Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C146  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 44.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 13.0
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 11.5
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 7.4
 LDTP12020  Histone-lysine N-methyltransferase SMYD3 (SMYD3) 6.9
 LDTP12509  N-lysine methyltransferase SMYD2 (SMYD2) 5.7
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 5.3
Transporter and channel
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 5.1
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.1

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587