Details of the Target

General Information of Target

Target ID LDTP10432
Target Name ATP synthase membrane subunit K, mitochondrial (ATP5MK)
Gene Name ATP5MK
Gene ID 84833
Synonyms
ATP5MD; DAPIT; HCVFTP2; USMG5; ATP synthase membrane subunit K, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; Diabetes-associated protein in insulin-sensitive tissues; HCV F-transactivated protein 2; Up-regulated during skeletal muscle growth protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMILSASVIRVRDGLPLSASTDYEQSTGMQECRKYFKMLSRKLAQLPDRCTLKTGHYNI
NFISSLGVSYMMLCTENYPNVLAFSFLDELQKEFITTYNMMKTNTAVRPYCFIEFDNFIQ
RTKQRYNNPRSLSTKINLSDMQTEIKLRPPYQISMCELGSANGVTSAFSVDCKGAGKISS
AHQRLEPATLSGIVGFILSLLCGALNLIRGFHAIESLLQSDGDDFNYIIAFFLGTAACLY
QCYLLVYYTGWRNVKSFLTFGLICLCNMYLYELRNLWQLFFHVTVGAFVTLQIWLRQAQG
KAPDYDV
Target Bioclass
Enzyme
Subcellular location
Mitochondrion membrane
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. ATP5MK is a minor subunit of the mitochondrial membrane ATP synthase required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria.
Uniprot ID
Q96IX5
Ensemble ID
ENST00000309579.7
HGNC ID
HGNC:30889

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.44  LDD0197  [1]
CHEMBL5175495
 Probe Info  		15.11  LDD0196  [2]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y18(11.56)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		K16(8.33)  LDD0275  [6]
Probe 1
 Probe Info  		Y18(6.21); Y22(20.46)  LDD3495  [7]
P26
 Probe Info  		2.90  LDD0409  [8]
Curcusone 37
 Probe Info  		3.79  LDD0188  [9]
Johansson_61
 Probe Info  		_(11.13)  LDD1487  [10]
Alkyne-RA190
 Probe Info  		4.39  LDD0299  [11]
IA-alkyne
 Probe Info  		C30(0.23)  LDD2207  [12]
DBIA
 Probe Info  		C30(0.87)  LDD1492  [13]
ATP probe
 Probe Info  		K16(0.00); K17(0.00)  LDD0199  [14]
NHS
 Probe Info  		N.A.  LDD0010  [15]
SF
 Probe Info  		Y22(0.00); Y10(0.00)  LDD0028  [16]
STPyne
 Probe Info  		K16(0.00); K17(0.00)  LDD0009  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		9.51  LDD1733  [18]
C040
 Probe Info  		9.71  LDD1740  [18]
C091
 Probe Info  		10.70  LDD1782  [18]
C092
 Probe Info  		20.39  LDD1783  [18]
C094
 Probe Info  		29.24  LDD1785  [18]
C206
 Probe Info  		16.68  LDD1881  [18]
C210
 Probe Info  		38.85  LDD1884  [18]
C228
 Probe Info  		16.45  LDD1901  [18]
C231
 Probe Info  		12.55  LDD1904  [18]
C235
 Probe Info  		19.56  LDD1908  [18]
C285
 Probe Info  		21.26  LDD1955  [18]
C289
 Probe Info  		28.64  LDD1959  [18]
C390
 Probe Info  		23.92  LDD2049  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C30(0.91)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C30(0.73)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C30(0.72)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C30(0.95)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C30(0.83)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C30(0.82)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C30(0.89)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C30(0.75)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C30(0.56)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C30(0.76)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C30(0.81)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C30(0.83)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C30(0.90)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C30(0.85)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C30(0.99)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C30(0.97)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C30(0.72)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C30(0.71)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C30(0.84)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C30(0.72)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C30(0.65)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C30(0.88)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C30(0.87)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C30(0.92)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C30(0.94)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C30(0.73)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C30(0.72)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C30(0.87)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C30(0.76)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C30(1.04)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C30(0.91)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C30(0.88)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C30(1.02)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C30(0.99)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C30(0.73)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C30(0.71)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C30(0.90)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C30(0.74)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C30(0.83)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C30(0.88)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C30(0.97)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C30(0.93)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C30(0.78)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C30(0.76)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C30(0.68)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C30(0.91)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C30(0.79)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C30(0.94)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C30(0.90)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C30(1.03)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C30(0.92)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C30(0.89)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C30(0.89)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C30(0.95)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C30(0.94)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C30(0.99)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C30(0.95)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C30(0.93)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C30(0.95)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C30(0.99)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C30(1.08)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C30(0.91)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C30(0.92)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C30(1.09)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C30(0.96)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C30(1.71)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C30(0.89)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C30(1.01)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C30(0.98)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C30(0.92)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C30(0.91)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C30(0.95)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C30(0.88)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C30(0.92)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C30(0.83)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C30(0.98)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C30(1.27)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C30(0.97)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C30(0.90)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C30(0.72)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C30(0.99)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C30(0.98)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C30(0.83)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C30(0.80)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C30(1.03)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C30(0.92)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C30(0.94)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C30(1.36)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C30(0.91)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C30(1.01)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C30(1.25)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C30(1.84)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C30(0.97)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C30(0.70)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C30(1.06)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C30(0.86)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C30(0.88)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C30(1.05)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C30(0.99)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C30(1.41)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C30(0.92)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C30(1.33)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C30(0.91)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C30(0.85)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C30(0.94)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C30(1.20)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C30(1.28)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C30(1.39)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C30(1.11)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C30(1.59)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C30(1.41)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C30(0.85)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C30(0.88)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C30(0.87)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C30(0.87)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C30(1.14)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C30(0.82)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C30(0.80)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C30(1.08)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C30(2.33)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C30(1.35)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C30(1.27)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C30(1.60)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C30(1.04)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C30(0.93)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C30(1.01)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C30(0.88)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C30(0.98)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C30(0.79)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C30(0.86)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C30(1.07)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C30(1.12)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C30(1.40)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C30(1.21)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C30(2.42)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C30(1.08)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C30(0.86)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C30(0.94)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C30(0.93)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C30(1.20)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C30(1.81)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C30(0.91)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C30(1.15)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C30(0.93)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C30(1.37)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C30(1.49)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C30(0.84)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C30(1.92)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C30(0.81)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C30(0.89)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C30(0.85)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C30(0.95)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C30(0.89)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C30(0.86)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C30(0.74)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C30(1.25)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C30(1.29)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C30(0.86)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C30(1.28)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C30(1.15)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C30(1.27)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C30(1.05)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C30(0.88)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C30(0.88)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C30(1.22)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C30(0.81)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C30(0.72)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C30(2.00)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C30(1.13)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C30(1.13)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C30(1.43)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C30(1.73)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C30(1.74)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C30(0.66)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C30(0.84)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C30(0.93)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C30(0.78)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C30(0.77)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C30(1.29)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C30(1.40)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C30(0.69)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C30(1.18)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C30(1.11)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C30(1.15)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C30(1.33)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C30(1.12)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C30(1.11)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C30(0.99)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C30(1.00)  LDD1697  [13]
 LDCM0033  Curcusone1d MCF-7 3.79  LDD0188  [9]
 LDCM0495  E2913 HEK-293T C30(0.95)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C30(1.03)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C30(0.87)  LDD1631  [13]
 LDCM0615  Fragment63-R Jurkat _(11.13)  LDD1487  [10]
 LDCM0022  KB02 HEK-293T C30(0.87)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C30(0.81)  LDD1497  [13]
 LDCM0024  KB05 HEK-293T C30(0.76)  LDD1502  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C30(0.23)  LDD2207  [12]
 LDCM0159  P28 BxPC-3 2.90  LDD0409  [8]
 LDCM0131  RA190 MM1.R 4.39  LDD0299  [11]

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587