Details of the Target

General Information of Target

Target ID LDTP13833
Target Name Integral membrane protein 2B (ITM2B)
Gene Name ITM2B
Gene ID 9445
Synonyms
BRI; BRI2; Integral membrane protein 2B; Immature BRI2; imBRI2; Protein E25B; Transmembrane protein BRI; Bri) [Cleaved into: BRI2, membrane form; Mature BRI2; mBRI2; BRI2 intracellular domain; BRI2 ICD; BRI2C, soluble form; Bri23 peptide; Bri2-23; ABri23; C-terminal peptide; P23 peptide)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHVRCSFSYPVDSQTDSDP
VHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLSIRDARMSDAGR
YFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLESGCFQNLTCSVPWACEQGTPP
MISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVSYPP
QNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQP
SNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQEYTGKMRPVSGVLLGAVGGAG
ATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSASQGNLTESWADDNPR
HHGLAAHSSGEEREIQYAPLSFHKGEPQDLSGQEATNNEYSEIKIPK
Target Bioclass
Transporter and channel
Family
ITM2 family
Subcellular location
Secreted; Golgi apparatus membrane; Cell membrane
Function
Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
Uniprot ID
Q9Y287
Ensemble ID
ENST00000378549.5
HGNC ID
HGNC:6174

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
P31FUJ SNV: p.I69N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		4.74  LDD0318  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K13(2.96); K3(1.05)  LDD0277  [3]
BTD
 Probe Info  		C38(0.82)  LDD2100  [4]
DBIA
 Probe Info  		C89(1.49)  LDD0602  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
IPM
 Probe Info  		C223(0.00); C38(0.00); C89(0.00)  LDD2156  [8]
AOyne
 Probe Info  		12.60  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.73  LDD1714  [11]
C070
 Probe Info  		10.70  LDD1766  [11]
C073
 Probe Info  		7.31  LDD1769  [11]
C091
 Probe Info  		12.47  LDD1782  [11]
C092
 Probe Info  		22.47  LDD1783  [11]
C106
 Probe Info  		22.47  LDD1793  [11]
C107
 Probe Info  		6.92  LDD1794  [11]
C108
 Probe Info  		10.41  LDD1795  [11]
C112
 Probe Info  		20.82  LDD1799  [11]
C115
 Probe Info  		11.79  LDD1802  [11]
C141
 Probe Info  		9.45  LDD1823  [11]
C143
 Probe Info  		16.11  LDD1825  [11]
C159
 Probe Info  		12.21  LDD1839  [11]
C160
 Probe Info  		13.00  LDD1840  [11]
C161
 Probe Info  		17.63  LDD1841  [11]
C169
 Probe Info  		29.45  LDD1849  [11]
C170
 Probe Info  		42.22  LDD1850  [11]
C171
 Probe Info  		6.45  LDD1851  [11]
C186
 Probe Info  		15.24  LDD1864  [11]
C229
 Probe Info  		13.18  LDD1902  [11]
C231
 Probe Info  		30.27  LDD1904  [11]
C232
 Probe Info  		88.65  LDD1905  [11]
C233
 Probe Info  		16.68  LDD1906  [11]
C234
 Probe Info  		7.67  LDD1907  [11]
C235
 Probe Info  		33.36  LDD1908  [11]
C243
 Probe Info  		17.75  LDD1916  [11]
C244
 Probe Info  		14.22  LDD1917  [11]
C246
 Probe Info  		16.34  LDD1919  [11]
C249
 Probe Info  		19.70  LDD1922  [11]
C280
 Probe Info  		9.78  LDD1950  [11]
C281
 Probe Info  		10.85  LDD1951  [11]
C282
 Probe Info  		15.89  LDD1952  [11]
C287
 Probe Info  		12.91  LDD1957  [11]
C288
 Probe Info  		10.63  LDD1958  [11]
C289
 Probe Info  		42.22  LDD1959  [11]
C310
 Probe Info  		37.01  LDD1977  [11]
C314
 Probe Info  		14.83  LDD1981  [11]
C425
 Probe Info  		13.36  LDD2080  [11]
FFF probe11
 Probe Info  		20.00  LDD0471  [12]
FFF probe12
 Probe Info  		20.00  LDD0473  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C38(0.68)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C38(0.86)  LDD2112  [4]
 LDCM0214  AC1 HEK-293T C38(1.02); C89(1.05); C265(0.94)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C38(0.90); C89(0.92); C248(1.07)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C38(0.94); C89(0.96)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C38(1.06); C89(0.94)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C38(1.06); C89(0.97); C265(1.13)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C38(0.99); C89(1.06); C265(0.86)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C38(0.93); C89(1.01); C265(0.89)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C38(0.93); C89(1.04); C248(1.03)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C38(1.09); C89(0.99)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C38(0.89); C89(0.93); C248(1.09)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C38(0.99); C89(0.92)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C38(1.00); C89(0.95)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C38(1.05); C89(1.02); C265(0.95)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C38(0.96); C89(1.07); C265(1.37)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C38(1.03); C89(0.94); C265(1.06)  LDD1523  [13]
 LDCM0285  AC25 HCT 116 C89(1.49)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C89(1.48)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C89(1.51)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C89(1.76)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C89(1.72)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C38(1.16); C89(0.95)  LDD1529  [13]
 LDCM0291  AC30 HCT 116 C89(1.60)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C89(1.56)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C89(1.77)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C89(1.17)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C89(1.04)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C38(1.05); C89(1.03)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C38(1.06); C89(0.92)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C38(1.03); C89(0.80)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C38(0.98); C89(1.06); C265(1.40)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C38(1.00); C89(1.00); C265(0.88)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C38(0.98); C89(0.88)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C38(0.96); C89(0.96); C265(1.02)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C38(1.00); C89(1.15); C265(0.85)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C38(0.96); C89(0.93); C248(1.20)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C38(1.02); C89(1.02)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C38(1.05); C89(0.98)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C38(1.01); C89(0.98)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C38(1.06); C89(0.93); C265(1.00)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C38(0.98); C89(0.97); C265(0.98)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C38(0.99); C89(1.15); C265(1.19)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C38(0.99); C89(0.98); C265(0.77)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C38(0.98); C89(1.44)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C38(0.93); C89(1.06); C248(1.10)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C38(0.97); C89(0.96)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C38(1.02); C89(0.98)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C38(1.01); C89(1.28)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C38(1.04); C89(0.97); C265(1.04)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C38(0.96); C89(1.06); C265(1.08)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C38(0.96); C89(1.02); C265(1.05)  LDD1558  [13]
 LDCM0320  AC57 HCT 116 C89(1.10)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C89(1.34)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C89(1.24)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C38(1.00); C89(1.18); C265(0.99)  LDD1562  [13]
 LDCM0324  AC60 HCT 116 C89(1.01)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C89(1.05)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C89(1.19)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C89(0.90)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C89(1.11)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C89(1.39)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C89(1.57)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C89(1.54)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C89(1.20)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C89(1.05)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C38(1.02); C89(1.01); C265(0.68)  LDD1568  [13]
 LDCM0335  AC70 HCT 116 C89(1.09)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C89(1.14)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C89(1.11)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C89(1.34)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C89(1.31)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C89(1.55)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C89(1.23)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C89(1.01)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C89(0.92)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C89(1.24)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C38(0.95); C89(0.97); C265(1.12)  LDD1569  [13]
 LDCM0346  AC80 HCT 116 C89(1.27)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C89(0.92)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C89(1.23)  LDD0665  [5]
 LDCM0248  AKOS034007472 HEK-293T C38(1.05); C89(1.11)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C38(0.96); C89(1.02); C265(0.94)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C38(0.97); C89(1.08); C265(1.02)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C38(1.02); C89(0.88)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C38(1.41); C89(1.23); C265(1.59)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C38(0.94); C89(0.94)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C38(1.01); C89(1.26)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C38(1.01); C89(0.93)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C38(1.03); C89(0.94)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C38(0.97); C89(0.95)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C38(0.98); C89(0.82)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C38(1.07); C89(0.99)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C38(1.05); C89(0.98)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C38(0.98); C89(0.88)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C38(0.95); C89(1.11)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C38(1.45); C89(1.30); C265(1.12)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C38(0.98); C89(0.95)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C38(1.00); C89(1.01)  LDD1585  [13]
 LDCM0382  CL112 HCT 116 C89(1.38)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C89(1.49)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C89(1.75)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C89(1.46)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C89(1.27)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C38(0.95); C89(1.37)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C38(1.05); C89(1.02)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C38(1.09); C89(0.98)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C38(1.22); C89(1.01); C265(1.07)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C38(0.96); C89(1.00)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C38(0.91); C89(0.92)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C38(1.02); C89(1.07)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C38(1.00); C89(1.22)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C38(1.00); C89(1.06)  LDD1599  [13]
 LDCM0396  CL125 HCT 116 C89(0.96)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C89(0.85)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C89(0.96)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C89(1.14)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C38(1.00); C89(1.10)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C38(1.01); C89(0.96)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C38(1.09); C89(1.16)  LDD1606  [13]
 LDCM0403  CL16 HCT 116 C89(0.85)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C89(0.87)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C89(0.65)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C89(0.83)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C38(1.03); C89(1.00)  LDD1611  [13]
 LDCM0408  CL20 HCT 116 C89(0.76)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C89(1.16)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C89(1.21)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C89(0.79)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C89(0.82)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C89(1.05)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C89(0.70)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C89(0.85)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C89(1.00)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C89(1.10)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C38(1.06); C89(1.19)  LDD1622  [13]
 LDCM0419  CL30 HCT 116 C89(0.71)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C38(1.09); C89(1.02)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C38(1.32); C89(1.03)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C38(1.41); C89(1.28)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C38(1.47); C89(1.12); C265(1.57)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C38(1.66); C89(1.19); C265(0.97)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C38(1.32); C89(1.25); C265(1.07)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C38(1.03); C89(1.00)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C38(1.04); C89(1.15)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C38(1.02); C89(1.02)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C38(0.99); C89(0.95)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C38(1.00); C89(0.96); C265(0.98)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C38(1.24); C89(1.00); C248(1.12)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C38(1.12); C89(1.03)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C38(1.20); C89(0.93)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C38(1.34); C89(1.25)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C38(1.39); C89(1.27); C265(1.17)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C38(1.63); C89(1.13); C265(0.71)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C38(1.40); C89(0.97); C265(0.97)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C38(0.95); C89(1.36)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C38(1.12); C89(1.15); C265(0.96)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C38(1.05); C89(0.97)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C38(1.04); C89(1.04)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C38(1.09); C89(1.05); C265(0.88)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C38(1.08); C89(1.09); C248(1.10)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C38(1.17); C89(1.17)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C38(1.38); C89(1.00)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C38(1.36); C89(1.32)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C38(1.56); C89(1.23); C265(1.19)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C38(1.65); C89(1.10); C265(1.34)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C38(1.09); C89(1.16); C248(1.26)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C38(1.31); C89(1.17); C265(1.03)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C38(0.93); C89(1.44)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C38(0.97); C89(0.97)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C38(1.03); C89(0.97)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C38(0.97); C89(1.01)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C38(1.04); C89(0.97); C265(0.83)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C38(1.11); C89(1.04); C248(1.02)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C38(1.07); C89(0.92)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C38(1.31); C89(1.17)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C38(1.52); C89(1.62)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C38(1.22); C89(1.06)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C38(1.56); C89(1.08); C265(1.19)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C38(1.56); C89(1.20); C265(0.74)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C38(1.22); C89(1.05); C265(1.20)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C38(0.94); C89(1.23)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C38(1.03); C89(0.91)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C38(0.98); C89(0.97)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C38(0.99); C89(1.11); C265(0.88)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C38(1.05); C89(1.04); C248(1.09)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C38(1.06); C89(0.92)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C38(1.19); C89(1.44)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C38(1.26); C89(0.92)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C38(1.43); C89(1.36)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C38(1.31); C89(1.09); C265(1.04)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C38(1.27); C89(1.12); C265(1.03)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C38(1.18); C89(0.97); C265(1.09)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C38(0.86); C89(1.38)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C38(0.95); C89(1.22)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C38(1.01); C89(1.21)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C38(0.93); C89(1.08)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C38(0.93); C89(1.03); C265(1.03)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C38(1.59); C89(1.24)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C38(0.93); C89(1.17); C248(1.24)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C38(1.03); C89(1.07)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C38(1.10); C89(1.02)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C38(1.33); C89(1.18)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C38(1.26); C89(1.27); C265(1.07)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C38(1.31); C89(1.37); C265(0.98)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C38(0.99); C89(1.27); C265(1.24)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C38(0.96); C89(1.82)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C38(0.93); C89(0.89)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C38(0.98); C89(1.04)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C38(1.05); C89(0.94)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C38(1.00); C89(1.01)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C38(0.96); C89(0.98)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C38(0.92)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C38(1.04)  LDD1497  [13]
 LDCM0024  KB05 MKN45 C38(2.12)  LDD3332  [14]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C38(0.82)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C38(0.74)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C38(0.66)  LDD2106  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C38(1.29)  LDD2108  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C38(1.10)  LDD2110  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C38(0.76)  LDD2114  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C223(1.31)  LDD2129  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C38(0.99)  LDD2141  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C38(2.10)  LDD2145  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-secretase 1 (BACE1) Peptidase A1 family P56817
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADL2) Peptidase M28 family Q58DX5
Ras-related protein Rab-3C (RAB3C) Rab family Q96E17
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nesprin-4 (SYNE4) Nesprin family Q8N205
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
Protein KASH5 (KASH5) . Q8N6L0

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840