Details of the Target

General Information of Target

Target ID LDTP09881
Target Name TATA-binding protein-associated factor 2N (TAF15)
Gene Name TAF15
Gene ID 8148
Synonyms
RBP56; TAF2N; TATA-binding protein-associated factor 2N; 68 kDa TATA-binding protein-associated factor; TAF(II)68; TAFII68; RNA-binding protein 56
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSYGEIEGKFLGPREEVTSEPRCKKLKSTTESYVFHNHSNADFHRIQEKTGNDWVPVTII
DVRGHSYLQENKIKTTDLHRPLHDEMPGNRPDVIESIDSQVLQEARPPLVSADDEIYSTS
KAFIGPIYKPPEKKKRNEGRNEAHVLNGINDRGGQKEKQKFNSEKSEIDNELFQFYKEIE
ELEKEKDGFENSCKESEPSQEQFVPFYEGHNNGLLKPDEEKKDLSNKAMPSHCDYQQNLG
NEPDKYPCNGQVIPTFCDTSFTSFRPEWQSVYPFIVPYGPPLPSLNYHLNIQRFSGPPNP
PSNIFQAQDDSQIQNGYYVNNCHVNWNCMTFDQNNEYTDCSENRSSVHPSGNGCSMQDRY
VSNGFCEVRERCWKDHCMDKHNGTDRFVNQQFQEEKLNKLQKLLILLRGLPGSGKTTLSR
ILLGQNRDGIVFSTDDYFHHQDGYRYNVNQLGDAHDWNQNRAKQAIDQGRSPVIIDNTNI
QAWEMKPYVEVAIGKGYRVEFHEPETWWKFDPEELEKRNKHGVSRKKIAQMLDRYEYQMS
ISIVMNSVEPSHKSTQRPPPPQGRQRWGGSLGSHNRVCVTNNH
Target Bioclass
Other
Family
RRM TET family
Subcellular location
Nucleus
Function RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
Uniprot ID
Q92804
Ensemble ID
ENST00000604841.5
HGNC ID
HGNC:11547

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.S433R
Substitution: p.S433G		 .
COLO792 SNV: p.G400D .
JURKAT Deletion: p.G530AfsTer116 .
KMCH1 SNV: p.G350V .
LS180 SNV: p.R588C .
MOLT4 SNV: p.I257T .
NCIH2291 SNV: p.S64Ter .
RKO Deletion: p.G530AfsTer116 .
SKOV3 Insertion: p.Y531LfsTer56 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y427(20.00); Y156(17.48)  LDD0260  [1]
C-Sul
 Probe Info  		9.39  LDD0066  [2]
STPyne
 Probe Info  		K268(5.26); K306(9.74)  LDD0277  [3]
AZ-9
 Probe Info  		D301(0.88)  LDD2208  [4]
Probe 1
 Probe Info  		Y83(3,696.21)  LDD3495  [5]
BTD
 Probe Info  		C376(0.84)  LDD2099  [6]
HHS-475
 Probe Info  		Y274(0.84); Y156(0.90); Y437(1.04); Y170(1.76)  LDD0264  [7]
HHS-465
 Probe Info  		Y156(10.00); Y170(10.00); Y427(10.00); Y549(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C360(1.01); C365(1.01)  LDD0078  [9]
5E-2FA
 Probe Info  		H309(0.00); H159(0.00); H158(0.00); H215(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K281(0.00); K283(0.00); K306(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H158(0.00); H309(0.00); H215(0.00)  LDD2231  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [12]
Lodoacetamide azide
 Probe Info  		C365(0.00); C360(0.00)  LDD0037  [13]
SF
 Probe Info  		Y274(0.00); Y549(0.00); Y177(0.00); Y471, Y479, Y558, Y455, Y427, Y463, Y446, Y566, Y494(0.00)  LDD0028  [14]
Phosphinate-6
 Probe Info  		C360(0.00); C365(0.00)  LDD0018  [15]
Ox-W18
 Probe Info  		N.A.  LDD2175  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [17]
1d-yne
 Probe Info  		N.A.  LDD0357  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
W1
 Probe Info  		C360(0.00); C365(0.00)  LDD0236  [19]
HHS-482
 Probe Info  		Y156(0.53); Y170(0.52); Y274(0.62); Y427(0.63)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 64 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.19  LDD1714  [20]
C039
 Probe Info  		5.21  LDD1739  [20]
C040
 Probe Info  		8.11  LDD1740  [20]
C063
 Probe Info  		12.30  LDD1760  [20]
C087
 Probe Info  		9.06  LDD1779  [20]
C092
 Probe Info  		17.15  LDD1783  [20]
C106
 Probe Info  		17.03  LDD1793  [20]
C108
 Probe Info  		9.06  LDD1795  [20]
C139
 Probe Info  		10.93  LDD1821  [20]
C145
 Probe Info  		8.40  LDD1827  [20]
C153
 Probe Info  		16.00  LDD1834  [20]
C165
 Probe Info  		26.54  LDD1845  [20]
C166
 Probe Info  		8.94  LDD1846  [20]
C170
 Probe Info  		8.22  LDD1850  [20]
C174
 Probe Info  		4.99  LDD1854  [20]
C196
 Probe Info  		11.31  LDD1872  [20]
C206
 Probe Info  		17.15  LDD1881  [20]
C214
 Probe Info  		5.66  LDD1888  [20]
C218
 Probe Info  		11.88  LDD1892  [20]
C220
 Probe Info  		12.64  LDD1894  [20]
C226
 Probe Info  		5.82  LDD1899  [20]
C228
 Probe Info  		15.03  LDD1901  [20]
C232
 Probe Info  		70.52  LDD1905  [20]
C235
 Probe Info  		17.27  LDD1908  [20]
C239
 Probe Info  		5.82  LDD1912  [20]
C249
 Probe Info  		16.45  LDD1922  [20]
C265
 Probe Info  		12.91  LDD1936  [20]
C286
 Probe Info  		5.10  LDD1956  [20]
C288
 Probe Info  		6.41  LDD1958  [20]
C290
 Probe Info  		5.06  LDD1960  [20]
C313
 Probe Info  		20.39  LDD1980  [20]
C314
 Probe Info  		14.42  LDD1981  [20]
C322
 Probe Info  		7.11  LDD1988  [20]
C326
 Probe Info  		9.25  LDD1990  [20]
C338
 Probe Info  		18.13  LDD2001  [20]
C346
 Probe Info  		15.56  LDD2007  [20]
C347
 Probe Info  		6.32  LDD2008  [20]
C348
 Probe Info  		10.06  LDD2009  [20]
C353
 Probe Info  		6.15  LDD2014  [20]
C355
 Probe Info  		25.81  LDD2016  [20]
C361
 Probe Info  		21.86  LDD2022  [20]
C363
 Probe Info  		16.68  LDD2024  [20]
C380
 Probe Info  		5.46  LDD2039  [20]
C382
 Probe Info  		8.75  LDD2041  [20]
C383
 Probe Info  		11.39  LDD2042  [20]
C390
 Probe Info  		23.43  LDD2049  [20]
C391
 Probe Info  		17.75  LDD2050  [20]
C413
 Probe Info  		12.73  LDD2069  [20]
C420
 Probe Info  		11.31  LDD2075  [20]
C428
 Probe Info  		5.10  LDD2083  [20]
C429
 Probe Info  		13.45  LDD2084  [20]
C430
 Probe Info  		6.28  LDD2085  [20]
C431
 Probe Info  		19.43  LDD2086  [20]
C433
 Probe Info  		6.96  LDD2088  [20]
FFF probe11
 Probe Info  		13.51  LDD0471  [21]
FFF probe12
 Probe Info  		6.65  LDD0473  [21]
FFF probe13
 Probe Info  		18.92  LDD0475  [21]
FFF probe2
 Probe Info  		19.99  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [21]
FFF probe6
 Probe Info  		7.12  LDD0468  [21]
FFF probe9
 Probe Info  		6.07  LDD0470  [21]
JN0003
 Probe Info  		13.72  LDD0469  [21]
DA-2
 Probe Info  		N.A.  LDD0072  [22]
OEA-DA
 Probe Info  		13.87  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C376(1.00)  LDD2152  [6]
 LDCM0214  AC1 HCT 116 C360(0.83); C365(0.92)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C360(1.05); C365(1.08); C376(1.20); C379(1.20)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C360(0.85); C365(0.88); C376(1.32); C379(1.32)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C360(0.81); C365(0.85); C376(0.81); C379(0.81)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C360(0.90); C365(0.86); C376(0.39); C379(0.39)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C360(1.13); C365(1.13); C376(0.63); C379(0.63)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C360(1.02); C365(1.03); C376(0.68); C379(0.68)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C360(1.09); C365(1.07); C376(0.92); C379(0.92)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C360(1.05); C365(1.05); C376(1.93); C379(1.93)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C360(1.40); C365(1.14); C376(1.47); C379(1.47)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C360(0.78); C365(0.88); C376(3.05); C379(3.05)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C360(0.80); C365(0.84); C376(1.03); C379(1.03)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C360(1.16); C365(1.18); C376(0.91); C379(0.91)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C360(0.94); C365(0.87); C376(0.99); C379(0.99)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C360(0.97); C365(0.92); C376(2.19); C379(2.19)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C360(0.91); C365(0.92); C376(1.75); C379(1.75)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C360(1.09); C365(1.10); C376(0.95); C379(0.95)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C360(1.35); C365(1.34)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C360(1.40); C365(1.39)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C360(1.30); C365(1.30)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C360(1.12); C365(1.15)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C360(1.14); C365(1.12)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C360(1.12); C365(1.14)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C360(0.99); C365(1.01); C376(0.85); C379(0.85)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C360(1.30); C365(1.23)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C360(1.15); C365(1.19)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C360(1.26); C365(1.26)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C360(1.11); C365(1.14)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C360(1.28); C365(1.29)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C360(1.16); C365(1.15)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C360(1.57); C365(1.58)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C360(1.40); C365(1.42)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C360(0.92); C365(0.96)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C360(0.73); C365(0.83)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C360(0.84); C365(0.89)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C360(0.99); C365(1.00)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C360(0.58); C365(0.69)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C360(0.79); C365(0.83)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C360(0.79); C365(0.85)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C360(0.78); C365(0.89)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C360(0.77); C365(0.87)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C360(0.65); C365(0.78)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C360(0.81); C365(0.93)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C360(0.76); C365(0.85)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C360(1.05); C365(1.00); C376(0.94); C379(0.94)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C360(0.79); C365(0.87)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C360(0.77); C365(0.84)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C360(0.61); C365(0.68)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C360(0.97); C365(0.97); C376(1.10); C379(1.10)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C379(0.82); C376(0.90); C365(1.29); C360(1.32)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C376(0.87); C379(0.97); C365(1.02); C360(1.06)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C379(0.76); C376(0.80); C365(1.26); C360(1.28)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C379(0.89); C376(1.13); C365(1.21); C360(1.21)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C376(0.79); C379(0.82); C365(1.44); C360(1.48)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C376(0.76); C379(0.83); C365(1.32); C360(1.36)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C360(1.01); C365(1.02); C376(1.05); C379(1.05)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C379(0.78); C376(0.97); C365(1.13); C360(1.14)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C379(0.81); C376(0.84); C365(1.17); C360(1.17)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C376(0.76); C379(0.77); C365(1.29); C360(1.30)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C376(0.41); C379(0.54); C365(1.77); C360(1.93)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C360(1.52); C365(1.51); C376(0.79); C379(0.87)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C360(1.40); C365(1.41); C376(0.61); C379(0.67)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C360(1.02); C365(0.99); C376(0.77); C379(0.77)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C360(1.34); C365(1.29); C376(0.70); C379(0.70)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C376(1.19); C379(1.19); C360(1.30); C365(1.30)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C376(0.47); C379(0.47); C360(1.02); C365(1.04)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C360(1.61); C365(1.62); C376(2.79); C379(2.79)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C360(0.70); C365(0.82)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C360(1.39); C365(1.39); C376(1.62); C379(1.62)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C376(1.04); C379(1.04); C360(1.71); C365(1.72)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C360(1.39); C365(1.40); C376(1.48); C379(1.48)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C360(1.07); C365(1.08); C376(1.61); C379(1.61)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C360(1.33); C365(1.34); C376(1.82); C379(1.82)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C376(1.60); C379(1.60); C360(2.89); C365(2.89)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C376(1.14); C379(1.14); C360(2.14); C365(2.14)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C376(1.52); C379(1.52); C360(2.10); C365(2.10)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C376(1.13); C379(1.13); C360(2.24); C365(2.24)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C376(2.26); C379(2.26); C360(2.54); C365(2.54)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C360(0.81); C365(0.92)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C376(1.08); C379(1.08); C360(2.97); C365(2.97)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C360(1.74); C365(1.74); C376(1.77); C379(1.77)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C376(1.84); C379(1.84); C360(1.95); C365(1.95)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C376(1.78); C379(1.78); C360(2.83); C365(2.83)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C376(1.13); C379(1.13); C360(3.26); C365(3.26)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C360(0.94); C365(0.94)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C360(0.98); C365(0.98)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C360(1.00); C365(1.00)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C360(1.04); C365(1.04)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C360(0.96); C365(0.96)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C365(0.84); C360(0.85)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C360(1.26); C365(1.26)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C360(1.10); C365(1.10)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C360(1.07); C365(1.07)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C360(1.28); C365(1.28)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C360(1.00); C365(1.00)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C360(1.20); C365(1.20)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C360(0.87); C365(0.88); C376(1.07); C379(1.07)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C360(0.95); C365(0.96); C376(1.82); C379(1.82)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C365(0.87); C360(0.89); C376(1.84); C379(1.84)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C376(0.98); C379(0.98); C360(1.31); C365(1.43)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C360(0.54); C365(0.63)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C376(1.54); C379(1.54); C360(1.62); C365(1.81)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C360(0.94); C365(0.96); C376(1.28); C379(1.28)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C360(1.01); C365(1.05); C376(1.11); C379(1.11)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C365(1.16); C360(1.17); C376(1.17); C379(1.17)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C376(0.92); C379(0.92); C360(1.30); C365(1.38)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C376(1.55); C379(1.55); C360(1.65); C365(1.74)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C360(2.40); C365(2.72); C376(2.84); C379(2.84)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C360(1.22); C365(1.24)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C365(1.26); C360(1.27)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C365(1.15); C360(1.25)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C360(1.07); C365(1.08); C376(1.31); C379(1.31)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C365(1.32); C360(1.36)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C365(1.03); C360(1.09)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C360(1.13); C365(1.14)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C365(1.35); C360(1.43)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C365(1.12); C360(1.20)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C365(0.75); C360(0.88)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C365(0.64); C360(0.73)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C365(0.87); C360(1.01)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C365(0.95); C360(0.97)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C360(0.94); C365(0.95)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C365(0.96); C360(0.98); C376(1.00); C379(1.00)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C360(0.76); C365(0.81)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C360(0.74); C365(0.76)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C360(0.93); C365(0.99)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C360(1.37); C365(1.42)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C360(1.22); C365(1.30)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C360(1.33); C365(1.38)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C360(0.88); C365(0.91)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C365(1.09); C360(1.10)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C365(0.91); C360(0.92)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C360(0.79); C365(0.83)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C360(0.98); C376(0.98); C379(0.98); C365(0.99)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C360(0.85); C365(0.90)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C360(0.77); C365(0.83)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C360(1.20); C365(1.21)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C376(1.36); C379(1.36); C360(1.44); C365(1.44)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C376(0.91); C379(0.91); C365(1.25); C360(1.25)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C376(0.87); C379(0.87); C360(1.11); C365(1.18)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C360(1.15); C365(1.15); C376(1.18); C379(1.18)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C376(0.97); C379(0.97); C360(0.99); C365(1.02)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C376(1.23); C379(1.23); C365(1.30); C360(1.31)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C365(1.30); C360(1.34); C376(1.84); C379(1.84)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C365(0.86); C360(0.88); C376(2.17); C379(2.17)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C365(1.62); C360(1.65); C376(1.78); C379(1.78)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C365(1.59); C360(1.64); C376(1.84); C379(1.84)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C376(1.08); C379(1.08); C365(1.26); C360(1.27)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C376(0.57); C379(0.57); C365(1.28); C360(1.28)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C365(1.25); C360(1.26); C376(1.40); C379(1.40)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C376(1.10); C379(1.10); C365(1.27); C360(1.30)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C376(1.41); C379(1.41); C365(1.51); C360(1.54)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C376(0.84); C379(0.84); C360(1.42); C365(1.43)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C376(0.65); C379(0.65); C360(0.76); C365(0.78)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C376(0.98); C379(0.98)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C360(0.91); C365(0.93); C376(1.13); C379(1.13)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C360(1.13); C365(1.16); C376(1.45); C379(1.45)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C360(1.39); C365(1.44); C376(1.53); C379(1.53)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C360(1.01); C365(1.01)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa H159(0.00); H158(0.00); H309(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C376(0.89); C379(0.89); C360(0.89); C365(0.89)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C365(1.18); C360(1.21); C376(1.76); C379(1.76)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C360(0.77); C365(0.88)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C365(1.36); C360(1.43); C376(2.16); C379(2.16)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C365(0.98); C360(0.98); C376(1.26); C379(1.26)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C365(1.07); C360(1.07); C376(1.24); C379(1.24)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C376(1.13); C379(1.13); C360(1.15); C365(1.17)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C360(0.94); C365(0.94); C376(1.25); C379(1.25)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C376(1.40); C379(1.40); C365(1.47); C360(1.48)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C360(1.00); C365(1.00); C376(1.11); C379(1.11)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C376(0.89); C379(0.89); C360(1.00); C365(1.01)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C360(1.25); C365(1.26); C376(1.45); C379(1.45)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C365(1.58); C360(1.59); C376(2.18); C379(2.18)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C360(1.08); C365(1.08); C376(1.58); C379(1.58)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C360(1.04); C365(1.05); C376(1.05); C379(1.05)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C376(0.83); C379(0.83); C360(1.36); C365(1.36)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C376(1.09); C379(1.09); C360(2.07); C365(2.07)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C376(1.05); C379(1.05); C360(2.11); C365(2.11)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C376(1.19); C379(1.19); C360(2.39); C365(2.39)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C376(0.98); C379(0.98); C360(2.71); C365(2.71)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C360(1.30); C365(1.30)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C360(0.87); C365(0.87)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C360(1.28); C365(1.28)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C376(1.53); C379(1.53); C365(1.66); C360(1.75)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C360(1.06); C365(1.06)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C376(1.68); C379(1.68); C360(2.05); C365(2.43)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C365(0.86); C376(0.90); C379(0.90); C360(0.94)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C360(0.99); C365(0.99); C376(1.14); C379(1.14)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C376(1.31); C379(1.31); C360(1.33); C365(1.42)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C360(0.86); C365(0.86)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C360(1.16); C365(1.19)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C365(0.93); C360(0.95)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C360(1.27); C365(1.29)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C360(1.51); C365(1.52); C376(1.81); C379(1.81)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C360(1.14); C365(1.15); C376(1.78); C379(1.78)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C360(1.36); C365(1.38); C376(1.60); C379(1.60)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C376(1.02); C379(1.02); C365(1.28); C360(1.29)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C365(0.89); C360(0.91); C376(1.09); C379(1.09)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C376(1.53); C379(1.53); C365(2.29); C360(2.30)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C376(1.30); C379(1.30); C365(1.44); C360(1.44)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C376(1.10); C379(1.10); C365(1.11); C360(1.13)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C360(1.59); C365(1.60); C376(1.74); C379(1.74)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C376(1.21); C379(1.21); C360(1.56); C365(1.57)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C376(1.97); C379(1.97); C360(2.33); C365(2.34)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C365(1.69); C360(1.72); C376(1.82); C379(1.82)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C360(2.00); C365(1.97); C376(1.94); C379(1.94)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C360(1.64); C365(1.61); C376(1.95); C379(1.95)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C360(1.30); C365(1.29); C376(1.06); C379(1.06)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C360(1.51); C365(1.50); C376(2.00); C379(2.00)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C360(1.65); C365(1.62); C376(2.23); C379(2.23)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C360(1.58); C365(1.55); C376(2.41); C379(2.41)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C360(1.41); C365(1.37); C376(1.19); C379(1.19)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C360(1.46); C365(1.46); C376(1.69); C379(1.69)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C360(1.17); C365(1.17)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C360(1.17); C365(1.17); C376(1.08); C379(1.08)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C360(0.92); C365(0.92); C376(0.74); C379(0.74)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C360(1.28); C365(1.28); C376(0.80); C379(0.80)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C360(1.62); C365(1.62); C376(1.20); C379(1.20)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C360(1.25); C365(1.25); C376(0.45); C379(0.45)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C360(1.34); C365(1.34); C376(0.83); C379(0.83)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C360(1.34); C365(1.34); C376(0.95); C379(0.95)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C360(1.29); C365(1.29); C376(1.25); C379(1.25)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C360(1.31); C365(1.31); C376(0.81); C379(0.81)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C360(1.31); C365(1.31); C376(0.72); C379(0.72)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C360(1.75); C365(1.75); C376(0.37); C379(0.37)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C360(1.93); C365(1.93); C376(1.03); C379(1.03)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C360(1.35); C365(1.35); C376(1.34); C379(1.34)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C360(1.59); C365(1.59); C376(0.94); C379(0.94)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C360(0.81); C365(0.80); C376(0.76); C379(0.76)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C360(0.83); C365(0.81); C376(0.70); C379(0.70)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C360(0.92); C365(0.91); C376(0.46); C379(0.46)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C360(1.03); C365(1.04); C376(0.70); C379(0.70)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C360(1.35); C365(1.33); C376(1.27); C379(1.27)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C360(0.89); C365(0.94); C376(0.74); C379(0.74)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C360(1.00); C365(1.02); C376(0.83); C379(0.83)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C360(1.10); C365(1.09); C376(0.91); C379(0.91)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C360(1.01); C365(0.98); C376(0.62); C379(0.62)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C360(1.00); C365(1.00); C376(0.97); C379(0.97)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C360(1.11); C365(1.12); C376(0.90); C379(0.90)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C360(1.03); C365(0.99); C376(0.58); C379(0.58)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C360(0.90); C365(0.92); C376(0.83); C379(0.83)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C360(1.06); C365(1.07); C376(1.14); C379(1.14)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C360(1.07); C365(1.06); C376(1.27); C379(1.27)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C360(1.39); C365(1.39); C376(1.42); C379(1.42)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C360(0.96); C365(0.97); C376(0.83); C379(0.83)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C360(0.93); C365(0.93); C376(1.18); C379(1.18)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C360(0.98); C365(0.94); C376(1.27); C379(1.27)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C360(1.02); C365(1.07); C376(1.11); C379(1.11)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C360(1.00); C365(1.02); C376(0.56); C379(0.56)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C360(0.81); C365(0.84); C376(0.86); C379(0.86)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C360(1.06); C365(1.13); C376(1.26); C379(1.26)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C360(1.05); C365(1.21); C376(1.11); C379(1.11)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C360(1.11); C365(1.16); C376(1.50); C379(1.50)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C360(1.17); C365(1.16); C376(1.21); C379(1.21)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C360(1.62); C365(1.61); C376(1.32); C379(1.32)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C360(1.11); C365(1.20); C376(1.06); C379(1.06)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C360(1.16); C365(1.20); C376(0.83); C379(0.83)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C360(0.94); C365(0.96); C376(1.37); C379(1.37)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C360(1.09); C365(1.09); C376(1.91); C379(1.91)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C360(1.08); C365(1.16); C376(1.78); C379(1.78)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C360(0.61); C365(0.58)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C360(0.57); C365(0.58)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C360(0.66); C365(0.64)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C360(0.66); C365(0.62)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C360(1.37); C365(1.34); C376(1.50); C379(1.50)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C360(0.65); C365(0.72)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C360(0.53); C365(0.64)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C360(0.59); C365(0.68)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C360(0.73); C365(0.69)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C360(0.82); C365(0.83)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C360(0.71); C365(0.72)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C360(0.75); C365(0.67)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C360(0.53); C365(0.57)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C360(0.63); C365(0.81)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C360(0.66); C365(0.75)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C360(1.35); C365(1.32); C376(1.15); C379(1.15)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C360(0.42); C365(0.44)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C360(0.86); C365(0.90)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C360(0.78); C365(0.84)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C360(0.84); C365(0.84)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C360(0.96); C365(1.08)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C360(0.88); C365(0.80)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C360(1.11); C365(1.05)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C360(0.84); C365(0.92)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C360(0.81); C365(0.83)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C360(0.79); C365(0.86)  LDD0811  [9]
 LDCM0189  Compound 16 HEK-293T 26.54  LDD0492  [21]
 LDCM0185  Compound 17 HEK-293T 5.81  LDD0512  [21]
 LDCM0182  Compound 18 HEK-293T 3.96  LDD0501  [21]
 LDCM0191  Compound 21 HEK-293T 5.14  LDD0493  [21]
 LDCM0190  Compound 34 HEK-293T 22.84  LDD0497  [21]
 LDCM0192  Compound 35 HEK-293T 5.31  LDD0491  [21]
 LDCM0193  Compound 36 HEK-293T 5.04  LDD0494  [21]
 LDCM0194  Compound 37 HEK-293T 8.39  LDD0498  [21]
 LDCM0195  Compound 38 HEK-293T 7.01  LDD0499  [21]
 LDCM0196  Compound 39 HEK-293T 4.86  LDD0496  [21]
 LDCM0197  Compound 40 HEK-293T 5.99  LDD0495  [21]
 LDCM0181  Compound 41 HEK-293T 4.55  LDD0502  [21]
 LDCM0183  Compound 42 HEK-293T 3.00  LDD0500  [21]
 LDCM0495  E2913 HEK-293T C365(1.17); C360(1.09)  LDD1698  [24]
 LDCM0468  Fragment33 HCT 116 C360(1.11); C365(1.14); C376(1.74); C379(1.74)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C360(1.96); C365(1.96); C376(0.69); C379(0.69)  LDD0744  [9]
 LDCM0116  HHS-0101 DM93 Y274(0.84); Y156(0.90); Y437(1.04); Y170(1.76)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y437(0.74); Y156(1.07); Y274(1.08); Y78(3.87)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y83(0.45); Y437(0.79); Y156(1.24); Y274(2.66)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y274(0.55); Y437(1.06); Y156(1.26); Y78(1.52)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y83(0.37); Y437(0.38); Y156(0.46); Y274(0.53)  LDD0268  [7]
 LDCM0107  IAA HeLa H159(0.00); H309(0.00); H158(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C365(1.54); C360(1.56)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C365(1.32); C360(1.35)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C365(1.98); C360(1.70)  LDD0082  [9]
 LDCM0109  NEM HeLa H159(0.00); H309(0.00); H158(0.00)  LDD0223  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C376(0.84)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C376(0.78)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C376(1.06); C379(1.02)  LDD2101  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C376(0.55); C379(0.45)  LDD2115  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C376(0.55); C379(0.66)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C376(0.52)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C379(0.65)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C376(0.56); C379(0.57)  LDD2134  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C376(1.24)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C376(0.65)  LDD2137  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C376(0.95)  LDD2141  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C376(0.42); C379(0.62)  LDD2148  [6]
 LDCM0021  THZ1 HCT 116 C360(1.60); C365(1.60)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FUS (FUS) RRM TET family P35637

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402