58)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C97(0.57)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C97(0.51)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C97(0.49)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C97(0.47)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C97(1.06)  LDD1512  [10]
 LDCM0260  AC140 HEK-293T C97(0.60)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C97(0.57)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C97(0.66)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C97(0.63)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C97(0.41)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C97(0.41)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C97(0.40)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C97(0.45)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C97(0.54)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C97(0.81)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C97(1.01)  LDD1513  [10]
 LDCM0271  AC150 HEK-293T C97(0.64)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C97(0.53)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C97(0.58)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C97(0.54)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C97(0.69)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C97(0.63)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C97(0.54)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C97(0.45)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C97(1.01)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C97(1.13)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C97(1.05)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C97(1.02)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C97(1.13)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C97(0.90)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C97(1.01)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C97(0.98)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C97(1.01)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C201(1.47)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C201(1.88)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C201(1.38)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C201(1.29)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C201(2.07)  LDD0887  [2]
 LDCM0290  AC3 HEK-293T C97(1.07)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C201(1.76)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C201(2.42)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C201(1.81)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C201(1.68)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C201(2.47)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C97(0.92)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C97(0.92)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C97(0.95)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C97(0.95)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C97(1.03)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C97(0.78)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C97(1.11)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C97(1.05)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C97(1.02)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C97(1.01)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C97(1.00)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C97(0.99)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C201(1.29); C97(1.88)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C201(1.34); C97(1.81)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C201(1.48); C97(1.47)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C201(1.20); C97(1.02)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C97(1.00)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C201(1.30); C97(1.27)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C201(1.24); C97(1.78)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C201(1.30); C97(1.52)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C201(0.99); C97(1.64)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C201(1.15); C97(1.40)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C201(1.16); C97(1.52)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C201(1.26); C97(1.41)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C201(1.26); C209(1.26)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C201(0.93); C209(0.93)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C201(0.88); C209(0.88)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C97(0.86)  LDD1562  [10]
 LDCM0324  AC60 HCT 116 C201(1.02); C209(1.02)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C201(1.15); C209(1.15)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C201(0.99); C209(0.99)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C201(1.04); C209(1.04)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C201(0.90); C209(0.90)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C201(1.13); C209(1.13)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C201(1.28); C209(1.28)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C201(0.78); C209(0.78)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C97(0.75)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C97(0.79)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C97(1.06)  LDD1568  [10]
 LDCM0335  AC70 HEK-293T C97(0.89)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C97(0.86)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C97(0.81)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C97(0.86)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C97(0.63)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C97(0.70)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C97(0.94)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C97(0.90)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C97(0.94)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C97(0.76)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C97(1.07)  LDD1569  [10]
 LDCM0346  AC80 HEK-293T C97(0.74)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C97(0.80)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C97(0.43)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C97(0.85)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C97(1.06)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C97(1.00)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C97(1.02)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C97(1.01)  LDD1514  [10]
 LDCM0020  ARS-1620 HCC44 C201(0.87); C209(0.87)  LDD2171  [2]
 LDCM0367  CL1 HCT 116 C201(1.15); C209(1.15)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C201(1.29); C209(1.29)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C97(0.64)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C97(1.01)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C97(1.14)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C97(1.11)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C97(1.06)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C97(0.96)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C97(0.94)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C97(1.06)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C97(1.02)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C97(0.95)  LDD1582  [10]
 LDCM0379  CL11 HCT 116 C201(0.92); C209(0.92)  LDD0696  [2]
 LDCM0380  CL110 HEK-293T C97(0.95)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C97(1.09)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C201(2.00)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C201(2.26)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C201(2.41)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C201(2.73)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C201(2.31)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C97(0.97)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C97(1.08)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C97(0.99)  LDD1593  [10]
 LDCM0390  CL12 HCT 116 C201(1.02); C209(1.02)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C97(1.04)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C201(1.02); C97(1.92)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C201(0.97); C97(1.44)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C201(1.19); C97(1.42)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C201(1.15); C97(1.29)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C201(1.03); C209(1.03)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C201(0.99); C209(0.99)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C201(1.31); C209(1.31)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C201(1.09); C209(1.09)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C201(0.97); C209(0.97)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C201(1.37); C209(1.37)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C201(1.36); C209(1.36)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C201(1.15); C209(1.15)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C201(1.42); C209(1.42)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C201(1.13); C209(1.13)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C201(1.15); C209(1.15)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C201(1.06); C209(1.06)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C201(0.98); C209(0.98)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C201(0.95); C209(0.95)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C201(0.67); C209(0.67)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C201(1.06); C209(1.06)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C201(0.86); C209(0.86)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C201(0.88); C209(0.88)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C201(0.95); C209(0.95)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C201(1.22); C209(1.22)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C201(1.06); C209(1.06)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C201(1.08); C209(1.08)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C201(1.23); C209(1.23)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C201(1.06); C209(1.06)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C201(1.40); C97(0.94)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C201(0.87); C97(1.52)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C201(0.82); C97(0.84)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C201(0.92); C97(0.98)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C201(1.01); C97(2.07)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C201(1.10); C97(1.25)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C201(0.97); C97(0.98)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C201(0.95); C97(0.48)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C201(1.28); C209(1.28)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C201(0.74); C97(1.26)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C201(1.29); C97(0.79)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C201(1.44); C97(0.75)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C201(1.43); C97(0.65)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C201(1.15); C97(1.23)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C201(0.98); C97(0.76)  LDD1033  [2]
 LDCM0436  CL46 HEK-293T C201(0.99)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C201(0.97)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C201(0.60)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C201(0.98)  LDD1037  [2]
 LDCM0440  CL5 HCT 116 C201(1.04); C209(1.04)  LDD0757  [2]
 LDCM0441  CL50 HEK-293T C201(1.53)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C201(1.19)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C201(0.80)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C201(0.75)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C201(1.33)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C201(1.37)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C201(0.77)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C201(1.03)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C201(0.88)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C201(1.05)  LDD1048  [2]
 LDCM0451  CL6 HCT 116 C201(1.35); C209(1.35)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C201(0.83)  LDD1050  [2]
 LDCM0453  CL61 HCT 116 C201(1.24); C209(1.24)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C201(1.21); C209(1.21)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C201(1.21); C209(1.21)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C201(1.12); C209(1.12)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C201(1.08); C209(1.08)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C201(1.06); C209(1.06)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C201(1.09); C209(1.09)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C201(1.10); C209(1.10)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C201(1.09); C209(1.09)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C201(0.94); C209(0.94)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C201(1.33); C209(1.33)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C201(1.03); C209(1.03)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C201(0.99); C209(0.99)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C201(1.14); C209(1.14)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C201(1.09); C209(1.09)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C97(1.10)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C97(0.94)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C97(1.12)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C97(1.04)  LDD1675  [10]
 LDCM0473  CL8 HCT 116 C201(0.82); C209(0.82)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C97(1.06)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C97(1.00)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C97(1.03)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C97(1.08)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C97(1.14)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C97(0.98)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C97(1.10)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C97(1.19)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C97(1.07)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C97(1.02)  LDD1686  [10]
 LDCM0484  CL9 HCT 116 C201(1.14); C209(1.14)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C97(1.13)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C97(0.62)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C97(0.61)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C97(0.65)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C97(0.50)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C97(0.47)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C97(0.68)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C97(0.78)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C97(0.70)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C97(0.66)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C97(1.14)  LDD1698  [10]
 LDCM0625  F8 Ramos C97(0.97)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C97(1.12)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C97(0.94)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C97(0.70)  LDD2191  [11]
 LDCM0576  Fragment14 Ramos C97(0.64)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C97(0.66)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C97(0.93)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C97(0.82)  LDD2196  [11]
 LDCM0588  Fragment30 Ramos C97(0.83)  LDD2199  [11]
 LDCM0590  Fragment32 Ramos C97(0.96)  LDD2201  [11]
 LDCM0468  Fragment33 HCT 116 C201(1.06); C209(1.06)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C97(0.53)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C97(0.51)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C201(1.07); C97(1.63)  LDD1025  [2]
 LDCM0614  Fragment56 Ramos C97(0.41)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C97(0.51)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C97(0.73)  LDD2188  [11]
 LDCM0022  KB02 Ramos C97(0.67)  LDD2182  [11]
 LDCM0023  KB03 Ramos C97(0.87)  LDD2183  [11]
 LDCM0024  KB05 COLO792 C97(1.66)  LDD3310  [12]
 LDCM0090  Rapamycin JHH-7 6.44  LDD0213  [8]
 LDCM0021  THZ1 HCT 116 C201(0.87); C209(0.87)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840