Details of the Target

General Information of Target

Target ID LDTP05960
Target Name Trophoblast glycoprotein (TPBG)
Gene Name TPBG
Gene ID 7162
Synonyms
5T4; Trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; M6P1; Wnt-activated inhibitory factor 1; WAIF1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cell membrane
Function May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
TTD ID
T09058
Uniprot ID
Q13641
DrugMap ID
TT70MLA
Ensemble ID
ENST00000369750.4
HGNC ID
HGNC:12004
ChEMBL ID
CHEMBL3712934

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		7.05  LDD0318  [1]
OPA-S-S-alkyne
 Probe Info  		K328(1.99); K76(2.54)  LDD3494  [2]
DBIA
 Probe Info  		C323(2.84)  LDD3313  [3]
BTD
 Probe Info  		C323(1.39)  LDD2101  [4]
Curcusone 37
 Probe Info  		2.91  LDD0188  [5]
m-APA
 Probe Info  		H140(0.00); H221(0.00)  LDD2231  [6]
IA-alkyne
 Probe Info  		C298(0.00); C323(0.00)  LDD0165  [7]
NAIA_5
 Probe Info  		C392(0.00); C323(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 58 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		13.18  LDD1740  [9]
C045
 Probe Info  		6.28  LDD1744  [9]
C055
 Probe Info  		12.55  LDD1752  [9]
C056
 Probe Info  		19.29  LDD1753  [9]
C063
 Probe Info  		11.63  LDD1760  [9]
C073
 Probe Info  		5.90  LDD1769  [9]
C087
 Probe Info  		7.36  LDD1779  [9]
C112
 Probe Info  		22.47  LDD1799  [9]
C115
 Probe Info  		5.10  LDD1802  [9]
C141
 Probe Info  		11.31  LDD1823  [9]
C143
 Probe Info  		17.63  LDD1825  [9]
C149
 Probe Info  		5.31  LDD1830  [9]
C158
 Probe Info  		12.38  LDD1838  [9]
C159
 Probe Info  		8.82  LDD1839  [9]
C161
 Probe Info  		11.88  LDD1841  [9]
C170
 Probe Info  		9.71  LDD1850  [9]
C176
 Probe Info  		5.13  LDD1855  [9]
C177
 Probe Info  		7.84  LDD1856  [9]
C178
 Probe Info  		30.48  LDD1857  [9]
C183
 Probe Info  		6.06  LDD1861  [9]
C187
 Probe Info  		16.80  LDD1865  [9]
C201
 Probe Info  		26.17  LDD1877  [9]
C206
 Probe Info  		15.24  LDD1881  [9]
C208
 Probe Info  		9.00  LDD1883  [9]
C210
 Probe Info  		49.18  LDD1884  [9]
C211
 Probe Info  		9.92  LDD1885  [9]
C213
 Probe Info  		15.14  LDD1887  [9]
C223
 Probe Info  		7.01  LDD1897  [9]
C228
 Probe Info  		16.45  LDD1901  [9]
C233
 Probe Info  		8.69  LDD1906  [9]
C235
 Probe Info  		17.15  LDD1908  [9]
C251
 Probe Info  		29.04  LDD1924  [9]
C252
 Probe Info  		25.46  LDD1925  [9]
C253
 Probe Info  		5.13  LDD1926  [9]
C255
 Probe Info  		7.41  LDD1928  [9]
C256
 Probe Info  		5.54  LDD1929  [9]
C278
 Probe Info  		78.79  LDD1948  [9]
C279
 Probe Info  		18.13  LDD1949  [9]
C280
 Probe Info  		10.56  LDD1950  [9]
C281
 Probe Info  		12.04  LDD1951  [9]
C282
 Probe Info  		27.28  LDD1952  [9]
C284
 Probe Info  		41.64  LDD1954  [9]
C286
 Probe Info  		5.28  LDD1956  [9]
C287
 Probe Info  		9.19  LDD1957  [9]
C288
 Probe Info  		6.32  LDD1958  [9]
C289
 Probe Info  		29.24  LDD1959  [9]
C302
 Probe Info  		7.46  LDD1971  [9]
C305
 Probe Info  		9.85  LDD1974  [9]
C310
 Probe Info  		13.64  LDD1977  [9]
C349
 Probe Info  		9.00  LDD2010  [9]
C350
 Probe Info  		24.42  LDD2011  [9]
C362
 Probe Info  		58.49  LDD2023  [9]
C363
 Probe Info  		24.76  LDD2024  [9]
C364
 Probe Info  		24.93  LDD2025  [9]
C366
 Probe Info  		5.70  LDD2027  [9]
C390
 Probe Info  		30.27  LDD2049  [9]
C403
 Probe Info  		18.25  LDD2061  [9]
C407
 Probe Info  		11.24  LDD2064  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C392(0.38)  LDD2227  [8]
 LDCM0033  Curcusone1d MCF-7 2.91  LDD0188  [5]
 LDCM0022  KB02 ICC108 C323(2.66)  LDD2381  [3]
 LDCM0023  KB03 ICC108 C323(3.72)  LDD2798  [3]
 LDCM0024  KB05 Hs 936.T C323(2.84)  LDD3313  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C323(1.39)  LDD2101  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C323(0.77)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C323(0.63)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C323(0.99)  LDD2127  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C323(0.68)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C323(1.54)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C323(0.96)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C323(0.69)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C323(0.91)  LDD2140  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C323(0.88)  LDD2148  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Trovax Vaccine D0L1OT
Naptumomab Estafenatox . D0T8HR
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cv-9201 Vaccine D02DVK
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gen1044 Antibody DQ15HJ
Pf-06263507 Antibody D03JZC
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anatumomab Mafenatox Antibody D0W5NP

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587