Details of the Target

General Information of Target

Target ID LDTP01773
Target Name Cytochrome c oxidase subunit 2 (MT-CO2)
Gene Name MT-CO2
Gene ID 4513
Synonyms
COII; COX2; COXII; MTCO2; Cytochrome c oxidase subunit 2; EC 7.1.1.9; Cytochrome c oxidase polypeptide II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE
METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS
YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN
QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
Target Bioclass
Enzyme
Family
Cytochrome c oxidase subunit 2 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Uniprot ID
P00403
Ensemble ID
ENST00000361739.1
HGNC ID
HGNC:7421
ChEMBL ID
CHEMBL6174

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		9.12  LDD0196  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
C-Sul
 Probe Info  		5.49  LDD0066  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
Jackson_14
 Probe Info  		2.00  LDD0123  [5]
HPAP
 Probe Info  		3.26  LDD0064  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
Acrolein
 Probe Info  		N.A.  LDD0222  [8]
DBIA
 Probe Info  		C196(0.85); C200(0.85)  LDD1094  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [10]
AOyne
 Probe Info  		6.70  LDD0443  [11]
MPP-AC
 Probe Info  		N.A.  LDD0428  [12]
TER-AC
 Probe Info  		N.A.  LDD0426  [12]
TPP-AC
 Probe Info  		N.A.  LDD0427  [12]
PAL-AfBPP Probe
Click To Hide/Show 88 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		15.78  LDD1714  [13]
C017
 Probe Info  		7.94  LDD1725  [13]
C022
 Probe Info  		10.13  LDD1728  [13]
C040
 Probe Info  		16.56  LDD1740  [13]
C055
 Probe Info  		21.86  LDD1752  [13]
C056
 Probe Info  		41.36  LDD1753  [13]
C063
 Probe Info  		15.78  LDD1760  [13]
C064
 Probe Info  		7.52  LDD1761  [13]
C070
 Probe Info  		20.53  LDD1766  [13]
C087
 Probe Info  		10.20  LDD1779  [13]
C091
 Probe Info  		23.59  LDD1782  [13]
C092
 Probe Info  		28.84  LDD1783  [13]
C094
 Probe Info  		32.90  LDD1785  [13]
C100
 Probe Info  		6.06  LDD1789  [13]
C106
 Probe Info  		27.86  LDD1793  [13]
C112
 Probe Info  		46.53  LDD1799  [13]
C129
 Probe Info  		6.77  LDD1811  [13]
C130
 Probe Info  		8.00  LDD1812  [13]
C134
 Probe Info  		33.36  LDD1816  [13]
C139
 Probe Info  		11.96  LDD1821  [13]
C143
 Probe Info  		12.38  LDD1825  [13]
C159
 Probe Info  		13.18  LDD1839  [13]
C161
 Probe Info  		16.22  LDD1841  [13]
C165
 Probe Info  		29.04  LDD1845  [13]
C169
 Probe Info  		27.47  LDD1849  [13]
C178
 Probe Info  		16.11  LDD1857  [13]
C198
 Probe Info  		9.65  LDD1874  [13]
C201
 Probe Info  		28.64  LDD1877  [13]
C218
 Probe Info  		29.24  LDD1892  [13]
C220
 Probe Info  		16.34  LDD1894  [13]
C225
 Probe Info  		5.10  LDD1898  [13]
C226
 Probe Info  		7.11  LDD1899  [13]
C228
 Probe Info  		28.25  LDD1901  [13]
C231
 Probe Info  		16.34  LDD1904  [13]
C232
 Probe Info  		40.79  LDD1905  [13]
C233
 Probe Info  		9.92  LDD1906  [13]
C235
 Probe Info  		31.12  LDD1908  [13]
C238
 Probe Info  		25.63  LDD1911  [13]
C252
 Probe Info  		21.41  LDD1925  [13]
C264
 Probe Info  		27.10  LDD1935  [13]
C265
 Probe Info  		15.78  LDD1936  [13]
C271
 Probe Info  		6.96  LDD1941  [13]
C278
 Probe Info  		99.73  LDD1948  [13]
C280
 Probe Info  		9.00  LDD1950  [13]
C282
 Probe Info  		27.47  LDD1952  [13]
C284
 Probe Info  		33.36  LDD1954  [13]
C299
 Probe Info  		6.73  LDD1968  [13]
C303
 Probe Info  		5.39  LDD1972  [13]
C304
 Probe Info  		9.65  LDD1973  [13]
C305
 Probe Info  		14.62  LDD1974  [13]
C314
 Probe Info  		39.95  LDD1981  [13]
C326
 Probe Info  		7.31  LDD1990  [13]
C343
 Probe Info  		12.47  LDD2005  [13]
C348
 Probe Info  		18.38  LDD2009  [13]
C349
 Probe Info  		35.02  LDD2010  [13]
C350
 Probe Info  		81.01  LDD2011  [13]
C353
 Probe Info  		6.63  LDD2014  [13]
C354
 Probe Info  		24.93  LDD2015  [13]
C356
 Probe Info  		8.22  LDD2017  [13]
C362
 Probe Info  		69.55  LDD2023  [13]
C363
 Probe Info  		20.39  LDD2024  [13]
C364
 Probe Info  		25.28  LDD2025  [13]
C366
 Probe Info  		8.40  LDD2027  [13]
C367
 Probe Info  		6.96  LDD2028  [13]
C380
 Probe Info  		8.22  LDD2039  [13]
C382
 Probe Info  		39.67  LDD2041  [13]
C388
 Probe Info  		80.45  LDD2047  [13]
C390
 Probe Info  		56.49  LDD2049  [13]
C403
 Probe Info  		27.28  LDD2061  [13]
C407
 Probe Info  		18.25  LDD2064  [13]
C413
 Probe Info  		19.16  LDD2069  [13]
C429
 Probe Info  		21.11  LDD2084  [13]
C430
 Probe Info  		17.75  LDD2085  [13]
C431
 Probe Info  		21.56  LDD2086  [13]
C433
 Probe Info  		7.62  LDD2088  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe12
 Probe Info  		15.13  LDD0473  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe15
 Probe Info  		7.84  LDD0478  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
FFF probe3
 Probe Info  		20.00  LDD0464  [14]
FFF probe4
 Probe Info  		15.62  LDD0466  [14]
FFF probe6
 Probe Info  		20.00  LDD0467  [14]
FFF probe9
 Probe Info  		18.76  LDD0470  [14]
JN0003
 Probe Info  		19.71  LDD0469  [14]
LD-F
 Probe Info  		T63(0.00); L50(0.00); E60(0.00)  LDD0015  [15]
OEA-DA
 Probe Info  		9.45  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C196(0.86); C200(1.10)  LDD1507  [17]
 LDCM0215  AC10 PaTu 8988t C196(0.85); C200(0.85)  LDD1094  [9]
 LDCM0226  AC11 PaTu 8988t C196(0.94); C200(0.94)  LDD1105  [9]
 LDCM0237  AC12 PaTu 8988t C196(0.50); C200(0.50)  LDD1116  [9]
 LDCM0259  AC14 PaTu 8988t C196(1.22); C200(1.22)  LDD1138  [9]
 LDCM0263  AC143 PaTu 8988t C196(0.53); C200(0.53)  LDD1142  [9]
 LDCM0264  AC144 PaTu 8988t C196(0.77); C200(0.77)  LDD1143  [9]
 LDCM0265  AC145 PaTu 8988t C196(0.68); C200(0.68)  LDD1144  [9]
 LDCM0266  AC146 PaTu 8988t C196(0.83); C200(0.83)  LDD1145  [9]
 LDCM0267  AC147 PaTu 8988t C196(1.29); C200(1.29)  LDD1146  [9]
 LDCM0268  AC148 PaTu 8988t C196(0.40); C200(0.40)  LDD1147  [9]
 LDCM0269  AC149 PaTu 8988t C196(0.81); C200(0.81)  LDD1148  [9]
 LDCM0270  AC15 PaTu 8988t C196(1.51); C200(1.51)  LDD1149  [9]
 LDCM0271  AC150 PaTu 8988t C196(0.80); C200(0.80)  LDD1150  [9]
 LDCM0272  AC151 PaTu 8988t C196(0.83); C200(0.83)  LDD1151  [9]
 LDCM0273  AC152 PaTu 8988t C196(0.79); C200(0.79)  LDD1152  [9]
 LDCM0274  AC153 PaTu 8988t C196(0.88); C200(0.88)  LDD1153  [9]
 LDCM0621  AC154 PaTu 8988t C196(0.63); C200(0.63)  LDD2166  [9]
 LDCM0622  AC155 PaTu 8988t C196(0.54); C200(0.54)  LDD2167  [9]
 LDCM0623  AC156 PaTu 8988t C196(0.93); C200(0.93)  LDD2168  [9]
 LDCM0624  AC157 PaTu 8988t C196(0.81); C200(0.81)  LDD2169  [9]
 LDCM0276  AC17 PaTu 8988t C196(0.79); C200(0.79)  LDD1155  [9]
 LDCM0277  AC18 PaTu 8988t C196(0.54); C200(0.54)  LDD1156  [9]
 LDCM0278  AC19 PaTu 8988t C196(0.78); C200(0.78)  LDD1157  [9]
 LDCM0279  AC2 HEK-293T C196(0.83); C200(0.82)  LDD1518  [17]
 LDCM0280  AC20 PaTu 8988t C196(0.56); C200(0.56)  LDD1159  [9]
 LDCM0281  AC21 PaTu 8988t C196(0.43); C200(0.43)  LDD1160  [9]
 LDCM0282  AC22 PaTu 8988t C196(0.51); C200(0.51)  LDD1161  [9]
 LDCM0283  AC23 PaTu 8988t C196(0.32); C200(0.32)  LDD1162  [9]
 LDCM0284  AC24 PaTu 8988t C196(0.33); C200(0.33)  LDD1163  [9]
 LDCM0285  AC25 PaTu 8988t C196(1.85); C200(1.85)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C196(1.00); C200(1.00)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C196(1.85); C200(1.85)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C196(1.42); C200(1.42)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C196(1.62); C200(1.62)  LDD1168  [9]
 LDCM0290  AC3 HEK-293T C196(0.92); C200(0.76)  LDD1529  [17]
 LDCM0291  AC30 PaTu 8988t C196(1.19); C200(1.19)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C196(1.67); C200(1.67)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C196(1.04); C200(1.04)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C196(1.07); C200(1.07)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C196(1.25); C200(1.25)  LDD1174  [9]
 LDCM0296  AC35 PaTu 8988t C196(0.84); C200(0.84)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C196(0.80); C200(0.80)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C196(0.50); C200(0.50)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C196(0.62); C200(0.62)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C196(0.86); C200(0.86)  LDD1179  [9]
 LDCM0301  AC4 HEK-293T C196(0.87); C200(0.73)  LDD1540  [17]
 LDCM0302  AC40 PaTu 8988t C196(0.77); C200(0.77)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C196(0.59); C200(0.59)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C196(0.63); C200(0.63)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C196(0.62); C200(0.62)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C196(0.25); C200(0.25)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C196(0.36); C200(0.36)  LDD1186  [9]
 LDCM0308  AC46 PaTu 8988t C196(0.85); C200(0.85)  LDD1187  [9]
 LDCM0309  AC47 PaTu 8988t C196(0.70); C200(0.70)  LDD1188  [9]
 LDCM0310  AC48 PaTu 8988t C196(0.61); C200(0.61)  LDD1189  [9]
 LDCM0311  AC49 PaTu 8988t C196(0.50); C200(0.50)  LDD1190  [9]
 LDCM0312  AC5 HEK-293T C196(1.01)  LDD1551  [17]
 LDCM0313  AC50 PaTu 8988t C196(0.44); C200(0.44)  LDD1192  [9]
 LDCM0314  AC51 PaTu 8988t C196(2.92); C200(2.92)  LDD1193  [9]
 LDCM0315  AC52 PaTu 8988t C196(0.65); C200(0.65)  LDD1194  [9]
 LDCM0316  AC53 PaTu 8988t C196(0.43); C200(0.43)  LDD1195  [9]
 LDCM0317  AC54 PaTu 8988t C196(0.37); C200(0.37)  LDD1196  [9]
 LDCM0318  AC55 PaTu 8988t C196(0.46); C200(0.46)  LDD1197  [9]
 LDCM0319  AC56 PaTu 8988t C196(0.28); C200(0.28)  LDD1198  [9]
 LDCM0320  AC57 HEK-293T C196(0.90); C200(1.12)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C196(0.88); C200(0.89)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C196(0.95); C200(0.72)  LDD1561  [17]
 LDCM0323  AC6 PaTu 8988t C196(0.71); C200(0.71)  LDD1202  [9]
 LDCM0324  AC60 HEK-293T C196(0.94); C200(0.74)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C196(1.06)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C196(0.92)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C196(0.92); C200(0.76)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C196(1.01)  LDD1567  [17]
 LDCM0334  AC7 PaTu 8988t C196(1.02); C200(1.02)  LDD1213  [9]
 LDCM0345  AC8 PaTu 8988t C196(1.57); C200(1.57)  LDD1224  [9]
 LDCM0248  AKOS034007472 PaTu 8988t C196(0.89); C200(0.89)  LDD1127  [9]
 LDCM0356  AKOS034007680 PaTu 8988t C196(0.85); C200(0.85)  LDD1235  [9]
 LDCM0275  AKOS034007705 PaTu 8988t C196(0.72); C200(0.72)  LDD1154  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C196(1.01); C200(0.76)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C196(0.94)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C196(0.93); C200(1.18)  LDD1573  [17]
 LDCM0370  CL101 PaTu 8988t C196(0.97); C200(0.97)  LDD1249  [9]
 LDCM0371  CL102 PaTu 8988t C196(1.04); C200(1.04)  LDD1250  [9]
 LDCM0372  CL103 PaTu 8988t C196(0.52); C200(0.52)  LDD1251  [9]
 LDCM0373  CL104 PaTu 8988t C196(1.01); C200(1.01)  LDD1252  [9]
 LDCM0374  CL105 PaTu 8988t C196(0.87); C200(0.87)  LDD1253  [9]
 LDCM0375  CL106 PaTu 8988t C196(1.17); C200(1.17)  LDD1254  [9]
 LDCM0376  CL107 PaTu 8988t C196(0.68); C200(0.68)  LDD1255  [9]
 LDCM0377  CL108 PaTu 8988t C196(0.51); C200(0.51)  LDD1256  [9]
 LDCM0378  CL109 PaTu 8988t C196(0.59); C200(0.59)  LDD1257  [9]
 LDCM0379  CL11 HEK-293T C196(1.21); C200(1.40)  LDD1583  [17]
 LDCM0380  CL110 PaTu 8988t C196(0.52); C200(0.52)  LDD1259  [9]
 LDCM0381  CL111 PaTu 8988t C196(0.34); C200(0.34)  LDD1260  [9]
 LDCM0382  CL112 PaTu 8988t C196(2.16); C200(2.16)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C196(2.00); C200(2.00)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C196(1.50); C200(1.50)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C196(2.06); C200(2.06)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C196(1.33); C200(1.33)  LDD1265  [9]
 LDCM0387  CL117 PaTu 8988t C196(0.49); C200(0.49)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C196(0.53); C200(0.53)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C196(0.71); C200(0.71)  LDD1268  [9]
 LDCM0390  CL12 HEK-293T C196(0.97)  LDD1594  [17]
 LDCM0391  CL120 PaTu 8988t C196(0.81); C200(0.81)  LDD1270  [9]
 LDCM0392  CL121 PaTu 8988t C196(0.95); C200(0.95)  LDD1271  [9]
 LDCM0393  CL122 PaTu 8988t C196(0.62); C200(0.62)  LDD1272  [9]
 LDCM0394  CL123 PaTu 8988t C196(0.56); C200(0.56)  LDD1273  [9]
 LDCM0395  CL124 PaTu 8988t C196(0.47); C200(0.47)  LDD1274  [9]
 LDCM0396  CL125 HEK-293T C196(0.99); C200(0.82)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C196(0.68)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C196(0.83)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C196(0.92); C200(1.23)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C196(0.95); C200(0.85)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C196(0.67)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C196(0.84)  LDD1606  [17]
 LDCM0403  CL16 PaTu 8988t C196(1.07); C200(1.07)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C196(1.23); C200(1.23)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C196(0.79); C200(0.79)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C196(0.72); C200(0.72)  LDD1285  [9]
 LDCM0407  CL2 HEK-293T C196(0.72)  LDD1611  [17]
 LDCM0408  CL20 PaTu 8988t C196(0.74); C200(0.74)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C196(0.35); C200(0.35)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C196(0.57); C200(0.57)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C196(0.52); C200(0.52)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C196(1.12); C200(1.12)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C196(0.70); C200(0.70)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C196(0.74); C200(0.74)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C196(0.84); C200(0.84)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C196(0.70); C200(0.70)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C196(0.35); C200(0.35)  LDD1296  [9]
 LDCM0418  CL3 HEK-293T C196(0.76)  LDD1622  [17]
 LDCM0419  CL30 PaTu 8988t C196(0.49); C200(0.49)  LDD1298  [9]
 LDCM0420  CL31 HEK-293T C196(0.92); C200(1.46)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C196(0.89); C200(1.25)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C196(0.78)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C196(0.80)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C196(1.14); C200(1.23)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C196(0.84)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C196(1.10); C200(0.84)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C196(0.96)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C196(0.84); C200(0.88)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C196(0.96); C200(1.19)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C196(0.98); C200(1.05)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C196(0.87); C200(1.07)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C196(0.95); C200(1.45)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C196(0.85); C200(1.23)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C196(0.87)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C196(0.81)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C196(1.12); C200(1.31)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C196(0.92)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C196(0.97); C200(0.74)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C196(0.84); C200(1.02)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C196(0.80)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C196(0.89); C200(0.99)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C196(0.92); C200(0.96)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C196(0.90); C200(1.26)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C196(0.97); C200(1.24)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C196(0.87); C200(1.71)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C196(0.75)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C196(0.78)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C196(1.11); C200(1.59)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C196(1.04); C200(1.22)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C196(0.89)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C196(1.02); C200(0.74)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C196(0.53)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C196(0.83)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C196(0.88); C200(1.20)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C196(0.98); C200(1.06)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C196(0.94); C200(1.08)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C196(0.91); C200(1.37)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C196(0.87); C200(1.33)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C196(0.87)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C196(0.87); C200(1.36)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C196(0.83)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C196(1.22); C200(1.45)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C196(0.88)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C196(1.06); C200(0.78)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C196(0.61)  LDD1670  [17]
 LDCM0469  CL76 PaTu 8988t C196(0.54); C200(0.54)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C196(0.59); C200(0.59)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C196(0.36); C200(0.36)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C196(1.20); C200(1.20)  LDD1351  [9]
 LDCM0473  CL8 HEK-293T C196(0.89); C200(1.47)  LDD1676  [17]
 LDCM0474  CL80 PaTu 8988t C196(0.36); C200(0.36)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C196(0.39); C200(0.39)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C196(0.47); C200(0.47)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C196(0.36); C200(0.36)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C196(0.33); C200(0.33)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C196(0.60); C200(0.60)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C196(0.35); C200(0.35)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C196(0.22); C200(0.22)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C196(0.31); C200(0.31)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C196(0.33); C200(0.33)  LDD1362  [9]
 LDCM0484  CL9 HEK-293T C196(0.82)  LDD1687  [17]
 LDCM0485  CL90 PaTu 8988t C196(0.53); C200(0.53)  LDD1364  [9]
 LDCM0486  CL91 HEK-293T C196(0.95); C200(1.19)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C196(0.98); C200(1.00)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C196(0.88)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C196(0.96)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C196(1.14); C200(0.89)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C196(1.07)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C196(1.00); C200(0.83)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C196(0.70)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C196(0.81)  LDD1697  [17]
 LDCM0189  Compound 16 HEK-293T 11.33  LDD0492  [14]
 LDCM0185  Compound 17 HEK-293T 6.61  LDD0504  [14]
 LDCM0182  Compound 18 HEK-293T 6.42  LDD0501  [14]
 LDCM0184  Compound 20 HEK-293T 7.66  LDD0503  [14]
 LDCM0191  Compound 21 HEK-293T 7.50  LDD0493  [14]
 LDCM0186  Compound 31 HEK-293T 7.07  LDD0506  [14]
 LDCM0188  Compound 33 HEK-293T 4.73  LDD0505  [14]
 LDCM0190  Compound 34 HEK-293T 13.41  LDD0497  [14]
 LDCM0192  Compound 35 HEK-293T 7.88  LDD0491  [14]
 LDCM0193  Compound 36 HEK-293T 7.57  LDD0494  [14]
 LDCM0194  Compound 37 HEK-293T 12.43  LDD0498  [14]
 LDCM0195  Compound 38 HEK-293T 13.90  LDD0499  [14]
 LDCM0196  Compound 39 HEK-293T 6.92  LDD0496  [14]
 LDCM0197  Compound 40 HEK-293T 8.84  LDD0495  [14]
 LDCM0183  Compound 42 HEK-293T 4.15  LDD0500  [14]
 LDCM0495  E2913 HEK-293T C196(0.91)  LDD1698  [17]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0468  Fragment33 HEK-293T C196(0.80)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C196(0.72)  LDD1631  [17]
 LDCM0022  KB02 HEK-293T C196(0.98); C200(0.85); C196(0.96); C200(0.96)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C196(0.99); C200(1.02); C196(0.98); C200(0.98)  LDD1497  [17]
 LDCM0024  KB05 HEK-293T C196(0.98); C200(0.87); C196(0.88); C200(0.88)  LDD1502  [17]
 LDCM0014  Panhematin hPBMC 3.26  LDD0064  [6]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cholic Acid Small molecular drug DB02659
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
N-formylmethionine Small molecular drug DB04464
Talmapimod Small molecular drug DB05412

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402