Details of the Target

General Information of Target

Target ID LDTP12586
Target Name Phenylalanine--tRNA ligase beta subunit (FARSB)
Gene Name FARSB
Gene ID 10056
Synonyms
FARSLB; FRSB; Phenylalanine--tRNA ligase beta subunit; EC 6.1.1.20; Phenylalanyl-tRNA synthetase beta subunit; PheRS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQM
IVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENAT
SPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLI
LGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNI
EDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELES
HC
Target Bioclass
Enzyme
Family
Phenylalanyl-tRNA synthetase beta subunit family, Type 2 subfamily
Subcellular location
Cytoplasm
Uniprot ID
Q9NSD9
Ensemble ID
ENST00000281828.8
HGNC ID
HGNC:17800
ChEMBL ID
CHEMBL4105969

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCFSTTG1 SNV: p.H147Y .
MELHO SNV: p.I462T DBIA    Probe Info 
MFE319 SNV: p.L75M; p.K467R DBIA    Probe Info 
NCIH23 SNV: p.E113V DBIA    Probe Info 
NUGC3 Substitution: p.R17L DBIA    Probe Info 
RCC10RGB SNV: p.R98P DBIA    Probe Info 
SBC5 SNV: p.P218S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		4.89  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y173(10.22); Y72(9.97)  LDD0260  [4]
SAHA-CA-4PAP
 Probe Info  		4.00  LDD0269  [5]
BTD
 Probe Info  		C151(2.64)  LDD1700  [6]
DA-P3
 Probe Info  		4.76  LDD0182  [7]
AHL-Pu-1
 Probe Info  		C195(6.19)  LDD0171  [8]
DBIA
 Probe Info  		C195(1.05); C151(0.92)  LDD0078  [9]
5E-2FA
 Probe Info  		H565(0.00); H297(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C362(0.00); C548(0.00); C195(0.00); C418(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [14]
IPIAA_L
 Probe Info  		C362(0.00); C76(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C362(0.00); C548(0.00); C195(0.00); C418(0.00)  LDD0037  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		C195(0.00); C362(0.00)  LDD2226  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneN
 Probe Info  		C548(0.00); C195(0.00); C76(0.00)  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		K53(0.00); K443(0.00); K560(0.00); K492(0.00)  LDD0010  [18]
OSF
 Probe Info  		H496(0.00); H297(0.00)  LDD0029  [20]
SF
 Probe Info  		N.A.  LDD0028  [20]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
1c-yne
 Probe Info  		K435(0.00); K560(0.00); K536(0.00); K176(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C255(0.00); C195(0.00); C76(0.00); H438(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C151(0.00); H297(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C76(0.00); C151(0.00); C195(0.00); C255(0.00)  LDD0218  [23]
W1
 Probe Info  		C76(0.00); C151(0.00)  LDD0236  [24]
AOyne
 Probe Info  		5.00  LDD0443  [25]
NAIA_5
 Probe Info  		C76(0.00); C548(0.00); C151(0.00); C195(0.00)  LDD2223  [17]
HHS-475
 Probe Info  		Y385(1.18)  LDD2238  [26]
HHS-482
 Probe Info  		Y372(1.73); Y385(1.07); Y63(1.78)  LDD2239  [26]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		22.16  LDD1753  [27]
C064
 Probe Info  		40.79  LDD1761  [27]
C160
 Probe Info  		6.87  LDD1840  [27]
C177
 Probe Info  		11.47  LDD1856  [27]
C185
 Probe Info  		5.74  LDD1863  [27]
C218
 Probe Info  		19.56  LDD1892  [27]
C220
 Probe Info  		13.36  LDD1894  [27]
C228
 Probe Info  		44.32  LDD1901  [27]
C243
 Probe Info  		20.82  LDD1916  [27]
C249
 Probe Info  		35.02  LDD1922  [27]
C252
 Probe Info  		8.75  LDD1925  [27]
C287
 Probe Info  		31.78  LDD1957  [27]
C289
 Probe Info  		38.59  LDD1959  [27]
C322
 Probe Info  		6.28  LDD1988  [27]
C356
 Probe Info  		12.30  LDD2017  [27]
C362
 Probe Info  		35.51  LDD2023  [27]
C363
 Probe Info  		52.71  LDD2024  [27]
C364
 Probe Info  		63.56  LDD2025  [27]
C413
 Probe Info  		27.10  LDD2069  [27]
FFF probe11
 Probe Info  		5.33  LDD0471  [28]
FFF probe13
 Probe Info  		8.49  LDD0475  [28]
FFF probe14
 Probe Info  		15.00  LDD0477  [28]
FFF probe2
 Probe Info  		10.92  LDD0463  [28]
FFF probe3
 Probe Info  		5.59  LDD0464  [28]
JN0003
 Probe Info  		12.00  LDD0469  [28]
STS-1
 Probe Info  		N.A.  LDD0136  [29]
STS-2
 Probe Info  		N.A.  LDD0138  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]
EN
 Probe Info  		2.09  LDD0418  [31]
DA-2
 Probe Info  		N.A.  LDD0072  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C151(0.56)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C151(1.05); C548(1.11); C498(0.65)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C151(1.52)  LDD2152  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C195(6.19)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C76(1.27); C151(1.19); C195(1.04); C548(1.04)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C151(0.93); C195(1.30); C548(1.17)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C195(1.19); C548(0.64)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C195(1.10); C548(0.74)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C195(1.21); C548(0.87)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C195(1.37); C548(0.74)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C195(1.34); C548(1.02)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C195(1.27); C548(0.87)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C195(1.33); C548(0.77)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C195(1.51); C548(0.73)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C195(1.09); C548(0.72)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C195(0.88); C548(0.90)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C151(0.94); C195(1.43); C548(1.11)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C195(1.21); C548(0.67)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C195(1.14); C548(0.66)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C195(1.39); C548(0.80)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C151(1.28); C195(1.13); C548(1.42)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C151(1.05); C195(1.27); C548(1.26)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C151(1.07); C195(1.45); C548(1.39)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C151(1.07); C195(1.46); C548(1.24)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C151(1.15); C195(1.11); C548(0.83)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C151(1.16); C195(1.05); C548(1.05)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C151(1.04); C195(1.24); C548(1.09)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C151(0.86); C195(1.29); C548(0.99)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C151(1.19); C195(1.38); C548(1.43)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C151(1.08); C195(1.09); C548(1.01)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C151(1.15); C195(1.14); C548(1.12)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C151(1.07); C195(1.07); C548(0.88)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C151(1.02); C195(1.08); C548(1.16)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C151(1.22); C195(1.26); C548(1.20)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C151(1.12); C195(1.26); C548(1.12)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C151(1.17); C195(1.24); C548(1.05)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C151(1.08); C195(1.21); C548(0.73)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C151(1.06); C195(0.93); C548(0.80)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C151(1.26); C195(1.31); C548(0.94)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C151(1.29); C195(0.96); C548(0.84)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C151(1.00); C195(1.08); C548(0.99)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C151(1.21); C195(1.10); C548(0.97)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C151(1.07); C195(1.36); C548(0.82)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C151(1.17); C195(1.19); C548(0.75)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C151(1.02); C195(1.17); C548(0.79)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C151(1.15); C195(1.28); C548(0.62)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C151(0.73); C195(1.40); C548(0.41)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C151(0.85); C195(1.28); C548(0.55)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C151(1.06); C195(1.23); C548(1.16)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C151(0.71); C195(1.34); C548(0.44)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C151(0.76); C195(1.45); C548(0.48)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C151(1.27); C195(1.11); C548(0.74)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C195(1.17); C498(0.95)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C498(0.82); C195(1.35)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C498(1.01); C195(1.14)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C498(0.79); C195(1.51)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C498(0.75); C195(1.70)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C498(0.22); C195(1.85)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C498(0.51); C195(1.65)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C151(1.00); C548(1.22); C195(1.24)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C498(1.09); C195(1.17)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C498(0.92); C195(1.20)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C498(0.56); C195(1.63)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C498(0.19); C195(2.16)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C195(1.37); C498(0.73)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C195(1.33); C498(0.99)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C195(1.20); C498(1.03)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C195(1.00); C498(0.95)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C498(0.88); C548(0.89); C195(1.08)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C548(0.87); C498(1.07); C195(1.50)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C548(0.91); C498(1.01); C195(1.04)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C548(1.05); C151(1.08); C76(1.18); C195(1.27)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C548(0.83); C498(1.07); C195(1.08)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C548(0.84); C195(1.09); C498(1.24)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C548(0.90); C195(1.04); C498(1.16)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C548(0.96); C195(1.16); C498(1.24)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C548(0.85); C498(0.89); C195(0.95)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C151(0.85); C76(0.96); C548(1.01); C195(1.08)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C151(0.94); C76(0.98); C548(1.04); C195(1.26)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C548(0.82); C151(0.91); C76(1.01); C195(1.21)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C151(0.83); C548(0.86); C76(0.93); C195(1.27)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C548(0.80); C151(1.01); C76(1.01); C195(1.16)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C548(0.93); C195(1.05); C151(1.13); C76(1.19)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C151(0.80); C548(0.81); C76(0.94); C195(1.32)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C548(0.86); C151(0.87); C76(1.05); C195(1.32)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C548(0.68); C76(0.71); C151(0.90); C195(1.43)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C76(0.70); C151(0.85); C548(0.98); C195(1.23)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C76(0.63); C151(0.83); C548(0.99); C195(1.59)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C195(0.82); C548(1.07); C151(1.12); C76(1.26)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C195(0.84); C548(0.90); C151(1.14); C76(1.38)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C195(0.78); C151(1.19); C548(1.21); C76(1.33)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C195(0.83); C548(0.96); C151(1.16); C76(1.53)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C195(0.98); C548(1.08); C151(1.12); C76(1.87)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C548(0.98); C76(1.09); C151(1.13); C195(1.49)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C76(0.88); C151(0.98); C548(1.03); C195(1.05)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C195(0.89); C151(1.11); C76(1.26); C548(1.33)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C195(1.00); C151(1.04); C76(1.04); C548(1.13)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C548(0.98); C195(1.02); C151(1.10); C76(1.25)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C195(0.95); C76(1.08); C151(1.13); C548(1.21)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C76(0.97); C195(1.01); C151(1.04); C548(1.29)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C151(0.97); C195(1.00); C548(1.04); C76(1.34)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C548(0.90); C76(1.00); C151(1.01); C195(1.07)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C151(1.01); C195(1.08); C76(1.34); C548(1.36)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C76(0.48); C548(0.66); C151(1.07); C195(1.39)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C548(0.90); C195(1.21); C151(1.21); C76(1.33)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C76(0.46); C548(0.69); C151(0.97); C195(1.30)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C195(0.92); C151(0.96); C548(1.02); C76(1.27)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C548(1.00); C76(1.02); C151(1.06); C195(1.06)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C76(0.62); C548(0.82); C151(0.95); C195(1.19)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C76(0.65); C548(0.75); C151(1.02); C195(1.11)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C76(0.42); C548(0.86); C151(1.06); C195(1.21)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C76(0.28); C548(0.67); C151(1.04); C195(1.53)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C151(0.97); C548(0.99); C195(1.41)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C548(0.83); C151(0.92); C195(1.40)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C548(0.73); C151(1.11); C195(1.38)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C548(1.00); C151(1.01); C195(1.37)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C548(0.99); C151(1.06); C195(1.40)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C151(1.08); C548(1.27); C195(1.28)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C548(0.76); C151(1.07); C195(1.45)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C548(0.93); C151(1.05); C195(1.33)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C548(0.87); C151(1.09); C195(1.57)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C548(1.01); C151(1.14); C195(1.48)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C151(0.99); C548(1.06); C195(1.51)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C548(0.68); C151(1.19); C195(1.71)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C498(0.80); C151(0.99); C76(1.06); C195(1.12)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C76(0.74); C498(0.78); C151(0.97); C195(1.22)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C151(0.96); C548(1.15); C195(1.31)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C498(0.31); C151(0.88); C76(0.89); C195(1.31)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C151(0.84); C76(1.05); C195(1.06); C498(1.08)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C498(0.78); C151(0.79); C76(0.89); C195(1.20)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C498(0.19); C76(0.66); C151(0.83); C195(1.70)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C498(0.20); C76(0.64); C151(0.83); C195(1.62)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C498(0.13); C76(0.63); C151(0.96); C195(1.88)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C498(0.48); C76(0.67); C151(0.85); C195(1.33)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C498(0.44); C76(0.70); C151(0.94); C195(1.27)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C76(0.92); C151(0.94); C498(1.02); C195(1.13)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C498(0.69); C151(0.90); C76(1.00); C195(1.16)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C151(0.93); C548(0.97); C195(1.38)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C498(0.56); C76(0.77); C151(0.98); C195(1.20)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C76(0.81); C151(0.91); C498(1.00); C195(1.19)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C498(0.08); C76(0.62); C151(0.93); C195(1.92)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C151(1.09); C548(1.25); C195(1.68)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C151(0.99); C548(1.31); C195(1.84)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C151(1.09); C548(1.39); C195(1.41)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C151(1.13); C195(1.21); C548(1.24)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C151(0.99); C195(1.21); C548(1.22)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C151(1.00); C195(1.12); C548(1.37)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C151(1.19); C548(1.25); C195(1.37)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C151(0.88); C195(1.04); C548(1.31)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C151(1.08); C548(1.36); C195(1.50)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C151(1.15); C548(1.23); C195(1.46)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C151(1.07); C548(1.24); C195(1.26)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C151(1.05); C195(1.35); C548(1.46)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C151(1.07); C195(1.13); C548(1.29)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C151(1.29); C195(1.36); C548(1.63)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C151(1.14); C548(1.30); C195(1.43)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C548(0.74); C195(1.63)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C548(0.81); C195(1.33)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C151(0.61)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C151(0.91); C195(1.24); C548(0.99)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C151(1.03); C195(1.20); C548(1.34)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C151(0.97); C548(1.08); C195(1.81)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.72  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C195(1.05); C151(0.92)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C151(0.84)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C195(1.53)  LDD2214  [33]
 LDCM0108  Chloroacetamide HeLa C255(0.00); C76(0.00); C195(0.00); C151(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C76(1.99); C195(1.55); C195(1.10); C498(1.05)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C195(0.94); C548(0.99); C76(1.04); C151(1.10)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C76(0.46); C151(0.90); C195(1.26); C548(1.26)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C548(1.04); C76(1.13); C195(1.14); C151(1.17)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C151(0.94); C548(1.16); C195(1.42)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C151(0.97); C548(1.12); C195(1.13)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C151(1.06); C195(1.12); C548(1.22)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C151(1.04); C548(1.11); C195(1.17)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C548(0.85); C498(1.02); C195(1.31)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C548(0.73); C498(1.11); C195(1.61)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C548(0.77); C498(0.90); C195(1.43)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C548(0.87); C498(0.93); C195(1.48)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C548(0.84); C195(1.20); C498(1.25)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C76(0.42); C548(0.89); C151(0.95); C195(1.35)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C548(0.60); C498(0.74); C195(1.28)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C548(0.71); C498(0.89); C195(1.25)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C151(0.82); C548(0.98); C76(0.99); C195(1.21)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C548(0.73); C76(0.83); C151(0.86); C195(1.50)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C548(0.73); C151(0.84); C76(1.07); C195(1.46)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C151(0.84); C548(0.90); C76(0.97); C195(1.32)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C151(0.87); C548(1.08); C76(1.09); C195(1.21)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C76(0.58); C151(0.79); C548(1.09); C195(1.21)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C195(0.90); C151(1.00); C548(1.15); C76(1.40)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C76(0.89); C151(0.93); C195(0.93); C548(1.36)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C76(0.35); C151(1.06); C548(1.19); C195(1.32)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C195(0.93); C548(1.01); C151(1.09); C76(1.78)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C195(0.87); C548(0.87); C76(0.89); C151(1.01)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C548(0.92); C151(1.00); C195(1.12); C76(1.18)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C76(0.51); C548(0.77); C151(0.92); C195(1.16)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C76(0.52); C548(0.73); C151(1.03); C195(1.30)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C151(1.02); C195(1.13); C548(1.32)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C195(0.99); C151(1.04); C548(1.12)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C195(1.09); C151(1.10); C548(1.11)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C548(0.92); C151(1.07); C195(1.36)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C76(0.61); C548(1.04); C151(1.10); C195(1.13)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C76(0.65); C195(1.00); C151(1.04); C548(1.16)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C76(0.56); C151(0.91); C195(1.09); C548(1.33)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C76(0.76); C151(0.95); C195(1.00)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C151(0.92); C76(0.99); C195(1.00)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C151(0.95); C195(0.96); C76(1.11)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C151(0.83); C195(0.96); C76(1.09)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C151(0.90); C195(0.98); C76(1.02); C548(1.04)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C76(0.58); C151(0.89); C195(1.07)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C76(0.40); C151(0.85); C195(1.42)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C76(0.24); C151(0.92); C195(1.55)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C76(0.60); C195(1.02); C151(1.06)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C76(0.44); C151(1.00); C195(1.19)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C76(0.61); C151(1.11); C195(1.11)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C76(0.72); C151(0.89); C195(1.03)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C76(0.93); C151(0.98); C195(0.95)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C76(0.62); C151(0.93); C195(1.06)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C76(0.63); C151(0.98); C195(1.09)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C76(0.79); C151(1.00); C195(0.99); C548(1.07)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C76(0.83); C151(1.03); C195(0.94)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C76(20.00); C151(0.95); C195(1.11); C498(0.96)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C76(20.00); C151(0.89); C195(1.34); C498(1.02)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C76(0.68); C151(0.91); C195(1.41); C498(0.89)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C76(0.42); C151(1.00); C195(1.56); C498(0.39)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C76(0.46); C151(0.98); C195(1.59); C498(0.52)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C76(0.50); C151(0.87); C195(1.29); C498(0.53)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C76(0.45); C151(0.85); C195(1.44); C498(0.35)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C76(0.60); C151(0.87); C195(1.60); C498(0.39)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C76(0.74); C151(0.80); C195(0.91); C548(1.04)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C76(0.59); C151(0.75); C195(1.48); C498(0.55)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C76(0.56); C151(0.89); C195(1.36); C498(0.53)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C76(0.24); C151(0.84); C195(2.56); C498(0.16)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C76(0.37); C151(0.91); C195(1.62); C498(0.37)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C76(0.79); C151(0.91); C195(1.45); C498(0.69)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C76(0.44); C151(0.93); C195(1.63); C498(0.42)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C76(1.20); C151(0.88); C195(0.80); C548(1.13)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C76(1.20); C151(0.88); C195(0.84); C548(1.37)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C76(1.16); C151(0.96); C195(0.81); C548(1.37)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C76(0.93); C151(0.90); C195(0.83); C548(1.31)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C76(0.89); C151(1.06); C195(0.97); C548(1.25)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C76(1.19); C151(0.93); C195(0.87); C548(0.92)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C76(1.17); C151(0.78); C195(0.82); C548(0.94)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C76(1.33); C151(0.92); C195(0.80); C548(0.83)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C76(1.08); C151(0.80); C195(0.84); C548(1.00)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C76(1.11); C151(0.84); C195(0.78); C548(1.22)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C76(1.12); C151(0.94); C195(0.79); C548(0.98)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C76(1.04); C151(0.99); C195(0.89); C548(0.95)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C76(1.19); C151(0.78); C195(0.76); C548(0.96)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C76(1.17); C151(0.95); C195(0.77); C548(1.13)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C76(1.04); C151(0.88); C195(0.85); C548(1.10)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C76(0.90); C151(1.00); C195(1.07); C548(1.17)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C76(0.93); C151(0.87); C195(0.93); C548(0.94)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C76(1.02); C151(1.11); C195(1.12); C548(1.08)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C76(0.88); C151(1.02); C195(1.15); C548(0.93)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C76(0.92); C151(1.09); C195(1.26); C548(1.04)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C76(0.74); C151(1.11); C195(1.30); C548(0.96)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C76(0.99); C151(1.02); C195(1.15); C548(1.32)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C76(0.54); C151(1.09); C195(1.54); C548(1.43)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C76(0.62); C151(0.97); C195(1.28); C548(1.32)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C76(0.96); C151(1.10); C195(1.27); C548(1.17)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C76(1.21); C151(1.06); C195(1.09); C548(1.26)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C76(0.52); C151(1.06); C195(1.14); C548(1.35)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C76(1.01); C151(1.10); C195(1.12); C548(1.28)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C76(0.71); C151(1.17); C195(1.39); C548(1.34)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C76(1.02); C151(1.09); C195(1.06); C548(1.24)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C76(0.82); C151(1.03); C195(1.22); C548(1.55)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C76(0.80); C151(1.05); C195(1.30); C548(1.52)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C76(0.88); C151(0.80); C195(1.16); C548(0.82)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C76(0.77); C151(0.80); C195(1.80); C548(0.79)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C76(0.85); C151(0.82); C195(1.25); C548(0.72)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C76(0.56); C151(0.80); C195(1.50); C548(0.94)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C76(0.30); C151(0.88); C195(1.53); C548(0.82)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C76(1.33); C151(0.87); C195(1.22); C548(0.85)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C76(0.70); C151(0.77); C195(1.16); C548(1.00)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C76(0.32); C151(0.83); C195(1.58); C548(0.94)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C76(0.45); C151(0.86); C195(1.98); C548(0.93)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C76(0.24); C151(0.85); C195(1.90); C548(0.70)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C76(0.81); C151(0.98); C195(1.34); C548(0.70)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C76(0.99); C151(0.90); C195(1.15); C548(0.98)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C76(0.96); C151(0.85); C195(1.42); C548(0.78)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C76(0.48); C151(0.80); C195(1.49); C548(0.83)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C76(0.22); C151(0.85); C195(2.61); C548(0.80)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C76(0.65); C151(1.01); C195(1.13); C548(0.95)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C76(0.69); C151(0.73); C195(0.90); C548(1.02)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C76(1.24); C151(1.00); C195(0.96); C548(0.93)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C76(0.88); C151(0.99); C195(1.08); C548(0.93)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C76(1.17); C151(1.05); C195(1.06); C548(1.05)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C76(1.06); C151(0.99); C195(1.24); C548(1.12)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C76(1.03); C151(0.98); C195(1.27); C548(1.09)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C76(1.08); C151(1.19); C195(1.06); C548(1.07)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C76(1.06); C151(1.02); C195(1.15); C548(1.03)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C76(0.95); C151(1.30); C195(1.03); C548(1.24)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C76(1.22); C151(1.32); C195(1.19); C548(1.31)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C498(1.00); C548(1.01); C195(0.93); C76(1.19)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C195(1.61); C151(1.34); C255(1.01)  LDD1702  [6]
 LDCM0163  Entinostat Hep-G2 2.09  LDD0418  [31]
 LDCM0625  F8 Ramos C195(1.33); C255(0.49); C548(1.03); C151(1.41)  LDD2187  [35]
 LDCM0572  Fragment10 Ramos C195(1.23); C255(0.57); C548(0.66); C151(0.52)  LDD2189  [35]
 LDCM0573  Fragment11 Ramos C195(0.38); C255(0.96); C548(5.13); C498(2.40)  LDD2190  [35]
 LDCM0574  Fragment12 Ramos C195(0.95); C255(0.57); C548(0.68); C151(0.50)  LDD2191  [35]
 LDCM0575  Fragment13 Ramos C195(1.06); C255(0.93); C548(1.25); C151(0.90)  LDD2192  [35]
 LDCM0576  Fragment14 Ramos C195(0.88); C255(0.77); C151(0.63); C498(0.42)  LDD2193  [35]
 LDCM0579  Fragment20 Ramos C195(0.91); C255(0.57); C548(1.00); C151(0.46)  LDD2194  [35]
 LDCM0580  Fragment21 Ramos C195(1.02); C255(1.07); C548(0.99); C151(0.80)  LDD2195  [35]
 LDCM0582  Fragment23 Ramos C195(1.09); C255(1.33); C548(1.13); C151(1.00)  LDD2196  [35]
 LDCM0578  Fragment27 Ramos C195(1.08); C255(1.06); C548(0.83); C151(0.81)  LDD2197  [35]
 LDCM0586  Fragment28 Ramos C195(1.03); C255(1.71); C548(0.66); C151(0.65)  LDD2198  [35]
 LDCM0588  Fragment30 Ramos C195(1.06); C255(0.80); C548(1.40); C151(1.28)  LDD2199  [35]
 LDCM0589  Fragment31 Ramos C195(1.14); C255(1.24); C548(1.61); C151(1.07)  LDD2200  [35]
 LDCM0590  Fragment32 Ramos C195(1.33); C255(0.53); C548(0.57); C151(0.69)  LDD2201  [35]
 LDCM0468  Fragment33 HCT 116 C76(0.75); C151(1.13); C195(1.21); C548(1.53)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C195(0.93); C255(0.87); C548(0.93); C151(1.21)  LDD2203  [35]
 LDCM0566  Fragment4 Ramos C195(0.95); C255(0.99); C548(1.02); C151(0.80)  LDD2184  [35]
 LDCM0427  Fragment51 HCT 116 C76(0.37); C151(0.63); C195(2.05); C498(0.23)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C195(0.81); C255(0.68); C548(1.43); C151(1.16)  LDD2204  [35]
 LDCM0614  Fragment56 Ramos C195(0.70); C255(0.79); C548(1.34); C151(1.10)  LDD2205  [35]
 LDCM0569  Fragment7 Ramos C195(1.15); C255(0.65); C548(0.63); C151(0.67)  LDD2186  [35]
 LDCM0571  Fragment9 Ramos C195(0.79); C255(0.60); C548(0.70); C151(0.42)  LDD2188  [35]
 LDCM0107  IAA HeLa C255(0.00); H512(0.00); H297(0.00); H438(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C195(2.77)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C195(1.06)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C195(1.29)  LDD0082  [9]
 LDCM0030  Luteolin HEK-293T 4.76  LDD0182  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C151(0.62)  LDD2121  [6]
 LDCM0109  NEM HeLa C255(0.00); H297(0.00); H512(0.00); H438(0.00)  LDD0223  [23]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C151(1.21)  LDD2093  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C151(1.30)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C151(0.25)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C151(1.22)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C151(1.21)  LDD2101  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C151(1.04); C498(1.03)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C151(0.64); C548(0.97)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C151(1.21)  LDD2111  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C151(2.30); C498(0.74)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C151(1.08)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C151(1.13); C548(1.04); C498(0.68); C255(1.02)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C151(0.98)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C151(1.18)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C151(1.24)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C151(1.67)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C151(0.73)  LDD2133  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C151(2.19)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C151(1.21)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C151(0.97); C548(1.00); C255(1.06)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C151(2.64)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C151(0.81)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C151(0.96)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C151(2.19)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C151(0.94)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C151(0.45)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C195(0.67)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C195(0.95)  LDD2207  [36]
 LDCM0131  RA190 MM1.R C255(1.23); C76(1.12); C195(1.05)  LDD0304  [37]
 LDCM0096  SAHA K562 4.00  LDD0269  [5]
 LDCM0170  Structure8 Ramos 16.89  LDD0433  [38]
 LDCM0021  THZ1 HCT 116 C195(1.08); C498(1.13)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase alpha subunit (FARSA) Class-II aminoacyl-tRNA synthetase family Q9Y285
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenylalanine Small molecular drug DB00120

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
31 Expanding the "minimalist" small molecule tagging approach to different bioactive compounds. Org Biomol Chem. 2019 Mar 13;17(11):3010-3017. doi: 10.1039/c8ob03175d.
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
38 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.