Details of the Target

General Information of Target

Target ID	LDTP10032
Target Name	7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B)
Gene Name	NT5C3B
Gene ID	115024
Synonyms	NT5C3L; 7-methylguanosine phosphate-specific 5'-nucleotidase; 7-methylguanosine nucleotidase; EC 3.1.3.91; Cytosolic 5'-nucleotidase 3B; Cytosolic 5'-nucleotidase III-like protein; cN-III-like protein; EC 3.1.3.5; N(7)-methylguanylate 5'-phosphatase
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLS TSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDY PFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLV GSIATQYLTNRAEHDRIARQWTKRYAT
Target Bioclass	Enzyme
Family	Pyrimidine 5'-nucleotidase family
Subcellular location	Cytoplasm
Function	Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.
Uniprot ID	Q969T7
Ensemble ID	ENST00000435506.7
HGNC ID	HGNC:28300
ChEMBL ID	CHEMBL4295921

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
NCIH1155	SNV: p.V172M			DBIA Probe Info

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 15 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
N1 Probe Info	100.00	LDD0242	[1]
STPyne Probe Info	K256(7.78)	LDD0277	[2]
IPM Probe Info	N.A.	LDD0241	[3]
BTD Probe Info	C73(1.11)	LDD2096	[4]
HHS-475 Probe Info	Y60(0.47); Y85(5.36)	LDD0264	[5]
HHS-465 Probe Info	Y60(10.00); Y85(10.00)	LDD2237	[6]
DBIA Probe Info	C210(1.43)	LDD0080	[7]
ATP probe Probe Info	N.A.	LDD0199	[8]
4-Iodoacetamidophenylacetylene Probe Info	C114(0.00); C73(0.00); C56(0.00)	LDD0038	[9]
IA-alkyne Probe Info	C114(0.00); C56(0.00); C73(0.00)	LDD0036	[9]
Lodoacetamide azide Probe Info	C114(0.00); C56(0.00); C73(0.00)	LDD0037	[9]
NAIA_4 Probe Info	N.A.	LDD2226	[10]
WYneN Probe Info	N.A.	LDD0021	[11]
VSF Probe Info	N.A.	LDD0007	[11]
AOyne Probe Info	15.00	LDD0443	[12]

PAL-AfBPP Probe

Click To Hide/Show 120 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C004 Probe Info	8.69	LDD1714	[13]
C007 Probe Info	17.88	LDD1716	[13]
C039 Probe Info	6.96	LDD1739	[13]
C040 Probe Info	7.73	LDD1740	[13]
C041 Probe Info	9.85	LDD1741	[13]
C044 Probe Info	8.75	LDD1743	[13]
C049 Probe Info	8.00	LDD1747	[13]
C059 Probe Info	6.82	LDD1756	[13]
C062 Probe Info	4.92	LDD1759	[13]
C064 Probe Info	8.40	LDD1761	[13]
C067 Probe Info	5.31	LDD1763	[13]
C069 Probe Info	6.77	LDD1765	[13]
C070 Probe Info	15.35	LDD1766	[13]
C071 Probe Info	12.21	LDD1767	[13]
C083 Probe Info	8.00	LDD1775	[13]
C084 Probe Info	7.26	LDD1776	[13]
C087 Probe Info	9.19	LDD1779	[13]
C106 Probe Info	21.86	LDD1793	[13]
C107 Probe Info	9.38	LDD1794	[13]
C112 Probe Info	17.39	LDD1799	[13]
C134 Probe Info	20.53	LDD1816	[13]
C136 Probe Info	5.86	LDD1818	[13]
C138 Probe Info	9.13	LDD1820	[13]
C139 Probe Info	27.28	LDD1821	[13]
C140 Probe Info	38.85	LDD1822	[13]
C146 Probe Info	44.32	LDD1828	[13]
C147 Probe Info	11.16	LDD1829	[13]
C159 Probe Info	9.78	LDD1839	[13]
C161 Probe Info	16.56	LDD1841	[13]
C165 Probe Info	14.32	LDD1845	[13]
C169 Probe Info	20.97	LDD1849	[13]
C177 Probe Info	12.13	LDD1856	[13]
C183 Probe Info	13.55	LDD1861	[13]
C185 Probe Info	6.77	LDD1863	[13]
C186 Probe Info	8.82	LDD1864	[13]
C187 Probe Info	20.82	LDD1865	[13]
C191 Probe Info	9.65	LDD1868	[13]
C194 Probe Info	18.64	LDD1870	[13]
C197 Probe Info	5.58	LDD1873	[13]
C204 Probe Info	9.85	LDD1879	[13]
C205 Probe Info	11.71	LDD1880	[13]
C206 Probe Info	38.85	LDD1881	[13]
C211 Probe Info	14.22	LDD1885	[13]
C216 Probe Info	28.84	LDD1890	[13]
C218 Probe Info	13.45	LDD1892	[13]
C219 Probe Info	11.79	LDD1893	[13]
C220 Probe Info	21.26	LDD1894	[13]
C225 Probe Info	7.73	LDD1898	[13]
C227 Probe Info	25.11	LDD1900	[13]
C228 Probe Info	26.35	LDD1901	[13]
C229 Probe Info	14.83	LDD1902	[13]
C231 Probe Info	11.71	LDD1904	[13]
C232 Probe Info	37.27	LDD1905	[13]
C233 Probe Info	48.50	LDD1906	[13]
C235 Probe Info	44.02	LDD1908	[13]
C240 Probe Info	12.47	LDD1913	[13]
C244 Probe Info	24.08	LDD1917	[13]
C246 Probe Info	23.75	LDD1919	[13]
C249 Probe Info	28.05	LDD1922	[13]
C258 Probe Info	9.51	LDD1931	[13]
C265 Probe Info	27.47	LDD1936	[13]
C277 Probe Info	11.55	LDD1947	[13]
C280 Probe Info	13.18	LDD1950	[13]
C282 Probe Info	19.84	LDD1952	[13]
C284 Probe Info	70.03	LDD1954	[13]
C286 Probe Info	7.67	LDD1956	[13]
C288 Probe Info	10.85	LDD1958	[13]
C290 Probe Info	25.63	LDD1960	[13]
C292 Probe Info	6.32	LDD1962	[13]
C293 Probe Info	20.82	LDD1963	[13]
C305 Probe Info	12.73	LDD1974	[13]
C307 Probe Info	14.12	LDD1975	[13]
C310 Probe Info	15.78	LDD1977	[13]
C317 Probe Info	10.85	LDD1983	[13]
C319 Probe Info	6.41	LDD1985	[13]
C322 Probe Info	6.15	LDD1988	[13]
C326 Probe Info	8.22	LDD1990	[13]
C335 Probe Info	8.46	LDD1998	[13]
C337 Probe Info	6.19	LDD2000	[13]
C342 Probe Info	42.81	LDD2004	[13]
C343 Probe Info	15.67	LDD2005	[13]
C346 Probe Info	11.24	LDD2007	[13]
C347 Probe Info	10.63	LDD2008	[13]
C349 Probe Info	8.51	LDD2010	[13]
C350 Probe Info	23.75	LDD2011	[13]
C356 Probe Info	27.10	LDD2017	[13]
C357 Probe Info	6.45	LDD2018	[13]
C361 Probe Info	18.25	LDD2022	[13]
C362 Probe Info	30.70	LDD2023	[13]
C363 Probe Info	15.89	LDD2024	[13]
C366 Probe Info	15.24	LDD2027	[13]
C374 Probe Info	5.21	LDD2034	[13]
C378 Probe Info	10.85	LDD2037	[13]
C380 Probe Info	7.31	LDD2039	[13]
C381 Probe Info	29.24	LDD2040	[13]
C386 Probe Info	8.11	LDD2045	[13]
C389 Probe Info	7.78	LDD2048	[13]
C390 Probe Info	56.10	LDD2049	[13]
C391 Probe Info	16.11	LDD2050	[13]
C392 Probe Info	6.06	LDD2051	[13]
C393 Probe Info	10.20	LDD2052	[13]
C395 Probe Info	5.98	LDD2054	[13]
C396 Probe Info	5.43	LDD2055	[13]
C399 Probe Info	12.64	LDD2058	[13]
C403 Probe Info	30.27	LDD2061	[13]
C408 Probe Info	5.39	LDD2065	[13]
C409 Probe Info	5.03	LDD2066	[13]
C411 Probe Info	19.84	LDD2067	[13]
C413 Probe Info	14.32	LDD2069	[13]
C414 Probe Info	18.25	LDD2070	[13]
C419 Probe Info	14.42	LDD2074	[13]
C420 Probe Info	12.04	LDD2075	[13]
C429 Probe Info	28.25	LDD2084	[13]
FFF probe11 Probe Info	14.77	LDD0471	[14]
FFF probe13 Probe Info	20.00	LDD0475	[14]
FFF probe14 Probe Info	18.13	LDD0477	[14]
FFF probe15 Probe Info	20.00	LDD0478	[14]
FFF probe2 Probe Info	20.00	LDD0463	[14]
FFF probe7 Probe Info	20.00	LDD0483	[14]
JN0003 Probe Info	20.00	LDD0469	[14]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HCT 116	C114(1.02); C210(1.05); C56(0.69)	LDD0531	[7]
LDCM0215	AC10	HCT 116	C114(1.03); C210(1.07); C56(0.75)	LDD0532	[7]
LDCM0216	AC100	HCT 116	C210(0.95)	LDD0533	[7]
LDCM0217	AC101	HCT 116	C210(0.91)	LDD0534	[7]
LDCM0218	AC102	HCT 116	C210(0.85)	LDD0535	[7]
LDCM0219	AC103	HCT 116	C210(0.90)	LDD0536	[7]
LDCM0220	AC104	HCT 116	C210(0.90)	LDD0537	[7]
LDCM0221	AC105	HCT 116	C210(0.98)	LDD0538	[7]
LDCM0222	AC106	HCT 116	C210(0.98)	LDD0539	[7]
LDCM0223	AC107	HCT 116	C210(0.82)	LDD0540	[7]
LDCM0224	AC108	HCT 116	C210(1.09)	LDD0541	[7]
LDCM0225	AC109	HCT 116	C210(1.34)	LDD0542	[7]
LDCM0226	AC11	HCT 116	C114(0.98); C210(0.94); C56(0.74)	LDD0543	[7]
LDCM0227	AC110	HCT 116	C210(1.19)	LDD0544	[7]
LDCM0228	AC111	HCT 116	C210(1.29)	LDD0545	[7]
LDCM0229	AC112	HCT 116	C210(0.91)	LDD0546	[7]
LDCM0230	AC113	HCT 116	C114(0.78); C210(1.02)	LDD0547	[7]
LDCM0231	AC114	HCT 116	C114(0.80); C210(1.02)	LDD0548	[7]
LDCM0232	AC115	HCT 116	C114(0.86); C210(1.11)	LDD0549	[7]
LDCM0233	AC116	HCT 116	C114(0.89); C210(1.21)	LDD0550	[7]
LDCM0234	AC117	HCT 116	C114(1.07); C210(0.95)	LDD0551	[7]
LDCM0235	AC118	HCT 116	C114(0.89); C210(1.07)	LDD0552	[7]
LDCM0236	AC119	HCT 116	C114(0.81); C210(1.10)	LDD0553	[7]
LDCM0237	AC12	HCT 116	C114(1.06); C210(0.92); C56(1.02)	LDD0554	[7]
LDCM0238	AC120	HCT 116	C114(0.79); C210(1.08)	LDD0555	[7]
LDCM0239	AC121	HCT 116	C114(1.06); C210(0.96)	LDD0556	[7]
LDCM0240	AC122	HCT 116	C114(0.91); C210(1.06)	LDD0557	[7]
LDCM0241	AC123	HCT 116	C114(0.96); C210(0.94)	LDD0558	[7]
LDCM0242	AC124	HCT 116	C114(0.96); C210(0.92)	LDD0559	[7]
LDCM0243	AC125	HCT 116	C114(0.93); C210(1.18)	LDD0560	[7]
LDCM0244	AC126	HCT 116	C114(0.97); C210(1.09)	LDD0561	[7]
LDCM0245	AC127	HCT 116	C114(0.95); C210(1.01)	LDD0562	[7]
LDCM0246	AC128	HCT 116	C210(1.08); C56(1.34)	LDD0563	[7]
LDCM0247	AC129	HCT 116	C210(1.05); C56(1.20)	LDD0564	[7]
LDCM0249	AC130	HCT 116	C210(0.99); C56(0.89)	LDD0566	[7]
LDCM0250	AC131	HCT 116	C210(1.11); C56(1.16)	LDD0567	[7]
LDCM0251	AC132	HCT 116	C210(1.20); C56(1.13)	LDD0568	[7]
LDCM0252	AC133	HCT 116	C210(1.09); C56(1.03)	LDD0569	[7]
LDCM0253	AC134	HCT 116	C210(1.24); C56(1.16)	LDD0570	[7]
LDCM0254	AC135	HCT 116	C210(1.17); C56(1.13)	LDD0571	[7]
LDCM0255	AC136	HCT 116	C210(1.17); C56(0.99)	LDD0572	[7]
LDCM0256	AC137	HCT 116	C210(1.11); C56(1.15)	LDD0573	[7]
LDCM0257	AC138	HCT 116	C210(1.23); C56(0.99)	LDD0574	[7]
LDCM0258	AC139	HCT 116	C210(1.30); C56(1.15)	LDD0575	[7]
LDCM0259	AC14	HCT 116	C114(1.16); C210(0.92); C56(0.78)	LDD0576	[7]
LDCM0260	AC140	HCT 116	C210(1.19); C56(1.15)	LDD0577	[7]
LDCM0261	AC141	HCT 116	C210(1.18); C56(1.15)	LDD0578	[7]
LDCM0262	AC142	HCT 116	C210(1.05); C56(1.01)	LDD0579	[7]
LDCM0263	AC143	HCT 116	C114(0.81); C210(1.04)	LDD0580	[7]
LDCM0264	AC144	HCT 116	C114(0.71); C210(0.99)	LDD0581	[7]
LDCM0265	AC145	HCT 116	C114(0.87); C210(1.08)	LDD0582	[7]
LDCM0266	AC146	HCT 116	C114(0.84); C210(1.13)	LDD0583	[7]
LDCM0267	AC147	HCT 116	C114(0.70); C210(1.07)	LDD0584	[7]
LDCM0268	AC148	HCT 116	C114(1.07); C210(1.19)	LDD0585	[7]
LDCM0269	AC149	HCT 116	C114(0.83); C210(1.02)	LDD0586	[7]
LDCM0270	AC15	HCT 116	C56(0.83); C210(0.97); C114(1.08)	LDD0587	[7]
LDCM0271	AC150	HCT 116	C114(0.89); C210(1.06)	LDD0588	[7]
LDCM0272	AC151	HCT 116	C114(0.92); C210(1.15)	LDD0589	[7]
LDCM0273	AC152	HCT 116	C114(0.86); C210(1.01)	LDD0590	[7]
LDCM0274	AC153	HCT 116	C114(0.81); C210(1.21)	LDD0591	[7]
LDCM0621	AC154	HCT 116	C114(0.75); C210(1.05)	LDD2158	[7]
LDCM0622	AC155	HCT 116	C114(0.83); C210(1.06)	LDD2159	[7]
LDCM0623	AC156	HCT 116	C114(0.78); C210(1.05)	LDD2160	[7]
LDCM0624	AC157	HCT 116	C114(0.82); C210(0.94)	LDD2161	[7]
LDCM0276	AC17	HCT 116	C210(0.88); C114(0.92); C56(0.95)	LDD0593	[7]
LDCM0277	AC18	HCT 116	C114(0.73); C56(0.93); C210(1.03)	LDD0594	[7]
LDCM0278	AC19	HCT 116	C114(0.87); C210(0.92); C56(0.99)	LDD0595	[7]
LDCM0279	AC2	HCT 116	C56(0.80); C114(0.84); C210(1.13)	LDD0596	[7]
LDCM0280	AC20	HCT 116	C210(0.85); C114(0.88); C56(1.10)	LDD0597	[7]
LDCM0281	AC21	HCT 116	C114(0.80); C210(0.88); C56(0.93)	LDD0598	[7]
LDCM0282	AC22	HCT 116	C114(0.81); C210(0.92); C56(1.09)	LDD0599	[7]
LDCM0283	AC23	HCT 116	C114(0.78); C210(0.91); C56(1.06)	LDD0600	[7]
LDCM0284	AC24	HCT 116	C210(0.90); C114(0.91); C56(1.05)	LDD0601	[7]
LDCM0285	AC25	HCT 116	C210(1.00); C56(1.01); C114(1.09)	LDD0602	[7]
LDCM0286	AC26	HCT 116	C56(0.95); C114(1.05); C210(1.05)	LDD0603	[7]
LDCM0287	AC27	HCT 116	C114(0.99); C56(1.05); C210(1.07)	LDD0604	[7]
LDCM0288	AC28	HCT 116	C56(0.97); C210(0.99); C114(1.00)	LDD0605	[7]
LDCM0289	AC29	HCT 116	C114(0.93); C56(0.96); C210(1.00)	LDD0606	[7]
LDCM0290	AC3	HCT 116	C56(0.82); C114(0.85); C210(1.07)	LDD0607	[7]
LDCM0291	AC30	HCT 116	C56(0.90); C114(1.03); C210(1.10)	LDD0608	[7]
LDCM0292	AC31	HCT 116	C210(1.00); C56(1.04); C114(1.09)	LDD0609	[7]
LDCM0293	AC32	HCT 116	C56(0.87); C114(0.92); C210(1.14)	LDD0610	[7]
LDCM0294	AC33	HCT 116	C56(0.88); C114(0.89); C210(1.06)	LDD0611	[7]
LDCM0295	AC34	HCT 116	C56(0.89); C114(0.92); C210(1.07)	LDD0612	[7]
LDCM0296	AC35	HCT 116	C210(0.92); C56(1.05); C114(1.19)	LDD0613	[7]
LDCM0297	AC36	HCT 116	C210(0.89); C56(0.94); C114(1.13)	LDD0614	[7]
LDCM0298	AC37	HCT 116	C56(0.69); C210(0.88); C114(1.10)	LDD0615	[7]
LDCM0299	AC38	HCT 116	C210(0.89); C56(0.91); C114(1.12)	LDD0616	[7]
LDCM0300	AC39	HCT 116	C210(0.88); C114(1.00); C56(1.12)	LDD0617	[7]
LDCM0301	AC4	HCT 116	C56(0.82); C114(0.85); C210(1.14)	LDD0618	[7]
LDCM0302	AC40	HCT 116	C56(0.80); C210(0.92); C114(1.00)	LDD0619	[7]
LDCM0303	AC41	HCT 116	C56(0.78); C210(0.97); C114(1.01)	LDD0620	[7]
LDCM0304	AC42	HCT 116	C56(0.87); C210(0.95); C114(0.95)	LDD0621	[7]
LDCM0305	AC43	HCT 116	C56(0.77); C114(0.93); C210(0.95)	LDD0622	[7]
LDCM0306	AC44	HCT 116	C56(0.66); C210(0.92); C114(0.97)	LDD0623	[7]
LDCM0307	AC45	HCT 116	C56(0.66); C210(0.90); C114(0.91)	LDD0624	[7]
LDCM0308	AC46	HCT 116	C114(0.88); C56(1.05); C210(1.05)	LDD0625	[7]
LDCM0309	AC47	HCT 116	C56(0.84); C114(0.90); C210(1.06)	LDD0626	[7]
LDCM0310	AC48	HCT 116	C114(0.90); C56(1.01); C210(1.09)	LDD0627	[7]
LDCM0311	AC49	HCT 116	C114(0.88); C56(0.92); C210(1.20)	LDD0628	[7]
LDCM0312	AC5	HCT 116	C56(0.78); C114(0.89); C210(1.12)	LDD0629	[7]
LDCM0313	AC50	HCT 116	C114(0.83); C56(0.86); C210(1.06)	LDD0630	[7]
LDCM0314	AC51	HCT 116	C210(1.04); C114(1.16); C56(1.24)	LDD0631	[7]
LDCM0315	AC52	HCT 116	C114(0.94); C56(0.95); C210(1.09)	LDD0632	[7]
LDCM0316	AC53	HCT 116	C114(0.80); C56(0.91); C210(1.03)	LDD0633	[7]
LDCM0317	AC54	HCT 116	C114(0.87); C56(0.95); C210(1.06)	LDD0634	[7]
LDCM0318	AC55	HCT 116	C114(0.81); C56(1.08); C210(1.09)	LDD0635	[7]
LDCM0319	AC56	HCT 116	C114(0.92); C56(1.00); C210(1.20)	LDD0636	[7]
LDCM0320	AC57	HCT 116	C114(0.44); C210(1.04); C56(1.11)	LDD0637	[7]
LDCM0321	AC58	HCT 116	C114(0.41); C210(1.17); C56(1.25)	LDD0638	[7]
LDCM0322	AC59	HCT 116	C114(0.40); C56(1.04); C210(1.08)	LDD0639	[7]
LDCM0323	AC6	HCT 116	C56(0.78); C210(0.91); C114(0.98)	LDD0640	[7]
LDCM0324	AC60	HCT 116	C114(0.40); C56(0.90); C210(1.00)	LDD0641	[7]
LDCM0325	AC61	HCT 116	C114(0.36); C210(1.03); C56(1.04)	LDD0642	[7]
LDCM0326	AC62	HCT 116	C114(0.40); C56(0.96); C210(1.09)	LDD0643	[7]
LDCM0327	AC63	HCT 116	C114(0.43); C210(1.03); C56(1.16)	LDD0644	[7]
LDCM0328	AC64	HCT 116	C114(0.40); C56(1.03); C210(1.17)	LDD0645	[7]
LDCM0329	AC65	HCT 116	C114(0.46); C56(0.89); C210(1.20)	LDD0646	[7]
LDCM0330	AC66	HCT 116	C114(0.46); C56(1.03); C210(1.22)	LDD0647	[7]
LDCM0331	AC67	HCT 116	C114(0.45); C56(0.79); C210(1.29)	LDD0648	[7]
LDCM0332	AC68	HCT 116	C56(0.73); C114(0.89); C210(0.96)	LDD0649	[7]
LDCM0333	AC69	HCT 116	C114(0.72); C56(0.81); C210(0.93)	LDD0650	[7]
LDCM0334	AC7	HCT 116	C114(0.80); C56(0.88); C210(0.90)	LDD0651	[7]
LDCM0335	AC70	HCT 116	C114(0.66); C56(0.71); C210(0.93)	LDD0652	[7]
LDCM0336	AC71	HCT 116	C114(0.89); C56(0.97); C210(0.99)	LDD0653	[7]
LDCM0337	AC72	HCT 116	C114(0.71); C56(0.83); C210(0.97)	LDD0654	[7]
LDCM0338	AC73	HCT 116	C114(0.74); C56(0.81); C210(1.17)	LDD0655	[7]
LDCM0339	AC74	HCT 116	C114(0.79); C56(0.88); C210(1.12)	LDD0656	[7]
LDCM0340	AC75	HCT 116	C114(0.81); C56(0.85); C210(1.20)	LDD0657	[7]
LDCM0341	AC76	HCT 116	C114(0.71); C56(0.84); C210(0.98)	LDD0658	[7]
LDCM0342	AC77	HCT 116	C114(0.68); C56(0.83); C210(1.01)	LDD0659	[7]
LDCM0343	AC78	HCT 116	C114(0.71); C56(0.83); C210(0.96)	LDD0660	[7]
LDCM0344	AC79	HCT 116	C114(0.80); C56(0.89); C210(1.06)	LDD0661	[7]
LDCM0345	AC8	HCT 116	C56(0.91); C114(0.93); C210(0.95)	LDD0662	[7]
LDCM0346	AC80	HCT 116	C114(0.72); C56(0.85); C210(0.96)	LDD0663	[7]
LDCM0347	AC81	HCT 116	C114(0.83); C56(0.88); C210(0.95)	LDD0664	[7]
LDCM0348	AC82	HCT 116	C114(0.79); C56(0.83); C210(1.25)	LDD0665	[7]
LDCM0349	AC83	HCT 116	C114(0.70); C56(0.79); C210(1.06)	LDD0666	[7]
LDCM0350	AC84	HCT 116	C114(0.70); C56(0.80); C210(1.05)	LDD0667	[7]
LDCM0351	AC85	HCT 116	C114(0.79); C56(0.90); C210(0.98)	LDD0668	[7]
LDCM0352	AC86	HCT 116	C114(0.82); C56(0.86); C210(1.10)	LDD0669	[7]
LDCM0353	AC87	HCT 116	C210(0.93); C56(0.95); C114(0.96)	LDD0670	[7]
LDCM0354	AC88	HCT 116	C210(1.06); C114(1.08); C56(1.21)	LDD0671	[7]
LDCM0355	AC89	HCT 116	C114(0.75); C56(0.89); C210(1.05)	LDD0672	[7]
LDCM0357	AC90	HCT 116	C210(1.11); C114(1.30); C56(1.61)	LDD0674	[7]
LDCM0358	AC91	HCT 116	C114(0.76); C56(0.91); C210(1.02)	LDD0675	[7]
LDCM0359	AC92	HCT 116	C114(0.75); C56(1.00); C210(1.04)	LDD0676	[7]
LDCM0360	AC93	HCT 116	C114(0.85); C210(0.95); C56(0.96)	LDD0677	[7]
LDCM0361	AC94	HCT 116	C114(0.74); C56(0.84); C210(0.97)	LDD0678	[7]
LDCM0362	AC95	HCT 116	C114(0.73); C56(0.81); C210(0.90)	LDD0679	[7]
LDCM0363	AC96	HCT 116	C114(0.72); C56(0.93); C210(1.00)	LDD0680	[7]
LDCM0364	AC97	HCT 116	C114(0.70); C56(0.78); C210(1.02)	LDD0681	[7]
LDCM0365	AC98	HCT 116	C210(1.01)	LDD0682	[7]
LDCM0366	AC99	HCT 116	C210(0.94)	LDD0683	[7]
LDCM0248	AKOS034007472	HCT 116	C114(1.11); C210(0.99); C56(1.03)	LDD0565	[7]
LDCM0356	AKOS034007680	HCT 116	C56(0.88); C210(0.96); C114(0.99)	LDD0673	[7]
LDCM0275	AKOS034007705	HCT 116	C56(0.63); C210(1.03); C114(1.05)	LDD0592	[7]
LDCM0367	CL1	HCT 116	C210(0.85); C56(1.09); C114(1.21)	LDD0684	[7]
LDCM0368	CL10	HCT 116	C114(0.80); C56(0.83); C210(0.92)	LDD0685	[7]
LDCM0369	CL100	HCT 116	C56(0.76); C114(0.90); C210(1.13)	LDD0686	[7]
LDCM0370	CL101	HCT 116	C56(0.76); C210(0.96); C114(0.99)	LDD0687	[7]
LDCM0371	CL102	HCT 116	C114(0.80); C56(0.88); C210(0.98)	LDD0688	[7]
LDCM0372	CL103	HCT 116	C210(0.86); C56(0.92); C114(1.05)	LDD0689	[7]
LDCM0373	CL104	HCT 116	C56(0.81); C114(0.90); C210(0.92)	LDD0690	[7]
LDCM0374	CL105	HCT 116	C114(0.81); C56(0.90); C210(0.97)	LDD0691	[7]
LDCM0375	CL106	HCT 116	C114(0.79); C56(0.92); C210(1.12)	LDD0692	[7]
LDCM0376	CL107	HCT 116	C114(0.78); C56(0.90); C210(1.07)	LDD0693	[7]
LDCM0377	CL108	HCT 116	C114(0.78); C56(0.92); C210(1.15)	LDD0694	[7]
LDCM0378	CL109	HCT 116	C114(0.76); C56(0.84); C210(0.95)	LDD0695	[7]
LDCM0379	CL11	HCT 116	C114(0.71); C56(0.83); C210(1.03)	LDD0696	[7]
LDCM0380	CL110	HCT 116	C114(0.73); C56(0.90); C210(1.02)	LDD0697	[7]
LDCM0381	CL111	HCT 116	C114(0.72); C56(0.86); C210(0.99)	LDD0698	[7]
LDCM0382	CL112	HCT 116	C114(0.99); C210(1.02); C56(1.44)	LDD0699	[7]
LDCM0383	CL113	HCT 116	C56(0.91); C114(1.01); C210(1.12)	LDD0700	[7]
LDCM0384	CL114	HCT 116	C114(0.90); C56(0.98); C210(1.03)	LDD0701	[7]
LDCM0385	CL115	HCT 116	C114(0.90); C210(0.99); C56(1.04)	LDD0702	[7]
LDCM0386	CL116	HCT 116	C114(0.85); C56(0.96); C210(1.04)	LDD0703	[7]
LDCM0387	CL117	HCT 116	C114(1.02); C56(1.05); C210(1.12)	LDD0704	[7]
LDCM0388	CL118	HCT 116	C56(0.73); C114(0.95); C210(1.00)	LDD0705	[7]
LDCM0389	CL119	HCT 116	C56(0.82); C114(0.90); C210(0.98)	LDD0706	[7]
LDCM0390	CL12	HCT 116	C56(0.79); C114(0.86); C210(1.03)	LDD0707	[7]
LDCM0391	CL120	HCT 116	C56(0.81); C114(0.98); C210(0.98)	LDD0708	[7]
LDCM0392	CL121	HCT 116	C210(0.88); C114(0.89); C56(1.04)	LDD0709	[7]
LDCM0393	CL122	HCT 116	C114(0.86); C56(0.91); C210(1.05)	LDD0710	[7]
LDCM0394	CL123	HCT 116	C56(0.82); C114(0.83); C210(1.04)	LDD0711	[7]
LDCM0395	CL124	HCT 116	C114(0.80); C56(0.98); C210(1.11)	LDD0712	[7]
LDCM0396	CL125	HCT 116	C114(0.89); C56(0.98); C210(1.07)	LDD0713	[7]
LDCM0397	CL126	HCT 116	C114(0.59); C56(0.93); C210(1.00)	LDD0714	[7]
LDCM0398	CL127	HCT 116	C114(0.59); C56(0.87); C210(1.01)	LDD0715	[7]
LDCM0399	CL128	HCT 116	C114(0.42); C56(0.98); C210(1.05)	LDD0716	[7]
LDCM0400	CL13	HCT 116	C56(0.73); C114(0.76); C210(0.93)	LDD0717	[7]
LDCM0401	CL14	HCT 116	C56(0.86); C210(0.88); C114(0.90)	LDD0718	[7]
LDCM0402	CL15	HCT 116	C114(0.77); C56(0.89); C210(0.99)	LDD0719	[7]
LDCM0403	CL16	HCT 116	C114(0.75); C56(0.80); C210(0.93)	LDD0720	[7]
LDCM0404	CL17	HCT 116	C114(0.63); C56(0.68); C210(0.93)	LDD0721	[7]
LDCM0405	CL18	HCT 116	C114(0.42); C56(0.55); C210(0.85)	LDD0722	[7]
LDCM0406	CL19	HCT 116	C114(0.61); C56(0.67); C210(0.99)	LDD0723	[7]
LDCM0407	CL2	HCT 116	C210(0.88); C56(0.94); C114(1.13)	LDD0724	[7]
LDCM0408	CL20	HCT 116	C114(0.53); C56(0.57); C210(0.98)	LDD0725	[7]
LDCM0409	CL21	HCT 116	C114(0.52); C56(0.60); C210(1.11)	LDD0726	[7]
LDCM0410	CL22	HCT 116	C56(0.66); C114(0.72); C210(1.28)	LDD0727	[7]
LDCM0411	CL23	HCT 116	C114(0.59); C56(0.66); C210(0.95)	LDD0728	[7]
LDCM0412	CL24	HCT 116	C114(0.53); C56(0.61); C210(1.07)	LDD0729	[7]
LDCM0413	CL25	HCT 116	C114(0.57); C210(1.08); C56(0.74)	LDD0730	[7]
LDCM0414	CL26	HCT 116	C114(0.62); C210(0.95); C56(0.69)	LDD0731	[7]
LDCM0415	CL27	HCT 116	C114(0.65); C210(1.06); C56(0.67)	LDD0732	[7]
LDCM0416	CL28	HCT 116	C114(0.57); C210(0.99); C56(0.61)	LDD0733	[7]
LDCM0417	CL29	HCT 116	C114(0.56); C210(1.09); C56(0.58)	LDD0734	[7]
LDCM0418	CL3	HCT 116	C114(0.96); C210(0.94); C56(0.99)	LDD0735	[7]
LDCM0419	CL30	HCT 116	C114(0.64); C210(1.02); C56(0.71)	LDD0736	[7]
LDCM0420	CL31	HCT 116	C114(0.75); C210(1.03); C56(0.86)	LDD0737	[7]
LDCM0421	CL32	HCT 116	C114(0.60); C210(1.02); C56(0.65)	LDD0738	[7]
LDCM0422	CL33	HCT 116	C114(0.56); C210(1.04); C56(0.72)	LDD0739	[7]
LDCM0423	CL34	HCT 116	C114(0.66); C210(1.15); C56(0.79)	LDD0740	[7]
LDCM0424	CL35	HCT 116	C114(0.51); C210(1.22); C56(0.76)	LDD0741	[7]
LDCM0425	CL36	HCT 116	C114(0.59); C210(1.08); C56(0.79)	LDD0742	[7]
LDCM0426	CL37	HCT 116	C114(0.63); C210(1.11); C56(0.84)	LDD0743	[7]
LDCM0428	CL39	HCT 116	C114(0.64); C210(1.19); C56(0.72)	LDD0745	[7]
LDCM0429	CL4	HCT 116	C114(1.00); C210(0.97); C56(0.82)	LDD0746	[7]
LDCM0430	CL40	HCT 116	C114(0.54); C210(1.04); C56(0.79)	LDD0747	[7]
LDCM0431	CL41	HCT 116	C114(0.56); C210(1.14); C56(0.74)	LDD0748	[7]
LDCM0432	CL42	HCT 116	C114(0.72); C210(1.27); C56(0.92)	LDD0749	[7]
LDCM0433	CL43	HCT 116	C114(0.56); C210(1.19); C56(0.69)	LDD0750	[7]
LDCM0434	CL44	HCT 116	C114(0.54); C210(1.05); C56(0.72)	LDD0751	[7]
LDCM0435	CL45	HCT 116	C114(0.66); C210(1.26); C56(0.69)	LDD0752	[7]
LDCM0436	CL46	HCT 116	C210(1.02); C56(0.74)	LDD0753	[7]
LDCM0437	CL47	HCT 116	C210(1.05); C56(0.74)	LDD0754	[7]
LDCM0438	CL48	HCT 116	C210(1.05); C56(0.76)	LDD0755	[7]
LDCM0439	CL49	HCT 116	C210(0.99); C56(0.88)	LDD0756	[7]
LDCM0440	CL5	HCT 116	C114(0.89); C210(0.87); C56(0.90)	LDD0757	[7]
LDCM0441	CL50	HCT 116	C210(1.06); C56(1.02)	LDD0758	[7]
LDCM0442	CL51	HCT 116	C210(1.09); C56(0.91)	LDD0759	[7]
LDCM0443	CL52	HCT 116	C210(1.12); C56(0.86)	LDD0760	[7]
LDCM0444	CL53	HCT 116	C210(1.03); C56(0.70)	LDD0761	[7]
LDCM0445	CL54	HCT 116	C210(1.02); C56(0.80)	LDD0762	[7]
LDCM0446	CL55	HCT 116	C210(0.98); C56(0.76)	LDD0763	[7]
LDCM0447	CL56	HCT 116	C210(0.95); C56(0.78)	LDD0764	[7]
LDCM0448	CL57	HCT 116	C210(1.02); C56(0.74)	LDD0765	[7]
LDCM0449	CL58	HCT 116	C210(1.12); C56(0.81)	LDD0766	[7]
LDCM0450	CL59	HCT 116	C210(1.06); C56(0.83)	LDD0767	[7]
LDCM0451	CL6	HCT 116	C114(0.86); C210(0.99); C56(0.74)	LDD0768	[7]
LDCM0452	CL60	HCT 116	C210(1.06); C56(0.82)	LDD0769	[7]
LDCM0453	CL61	HCT 116	C114(0.92); C210(1.04); C56(1.01)	LDD0770	[7]
LDCM0454	CL62	HCT 116	C114(0.91); C210(0.97); C56(1.03)	LDD0771	[7]
LDCM0455	CL63	HCT 116	C114(0.74); C210(1.13); C56(0.93)	LDD0772	[7]
LDCM0456	CL64	HCT 116	C114(0.75); C210(1.15); C56(0.87)	LDD0773	[7]
LDCM0457	CL65	HCT 116	C114(0.90); C210(0.98); C56(1.03)	LDD0774	[7]
LDCM0458	CL66	HCT 116	C114(0.78); C210(1.12); C56(0.98)	LDD0775	[7]
LDCM0459	CL67	HCT 116	C114(0.78); C210(1.08); C56(0.89)	LDD0776	[7]
LDCM0460	CL68	HCT 116	C114(0.74); C210(1.04); C56(0.84)	LDD0777	[7]
LDCM0461	CL69	HCT 116	C114(0.67); C210(0.86); C56(0.82)	LDD0778	[7]
LDCM0462	CL7	HCT 116	C114(0.80); C210(1.00); C56(0.78)	LDD0779	[7]
LDCM0463	CL70	HCT 116	C114(0.80); C210(1.00); C56(0.98)	LDD0780	[7]
LDCM0464	CL71	HCT 116	C114(0.85); C210(1.03); C56(1.07)	LDD0781	[7]
LDCM0465	CL72	HCT 116	C114(0.94); C210(1.06); C56(0.87)	LDD0782	[7]
LDCM0466	CL73	HCT 116	C114(0.84); C210(1.05); C56(0.97)	LDD0783	[7]
LDCM0467	CL74	HCT 116	C114(0.81); C210(1.05); C56(1.01)	LDD0784	[7]
LDCM0469	CL76	HCT 116	C114(0.79); C210(0.88); C56(0.75)	LDD0786	[7]
LDCM0470	CL77	HCT 116	C114(0.81); C210(0.92); C56(0.95)	LDD0787	[7]
LDCM0471	CL78	HCT 116	C114(0.95); C210(0.95); C56(0.91)	LDD0788	[7]
LDCM0472	CL79	HCT 116	C114(0.83); C210(1.00); C56(0.73)	LDD0789	[7]
LDCM0473	CL8	HCT 116	C114(0.79); C210(1.01); C56(0.78)	LDD0790	[7]
LDCM0474	CL80	HCT 116	C114(0.91); C210(0.87); C56(0.77)	LDD0791	[7]
LDCM0475	CL81	HCT 116	C114(0.84); C210(0.96); C56(0.85)	LDD0792	[7]
LDCM0476	CL82	HCT 116	C114(0.90); C210(0.96); C56(0.67)	LDD0793	[7]
LDCM0477	CL83	HCT 116	C114(0.93); C210(1.06); C56(0.74)	LDD0794	[7]
LDCM0478	CL84	HCT 116	C114(0.85); C210(1.13); C56(0.72)	LDD0795	[7]
LDCM0479	CL85	HCT 116	C114(0.75); C210(0.95); C56(0.76)	LDD0796	[7]
LDCM0480	CL86	HCT 116	C114(0.83); C210(0.95); C56(0.85)	LDD0797	[7]
LDCM0481	CL87	HCT 116	C114(0.78); C210(1.00); C56(0.75)	LDD0798	[7]
LDCM0482	CL88	HCT 116	C114(0.79); C210(0.98); C56(0.67)	LDD0799	[7]
LDCM0483	CL89	HCT 116	C114(1.00); C210(1.20); C56(0.88)	LDD0800	[7]
LDCM0484	CL9	HCT 116	C114(0.90); C210(0.95); C56(0.76)	LDD0801	[7]
LDCM0485	CL90	HCT 116	C114(0.74); C210(0.87); C56(1.12)	LDD0802	[7]
LDCM0486	CL91	HCT 116	C114(0.83); C210(1.11); C56(0.83)	LDD0803	[7]
LDCM0487	CL92	HCT 116	C114(0.84); C210(1.06); C56(0.86)	LDD0804	[7]
LDCM0488	CL93	HCT 116	C114(0.90); C210(1.03); C56(0.84)	LDD0805	[7]
LDCM0489	CL94	HCT 116	C114(1.07); C210(1.10); C56(0.80)	LDD0806	[7]
LDCM0490	CL95	HCT 116	C114(0.90); C210(1.15); C56(0.81)	LDD0807	[7]
LDCM0491	CL96	HCT 116	C114(0.91); C210(1.11); C56(0.81)	LDD0808	[7]
LDCM0492	CL97	HCT 116	C114(1.03); C210(1.15); C56(0.75)	LDD0809	[7]
LDCM0493	CL98	HCT 116	C114(0.82); C210(1.13); C56(0.75)	LDD0810	[7]
LDCM0494	CL99	HCT 116	C114(0.88); C210(1.09); C56(0.71)	LDD0811	[7]
LDCM0185	Compound 17	HEK-293T	4.65	LDD0512	[14]
LDCM0495	E2913	HEK-293T	C210(0.81); C56(1.16); C290(0.88); C73(1.06)	LDD1698	[15]
LDCM0468	Fragment33	HCT 116	C114(0.82); C210(0.99); C56(0.83)	LDD0785	[7]
LDCM0427	Fragment51	HCT 116	C114(0.70); C210(1.36); C56(0.97)	LDD0744	[7]
LDCM0116	HHS-0101	DM93	Y60(0.47); Y85(5.36)	LDD0264	[5]
LDCM0117	HHS-0201	DM93	Y60(0.23); Y85(1.50)	LDD0265	[5]
LDCM0118	HHS-0301	DM93	Y60(4.12)	LDD0266	[5]
LDCM0119	HHS-0401	DM93	Y60(4.43)	LDD0267	[5]
LDCM0120	HHS-0701	DM93	Y85(0.17); Y60(1.20)	LDD0268	[5]
LDCM0022	KB02	HCT 116	C210(1.43)	LDD0080	[7]
LDCM0023	KB03	HCT 116	C210(1.17)	LDD0081	[7]
LDCM0024	KB05	HCT 116	C210(1.31)	LDD0082	[7]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C73(1.11)	LDD2096	[4]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C73(0.64)	LDD2124	[4]
LDCM0627	NUDT7-COV-1	HEK-293T	C210(0.68)	LDD2206	[16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1)				DNA mismatch repair MutL/HexB family	P40692

References

1	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
3	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
5	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6	Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
10	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
11	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
14	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
16	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

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Prof. Feng Zhu

Prof. Feng Ni