Details of the Target

General Information of Target

Target ID LDTP09907
Target Name Neogenin (NEO1)
Gene Name NEO1
Gene ID 4756
Synonyms
IGDCC2; NGN; Neogenin; Immunoglobulin superfamily DCC subclass member 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRLLHAEEWAEVKELGDHHRQPQPHHLPQPPPPPQPPATLQAREHPVYPPELSLLDSTD
PRAWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPG
PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFD
QLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPASCKSDHHHLRT
AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDS
ALTAMMAQKNLSPSLPGSILQPVQEENSKTSPRSHRSDGEFSPHSHYSDSDEAS
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, DCC family
Subcellular location
Cell membrane
Function
Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.
Uniprot ID
Q92859
Ensemble ID
ENST00000261908.11
HGNC ID
HGNC:7754

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.P1189S .
COLO679 SNV: p.G1406E .
HCT116 SNV: p.V223M; p.T1350I .
KMS27 SNV: p.I329S .
KYSE150 SNV: p.S403L .
LUDLU1 Insertion: p.E927VfsTer5; p.E927_F928insLGFALK .
MEWO SNV: p.S1144L .
RKO SNV: p.A447P .
SNU1196 SNV: p.S451F .
SUPT1 SNV: p.R889Ter .
SW948 SNV: p.T685I .
TOV21G SNV: p.E1221Ter .
U118MG SNV: p.S161C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C270(1.02)  LDD1576  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C045
 Probe Info  		8.69  LDD1744  [3]
C063
 Probe Info  		11.39  LDD1760  [3]
C073
 Probe Info  		12.91  LDD1769  [3]
C106
 Probe Info  		17.27  LDD1793  [3]
C115
 Probe Info  		16.91  LDD1802  [3]
C149
 Probe Info  		12.21  LDD1830  [3]
C170
 Probe Info  		8.17  LDD1850  [3]
C184
 Probe Info  		6.82  LDD1862  [3]
C186
 Probe Info  		16.80  LDD1864  [3]
C223
 Probe Info  		18.51  LDD1897  [3]
C237
 Probe Info  		11.88  LDD1910  [3]
C281
 Probe Info  		10.27  LDD1951  [3]
C328
 Probe Info  		5.66  LDD1992  [3]
C329
 Probe Info  		4.96  LDD1993  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0372  CL103 HEK-293T C270(1.02)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C270(1.18)  LDD1580  [1]
 LDCM0381  CL111 HEK-293T C270(1.23)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C270(1.03)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C270(1.05)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C270(1.12)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C270(1.26)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C270(1.07)  LDD1606  [1]
 LDCM0415  CL27 HEK-293T C270(1.19)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C270(1.20)  LDD1622  [1]
 LDCM0428  CL39 HEK-293T C270(1.05)  LDD1632  [1]
 LDCM0455  CL63 HEK-293T C270(1.23)  LDD1658  [1]
 LDCM0481  CL87 HEK-293T C270(0.79)  LDD1684  [1]
 LDCM0494  CL99 HEK-293T C270(0.93)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C270(1.01)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C270(1.09)  LDD1671  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemojuvelin (HJV) Repulsive guidance molecule (RGM) family Q6ZVN8

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587