Details of the Target

General Information of Target

Target ID LDTP13702
Target Name E3 ubiquitin-protein ligase TRIM33 (TRIM33)
Gene Name TRIM33
Gene ID 51592
Synonyms
KIAA1113; RFG7; TIF1G; E3 ubiquitin-protein ligase TRIM33; EC 2.3.2.27; Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAW
VTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLL
ASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQ
DVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLA
TLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLE
LLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVK
LLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSS
PETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEK
GPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKE
FNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNAD
DENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPP
GVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVP
TDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQ
EATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQT
TEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSQ
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Nucleus
Function
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According todoes not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Uniprot ID
Q9UPN9
Ensemble ID
ENST00000358465.7
HGNC ID
HGNC:16290
ChEMBL ID
CHEMBL2176772

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.G168AfsTer11 .
ETK1 SNV: p.R180W DBIA    Probe Info 
HSC4 SNV: p.S79L DBIA    Probe Info 
MDST8 Deletion: p.E977DfsTer14 DBIA    Probe Info 
NCIH1993 SNV: p.E158D .
NUGC3 Deletion: p.S720del DBIA    Probe Info 
PATU8988T SNV: p.D942H DBIA    Probe Info 
PF382 SNV: p.I1031V DBIA    Probe Info 
RPMI7951 SNV: p.P451L DBIA    Probe Info 
SKMEL24 SNV: p.R865Ter DBIA    Probe Info 
SKMEL28 SNV: p.D63N DBIA    Probe Info 
SSP25 SNV: p.R180W DBIA    Probe Info 
SUPT1 SNV: p.N196D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH216
 Probe Info  		Y309(7.87)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K334(0.75); K378(1.32)  LDD0277  [4]
Probe 1
 Probe Info  		Y197(31.94); Y336(10.20); Y524(19.22); Y1081(27.09)  LDD3495  [5]
BTD
 Probe Info  		C276(0.90); C754(0.86)  LDD2092  [6]
AHL-Pu-1
 Probe Info  		C461(2.42)  LDD0168  [7]
HHS-475
 Probe Info  		Y309(0.78); Y524(0.89); Y336(0.95)  LDD0264  [8]
HHS-465
 Probe Info  		Y524(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C582(1.07); C786(1.00); C288(0.97); C291(0.97)  LDD0078  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C447(0.00); C299(0.00); C943(0.00); C754(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C447(0.00); C943(0.00); C461(0.00); C786(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		C447(0.00); C786(0.00); C805(0.00)  LDD2226  [14]
TFBX
 Probe Info  		C582(0.00); C447(0.00)  LDD0027  [15]
Compound 10
 Probe Info  		C582(0.00); C786(0.00)  LDD2216  [16]
Compound 11
 Probe Info  		C582(0.00); C786(0.00)  LDD2213  [16]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		C786(0.00); C754(0.00)  LDD0005  [17]
NPM
 Probe Info  		N.A.  LDD0016  [17]
VSF
 Probe Info  		C849(0.00); C786(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info  		C786(0.00); C582(0.00); C943(0.00)  LDD0018  [18]
Acrolein
 Probe Info  		C943(0.00); C461(0.00)  LDD0217  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
AOyne
 Probe Info  		12.70  LDD0443  [20]
NAIA_5
 Probe Info  		C447(0.00); C943(0.00); C461(0.00); C754(0.00)  LDD2223  [14]
HHS-482
 Probe Info  		Y336(1.09); Y524(1.01)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		12.82  LDD1845  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe6
 Probe Info  		20.00  LDD0467  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C754(0.88)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C276(0.67); C754(0.92)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C241(0.78)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C754(0.81); C299(1.02)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C241(1.38)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C241(0.50)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C241(1.04)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C461(2.42)  LDD0168  [7]
 LDCM0214  AC1 HCT 116 C145(0.99); C150(0.80); C754(0.71); C288(1.28)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C145(4.91); C150(3.71); C153(0.82); C276(1.29)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C145(0.39); C150(0.39); C754(1.25); C288(1.02)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C145(1.13); C150(1.13); C754(0.95); C288(1.01)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C145(1.24); C150(1.24); C754(0.87); C288(1.08)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C145(1.19); C150(1.19); C754(1.20); C288(1.10)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C145(1.19); C150(1.19); C754(1.05); C288(1.15)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C145(1.18); C150(1.18); C754(1.15); C288(1.11)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C145(0.75); C150(0.75); C754(1.13); C288(1.01)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C145(0.89); C150(0.89); C754(1.24); C288(1.12)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C145(0.25); C150(0.25); C754(1.01); C288(1.27)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C145(0.85); C150(0.85); C754(1.10); C288(1.15)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C145(10.22); C150(6.79); C153(1.23); C276(1.94)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C145(1.12); C150(1.12); C754(1.05); C288(1.24)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C145(0.90); C150(0.90); C754(1.21); C288(1.05)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C145(0.98); C150(0.98); C754(1.60); C288(1.29)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C754(1.02); C153(1.06); C276(1.29); C288(1.07)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C754(1.05); C153(1.38); C276(1.24); C288(1.12)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C754(0.87); C153(1.25); C276(1.12); C288(0.97)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C754(1.07); C153(1.20); C276(1.04); C288(3.13)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C754(0.91); C153(1.18); C276(1.12); C288(1.40)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C754(1.34); C153(1.16); C276(1.17); C288(0.84)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C754(0.84); C153(1.21); C276(1.39); C288(1.34)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C145(1.19); C150(1.03); C153(0.91); C276(1.74)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C754(1.13); C153(1.06); C276(1.00); C288(0.83)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C754(1.21); C153(0.89); C276(1.07); C288(0.92)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C754(1.22); C153(1.11); C276(1.34); C288(1.24)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C754(1.20); C153(1.03); C276(1.14); C288(1.40)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C754(1.13); C153(1.12); C276(1.24); C288(1.10)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C754(1.23); C153(1.27); C276(1.27); C288(1.00)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C754(1.31); C153(1.25); C276(1.21); C288(1.23)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C754(1.44); C153(1.20); C276(1.28); C288(1.34)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C145(1.01); C150(1.01); C153(1.30); C276(0.86)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C145(0.74); C150(0.74); C153(1.01); C276(1.15)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C145(0.65); C150(0.65); C153(1.25); C276(1.66)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C145(0.95); C150(0.95); C153(0.91); C276(1.12)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C145(0.53); C150(0.53); C153(1.10); C276(1.14)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C145(0.77); C150(0.77); C153(1.02); C276(0.99)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C145(1.01); C150(1.01); C153(1.56); C276(1.04)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C145(0.86); C150(0.86); C153(1.45); C276(1.18)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C145(0.70); C150(0.70); C153(1.08); C276(1.05)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C145(0.79); C150(0.79); C153(1.09); C276(0.96)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C145(0.80); C150(0.80); C153(1.17); C276(1.25)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C145(0.83); C150(0.83); C153(1.11); C276(1.27)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C145(16.87); C150(10.53); C153(0.91); C276(1.92)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C145(0.91); C150(0.91); C153(1.29); C276(1.38)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C145(0.81); C150(0.81); C153(1.20); C276(1.36)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C145(0.74); C150(0.74); C153(1.23); C276(1.13)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C145(1.17); C150(1.17); C754(0.95); C276(0.91)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C145(0.54); C150(0.54); C754(0.82); C447(0.94)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C447(0.90); C582(0.98); C276(0.98); C754(0.99)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C893(0.93); C901(0.93); C754(1.01); C291(1.06)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C754(0.77); C447(0.88); C291(0.89); C288(0.92)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C754(0.89); C291(0.93); C447(0.99); C288(1.00)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C754(0.88); C291(1.03); C288(1.04); C447(1.08)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C288(0.78); C582(0.84); C943(0.84); C153(0.87)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C447(0.87); C893(0.88); C901(0.88); C754(1.00)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C145(0.46); C150(0.46); C893(0.96); C901(0.96)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C754(0.89); C291(0.95); C447(0.97); C288(0.97)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C754(0.93); C291(1.06); C447(1.10); C288(1.15)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C145(2.03); C150(2.03); C754(0.85); C153(1.60)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C145(0.45); C150(0.45); C754(0.80); C153(1.46)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C145(2.46); C150(2.46); C754(1.08); C153(1.30)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C145(2.88); C150(2.88); C754(0.92); C153(1.16)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C145(0.22); C150(0.22); C754(0.55); C582(0.68)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C754(0.51); C893(0.76); C901(0.76); C582(0.80)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C754(0.52); C582(0.81); C893(0.86); C901(0.86)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C150(0.52); C754(0.71); C145(0.77); C786(0.94)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C582(0.53); C145(0.69); C150(0.69); C893(0.81)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C582(0.61); C754(0.61); C893(0.75); C901(0.75)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C145(0.20); C150(0.20); C582(0.70); C754(0.73)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C145(0.28); C150(0.28); C754(0.62); C893(0.67)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C754(0.77); C582(0.80); C447(0.88); C893(0.89)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C754(0.72); C582(0.85); C288(0.86); C291(0.89)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C754(0.77); C582(0.87); C276(0.91); C461(0.95)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C461(0.92); C754(0.95); C276(1.04); C582(1.06)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C276(0.88); C461(1.04); C582(1.09); C291(1.13)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C276(0.88); C582(1.03); C461(1.09); C291(1.09)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C150(0.38); C145(0.56); C754(0.89); C786(0.91)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C276(0.75); C582(0.84); C461(1.09); C288(1.12)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C582(0.95); C754(0.98); C461(1.02); C288(1.08)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C461(0.94); C582(1.09); C276(1.10); C291(1.19)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C276(0.83); C461(0.90); C582(1.00); C291(1.15)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C276(0.74); C754(0.92); C582(0.99); C461(1.02)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C447(0.80); C582(0.82); C754(0.89); C153(0.89)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C943(0.65); C582(0.72); C153(0.93); C299(0.98)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C943(0.57); C786(0.79); C582(0.84); C461(0.94)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C943(0.89); C299(0.96); C786(0.99); C461(1.00)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C943(0.84); C447(0.87); C276(0.92); C786(1.01)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C150(0.54); C754(0.71); C145(0.77); C786(0.80)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C786(0.86); C276(0.87); C943(0.91); C299(1.09)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C276(0.84); C943(0.86); C299(0.96); C447(0.98)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C943(0.80); C276(0.91); C299(0.96); C461(1.06)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C943(0.79); C153(0.94); C299(1.00); C461(1.07)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C276(0.81); C943(0.93); C299(0.98); C786(1.00)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C276(0.71); C786(0.84); C582(0.88); C153(0.90)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C943(0.76); C153(0.91); C461(1.01); C288(1.08)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C943(1.03); C461(1.07); C288(1.09); C153(1.10)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C943(0.84); C461(0.96); C299(1.09); C582(1.09)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C943(0.90); C754(1.19); C288(1.26); C299(1.26)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C150(0.47); C754(0.53); C145(0.71); C786(0.79)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C943(0.89); C288(1.14); C461(1.20); C299(1.21)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C153(0.86); C461(0.90); C288(0.95); C943(0.96)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C299(0.94); C461(0.96); C288(1.07); C291(1.10)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C943(0.87); C754(1.01); C299(1.02); C461(1.08)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C943(0.95); C447(0.98); C582(1.03); C461(1.05)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C299(1.14); C943(1.15); C461(1.19); C754(1.20)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C754(0.89); C943(1.09); C582(1.16); C299(1.33)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C893(0.63); C901(0.63); C754(0.81); C276(0.94)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C893(0.68); C901(0.68); C754(0.82); C276(0.83)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C893(0.74); C901(0.74); C276(0.94); C754(0.98)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C943(0.81); C288(0.87); C786(0.91); C153(0.91)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C893(0.66); C901(0.66); C754(0.71); C276(0.80)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C893(0.63); C901(0.63); C754(0.70); C276(0.76)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C893(0.63); C901(0.63); C754(0.77); C276(0.89)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C276(0.67); C893(0.70); C901(0.70); C447(0.97)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C893(0.61); C901(0.61); C276(0.78); C754(0.94)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C893(0.64); C901(0.64); C582(0.64); C276(0.72)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C582(0.56); C893(0.56); C901(0.56); C276(0.65)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C893(0.49); C901(0.49); C754(0.55); C582(0.64)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C276(0.78); C447(0.92); C291(1.03); C288(1.03)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C276(0.73); C288(0.90); C447(0.93); C291(0.93)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C943(0.80); C786(0.83); C288(0.88); C153(0.99)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C447(0.90); C291(1.03); C276(1.04); C288(1.04)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C276(0.79); C447(0.84); C288(0.90); C299(0.91)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C276(0.92); C288(0.94); C291(0.97); C299(0.98)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C754(7.47); C276(0.99); C288(1.18); C299(1.18)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C276(0.72); C447(1.05); C299(1.12); C288(1.15)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C276(0.79); C288(1.18); C291(1.22); C299(1.23)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C276(0.68); C288(0.94); C299(0.96); C291(0.98)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C276(0.62); C288(1.03); C291(1.04); C299(1.07)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C276(0.58); C291(0.84); C288(0.88); C447(0.94)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C276(0.69); C288(0.86); C291(0.87); C447(0.96)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C786(0.82); C153(0.83); C447(0.97); C288(0.99)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C276(0.76); C447(0.91); C299(0.95); C288(1.01)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C276(0.71); C447(0.79); C299(0.86); C291(0.88)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C276(0.78); C447(1.14); C901(1.25); C299(1.29)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C447(1.13); C943(1.16); C291(1.21); C153(1.32)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C153(1.14); C447(1.16); C754(1.21); C943(1.23)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C943(1.11); C153(1.13); C288(1.13); C582(1.15)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C288(0.82); C943(0.83); C291(0.91); C582(1.15)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C288(0.86); C291(0.90); C461(1.10); C582(1.13)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C943(0.95); C288(1.13); C461(1.19); C291(1.21)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C943(0.90); C754(1.11); C291(1.14); C447(1.16)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C582(0.84); C288(0.91); C943(0.94); C291(0.99)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C288(1.13); C943(1.15); C291(1.17); C754(1.19)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C943(1.11); C153(1.14); C447(1.18); C754(1.18)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C943(1.02); C153(1.04); C288(1.08); C447(1.13)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C153(0.86); C291(0.94); C754(0.94); C943(0.98)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C291(0.92); C943(0.96); C288(1.00); C754(1.07)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C153(0.95); C447(1.00); C291(1.05); C943(1.09)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C943(1.03); C447(1.26); C461(1.29); C288(1.30)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C943(0.76); C145(0.84); C150(0.84); C893(1.06)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C893(0.81); C901(0.81); C943(0.82); C447(0.90)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C241(1.08); C299(1.02)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C145(2.81); C150(2.27); C153(0.96); C276(1.54)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C153(0.91); C288(0.93); C943(0.95); C461(0.96)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C288(0.84); C153(0.89); C582(0.96); C786(1.01)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C582(1.07); C786(1.00); C288(0.97); C291(0.97)  LDD0078  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C299(20.00); C943(20.00); C582(20.00); C754(1.48)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C291(0.89); C145(0.90); C150(0.90); C461(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C145(0.25); C150(0.25); C786(0.80); C288(1.16)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C150(0.65); C786(0.93); C145(0.94); C299(0.98)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C288(0.74); C153(0.89); C291(0.93); C786(0.96)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C288(0.60); C291(0.76); C153(0.79); C943(0.86)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C288(0.69); C153(0.84); C786(0.87); C291(0.93)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C153(0.77); C943(0.81); C288(0.81); C786(0.82)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C145(0.22); C150(0.22); C754(0.67); C447(0.73)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C145(0.25); C150(0.25); C754(0.44); C447(0.70)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C145(0.09); C150(0.09); C754(0.62); C447(0.80)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C145(0.09); C150(0.09); C754(0.50); C786(0.72)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C145(0.08); C150(0.08); C754(0.58); C582(0.75)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C145(0.39); C150(0.39); C786(0.84); C276(0.86)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C145(0.13); C150(0.13); C754(0.40); C893(0.67)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C754(0.33); C447(0.86); C893(0.89); C901(0.89)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C288(0.66); C291(0.79); C447(0.91); C461(0.95)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C461(0.96); C276(0.98); C288(1.02); C582(1.02)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C288(0.89); C461(0.93); C291(0.96); C582(1.01)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C461(0.99); C288(0.99); C582(0.99); C276(1.04)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C582(0.87); C288(1.02); C461(1.03); C291(1.05)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C276(0.80); C786(0.96); C943(1.01); C153(1.04)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C153(0.73); C582(0.76); C754(0.84); C943(0.95)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C943(0.85); C153(0.85); C276(0.96); C447(1.08)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C145(0.12); C150(0.12); C786(0.97); C288(1.16)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C943(0.86); C299(1.00); C461(1.03); C153(1.05)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C943(0.56); C582(0.88); C461(1.02); C447(1.09)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C943(0.97); C461(1.07); C447(1.09); C299(1.12)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C754(0.91); C299(1.02); C943(1.06); C447(1.07)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C582(0.94); C943(0.96); C299(1.16); C461(1.22)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C893(0.73); C901(0.73); C786(0.87); C754(0.91)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C893(0.67); C901(0.67); C786(0.70); C447(0.84)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C754(0.64); C893(0.66); C901(0.66); C786(0.84)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C754(0.65); C893(0.71); C901(0.71); C786(0.88)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C786(0.81); C276(0.84); C461(1.11); C447(1.14)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C145(0.48); C150(0.48); C786(0.86); C291(0.88)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C786(0.73); C276(0.85); C291(1.03); C288(1.05)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C582(0.90); C461(0.94); C447(1.01); C299(1.03)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C145(0.58); C150(0.58); C582(0.78); C786(0.87)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C461(0.94); C786(0.95); C582(0.97); C153(1.08)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C754(0.79); C786(0.95); C582(0.98); C461(1.01)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C291(0.87); C447(0.94); C786(0.94); C754(0.97)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C786(1.01); C461(1.03); C754(1.03); C582(1.04)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C786(0.94); C461(1.07); C153(1.10); C582(1.14)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C754(0.85); C786(0.86); C582(0.96); C145(0.98)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C145(0.68); C150(0.68); C582(0.89); C786(0.94)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C754(0.94); C145(1.14); C150(1.14); C153(1.03)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C145(0.95); C150(0.95); C754(1.11); C153(0.88)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C145(1.41); C150(1.41); C754(1.80); C153(0.93)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C145(1.58); C150(1.58); C754(0.89); C153(1.00)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C145(1.17); C150(1.17); C754(1.18); C153(1.24)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C145(0.92); C150(0.92); C754(0.94); C153(1.08)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C145(1.37); C150(1.37); C754(0.90); C276(0.95)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C145(1.01); C150(1.01); C754(1.07); C153(1.10)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C145(0.54); C150(0.54); C153(0.97); C288(1.05)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C153(0.93); C276(0.99); C288(0.99); C291(1.33)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C153(1.05); C276(0.93); C288(1.11); C291(1.09)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C153(1.14); C276(0.81); C288(1.00); C291(1.42)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C153(1.10); C276(1.21); C288(1.17); C291(1.24)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C153(0.98); C276(0.69); C288(0.84); C291(1.04)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C153(1.15); C276(0.75); C288(0.98); C291(1.41)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C153(1.07); C276(1.02); C288(1.36); C291(1.67)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C145(0.74); C150(0.74); C754(1.17); C276(0.83)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C153(1.03); C276(0.72); C288(0.99); C291(1.22)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C153(1.06); C276(0.67); C288(0.98); C291(1.32)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C153(1.01); C276(0.61); C288(1.09); C291(1.64)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C153(1.04); C276(0.71); C288(1.09); C291(1.51)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C153(1.13); C276(0.94); C288(1.16); C291(1.46)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C153(1.03); C276(0.91); C288(1.12); C291(1.39)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C145(0.63); C150(0.63); C754(1.40); C153(1.06)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C145(0.92); C150(0.92); C754(2.79); C153(1.02)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C145(2.24); C150(2.24); C754(2.19); C153(1.07)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C145(0.66); C150(0.66); C754(1.20); C153(1.02)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C145(1.30); C150(1.30); C754(1.16); C276(1.09)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C145(2.07); C150(2.07); C754(2.11); C153(1.04)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C145(0.76); C150(0.76); C754(2.38); C153(1.07)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C145(1.87); C150(1.87); C754(1.57); C153(1.07)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C145(3.03); C150(3.03); C754(1.14); C153(0.97)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C145(1.79); C150(1.79); C754(1.60); C153(0.94)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C145(1.79); C150(1.79); C754(1.73); C153(1.03)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C145(1.56); C150(1.56); C754(1.35); C153(0.99)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C145(1.68); C150(1.68); C754(1.60); C153(0.99)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C145(1.39); C150(1.39); C754(1.87); C153(1.02)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C145(1.41); C150(1.41); C754(1.95); C153(0.95)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C145(1.91); C150(1.91); C754(1.34); C276(1.15)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C145(1.86); C150(1.86); C754(1.58); C153(1.01)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C153(0.91); C288(1.23); C291(1.16); C299(1.04)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C153(1.17); C288(1.40); C291(1.19); C299(1.05)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C153(1.21); C288(1.45); C291(1.35); C299(1.20)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C153(0.91); C288(1.40); C291(1.34); C299(1.19)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C153(0.94); C288(1.13); C291(1.16); C299(1.10)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C153(1.04); C288(1.52); C291(1.41); C299(1.46)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C153(0.95); C288(1.45); C291(1.57); C299(1.18)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C153(1.01); C288(1.46); C291(1.29); C299(1.13)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C153(1.20); C288(1.21); C291(1.10); C299(1.02)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C145(0.93); C150(0.93); C754(1.27); C276(1.19)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C153(1.11); C288(1.21); C291(1.33); C299(1.14)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C153(1.30); C288(1.26); C291(1.34); C299(1.17)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C153(0.90); C288(1.05); C291(1.12); C299(1.01)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C153(1.17); C288(1.39); C291(1.29); C299(1.07)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C153(1.08); C288(1.22); C291(1.30); C299(1.08)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C754(0.78); C276(0.59); C288(0.75); C291(1.01)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C754(1.26); C276(0.66); C288(0.82); C291(0.96)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C754(0.96); C276(0.71); C288(0.82); C291(1.02)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C754(0.88); C276(0.75); C288(0.97); C291(1.00)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C145(2.41); C150(2.41); C754(2.84); C276(0.78)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C754(0.95); C276(0.84); C288(0.93); C291(0.96)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C754(0.90); C276(0.79); C288(1.05); C291(1.18)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C754(0.64); C276(0.82); C288(0.96); C291(1.82)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C754(0.98); C276(0.94); C288(0.78); C291(1.15)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C754(1.33); C276(0.77); C288(0.82); C291(1.68)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C754(1.59); C276(0.50); C288(0.78); C291(0.95)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C754(1.25); C276(0.40); C288(0.85); C291(0.86)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C754(1.28); C276(0.46); C288(0.84); C291(0.93)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C754(0.98); C276(0.37); C288(0.79); C291(1.08)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C754(0.87); C276(0.48); C288(0.73); C291(1.34)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C145(0.53); C150(0.53); C754(1.40); C276(0.99)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C754(1.07); C276(0.44); C288(0.74); C291(0.72)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C145(0.80); C150(0.88); C754(1.10); C288(1.35)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C145(1.18); C150(1.35); C754(0.79); C288(1.30)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C145(0.44); C150(0.30); C754(0.76); C288(1.16)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C145(1.10); C150(0.77); C754(0.90); C288(1.13)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C145(1.16); C150(0.88); C754(0.97); C288(1.33)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C145(1.51); C150(1.15); C754(0.79); C288(1.12)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C145(1.37); C150(0.96); C754(0.94); C288(1.23)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C145(1.02); C150(0.77); C754(0.80); C288(1.24)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C145(1.05); C150(0.83); C754(0.95); C288(1.30)  LDD0811  [10]
 LDCM0189  Compound 16 HEK-293T 12.58  LDD0492  [22]
 LDCM0182  Compound 18 HEK-293T 10.15  LDD0501  [22]
 LDCM0192  Compound 35 HEK-293T 12.27  LDD0491  [22]
 LDCM0194  Compound 37 HEK-293T 15.50  LDD0498  [22]
 LDCM0195  Compound 38 HEK-293T 19.23  LDD0499  [22]
 LDCM0196  Compound 39 HEK-293T 15.04  LDD0496  [22]
 LDCM0181  Compound 41 HEK-293T 11.70  LDD0502  [22]
 LDCM0183  Compound 42 HEK-293T 6.45  LDD0500  [22]
 LDCM0634  CY-0357 Hep-G2 C754(4.00); C447(1.52); C943(0.87); C786(0.71)  LDD2228  [14]
 LDCM0495  E2913 HEK-293T C754(1.04); C582(1.27); C153(0.92); C849(1.02)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C461(3.67); C754(1.28); C943(0.90)  LDD1702  [6]
 LDCM0625  F8 Ramos C153(0.69); C461(1.14); C447(1.38); C1035(1.10)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C153(1.85); C461(2.46); C447(1.37); 0.28  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C153(0.30); C461(0.65); C447(2.32); C1035(3.49)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C153(2.06); C461(1.50); C447(1.25); 0.11  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C153(1.22); C461(0.98); C447(1.01); 0.91  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C153(0.45); C461(0.48); C447(1.61); 0.83  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C153(2.21); C461(2.34); C447(2.27); 0.38  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C153(1.14); C461(0.89); C447(1.17); 0.16  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C153(3.26); C461(1.90); C447(1.95); 0.42  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C153(1.04); C461(1.01); C447(1.10); 0.31  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C153(0.69); C461(1.16); C447(0.85); C1035(0.64)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C153(1.78); C461(1.04); C447(1.20); 0.15  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C153(1.41); C461(1.09); C447(1.33); 0.22  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C153(1.13); C461(1.19); C447(1.36); 0.18  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C153(0.96); C288(1.44); C291(1.28); C299(1.19)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C153(1.45); C461(1.26); C447(1.02); 0.46  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C153(0.91); C461(1.20); C447(1.29); 0.98  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C153(0.75); C276(0.71); C288(0.99); C291(1.72)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C153(1.94); C461(1.03); C447(1.27); 0.41  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C153(1.70); C461(0.93); C447(1.27); 0.26  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C153(1.09); C461(1.86); C447(1.29); C1035(1.62)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C153(2.13); C461(2.41); C447(1.79); 0.32  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y309(0.78); Y524(0.89); Y336(0.95)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y309(0.62); Y524(0.88); Y336(1.12)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y309(0.76); Y524(1.03); Y336(1.65)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y309(0.85); Y336(1.43); Y524(1.93)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y309(0.91); Y524(1.98); Y336(2.19)  LDD0268  [8]
 LDCM0022  KB02 HCT 116 C461(2.44); C288(2.38); C291(2.38); C786(2.64)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C461(2.75); C288(3.67); C291(3.67); C786(1.63)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C461(3.24); C288(1.95); C291(1.95); C786(1.49)  LDD0082  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C276(0.90); C754(0.86)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C754(0.93)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C276(0.64); C754(0.92)  LDD2094  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C754(1.21)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C241(1.27); C276(0.85); C754(0.73); C299(1.05)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C754(0.72)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C241(1.40); C754(1.07); C299(1.38)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C276(0.97); C754(1.00)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C754(1.28)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C241(0.88); C754(1.17); C299(0.77)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C754(0.82)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C241(0.64); C276(1.13); C754(0.52); C299(0.98)  LDD2109  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C241(0.97); C299(0.95)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C754(0.88)  LDD2118  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C276(0.91)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C754(0.94)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C276(0.63); C754(0.80); C461(0.79)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C754(0.92)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C241(1.27); C754(0.81)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C241(1.26); C276(0.97); C754(0.93)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C241(0.58)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C241(1.08); C754(0.61); C299(0.77)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C299(1.28)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C276(0.99); C299(1.21)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C241(0.84); C754(1.02); C299(0.96)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C241(0.95); C276(0.93)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C754(0.75)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C754(1.16)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C276(2.55)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C276(0.88)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C276(0.50)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C461(1.01); C447(0.43)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C582(0.98); C461(0.74)  LDD2207  [26]
 LDCM0021  THZ1 HCT 116 C754(1.14); C299(1.13); C582(0.95); C447(1.03)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 2 (SMAD2) Dwarfin/SMAD family Q15796
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.