Details of the Target

General Information of Target

Target ID LDTP00783
Target Name Beta-1,4-glucuronyltransferase 1 (B4GAT1)
Gene Name B4GAT1
Gene ID 11041
Synonyms
B3GNT1; B3GNT6; Beta-1,4-glucuronyltransferase 1; EC 2.4.1.-; I-beta-1,3-N-acetylglucosaminyltransferase; iGnT; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase; Poly-N-acetyllactosamine extension enzyme; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVK
AQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPL
SVSVFAATKEEAQLATVLAYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLR
SCQEVFDKLARVAQPGINYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRGL
REMLDQSNQWGGTALVVPAFEIRRARRMPMNKNELVQLYQVGEVRPFYYGLCTPCQAPTN
YSRWVNLPEESLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAG
FDFEVLNEGFLVHKGFKEALKFHPQKEAENQHNKILYRQFKQELKAKYPNSPRRC
Target Bioclass
Enzyme
Family
Glycosyltransferase 49 family
Subcellular location
Golgi apparatus membrane
Function
Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1).
Uniprot ID
O43505
Ensemble ID
ENST00000311181.5
HGNC ID
HGNC:15685

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		N.A.  LDD0273  [1]
OPA-S-S-alkyne
 Probe Info  		K60(7.80)  LDD3494  [2]
DBIA
 Probe Info  		C182(3.08)  LDD3360  [3]
BTD
 Probe Info  		C159(0.75)  LDD2107  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
STPyne
 Probe Info  		K386(0.00); K60(0.00)  LDD0009  [8]
AOyne
 Probe Info  		12.60  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 57 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		5.39  LDD1719  [11]
C022
 Probe Info  		8.06  LDD1728  [11]
C040
 Probe Info  		8.69  LDD1740  [11]
C041
 Probe Info  		7.36  LDD1741  [11]
C082
 Probe Info  		5.13  LDD1774  [11]
C106
 Probe Info  		24.93  LDD1793  [11]
C107
 Probe Info  		6.68  LDD1794  [11]
C108
 Probe Info  		10.78  LDD1795  [11]
C112
 Probe Info  		20.11  LDD1799  [11]
C147
 Probe Info  		7.46  LDD1829  [11]
C153
 Probe Info  		15.89  LDD1834  [11]
C160
 Probe Info  		9.51  LDD1840  [11]
C161
 Probe Info  		9.85  LDD1841  [11]
C170
 Probe Info  		14.32  LDD1850  [11]
C185
 Probe Info  		6.36  LDD1863  [11]
C186
 Probe Info  		17.39  LDD1864  [11]
C197
 Probe Info  		7.36  LDD1873  [11]
C208
 Probe Info  		10.48  LDD1883  [11]
C217
 Probe Info  		5.78  LDD1891  [11]
C219
 Probe Info  		6.32  LDD1893  [11]
C220
 Probe Info  		19.56  LDD1894  [11]
C223
 Probe Info  		7.16  LDD1897  [11]
C225
 Probe Info  		5.39  LDD1898  [11]
C226
 Probe Info  		7.62  LDD1899  [11]
C228
 Probe Info  		19.84  LDD1901  [11]
C231
 Probe Info  		12.21  LDD1904  [11]
C237
 Probe Info  		5.06  LDD1910  [11]
C246
 Probe Info  		13.00  LDD1919  [11]
C277
 Probe Info  		9.32  LDD1947  [11]
C281
 Probe Info  		4.96  LDD1951  [11]
C288
 Probe Info  		7.06  LDD1958  [11]
C290
 Probe Info  		6.15  LDD1960  [11]
C293
 Probe Info  		16.00  LDD1963  [11]
C296
 Probe Info  		11.24  LDD1966  [11]
C302
 Probe Info  		6.59  LDD1971  [11]
C310
 Probe Info  		12.30  LDD1977  [11]
C314
 Probe Info  		11.31  LDD1981  [11]
C326
 Probe Info  		8.75  LDD1990  [11]
C349
 Probe Info  		12.55  LDD2010  [11]
C350
 Probe Info  		43.71  LDD2011  [11]
C353
 Probe Info  		10.78  LDD2014  [11]
C354
 Probe Info  		12.91  LDD2015  [11]
C367
 Probe Info  		6.63  LDD2028  [11]
C376
 Probe Info  		13.36  LDD2036  [11]
C380
 Probe Info  		9.58  LDD2039  [11]
C386
 Probe Info  		9.06  LDD2045  [11]
C390
 Probe Info  		55.72  LDD2049  [11]
C391
 Probe Info  		19.03  LDD2050  [11]
C393
 Probe Info  		6.19  LDD2052  [11]
C407
 Probe Info  		13.36  LDD2064  [11]
C428
 Probe Info  		5.70  LDD2083  [11]
FFF probe11
 Probe Info  		20.00  LDD0471  [12]
FFF probe12
 Probe Info  		20.00  LDD0473  [12]
FFF probe15
 Probe Info  		5.89  LDD0478  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]
FFF probe3
 Probe Info  		20.00  LDD0464  [12]
OEA-DA
 Probe Info  		7.68  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C159(5.24)  LDD0372  [14]
 LDCM0214  AC1 HEK-293T C159(0.94); C146(0.97); C182(0.89); C354(0.98)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C159(1.07); C182(1.05); C354(1.01)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C159(0.98); C146(1.01); C182(0.92); C354(1.04)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C159(0.97); C146(0.89); C182(0.94); C354(1.05)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C159(1.00); C182(0.99); C354(1.19); C295(1.13)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C159(0.95); C146(0.99); C182(1.08); C354(1.06)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C159(0.93); C146(1.02); C182(1.04); C354(0.99)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C159(1.01); C182(1.01); C354(0.91)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C159(0.96); C146(1.05); C182(1.01); C354(0.90)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C159(1.06); C182(1.01); C354(0.97)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C159(1.00); C146(0.97); C182(0.87); C354(1.11)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C159(1.00); C146(0.91); C182(0.95); C354(1.11)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C159(1.00); C182(0.99); C354(1.06); C295(1.06)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C159(0.96); C146(1.00); C182(0.99); C354(1.11)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C159(0.90); C146(0.97); C182(0.96); C295(0.92)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C159(0.98); C146(0.97); C182(1.01); C354(1.00)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C159(1.09); C182(0.99); C354(0.92)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C159(0.91); C146(1.06); C182(0.90); C354(0.99)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C159(1.00); C146(1.10); C182(1.01); C354(1.02)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C159(1.06); C146(0.80); C182(0.91); C354(1.15)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C159(0.93); C146(1.05); C182(1.03); C354(1.06)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C159(0.96); C182(1.05); C354(1.11); C295(0.94)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C159(1.04); C146(0.94); C182(0.98); C354(1.00)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C159(0.92); C146(0.83); C182(1.00); C295(0.95)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C159(0.97); C146(1.12); C182(0.88); C354(0.93)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C159(1.07); C182(0.96); C354(1.04)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C159(0.93); C146(1.13); C182(0.95); C354(1.02)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C159(0.99); C146(1.04); C182(0.92); C354(1.13)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C159(0.98); C146(0.87); C182(1.06); C354(1.23)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C159(0.98); C182(0.99); C354(1.19); C295(1.25)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C159(0.95); C146(1.11); C182(0.89); C354(1.16)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C159(1.04); C146(0.88); C182(1.01); C354(1.02)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C159(0.96); C146(1.11); C182(1.01); C295(0.98)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C159(0.95); C146(1.12); C182(0.91); C354(1.01)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C159(1.05); C182(0.97); C354(0.99)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C159(0.89); C146(1.16); C182(0.89); C354(1.10)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C159(0.96); C146(0.98); C182(0.97); C354(1.08)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C159(1.00); C146(0.93); C182(0.87); C354(1.09)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C159(0.94); C182(0.93); C354(1.02); C295(1.02)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C159(0.98); C146(1.22); C182(0.91); C354(1.11)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C159(0.91); C146(1.18); C182(0.93); C295(0.93)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C159(0.96); C146(0.94); C182(0.99); C354(0.90)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C159(0.93); C146(0.96); C182(1.03); C354(1.05)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C159(1.04); C182(0.95); C354(0.94)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C159(1.02); C146(0.89); C182(0.89); C354(1.16)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C159(0.95); C146(0.98); C182(1.02); C354(1.03)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C159(1.01); C146(1.01); C182(1.00); C354(1.09)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C159(0.97); C182(0.95); C354(1.03); C295(1.05)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C159(0.96); C146(0.98); C182(0.96); C354(1.01)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C159(0.93); C146(0.95); C182(0.99); C295(1.00)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C159(0.94); C146(1.00); C182(1.02); C354(1.04)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C159(1.04); C182(0.94); C354(0.98)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C159(1.00); C146(0.73); C182(0.86); C354(1.09)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C159(1.00); C182(1.07); C354(1.07); C295(1.06)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C159(0.93); C146(1.04); C182(0.93); C354(1.07)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C159(0.96); C146(0.97); C182(0.88); C354(1.11)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C159(0.91); C182(0.98); C354(1.16); C295(1.07)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C159(0.96); C146(1.02); C182(0.96); C354(1.09)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C159(0.93); C146(1.04); C182(0.92); C295(1.26)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C159(0.91); C146(1.01); C182(1.02); C354(1.14)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C159(1.00); C146(0.84); C182(1.04); C295(1.15)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C159(0.96); C146(1.08); C182(1.00); C354(1.08)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C159(0.98); C146(0.95); C182(1.00); C354(0.99)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C159(0.95); C146(1.28); C182(1.06); C295(1.02)  LDD1514  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C159(1.11); C146(0.87)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C159(1.11); C182(1.13); C354(1.58); C295(0.88)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C159(1.00); C146(1.04); C182(1.03); C354(0.85)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C159(1.08); C146(0.85)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C159(0.94); C146(0.86); C182(1.02); C354(1.06)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C159(0.90); C182(0.95); C354(1.03); C295(0.98)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C159(1.06); C146(0.93); C182(0.97); C354(1.06)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C159(1.00); C146(0.81)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C159(0.86); C146(0.90); C182(1.03); C354(1.10)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C159(0.96); C182(1.02); C354(1.11); C295(1.05)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C159(1.09); C146(1.13); C182(0.96); C354(0.91)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C159(1.04); C146(1.01)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C159(1.03); C146(1.15); C182(0.98); C354(1.30)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C159(0.98); C146(0.89); C182(1.10); C354(1.07)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C159(1.06); C182(1.06); C354(1.20); C295(1.00)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C159(1.03); C146(1.11); C182(1.09); C354(0.92)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C159(1.06); C146(0.96)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C159(0.99); C146(0.84); C182(1.06); C354(1.23)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C159(0.97); C182(0.97); C354(1.10); C295(1.31)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C159(1.09); C146(1.01); C182(0.94); C354(1.05)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C159(1.02); C146(1.15)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C159(0.97); C146(0.91); C182(0.94); C354(0.94)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C159(0.98); C182(1.00); C354(1.09); C295(1.12)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C159(0.96); C146(1.02); C182(1.11); C295(0.99)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C159(1.01); C146(1.02); C182(0.98); C354(0.98)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C159(0.95); C146(0.82)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C159(0.95); C146(0.93); C182(0.97); C354(0.95)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C159(0.94); C182(0.98); C354(1.21); C295(1.23)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C159(1.06); C146(0.92); C182(0.93); C354(1.03)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C159(1.02); C146(0.90)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C159(0.91); C146(0.96); C182(1.00); C354(1.00)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C159(0.98); C182(0.92); C354(1.05); C295(1.16)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C159(1.08); C146(1.02); C182(0.97); C354(0.92)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C159(1.01); C146(0.91)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C159(0.93); C146(0.92); C182(0.99); C354(0.98)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C159(1.06); C182(1.03); C354(1.16); C295(0.83)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C159(1.06); C146(1.02); C182(0.94); C354(0.92)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C159(1.05); C146(0.98); C182(0.98); C354(1.21)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C159(1.11); C182(1.01); C354(1.10)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C159(1.14); C146(0.83); C182(1.03); C354(1.07)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C159(0.95); C146(0.96); C182(1.06); C354(0.99)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C159(1.00); C146(1.07); C182(1.00); C354(1.31)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C159(0.97); C146(1.07); C182(0.89); C354(1.35)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C159(1.01); C182(1.04); C354(1.36); C295(0.83)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C159(1.03); C146(1.10); C182(1.02); C354(1.11)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C159(0.94); C146(1.30); C182(1.01); C295(1.16)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C159(1.00); C146(0.91)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C159(0.89); C146(0.83); C182(0.97); C354(1.08)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C159(0.97); C182(1.06); C354(0.95); C295(1.29)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C159(1.01); C146(0.94); C182(0.98); C354(1.08)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C159(0.96); C146(0.89); C182(0.97); C354(1.05)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C159(1.01); C182(0.93); C354(1.13); C295(1.27)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C159(1.09); C182(1.00); C354(0.93)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C159(1.09); C146(1.06); C182(1.01); C354(1.01)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C159(0.99); C146(0.85); C182(1.05); C354(1.08)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C159(1.06); C146(0.94); C182(1.14); C354(1.38)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C159(1.02); C182(1.04); C354(1.26); C295(1.15)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C159(1.04); C146(1.11); C182(1.06); C354(1.29)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C159(0.91); C146(0.97); C182(1.02); C295(0.79)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C159(1.01); C146(0.95)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C159(1.05); C182(1.01); C354(1.10); C295(0.98)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C159(1.04); C146(0.95); C182(1.01); C354(0.97)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C159(1.04); C146(0.93); C182(0.95); C354(1.10)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C159(0.92); C146(0.97); C182(0.96); C354(1.00)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C159(1.11); C182(1.10); C354(0.91)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C159(1.04); C146(0.86); C182(0.92); C354(1.04)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C159(1.01); C146(0.87); C182(1.07); C354(1.01)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C159(0.99); C146(0.56); C182(1.05); C354(1.34)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C159(1.07); C182(1.11); C354(1.05); C295(0.84)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C159(1.01); C146(1.04); C182(0.94); C354(1.04)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C159(0.88); C146(0.86); C182(0.96); C295(0.81)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C159(1.06); C146(0.96)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C159(0.97); C146(1.02); C182(1.01); C354(1.10)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C159(0.93); C146(0.99); C182(1.02); C354(1.13)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C159(1.08); C146(0.97); C182(1.00); C354(1.08)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C159(0.88); C146(0.93); C182(0.99); C354(1.06)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C159(1.14); C182(0.98); C354(1.06)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C159(1.10); C146(0.95); C182(0.83); C354(1.00)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C159(0.94); C146(0.97); C182(0.86); C354(1.00)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C159(1.02); C146(0.70); C182(0.95); C354(1.34)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C159(1.01); C182(1.12); C354(1.18); C295(0.96)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C159(1.10); C146(1.20); C182(0.93); C354(1.17)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C159(1.04); C182(1.06); C354(1.18)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C159(0.90); C146(1.07); C182(1.03); C295(0.91)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C159(1.00); C146(0.90)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C159(0.95); C146(1.02); C182(0.96); C354(1.01)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C159(0.96); C182(0.97); C354(0.97); C295(1.06)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C159(1.07); C146(0.99); C182(1.04); C354(0.98)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C159(0.97); C146(1.04); C182(0.97); C354(0.98)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C159(1.02); C182(0.97); C354(0.99)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C159(1.05); C146(0.84); C182(0.87); C354(1.11)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C159(0.98); C146(0.92); C182(0.95); C354(1.04)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C159(0.97); C146(0.50); C182(1.03); C354(1.16)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C159(1.08); C146(0.74); C182(0.89); C354(1.04)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C159(1.02); C182(1.07); C354(1.29); C295(0.89)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C159(1.05); C146(1.04); C182(1.02); C354(1.25)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C159(0.96); C146(0.91); C182(1.03); C295(0.96)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C159(1.10); C146(0.91)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C159(0.95); C146(0.83); C182(0.94); C354(0.98)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C159(0.97); C146(0.99); C182(0.92); C354(0.92)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C159(1.01); C146(0.81); C182(1.09); C354(1.09)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C159(1.12); C182(0.92); C354(1.05)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C159(1.08); C146(0.84); C182(0.99); C354(1.02)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C159(0.93); C146(1.19); C182(1.26); C354(1.35)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C159(1.06); C146(1.01); C182(1.03); C354(1.09)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C159(1.00); C146(0.98); C182(0.95); C354(1.13)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C159(1.08); C182(0.99); C354(1.02); C295(1.01)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C159(1.05); C146(1.15); C182(1.03); C354(1.06)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C159(0.90); C146(0.94); C182(1.03); C295(0.96)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C159(1.05); C146(1.02)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C159(0.87); C146(0.96); C182(0.97); C354(1.05)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C159(0.94); C182(1.00); C354(0.99); C295(0.90)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C159(1.03); C146(1.01); C182(0.98); C354(0.95)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C159(0.86); C146(0.83); C182(0.92); C354(1.07)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C159(1.02); C146(0.95); C182(1.00); C354(1.39)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C159(0.99); C182(1.09); C354(1.15)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C159(1.02); C146(1.08); C182(0.97); C354(1.03)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C159(0.83); C146(0.95); C182(1.01); C354(0.93)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C159(1.00); C146(0.97); C182(0.97); C354(1.25)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C159(0.95); C182(1.06); C354(1.24); C295(1.00)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C159(1.08); C146(0.95); C182(1.17); C354(1.21)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C159(0.97); C146(1.15); C182(1.00); C295(0.88)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C159(0.96); C146(0.83)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C159(0.97); C146(1.13); C182(0.99); C354(1.15)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C159(0.98); C182(1.01); C354(1.11); C295(0.89)  LDD1697  [15]
 LDCM0191  Compound 21 HEK-293T 4.74  LDD0508  [12]
 LDCM0190  Compound 34 HEK-293T 6.10  LDD0510  [12]
 LDCM0192  Compound 35 HEK-293T 4.93  LDD0509  [12]
 LDCM0193  Compound 36 HEK-293T 7.75  LDD0511  [12]
 LDCM0495  E2913 HEK-293T C159(0.89); C182(0.93); C354(0.93); C295(1.03)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C159(1.04); C182(0.93); C354(1.16); C295(1.01)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C159(1.02); C146(0.89); C182(0.99); C354(1.09)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C159(0.98); C354(1.13)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C159(0.96); C354(1.14)  LDD1497  [15]
 LDCM0024  KB05 NCI-H3122 C182(3.08)  LDD3360  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C159(0.75)  LDD2107  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C182(1.25)  LDD2125  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Xylosyl- and glucuronyltransferase LARGE2 (LARGE2) Glycosyltransferase 49 family; Glycosyltransferase 8 family Q8N3Y3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402