Details of the Target

General Information of Target

Target ID LDTP18459
Target Name StAR-related lipid transfer protein 7, mitochondrial (STARD7)
Gene Name STARD7
Gene ID 56910
Synonyms
GTT1; StAR-related lipid transfer protein 7, mitochondrial; Gestational trophoblastic tumor protein 1; START domain-containing protein 7; StARD7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQGLVTFADVAIDFSQEEWACLNSAQRDLYWDVMLENYSNLVSLDLESAYENKSLPTEK
NIHEIRASKRNSDRRSKSLGRNWICEGTLERPQRSRGRYVNQMIINYVKRPATREGTPPR
THQRHHKENSFECKDCGKAFSRGYQLSQHQKIHTGEKPYECKECKKAFRWGNQLTQHQKI
HTGEKPYECKDCGKAFRWGSSLVIHKRIHTGEKPYECKDCGKAFRRGDELTQHQRFHTGE
KDYECKDCGKTFSRVYKLIQHKRIHSGEKPYECKDCGKAFICGSSLIQHKRIHTGEKPYE
CQECGKAFTRVNYLTQHQKIHTGEKPHECKECGKAFRWGSSLVKHERIHTGEKPYKCTEC
GKAFNCGYHLTQHERIHTGETPYKCKECGKAFIYGSSLVKHERIHTGVKPYGCTECGKSF
SHGHQLTQHQKTHSGAKSYECKECGKACNHLNHLREHQRIHNS
Target Bioclass
Transporter and channel
Subcellular location
Mitochondrion
Function May play a protective role in mucosal tissues by preventing exaggerated allergic responses.
Uniprot ID
Q9NQZ5
Ensemble ID
ENST00000337288.10
HGNC ID
HGNC:18063
ChEMBL ID
CHEMBL3399912

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Curcusone 37
 Probe Info  		3.23  LDD0188  [2]
YY4-yne
 Probe Info  		2.24  LDD0400  [3]
HHS-475
 Probe Info  		Y267(0.80)  LDD0264  [4]
DBIA
 Probe Info  		C362(1.06)  LDD0078  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
NAIA_5
 Probe Info  		N.A.  LDD2225  [9]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		C362(0.00); C302(0.00)  LDD0018  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 75 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C011
 Probe Info  		10.93  LDD1720  [13]
C022
 Probe Info  		11.63  LDD1728  [13]
C040
 Probe Info  		6.36  LDD1740  [13]
C041
 Probe Info  		8.57  LDD1741  [13]
C055
 Probe Info  		24.59  LDD1752  [13]
C063
 Probe Info  		12.47  LDD1760  [13]
C070
 Probe Info  		17.15  LDD1766  [13]
C071
 Probe Info  		10.56  LDD1767  [13]
C085
 Probe Info  		16.56  LDD1777  [13]
C087
 Probe Info  		7.36  LDD1779  [13]
C091
 Probe Info  		10.13  LDD1782  [13]
C092
 Probe Info  		17.27  LDD1783  [13]
C094
 Probe Info  		26.91  LDD1785  [13]
C100
 Probe Info  		7.16  LDD1789  [13]
C106
 Probe Info  		26.91  LDD1793  [13]
C107
 Probe Info  		8.17  LDD1794  [13]
C108
 Probe Info  		17.27  LDD1795  [13]
C112
 Probe Info  		22.78  LDD1799  [13]
C129
 Probe Info  		10.48  LDD1811  [13]
C130
 Probe Info  		7.94  LDD1812  [13]
C134
 Probe Info  		28.05  LDD1816  [13]
C135
 Probe Info  		9.92  LDD1817  [13]
C139
 Probe Info  		15.14  LDD1821  [13]
C143
 Probe Info  		24.42  LDD1825  [13]
C147
 Probe Info  		11.39  LDD1829  [13]
C158
 Probe Info  		13.55  LDD1838  [13]
C159
 Probe Info  		18.90  LDD1839  [13]
C160
 Probe Info  		14.83  LDD1840  [13]
C161
 Probe Info  		43.41  LDD1841  [13]
C165
 Probe Info  		16.91  LDD1845  [13]
C169
 Probe Info  		22.78  LDD1849  [13]
C183
 Probe Info  		5.17  LDD1861  [13]
C185
 Probe Info  		19.84  LDD1863  [13]
C193
 Probe Info  		6.36  LDD1869  [13]
C194
 Probe Info  		15.67  LDD1870  [13]
C197
 Probe Info  		6.59  LDD1873  [13]
C198
 Probe Info  		13.83  LDD1874  [13]
C218
 Probe Info  		17.39  LDD1892  [13]
C220
 Probe Info  		16.00  LDD1894  [13]
C232
 Probe Info  		36.76  LDD1905  [13]
C233
 Probe Info  		9.13  LDD1906  [13]
C249
 Probe Info  		12.21  LDD1922  [13]
C264
 Probe Info  		19.70  LDD1935  [13]
C285
 Probe Info  		23.92  LDD1955  [13]
C288
 Probe Info  		14.93  LDD1958  [13]
C289
 Probe Info  		31.34  LDD1959  [13]
C290
 Probe Info  		6.41  LDD1960  [13]
C293
 Probe Info  		31.78  LDD1963  [13]
C296
 Probe Info  		12.55  LDD1966  [13]
C299
 Probe Info  		6.63  LDD1968  [13]
C322
 Probe Info  		5.78  LDD1988  [13]
C326
 Probe Info  		13.36  LDD1990  [13]
C333
 Probe Info  		5.39  LDD1996  [13]
C348
 Probe Info  		12.91  LDD2009  [13]
C349
 Probe Info  		16.34  LDD2010  [13]
C350
 Probe Info  		41.36  LDD2011  [13]
C353
 Probe Info  		10.85  LDD2014  [13]
C354
 Probe Info  		7.36  LDD2015  [13]
C355
 Probe Info  		30.06  LDD2016  [13]
C362
 Probe Info  		42.81  LDD2023  [13]
C363
 Probe Info  		17.88  LDD2024  [13]
C364
 Probe Info  		18.00  LDD2025  [13]
C366
 Probe Info  		7.31  LDD2027  [13]
C367
 Probe Info  		5.66  LDD2028  [13]
C388
 Probe Info  		37.27  LDD2047  [13]
C390
 Probe Info  		29.86  LDD2049  [13]
C391
 Probe Info  		13.27  LDD2050  [13]
C405
 Probe Info  		6.73  LDD2063  [13]
C407
 Probe Info  		12.64  LDD2064  [13]
C419
 Probe Info  		37.79  LDD2074  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe4
 Probe Info  		20.00  LDD0466  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]
OEA-DA
 Probe Info  		12.19  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C362(0.86)  LDD2142  [17]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C362(0.87)  LDD2112  [17]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C362(0.83)  LDD2117  [17]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C362(0.94)  LDD2152  [17]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C362(0.97)  LDD2103  [17]
 LDCM0214  AC1 HCT 116 C362(0.97)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C362(1.05)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C362(0.89)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C362(0.99)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C362(0.68)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C362(0.96)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C362(0.80)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C362(0.79)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C362(1.02)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C362(0.96)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C362(0.86)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C362(0.83)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C362(1.23)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C362(1.00)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C362(1.02)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C362(1.14)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C362(1.55)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C362(1.40)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C362(1.70)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C362(2.25)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C362(1.56)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C362(1.56)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C362(2.12)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C362(1.05)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C362(1.84)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C362(1.81)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C362(2.58)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C362(1.82)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C362(1.67)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C362(1.89)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C362(1.80)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C362(2.39)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C362(1.24)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C362(0.92)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C362(1.13)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C362(0.86)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C362(0.98)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C362(1.16)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C362(1.19)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C362(1.26)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C362(1.11)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C362(0.82)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C362(1.02)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C362(0.96)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C362(1.30)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C362(1.02)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C362(1.04)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C362(0.87)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C362(1.03)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C362(1.32)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C362(0.98)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C362(1.23)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C362(1.37)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C362(1.53)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C362(1.58)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C362(1.16)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C362(1.14)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C362(0.96)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C362(1.22)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C362(2.03)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C362(1.38)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C362(1.32)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C362(1.11)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C362(1.10)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C362(0.83)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C362(1.74)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C362(0.93)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C362(0.93)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C362(0.83)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C362(1.21)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C362(0.89)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C362(0.79)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C362(0.73)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C362(1.00)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C362(1.21)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C362(1.04)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C362(0.75)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C362(0.94)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C362(0.86)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C362(0.79)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C362(0.75)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C362(0.98)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C362(1.46)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C362(1.51)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C362(1.74)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C362(1.02)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C362(1.58)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C362(2.36)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C362(1.75)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C362(0.97)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C362(1.94)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C362(3.49)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C362(3.29)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C362(4.16)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C362(3.51)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C362(3.40)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C362(1.03)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C362(1.03)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C362(1.23)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C362(0.85)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C362(0.96)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C362(1.35)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C362(0.91)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C362(1.06)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C362(1.26)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C362(0.78)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C362(1.35)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C362(1.48)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C362(1.58)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C362(1.26)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C362(1.31)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C362(1.35)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C362(1.64)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C362(1.11)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C362(1.68)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C362(1.27)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C362(1.39)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C362(1.46)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C362(1.13)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C362(1.28)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C362(1.16)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C362(1.34)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C362(1.21)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C362(1.35)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C362(1.08)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C362(1.14)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C362(1.73)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C362(1.51)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C362(1.40)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C362(1.31)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C362(1.92)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C362(1.28)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C362(1.12)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C362(1.17)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C362(1.03)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C362(0.84)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C362(1.53)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C362(1.45)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C362(1.38)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C362(1.12)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C362(1.29)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C362(1.13)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C362(1.22)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C362(1.28)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C362(1.08)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C362(1.61)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C362(1.47)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C362(1.14)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C362(1.12)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C362(1.19)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C362(1.31)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C362(1.42)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C362(1.37)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C362(0.94)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C362(0.34)  LDD2138  [17]
 LDCM0248  AKOS034007472 HCT 116 C362(1.04)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C362(1.02)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C362(1.96)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C362(1.06)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C362(0.33)  LDD2091  [17]
 LDCM0632  CL-Sc Hep-G2 C362(0.29)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C362(0.92)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C362(1.13)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C362(0.95)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C362(1.19)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C362(0.85)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C362(1.05)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C362(0.82)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C362(1.00)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C362(1.01)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C362(1.09)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C362(1.27)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C362(0.90)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C362(1.17)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C362(0.89)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C362(0.87)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C362(0.91)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C362(1.12)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C362(1.06)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C362(1.12)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C362(1.20)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C362(2.63)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C362(3.41)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C362(3.70)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C362(1.54)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C362(4.80)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C362(1.09)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C362(1.08)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C362(0.96)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C362(1.07)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C362(1.12)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C362(0.98)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C362(1.09)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C362(1.53)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C362(1.21)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C362(1.05)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C362(1.03)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C362(1.22)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C362(1.05)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C362(1.15)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C362(1.25)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C362(0.99)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C362(1.74)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C362(1.39)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C362(2.45)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C362(1.19)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C362(1.28)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C362(1.43)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C362(1.31)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C362(1.48)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C362(1.50)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C362(1.39)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C362(1.04)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C362(0.91)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C362(1.21)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C362(1.04)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C362(0.93)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C362(1.45)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C362(2.04)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C362(1.52)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C362(1.31)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C362(1.47)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C362(1.07)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C362(2.39)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C362(1.20)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C362(2.16)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C362(1.43)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C362(1.37)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C362(1.50)  LDD0752  [5]
 LDCM0436  CL46 PaTu 8988t C302(1.14); C362(1.14)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C302(1.10); C362(1.05)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C302(1.27); C362(1.31)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C302(1.18); C362(1.39)  LDD1318  [5]
 LDCM0440  CL5 HCT 116 C362(1.18)  LDD0757  [5]
 LDCM0441  CL50 PaTu 8988t C302(1.20); C362(1.41)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C302(1.23); C362(1.49)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C302(1.28); C362(1.54)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C302(1.34); C362(2.20)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C302(1.22); C362(1.19)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C302(1.37); C362(1.61)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C302(0.78); C362(0.70)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C302(1.85); C362(1.95)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C302(1.35); C362(1.46)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C302(1.72); C362(2.19)  LDD1329  [5]
 LDCM0451  CL6 HCT 116 C362(1.02)  LDD0768  [5]
 LDCM0452  CL60 PaTu 8988t C302(1.50); C362(1.75)  LDD1331  [5]
 LDCM0453  CL61 HCT 116 C362(1.08)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C362(1.05)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C362(1.25)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C362(1.12)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C362(1.06)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C362(1.43)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C362(1.12)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C362(1.03)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C362(0.90)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C362(1.09)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C362(0.88)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C362(1.03)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C362(0.88)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C362(0.88)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C362(0.96)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C362(1.05)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C362(0.78)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C362(1.20)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C362(1.46)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C362(1.42)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C362(0.99)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C362(1.42)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C362(1.57)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C362(1.36)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C362(1.39)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C362(1.01)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C362(0.92)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C362(0.99)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C362(1.34)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C362(1.57)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C362(1.08)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C362(0.79)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C362(1.11)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C362(1.11)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C362(1.02)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C362(1.05)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C362(1.14)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C362(1.05)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C362(0.88)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C362(1.07)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C362(0.98)  LDD0811  [5]
 LDCM0033  Curcusone1d MCF-7 3.23  LDD0188  [2]
 LDCM0495  E2913 HEK-293T C362(1.14); C302(1.04)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C362(1.07)  LDD1702  [17]
 LDCM0625  F8 Ramos C362(1.40)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C362(1.63)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C362(0.90)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C362(0.96)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C362(1.05)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C362(0.86)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C362(0.81)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C362(0.99)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C362(1.05)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C362(1.09)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C362(0.52)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C362(1.48)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C362(0.89)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C362(1.82)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C362(0.97)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C362(1.30)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C362(1.02)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C362(2.01)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C362(1.33)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C362(1.45)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C362(1.01)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C362(0.95)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y267(0.80)  LDD0264  [4]
 LDCM0118  HHS-0301 DM93 Y267(1.01)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y267(0.47)  LDD0267  [4]
 LDCM0022  KB02 HCT 116 C362(1.49)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C362(1.55)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C362(1.88)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C362(0.95)  LDD2102  [17]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C362(0.41)  LDD2121  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C362(0.85)  LDD2089  [17]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C362(1.14)  LDD2090  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C362(0.86)  LDD2092  [17]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C362(0.89)  LDD2093  [17]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C362(1.10)  LDD2094  [17]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C362(0.87)  LDD2096  [17]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C362(0.87)  LDD2098  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C362(0.67)  LDD2099  [17]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C362(0.87)  LDD2100  [17]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C362(0.83)  LDD2104  [17]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C362(1.55)  LDD2105  [17]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C362(0.66)  LDD2106  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C362(0.81)  LDD2107  [17]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C362(0.79)  LDD2108  [17]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C362(0.73)  LDD2109  [17]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C362(0.72)  LDD2111  [17]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C362(0.84)  LDD2114  [17]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C362(1.02)  LDD2116  [17]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C362(0.64)  LDD2118  [17]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C362(2.48)  LDD2119  [17]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C362(1.06)  LDD2122  [17]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C362(0.98)  LDD2123  [17]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C362(0.87)  LDD2124  [17]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C362(0.86)  LDD2125  [17]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C362(0.99)  LDD2126  [17]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C362(0.80)  LDD2127  [17]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C362(0.84)  LDD2128  [17]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C362(0.61)  LDD2129  [17]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C362(0.48)  LDD2134  [17]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C362(0.98)  LDD2136  [17]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C362(0.96)  LDD2137  [17]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C362(0.77)  LDD1700  [17]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C362(0.60)  LDD2140  [17]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C362(1.11)  LDD2141  [17]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C362(3.70)  LDD2144  [17]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C362(7.19)  LDD2145  [17]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C362(0.58)  LDD2146  [17]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C362(1.17)  LDD2149  [17]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C362(0.58)  LDD2150  [17]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C362(1.51)  LDD2151  [17]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C362(1.65)  LDD2153  [17]
 LDCM0627  NUDT7-COV-1 HEK-293T C302(1.13)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C302(1.69)  LDD2207  [20]
 LDCM0154  YY4 T cell 2.24  LDD0400  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) DapA family Q86XE5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.