Details of the Target

General Information of Target

Target ID LDTP09297
Target Name Large ribosomal subunit protein mL64 (GADD45GIP1)
Gene Name GADD45GIP1
Gene ID 90480
Synonyms
MRPL59; PLINP1; PRG6; Large ribosomal subunit protein mL64; 39S ribosomal protein L59, mitochondrial; MRP-L59; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Growth arrest and DNA damage-inducible proteins-interacting protein 1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive gene 6 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASVRQARSLLGVAATLAPGSRGYRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQ
FARYGAASGVVPGSLWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQH
IAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQELLQ
DLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASGAPSS
Target Bioclass
Other
Family
Mitochondrion-specific ribosomal protein mL64 family
Subcellular location
Mitochondrion
Function
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Uniprot ID
Q8TAE8
Ensemble ID
ENST00000316939.3
HGNC ID
HGNC:29996

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.98  LDD0402  [1]
Probe 1
 Probe Info  		Y93(21.03)  LDD3495  [2]
BTD
 Probe Info  		C124(1.07)  LDD2104  [3]
DBIA
 Probe Info  		C124(1.70)  LDD0080  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
ATP probe
 Probe Info  		K184(0.00); K185(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
TER-AC
 Probe Info  		N.A.  LDD0426  [15]
TPP-AC
 Probe Info  		N.A.  LDD0427  [15]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.26  LDD1725  [16]
C055
 Probe Info  		33.59  LDD1752  [16]
C063
 Probe Info  		40.50  LDD1760  [16]
C068
 Probe Info  		7.11  LDD1764  [16]
C161
 Probe Info  		10.06  LDD1841  [16]
C196
 Probe Info  		13.93  LDD1872  [16]
C219
 Probe Info  		7.01  LDD1893  [16]
C231
 Probe Info  		11.47  LDD1904  [16]
C233
 Probe Info  		10.27  LDD1906  [16]
C265
 Probe Info  		15.67  LDD1936  [16]
C285
 Probe Info  		20.68  LDD1955  [16]
C288
 Probe Info  		6.50  LDD1958  [16]
C313
 Probe Info  		19.16  LDD1980  [16]
C319
 Probe Info  		6.23  LDD1985  [16]
C337
 Probe Info  		4.96  LDD2000  [16]
C347
 Probe Info  		5.24  LDD2008  [16]
C349
 Probe Info  		13.93  LDD2010  [16]
C355
 Probe Info  		24.76  LDD2016  [16]
C356
 Probe Info  		8.88  LDD2017  [16]
C359
 Probe Info  		6.23  LDD2020  [16]
C382
 Probe Info  		10.41  LDD2041  [16]
C383
 Probe Info  		22.47  LDD2042  [16]
C388
 Probe Info  		36.50  LDD2047  [16]
C390
 Probe Info  		25.28  LDD2049  [16]
C391
 Probe Info  		14.32  LDD2050  [16]
C400
 Probe Info  		6.82  LDD2059  [16]
C409
 Probe Info  		13.45  LDD2066  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C124(1.10)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C124(0.88)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C124(0.68)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C124(0.74)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C124(0.63)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C124(0.66)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C124(0.61)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C124(0.61)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C124(0.63)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C124(0.74)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C124(0.73)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C124(0.76)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C124(0.85)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C124(0.74)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C124(0.77)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C124(0.75)  LDD0546  [4]
 LDCM0230  AC113 PaTu 8988t C124(0.80)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C124(0.96)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C124(0.92)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C124(0.80)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C124(0.73)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C124(0.94)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C124(0.81)  LDD1115  [4]
 LDCM0237  AC12 HCT 116 C124(1.00)  LDD0554  [4]
 LDCM0238  AC120 PaTu 8988t C124(0.68)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C124(0.74)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C124(0.93)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C124(0.69)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C124(0.76)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C124(0.76)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C124(0.82)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C124(0.74)  LDD1124  [4]
 LDCM0246  AC128 HCT 116 C124(1.45)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C124(1.32)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C124(1.12)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C124(1.13)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C124(1.25)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C124(1.19)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C124(1.14)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C124(1.19)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C124(1.15)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C124(1.01)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C124(0.97)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C124(1.24)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C124(0.87)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C124(1.17)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C124(1.16)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C124(1.72)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C124(1.11)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C124(1.00)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C124(0.94)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C124(0.94)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C124(1.01)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C124(0.80)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C124(0.90)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C124(0.77)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C124(1.05)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C124(1.07)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C124(1.10)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C124(1.07)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C124(1.05)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C124(1.04)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C124(1.08)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C124(1.07)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C124(1.20)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C124(0.82)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C124(0.77)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C124(1.03)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C124(0.98)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C124(0.86)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C124(0.96)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C124(0.86)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C124(0.84)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C124(0.76)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C124(0.76)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C124(0.67)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C124(0.65)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C124(0.76)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C124(1.19)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C124(0.73)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C124(0.79)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C124(0.75)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C124(0.62)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C124(0.67)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C124(0.81)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C124(0.79)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C124(0.80)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C124(0.92)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C124(0.93)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C124(1.26)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C124(1.02)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C124(0.85)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C124(0.94)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C124(0.95)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C124(0.88)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C124(1.06)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C124(1.08)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C124(1.05)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C124(1.54)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C124(1.77)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C124(1.24)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C124(1.40)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C124(1.15)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C124(0.96)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C124(1.15)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C124(1.12)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C124(1.61)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C124(2.48)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C124(0.93)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C124(0.96)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C124(1.01)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C124(0.87)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C124(0.91)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C124(1.21)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C124(1.02)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C124(0.83)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C124(0.96)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C124(0.95)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C124(0.95)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C124(1.03)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C124(1.12)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C124(1.12)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C124(0.92)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C124(1.60)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C124(1.22)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C124(1.29)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C124(1.41)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C124(1.41)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C124(1.57)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C124(1.16)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C124(1.00)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C124(1.24)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C124(1.15)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C124(0.86)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C124(1.06)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C124(1.22)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C124(1.76)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C124(1.03)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C124(0.96)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C124(0.95)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C124(0.90)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C124(0.98)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C124(0.84)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C124(0.91)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C124(0.96)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C124(0.77)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C124(0.79)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C124(0.80)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C124(0.79)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C124(0.94)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C124(0.84)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C124(0.79)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C124(0.90)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C124(0.85)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C124(1.05)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C124(0.93)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C124(1.00)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.45  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C124(1.12); C124(0.36)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C124(0.84)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C124(0.91)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C124(0.87)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C124(0.75)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C124(0.91)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C124(0.96)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C124(0.96)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C124(1.14)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C124(1.09)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C124(1.03)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C124(1.24)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C124(0.81)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C124(1.01)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C124(0.94)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C124(0.92)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C124(0.82)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C124(0.68)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C124(0.97)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C124(0.69)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C124(0.77)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C124(1.76)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C124(0.87)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C124(0.97)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C124(0.93)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C124(0.86)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C124(1.02)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C124(1.03)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C124(1.08)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C124(1.37)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C124(1.11)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C124(1.01)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C124(0.90)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C124(0.99)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C124(0.90)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C124(0.89)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C124(0.80)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C124(0.84)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C124(0.90)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C124(1.01)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C124(0.90)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C124(0.77)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C124(0.84)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C124(0.92)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C124(1.39)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C124(0.75)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C124(0.97)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C124(1.05)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C124(0.85)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C124(0.96)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C124(0.84)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C124(0.79)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C124(0.85)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C124(0.78)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C124(0.84)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C124(1.10)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C124(0.91)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C124(1.25)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C124(0.94)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C124(0.81)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C124(0.98)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C124(0.90)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C124(0.74)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C124(0.83)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C124(0.80)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C124(1.36)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C124(1.11)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C124(0.95)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C124(1.07)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C124(1.07)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C124(1.15)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C124(1.11)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C124(0.89)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C124(0.72)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C124(1.01)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C124(1.00)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C124(1.10)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C124(0.90)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C124(0.82)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C124(0.88)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C124(1.01)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C124(1.03)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C124(1.12)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C124(0.99)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C124(0.75)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C124(0.94)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C124(0.99)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C124(1.01)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C124(0.95)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C124(1.01)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C124(1.02)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C124(1.25)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C124(1.01)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C124(1.01)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C124(1.02)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C124(0.97)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C124(1.08)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C124(0.97)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C124(1.02)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C124(0.93)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C124(0.94)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C124(1.04)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C124(0.89)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C124(0.94)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C124(1.03)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C124(0.95)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C124(1.11)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C124(0.89)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C124(1.45)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C124(1.15)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C124(1.53)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C124(0.89)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C124(0.99)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C124(0.91)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C124(1.08)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C124(2.02)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C124(0.88)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C124(1.01)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C124(1.02)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C124(0.93)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C124(0.83)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C124(0.67)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C124(0.93)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C124(0.97)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C124(0.92)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C124(1.09)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C124(1.05)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C124(1.05)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C124(1.74)  LDD1702  [3]
 LDCM0625  F8 Ramos C124(1.84)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C124(1.16)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C124(1.19)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C124(0.98)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C124(0.95)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C124(0.89)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C124(1.01)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C124(1.05)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C124(1.10)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C124(1.62)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C124(0.78)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C124(1.73)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C124(1.22)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C124(1.37)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C124(1.02)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C124(1.08)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C124(0.95)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C124(1.57)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C124(1.07)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C124(1.06)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C124(0.91)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C124(0.76)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C124(1.70)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C124(1.40)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C124(2.34)  LDD0082  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C124(1.07)  LDD2104  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C124(1.48)  LDD2127  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C124(0.59)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C124(1.42)  LDD2146  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C124(1.78); C124(0.69)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C124(1.03); C124(0.97)  LDD2207  [19]
 LDCM0131  RA190 MM1.R C124(2.15)  LDD0304  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
GTP-binding protein GEM (GEM) RGK family P55040
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 33 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Cyclin-C (CCNC) Cyclin family P24863
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
ELL-associated factor 1 (EAF1) EAF family Q96JC9
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) GADD45 family P24522
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein Mis18-beta (OIP5) Mis18 family O43482
Large ribosomal subunit protein mL38 (MRPL38) Phosphatidylethanolamine-binding protein family Q96DV4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Spectrin alpha chain, erythrocytic 1 (SPTA1) Spectrin family P02549
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Leucine-rich repeat-containing protein 73 (LRRC73) . Q5JTD7
Melanoma-associated antigen 11 (MAGEA11) . P43364
Melanoma-associated antigen 6 (MAGEA6) . P43360
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
PRKCA-binding protein (PICK1) . Q9NRD5
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) . O15084
Splicing regulator RBM11 (RBM11) . P57052
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.