Details of the Target

General Information of Target

Target ID LDTP03419
Target Name Proteasome subunit beta type-5 (PSMB5)
Gene Name PSMB5
Gene ID 5693
Synonyms
LMPX; MB1; X; Proteasome subunit beta type-5; EC 3.4.25.1; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit MB1; Proteasome subunit X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase T1B family
Subcellular location
Cytoplasm
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.
TTD ID
T49031
Uniprot ID
P28074
DrugMap ID
TT68GPI
Ensemble ID
ENST00000361611.11
HGNC ID
HGNC:9542
ChEMBL ID
CHEMBL4662

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S36G DBIA    Probe Info 
HEC1 SNV: p.S248R DBIA    Probe Info 
HEC1B SNV: p.R68H; p.S248R .
MFE319 SNV: p.D226E DBIA    Probe Info 
MOLT4 SNV: p.E207K IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.85  LDD0402  [1]
A-EBA
 Probe Info  		3.45  LDD0215  [2]
CHEMBL5175495
 Probe Info  		5.45  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y220(17.23); Y224(15.44); Y149(13.89); Y171(6.24)  LDD0257  [5]
TH216
 Probe Info  		Y171(11.56)  LDD0259  [5]
STPyne
 Probe Info  		K66(1.08); K91(2.50)  LDD0277  [6]
Probe 1
 Probe Info  		Y84(142.68); Y149(203.43); Y204(7.62); Y220(34.91)  LDD3495  [7]
Cep-alkyne
 Probe Info  		6.62  LDD0284  [8]
Johansson_61
 Probe Info  		_(10.39)  LDD1485  [9]
DA-P3
 Probe Info  		5.09  LDD0183  [10]
AHL-Pu-1
 Probe Info  		C111(2.03)  LDD0168  [11]
EA-probe
 Probe Info  		C111(0.96)  LDD2210  [12]
HHS-482
 Probe Info  		Y149(0.52); Y228(0.79)  LDD0285  [13]
HHS-475
 Probe Info  		Y228(0.91); Y149(1.05)  LDD0264  [14]
HHS-465
 Probe Info  		Y204(7.43); Y228(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C161(1.24)  LDD0531  [16]
ATP probe
 Probe Info  		K91(0.00); K92(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C161(0.00); C111(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C161(0.00); C111(0.00)  LDD0036  [18]
Lodoacetamide azide
 Probe Info  		C161(0.00); C111(0.00)  LDD0037  [18]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
KY-26
 Probe Info  		N.A.  LDD0301  [20]
IPM
 Probe Info  		N.A.  LDD2156  [21]
NHS
 Probe Info  		K92(0.00); K91(0.00)  LDD0010  [22]
OSF
 Probe Info  		H237(0.00); Y228(0.00); Y149(0.00); Y236(0.00)  LDD0029  [23]
SF
 Probe Info  		K150(0.00); Y149(0.00); Y228(0.00)  LDD0028  [23]
YN-1
 Probe Info  		N.A.  LDD0447  [24]
1c-yne
 Probe Info  		N.A.  LDD0228  [25]
Acrolein
 Probe Info  		H255(0.00); H69(0.00)  LDD0217  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
AOyne
 Probe Info  		6.20  LDD0443  [27]
MPP-AC
 Probe Info  		N.A.  LDD0428  [28]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [28]
TPP-AC
 Probe Info  		N.A.  LDD0427  [28]
PAL-AfBPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C059
 Probe Info  		6.50  LDD1756  [29]
C082
 Probe Info  		6.87  LDD1774  [29]
C087
 Probe Info  		12.64  LDD1779  [29]
C091
 Probe Info  		15.89  LDD1782  [29]
C092
 Probe Info  		19.43  LDD1783  [29]
C107
 Probe Info  		6.11  LDD1794  [29]
C145
 Probe Info  		8.28  LDD1827  [29]
C147
 Probe Info  		6.73  LDD1829  [29]
C158
 Probe Info  		11.55  LDD1838  [29]
C174
 Probe Info  		5.74  LDD1854  [29]
C177
 Probe Info  		9.45  LDD1856  [29]
C187
 Probe Info  		42.22  LDD1865  [29]
C191
 Probe Info  		12.30  LDD1868  [29]
C193
 Probe Info  		5.54  LDD1869  [29]
C219
 Probe Info  		9.85  LDD1893  [29]
C252
 Probe Info  		12.82  LDD1925  [29]
C258
 Probe Info  		6.02  LDD1931  [29]
C288
 Probe Info  		6.63  LDD1958  [29]
C314
 Probe Info  		12.30  LDD1981  [29]
C320
 Probe Info  		5.28  LDD1986  [29]
C390
 Probe Info  		46.21  LDD2049  [29]
C400
 Probe Info  		7.31  LDD2059  [29]
C413
 Probe Info  		12.30  LDD2069  [29]
C414
 Probe Info  		5.28  LDD2070  [29]
C420
 Probe Info  		13.64  LDD2075  [29]
C424
 Probe Info  		15.03  LDD2079  [29]
C428
 Probe Info  		4.96  LDD2083  [29]
FFF probe12
 Probe Info  		10.20  LDD0473  [30]
FFF probe13
 Probe Info  		10.13  LDD0475  [30]
FFF probe14
 Probe Info  		12.46  LDD0477  [30]
FFF probe15
 Probe Info  		6.45  LDD0478  [30]
FFF probe2
 Probe Info  		5.47  LDD0463  [30]
FFF probe3
 Probe Info  		19.28  LDD0464  [30]
FFF probe4
 Probe Info  		14.44  LDD0466  [30]
FFF probe6
 Probe Info  		15.33  LDD0467  [30]
FFF probe7
 Probe Info  		5.04  LDD0483  [30]
JN0003
 Probe Info  		17.83  LDD0469  [30]
Kambe_22
 Probe Info  		3.23  LDD0125  [31]
Diazir
 Probe Info  		N.A.  LDD0011  [22]
DA-2
 Probe Info  		N.A.  LDD0072  [32]
OEA-DA
 Probe Info  		13.38  LDD0046  [33]
STS-1
 Probe Info  		N.A.  LDD0069  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C111(2.03)  LDD0168  [11]
 LDCM0214  AC1 HCT 116 C161(1.24)  LDD0531  [16]
 LDCM0215  AC10 HEK-293T C111(1.11); C161(1.09)  LDD0813  [16]
 LDCM0216  AC100 PaTu 8988t C111(0.90)  LDD1095  [16]
 LDCM0217  AC101 PaTu 8988t C111(1.08)  LDD1096  [16]
 LDCM0218  AC102 PaTu 8988t C111(0.62)  LDD1097  [16]
 LDCM0219  AC103 PaTu 8988t C111(1.01)  LDD1098  [16]
 LDCM0220  AC104 PaTu 8988t C111(0.93)  LDD1099  [16]
 LDCM0221  AC105 PaTu 8988t C111(0.62)  LDD1100  [16]
 LDCM0222  AC106 PaTu 8988t C111(0.78)  LDD1101  [16]
 LDCM0223  AC107 PaTu 8988t C111(0.58)  LDD1102  [16]
 LDCM0224  AC108 PaTu 8988t C111(0.87)  LDD1103  [16]
 LDCM0225  AC109 PaTu 8988t C111(0.75)  LDD1104  [16]
 LDCM0226  AC11 HEK-293T C111(1.05); C161(0.96)  LDD0824  [16]
 LDCM0227  AC110 PaTu 8988t C111(0.95)  LDD1106  [16]
 LDCM0228  AC111 PaTu 8988t C111(0.66)  LDD1107  [16]
 LDCM0229  AC112 PaTu 8988t C111(1.17)  LDD1108  [16]
 LDCM0230  AC113 HCT 116 C111(1.06); C161(1.15)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C111(0.93); C161(0.94)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C111(0.85); C161(0.97)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C111(0.82); C161(0.95)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C111(1.01); C161(0.85)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C111(0.77); C161(0.93)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C111(0.63); C161(0.95)  LDD0553  [16]
 LDCM0237  AC12 HEK-293T C111(1.00); C161(1.17)  LDD0835  [16]
 LDCM0238  AC120 HCT 116 C111(1.16); C161(0.92)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C111(0.84); C161(0.86)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C111(0.72); C161(1.00)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C111(0.95); C161(0.87)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C111(0.81); C161(0.93)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C111(0.71); C161(1.04)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C111(0.54); C161(1.08)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C111(0.51); C161(0.96)  LDD0562  [16]
 LDCM0246  AC128 PaTu 8988t C111(0.86)  LDD1125  [16]
 LDCM0247  AC129 PaTu 8988t C111(0.76)  LDD1126  [16]
 LDCM0249  AC130 PaTu 8988t C111(0.69)  LDD1128  [16]
 LDCM0250  AC131 PaTu 8988t C111(1.39)  LDD1129  [16]
 LDCM0251  AC132 PaTu 8988t C111(1.90)  LDD1130  [16]
 LDCM0252  AC133 PaTu 8988t C111(0.88)  LDD1131  [16]
 LDCM0253  AC134 PaTu 8988t C111(0.97)  LDD1132  [16]
 LDCM0254  AC135 PaTu 8988t C111(0.63)  LDD1133  [16]
 LDCM0255  AC136 PaTu 8988t C111(0.64)  LDD1134  [16]
 LDCM0256  AC137 PaTu 8988t C111(0.57)  LDD1135  [16]
 LDCM0257  AC138 PaTu 8988t C111(0.82)  LDD1136  [16]
 LDCM0258  AC139 PaTu 8988t C111(0.51)  LDD1137  [16]
 LDCM0259  AC14 HEK-293T C111(1.24); C161(0.80)  LDD0857  [16]
 LDCM0260  AC140 PaTu 8988t C111(0.75)  LDD1139  [16]
 LDCM0261  AC141 PaTu 8988t C111(1.18)  LDD1140  [16]
 LDCM0262  AC142 PaTu 8988t C111(0.65)  LDD1141  [16]
 LDCM0263  AC143 HCT 116 C111(1.18)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C111(1.02)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C111(1.53)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C111(1.00)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C111(1.00)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C111(0.97)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C111(1.36)  LDD0586  [16]
 LDCM0270  AC15 HEK-293T C111(1.37); C161(0.88)  LDD0868  [16]
 LDCM0271  AC150 HCT 116 C111(1.47)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C111(1.21)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C111(1.21)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C111(0.84)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C111(1.13)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C111(1.10)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C111(1.30)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C111(1.16)  LDD2161  [16]
 LDCM0276  AC17 PaTu 8988t C111(0.46)  LDD1155  [16]
 LDCM0277  AC18 PaTu 8988t C111(0.55)  LDD1156  [16]
 LDCM0278  AC19 PaTu 8988t C111(0.71)  LDD1157  [16]
 LDCM0279  AC2 HCT 116 C161(1.13)  LDD0596  [16]
 LDCM0280  AC20 PaTu 8988t C111(0.87)  LDD1159  [16]
 LDCM0281  AC21 PaTu 8988t C111(0.72)  LDD1160  [16]
 LDCM0282  AC22 PaTu 8988t C111(0.94)  LDD1161  [16]
 LDCM0283  AC23 PaTu 8988t C111(0.97)  LDD1162  [16]
 LDCM0284  AC24 PaTu 8988t C111(0.84)  LDD1163  [16]
 LDCM0285  AC25 HCT 116 C161(1.19)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C161(0.91)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C161(0.92)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C161(1.01)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C161(0.86)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C161(1.25)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C161(0.84)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C161(0.84)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C161(0.84)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C161(0.90)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C161(0.91)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C161(1.57)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C161(1.74)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C161(1.31)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C161(1.47)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C161(1.09)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C161(1.26)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C161(0.71)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C161(1.13)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C161(1.00)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C161(1.15)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C161(0.99)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C161(0.76)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C161(1.05)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C161(1.00)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C161(1.01)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C161(0.59)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C161(1.32)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C161(0.64)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C161(0.99)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C161(1.21)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C161(0.81)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C161(0.80)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C161(0.61)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C161(0.59)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C161(0.77)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C161(0.77)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C161(0.65)  LDD0639  [16]
 LDCM0323  AC6 HEK-293T C111(1.00); C161(0.74)  LDD0921  [16]
 LDCM0324  AC60 HCT 116 C161(0.80)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C161(1.02)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C161(0.56)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C161(0.83)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C161(0.65)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C161(0.87)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C161(1.02)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C161(0.46)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C161(0.80); C111(0.82)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C161(0.77); C111(0.83)  LDD0650  [16]
 LDCM0334  AC7 HEK-293T C111(0.98); C161(0.41)  LDD0932  [16]
 LDCM0335  AC70 HCT 116 C111(0.64); C161(0.64)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C161(0.88); C111(0.94)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C111(0.85); C161(0.88)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C111(0.57); C161(0.69)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C161(0.72); C111(0.72)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C111(0.58); C161(0.74)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C161(0.70); C111(0.80)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C111(0.64); C161(0.74)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C111(0.70); C161(0.83)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C111(0.83); C161(0.86)  LDD0661  [16]
 LDCM0345  AC8 HEK-293T C111(1.51); C161(0.53)  LDD0943  [16]
 LDCM0346  AC80 HCT 116 C161(0.80); C111(0.93)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C111(0.80); C161(0.86)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C161(0.55); C111(0.66)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C161(0.51)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C161(0.58)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C161(0.74)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C161(0.82)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C161(0.82)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C161(0.77)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C161(0.70)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C161(1.01)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C161(0.47)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C161(0.54)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C161(0.71)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C161(0.83)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C161(0.74)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C161(0.67)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C161(0.57)  LDD0681  [16]
 LDCM0365  AC98 PaTu 8988t C111(0.83)  LDD1244  [16]
 LDCM0366  AC99 PaTu 8988t C111(0.80)  LDD1245  [16]
 LDCM0248  AKOS034007472 HEK-293T C111(1.11); C161(1.04)  LDD0846  [16]
 LDCM0356  AKOS034007680 HEK-293T C111(1.27); C161(0.67)  LDD0954  [16]
 LDCM0275  AKOS034007705 HEK-293T C111(1.38); C161(0.68)  LDD0873  [16]
 LDCM0156  Aniline NCI-H1299 11.35  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C161(0.97)  LDD2171  [16]
 LDCM0630  CCW28-3 231MFP C111(1.18)  LDD2214  [35]
 LDCM0122  Cepafungin 1 RPMI-8226 6.62  LDD0284  [8]
 LDCM0108  Chloroacetamide HeLa H255(0.00); H69(0.00)  LDD0222  [26]
 LDCM0367  CL1 HCT 116 C161(0.59); C111(0.78)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C161(0.54); C111(0.78)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C161(1.12)  LDD0686  [16]
 LDCM0370  CL101 HEK-293T C111(1.24); C161(0.64)  LDD0968  [16]
 LDCM0371  CL102 HEK-293T C111(1.30); C161(0.55)  LDD0969  [16]
 LDCM0372  CL103 HEK-293T C111(1.32); C161(0.51)  LDD0970  [16]
 LDCM0373  CL104 HEK-293T C111(1.31); C161(0.74)  LDD0971  [16]
 LDCM0374  CL105 PaTu 8988t C111(0.58)  LDD1253  [16]
 LDCM0375  CL106 PaTu 8988t C111(1.13)  LDD1254  [16]
 LDCM0376  CL107 PaTu 8988t C111(0.98)  LDD1255  [16]
 LDCM0377  CL108 PaTu 8988t C111(0.61)  LDD1256  [16]
 LDCM0378  CL109 PaTu 8988t C111(0.94)  LDD1257  [16]
 LDCM0379  CL11 HCT 116 C161(0.34); C111(0.66)  LDD0696  [16]
 LDCM0380  CL110 PaTu 8988t C111(0.46)  LDD1259  [16]
 LDCM0381  CL111 PaTu 8988t C111(0.97)  LDD1260  [16]
 LDCM0382  CL112 HCT 116 C161(1.00)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C161(0.79)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C161(0.64)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C161(0.81)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C161(0.91)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C161(0.51)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C161(1.04)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C161(0.73)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C161(0.35); C111(0.89)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C161(1.13)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C161(0.76)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C161(0.99)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C161(0.73)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C161(0.64)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C161(1.02)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C161(0.95)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C161(0.96)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C161(0.73)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C161(0.56); C111(0.93)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C161(0.53); C111(0.75)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C161(0.31); C111(0.81)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C161(1.01)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C161(0.90)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C161(0.91)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C161(0.94)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C161(0.58); C111(0.97)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C161(0.65)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C161(0.52)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C161(0.41)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C161(0.75)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C161(0.48)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C161(0.51)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C161(0.75)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C161(0.82)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C161(0.69)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C161(0.72)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C111(0.78); C161(0.48)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C161(0.92)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C161(0.91)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C161(0.89)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C161(0.74)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C161(0.50)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C161(0.45)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C161(0.55)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C161(0.42)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C161(0.50)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C111(0.75); C161(0.98)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C161(0.56)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C161(0.62)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C161(0.34)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C161(0.39)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C161(0.57)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C161(0.56)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C111(0.41); C161(1.27)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C111(0.63); C161(1.23)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C111(0.96); C161(1.44)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C111(0.65); C161(1.07)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C111(0.82); C161(0.80)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C111(0.64); C161(1.21)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C111(0.63); C161(1.32)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C111(0.59); C161(1.29)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C111(0.64); C161(1.18)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C111(0.43); C161(1.40)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C111(0.58); C161(1.35)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C111(0.63); C161(1.12)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C111(0.67); C161(1.18)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C111(0.68); C161(1.41)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C111(0.80); C161(1.11)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C111(0.75); C161(0.61)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C111(0.85); C161(1.17)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C111(0.80); C161(0.98)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C111(0.66); C161(0.99)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C111(0.68); C161(0.85)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C111(0.78); C161(0.64)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C111(0.81); C161(0.95)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C111(0.71); C161(0.51)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C111(0.94); C161(0.68)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C111(0.98); C161(0.77)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C111(0.88); C161(0.94)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C111(0.78); C161(0.63)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C111(0.90); C161(0.96)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C111(0.87); C161(0.78)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C111(0.87); C161(1.08)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C111(0.79); C161(0.77)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C111(0.95); C161(0.79)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C161(0.93)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C161(0.79)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C161(0.85)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C161(0.65)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C111(0.85); C161(0.32)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C161(0.97)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C161(0.77)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C161(0.49)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C161(0.58)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C161(0.46)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C161(0.86)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C161(1.02)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C161(0.87)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C161(0.59)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C161(0.49)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C111(0.81); C161(0.45)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C161(1.06)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C161(0.84)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C161(0.91)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C161(1.01)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C161(0.97)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C161(0.89)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C161(1.06)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C161(1.06)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C161(1.11)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C161(1.16)  LDD0811  [16]
 LDCM0189  Compound 16 HEK-293T 13.33  LDD0492  [30]
 LDCM0185  Compound 17 HEK-293T 4.16  LDD0512  [30]
 LDCM0182  Compound 18 HEK-293T 9.52  LDD0501  [30]
 LDCM0191  Compound 21 HEK-293T 10.53  LDD0493  [30]
 LDCM0190  Compound 34 HEK-293T 16.39  LDD0497  [30]
 LDCM0192  Compound 35 HEK-293T 8.00  LDD0491  [30]
 LDCM0193  Compound 36 HEK-293T 5.49  LDD0494  [30]
 LDCM0194  Compound 37 HEK-293T 11.70  LDD0498  [30]
 LDCM0195  Compound 38 HEK-293T 6.73  LDD0499  [30]
 LDCM0196  Compound 39 HEK-293T 12.74  LDD0496  [30]
 LDCM0197  Compound 40 HEK-293T 10.47  LDD0495  [30]
 LDCM0181  Compound 41 HEK-293T 10.20  LDD0502  [30]
 LDCM0183  Compound 42 HEK-293T 4.85  LDD0500  [30]
 LDCM0495  E2913 HEK-293T C111(0.97)  LDD1698  [36]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.09  LDD0183  [10]
 LDCM0175  Ethacrynic acid HeLa C111(0.96)  LDD2210  [12]
 LDCM0625  F8 Ramos C111(0.53)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C111(0.24)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C111(2.48)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C111(0.12)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C111(0.44)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C111(1.47)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C111(0.14)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C111(0.32)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C111(0.40)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C111(0.26)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C111(0.18)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C111(0.28)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C111(0.37)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C111(0.16)  LDD2201  [37]
 LDCM0468  Fragment33 HCT 116 C111(0.87); C161(0.77)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos C111(0.17)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C111(0.57)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C161(0.32)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C111(0.30)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C111(0.25)  LDD2205  [37]
 LDCM0569  Fragment7 Jurkat _(10.39)  LDD1485  [9]
 LDCM0571  Fragment9 Ramos C111(0.33)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y228(0.91); Y149(1.05)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y228(0.84); Y149(1.16)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y228(0.94); Y149(1.22)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y228(0.95); Y149(1.68)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y228(1.21); Y149(2.91)  LDD0268  [14]
 LDCM0107  IAA HeLa H255(0.00); H69(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y149(0.52); Y228(0.79)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y149(0.52); Y228(0.57)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y149(1.48); Y228(0.98)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y149(1.92); Y228(2.50)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y149(3.54); Y228(1.60)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y149(1.08); Y228(0.90)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y149(0.64); Y228(0.34)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y149(0.98); Y228(0.85)  LDD0292  [13]
 LDCM0073  Kambe_cp3 PC-3 3.23  LDD0125  [31]
 LDCM0022  KB02 HEK-293T C111(1.10)  LDD1492  [36]
 LDCM0023  KB03 HEK-293T C111(1.07)  LDD1497  [36]
 LDCM0024  KB05 COLO792 C111(1.19)  LDD3310  [38]
 LDCM0109  NEM HeLa H255(0.00); H69(0.00)  LDD0223  [26]
 LDCM0131  RA190 MM1.R C111(1.20)  LDD0304  [39]
 LDCM0021  THZ1 HCT 116 C161(0.97)  LDD2173  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1) Clp1 family Q92989
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Proteasome subunit beta type-3 (PSMB3) Peptidase T1B family P49720
Proteasome subunit beta type-7 (PSMB7) Peptidase T1B family Q99436
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome maturation protein (POMP) POMP/UMP1 family Q9Y244
U6 snRNA-associated Sm-like protein LSm1 (LSM1) SnRNP Sm proteins family O15116
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
BAG family molecular chaperone regulator 4 (BAG4) . O95429
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bortezomib Small molecular drug DB00188
Carfilzomib Small molecular drug DB08889
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid24946214c3b Small molecular drug D0Y6HD
(3ar6r6as)-6-((S)-((S)-cyclohex-2-enyl)(Hydroxy)Methyl)-6a-methyl-4-oxo-hexahydro-2h-furo[32-c]Pyrrole-6-carbaldehyde . DB08515
Patented
Click To Hide/Show 26 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Peptide Analog 11 Small molecular drug D0E6ED
Peptide Analog 13 Small molecular drug D0AR6B
Peptide Analog 17 Small molecular drug D0L1TT
Peptide Analog 19 Small molecular drug D0Q0XN
Peptide Analog 21 Small molecular drug D02PJI
Peptide Analog 23 Small molecular drug D0T1YB
Peptide Analog 25 Small molecular drug D0DK3R
Peptide Analog 27 Small molecular drug D02SYR
Peptide Analog 28 Small molecular drug D03JMZ
Peptide Analog 31 Small molecular drug D07SSU
Peptide Analog 33 Small molecular drug D06OXO
Peptide Analog 34 Small molecular drug D05MVF
Peptide Analog 36 Small molecular drug D0DY3A
Peptide Analog 37 Small molecular drug D00GGB
Peptide Analog 38 Small molecular drug D01GON
Peptide Analog 39 Small molecular drug D02CQG
Peptide Analog 41 Small molecular drug D01OOO
Pmid29865878-compound-43 Small molecular drug D09WUW
Pmid29865878-compound-44 Small molecular drug D08HPR
Pmid29865878-compound-46 Small molecular drug D0C2MH
Pmid29865878-compound-48 Small molecular drug D0K0GJ
Pmid29865878-compound-49 Small molecular drug D0TU5R
Pmid29865878-compound-51 Small molecular drug D0NE8M
Pmid29865878-compound-53 Small molecular drug D01VMN
Pmid29865878-compound-55 Small molecular drug D03CMD
Pmid29865878-compound-8 Small molecular drug D0P8VL

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I. Cell Chem Biol. 2020 Oct 15;27(10):1318-1326.e18. doi: 10.1016/j.chembiol.2020.07.012. Epub 2020 Aug 6.
9 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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