Details of the Target

General Information of Target

Target ID LDTP03998
Target Name 3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)
Gene Name ACAA2
Gene ID 10449
Synonyms
3-ketoacyl-CoA thiolase, mitochondrial; EC 2.3.1.16; Acetyl-CoA acetyltransferase; EC 2.3.1.9; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVL
QSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTE
SMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECD
KYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFK
KDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAI
SGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSR
ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Thiolase-like superfamily, Thiolase family
Subcellular location
Mitochondrion
Function
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
TTD ID
T63218
Uniprot ID
P42765
DrugMap ID
TTM3F49
Ensemble ID
ENST00000285093.15
HGNC ID
HGNC:83

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.59  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
W1
 Probe Info  		51.61  LDD0235  [3]
TH211
 Probe Info  		Y20(11.83); Y182(10.12)  LDD0257  [4]
TH214
 Probe Info  		Y182(20.00)  LDD0258  [4]
TH216
 Probe Info  		Y182(20.00); Y20(12.82)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K137(6.49); K181(7.14); K209(10.00); K240(4.59)  LDD0277  [6]
Probe 1
 Probe Info  		Y20(10.45); Y182(323.20); Y198(46.05); Y327(6.32)  LDD3495  [7]
P26
 Probe Info  		1.61  LDD0409  [8]
BTD
 Probe Info  		C179(2.84)  LDD1700  [9]
DBIA
 Probe Info  		C103(0.87); C107(0.87); C92(0.87)  LDD0078  [10]
5E-2FA
 Probe Info  		H271(0.00); H222(0.00); H352(0.00)  LDD2235  [11]
AMP probe
 Probe Info  		N.A.  LDD0200  [12]
ATP probe
 Probe Info  		K137(0.00); K81(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C179(0.00); C287(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C179(0.00); C287(0.00)  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C179(0.00); C287(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K305(0.00); K137(0.00)  LDD0035  [15]
IPM
 Probe Info  		C287(0.00); C179(0.00); C92(0.00)  LDD0025  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		C179(0.00); C287(0.00)  LDD2226  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
NHS
 Probe Info  		N.A.  LDD0010  [18]
TFBX
 Probe Info  		C179(0.00); C287(0.00)  LDD0148  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		K191(0.00); K241(0.00); K269(0.00); K38(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H364(0.00); C179(0.00); C107(0.00); C287(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C179(0.00); H352(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
NAIA_5
 Probe Info  		C179(0.00); C287(0.00)  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [23]
DA-2
 Probe Info  		N.A.  LDD0072  [24]
STS-1
 Probe Info  		N.A.  LDD0068  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C179(1.01)  LDD2117  [9]
 LDCM0214  AC1 HCT 116 C92(0.79)  LDD0531  [10]
 LDCM0215  AC10 HEK-293T C103(0.82); C92(0.83)  LDD0813  [10]
 LDCM0216  AC100 HEK-293T C103(1.04); C116(0.45); C128(0.53); C92(1.13)  LDD0814  [10]
 LDCM0217  AC101 HEK-293T C103(0.72); C116(0.37); C128(0.60); C92(0.97)  LDD0815  [10]
 LDCM0218  AC102 HEK-293T C103(1.10); C116(0.47); C128(0.50); C92(1.07)  LDD0816  [10]
 LDCM0219  AC103 HEK-293T C103(1.07); C116(0.47); C128(0.37); C92(0.91)  LDD0817  [10]
 LDCM0220  AC104 HEK-293T C103(0.78); C116(0.84); C128(0.74); C92(1.00)  LDD0818  [10]
 LDCM0221  AC105 HEK-293T C103(0.75); C116(0.39); C128(0.71); C92(1.09)  LDD0819  [10]
 LDCM0222  AC106 HEK-293T C103(0.96); C116(0.31); C128(0.49); C92(0.90)  LDD0820  [10]
 LDCM0223  AC107 HEK-293T C103(0.68); C116(0.37); C128(0.43); C92(0.95)  LDD0821  [10]
 LDCM0224  AC108 HEK-293T C103(0.63); C116(0.44); C128(0.54); C92(0.98)  LDD0822  [10]
 LDCM0225  AC109 HEK-293T C103(0.79); C116(0.51); C128(0.49); C92(1.01)  LDD0823  [10]
 LDCM0226  AC11 HEK-293T C103(0.81); C92(0.82)  LDD0824  [10]
 LDCM0227  AC110 HEK-293T C103(3.12); C116(0.39); C128(0.28); C92(1.12)  LDD0825  [10]
 LDCM0228  AC111 HEK-293T C103(0.75); C116(0.52); C128(0.38); C92(1.00)  LDD0826  [10]
 LDCM0229  AC112 HEK-293T C103(2.00); C116(0.58); C128(0.39); C92(1.01)  LDD0827  [10]
 LDCM0230  AC113 HCT 116 C92(1.07)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C92(1.22)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C92(1.22)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C92(1.19)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C92(1.24)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C92(1.19)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C92(1.15)  LDD0553  [10]
 LDCM0237  AC12 HEK-293T C103(0.74); C92(0.77)  LDD0835  [10]
 LDCM0238  AC120 HCT 116 C92(1.20)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C92(1.05)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C92(1.06)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C92(1.15)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C92(1.18)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C92(1.17)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C92(1.18)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C92(1.27)  LDD0562  [10]
 LDCM0246  AC128 HEK-293T C103(0.94); C107(2.82); C116(1.27); C128(1.27)  LDD0844  [10]
 LDCM0247  AC129 HEK-293T C103(1.03); C107(0.77); C116(1.60); C128(1.60)  LDD0845  [10]
 LDCM0249  AC130 HEK-293T C103(0.93); C107(1.09); C116(2.03); C128(2.03)  LDD0847  [10]
 LDCM0250  AC131 HEK-293T C103(1.03); C107(1.55); C116(1.40); C128(1.40)  LDD0848  [10]
 LDCM0251  AC132 HEK-293T C103(1.04); C107(1.24); C116(1.54); C128(1.54)  LDD0849  [10]
 LDCM0252  AC133 HEK-293T C103(1.06); C107(0.25); C116(1.31); C128(1.31)  LDD0850  [10]
 LDCM0253  AC134 HEK-293T C103(1.07); C107(0.45); C116(1.65); C128(1.65)  LDD0851  [10]
 LDCM0254  AC135 HEK-293T C103(1.06); C107(0.87); C116(1.06); C128(1.06)  LDD0852  [10]
 LDCM0255  AC136 HEK-293T C103(1.25); C107(0.75); C116(0.77); C128(0.77)  LDD0853  [10]
 LDCM0256  AC137 HEK-293T C103(1.35); C107(0.13); C116(1.19); C128(1.19)  LDD0854  [10]
 LDCM0257  AC138 HEK-293T C103(2.52); C107(0.15); C116(1.90); C128(1.90)  LDD0855  [10]
 LDCM0258  AC139 HEK-293T C103(1.28); C107(0.16); C116(1.64); C128(1.64)  LDD0856  [10]
 LDCM0259  AC14 HEK-293T C103(0.88); C92(0.92)  LDD0857  [10]
 LDCM0260  AC140 HEK-293T C103(1.13); C107(0.27); C116(1.30); C128(1.30)  LDD0858  [10]
 LDCM0261  AC141 HEK-293T C103(1.29); C107(0.14); C116(0.88); C128(0.88)  LDD0859  [10]
 LDCM0262  AC142 HEK-293T C103(1.24); C107(0.32); C116(1.30); C128(1.30)  LDD0860  [10]
 LDCM0263  AC143 HEK-293T C103(1.04); C107(1.44); C128(1.00); C92(0.89)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C103(1.69); C107(0.67); C128(0.15); C92(1.04)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C103(1.67); C107(1.35); C128(0.15); C92(1.29)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C103(1.65); C107(1.18); C128(0.16); C92(1.35)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C103(2.17); C107(1.12); C128(0.17); C92(1.27)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C103(1.54); C107(1.04); C128(0.17); C92(1.76)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C103(0.94); C107(1.19); C128(1.34); C92(0.91)  LDD0867  [10]
 LDCM0270  AC15 HEK-293T C103(0.79); C92(1.02)  LDD0868  [10]
 LDCM0271  AC150 HEK-293T C103(1.23); C107(1.00); C128(0.40); C92(1.13)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C103(1.29); C107(1.23); C128(0.25); C92(1.38)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C103(1.12); C107(0.86); C128(0.65); C92(0.89)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C103(1.22); C107(0.57); C128(0.26); C92(0.83)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C103(1.18); C107(1.20); C128(0.99); C92(1.02)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C103(1.05); C107(0.78); C128(0.77); C92(1.02)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C103(1.96); C107(0.68); C128(0.16); C92(1.15)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C103(2.78); C107(0.48); C128(0.18); C92(0.96)  LDD2165  [10]
 LDCM0276  AC17 HCT 116 C92(0.84)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C92(0.92)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C92(0.92)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C92(0.79)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C92(0.91)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C92(0.80)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C92(1.03)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C92(0.96)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C92(1.13)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C92(0.98)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C92(1.16)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C92(1.15)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C92(1.10)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C92(1.43)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C92(0.66)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C92(1.59)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C92(1.24)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C92(1.36)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C92(1.20)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C92(1.23)  LDD0612  [10]
 LDCM0296  AC35 HEK-293T C116(1.38); C128(1.38); C92(0.99)  LDD0894  [10]
 LDCM0297  AC36 HEK-293T C116(1.01); C128(1.01); C92(0.90)  LDD0895  [10]
 LDCM0298  AC37 HEK-293T C116(1.72); C128(1.72); C92(1.92)  LDD0896  [10]
 LDCM0299  AC38 HEK-293T C116(1.19); C128(1.19); C92(0.92)  LDD0897  [10]
 LDCM0300  AC39 HEK-293T C116(1.43); C128(1.43); C92(0.93)  LDD0898  [10]
 LDCM0301  AC4 HCT 116 C92(0.69)  LDD0618  [10]
 LDCM0302  AC40 HEK-293T C116(1.08); C128(1.08); C92(0.89)  LDD0900  [10]
 LDCM0303  AC41 HEK-293T C116(1.20); C128(1.20); C92(0.87)  LDD0901  [10]
 LDCM0304  AC42 HEK-293T C116(1.39); C128(1.39); C92(1.08)  LDD0902  [10]
 LDCM0305  AC43 HEK-293T C116(1.64); C128(1.64); C92(0.96)  LDD0903  [10]
 LDCM0306  AC44 HEK-293T C116(1.18); C128(1.18); C92(0.88)  LDD0904  [10]
 LDCM0307  AC45 HEK-293T C116(1.43); C128(1.43); C92(0.95)  LDD0905  [10]
 LDCM0308  AC46 HEK-293T C103(1.16); C116(1.05); C128(0.90); C92(1.37)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C103(1.11); C116(1.30); C128(1.09); C92(1.18)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C103(1.12); C116(1.42); C128(1.20); C92(1.29)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C103(1.38); C116(0.85); C128(0.92); C92(1.44)  LDD0909  [10]
 LDCM0312  AC5 HCT 116 C92(0.74)  LDD0629  [10]
 LDCM0313  AC50 HEK-293T C103(1.18); C116(1.01); C128(0.95); C92(1.30)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C103(1.26); C116(1.15); C128(0.99); C92(1.78)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C103(1.26); C116(1.23); C128(1.05); C92(1.86)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C103(1.24); C116(1.65); C128(1.22); C92(1.43)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C103(1.62); C116(1.29); C128(1.08); C92(1.44)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C103(1.47); C116(1.48); C128(1.18); C92(1.53)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C103(1.32); C116(0.96); C128(0.90); C92(1.17)  LDD0917  [10]
 LDCM0320  AC57 HCT 116 C92(0.71)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C92(0.98)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C92(0.74)  LDD0639  [10]
 LDCM0323  AC6 HEK-293T C103(0.99); C92(1.08)  LDD0921  [10]
 LDCM0324  AC60 HCT 116 C92(0.89)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C92(0.77)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C92(0.61)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C92(0.63)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C92(0.56)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C92(0.66)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C92(0.79)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C92(0.71)  LDD0648  [10]
 LDCM0332  AC68 HEK-293T C103(0.84); C92(0.95)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C103(0.95); C92(1.00)  LDD0931  [10]
 LDCM0334  AC7 HEK-293T C103(0.90); C92(1.07)  LDD0932  [10]
 LDCM0335  AC70 HEK-293T C103(0.95); C92(1.15)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C103(1.02); C92(1.08)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C103(1.08); C92(1.10)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C103(0.81); C92(0.96)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C103(0.78); C92(0.89)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C103(1.03); C92(1.20)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C103(0.79); C92(0.77)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C103(1.01); C92(1.10)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C103(0.89); C92(0.99)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C103(0.75); C92(0.84)  LDD0942  [10]
 LDCM0345  AC8 HEK-293T C103(0.98); C92(1.19)  LDD0943  [10]
 LDCM0346  AC80 HEK-293T C103(1.03); C92(0.99)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C103(0.91); C92(1.03)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C103(0.99); C92(1.24)  LDD0946  [10]
 LDCM0349  AC83 HCT 116 C92(1.87)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C92(1.49)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C92(2.74)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C92(1.24)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C92(1.21)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C92(2.61)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C92(1.72)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C92(1.52)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C92(2.99)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C92(1.89)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C92(1.32)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C92(2.24)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C92(1.96)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C92(1.38)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C92(2.24)  LDD0681  [10]
 LDCM0365  AC98 HEK-293T C103(0.81); C116(0.50); C128(0.68); C92(0.99)  LDD0963  [10]
 LDCM0366  AC99 HEK-293T C103(1.01); C116(0.62); C128(0.61); C92(0.83)  LDD0964  [10]
 LDCM0248  AKOS034007472 HEK-293T C103(0.91); C92(1.00)  LDD0846  [10]
 LDCM0356  AKOS034007680 HEK-293T C103(0.75); C92(0.98)  LDD0954  [10]
 LDCM0275  AKOS034007705 HEK-293T C103(0.95); C92(1.08)  LDD0873  [10]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C103(0.87); C107(0.87); C92(0.87)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C179(0.73)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C287(0.00); C179(0.00); H364(0.00); H367(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C179(3.40); C179(1.51); C287(0.76)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C103(0.65); C107(0.83); C116(1.12); C92(1.62)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C103(2.83); C107(0.13); C116(0.34); C92(2.78)  LDD0966  [10]
 LDCM0369  CL100 HCT 116 C92(0.69)  LDD0686  [10]
 LDCM0370  CL101 HEK-293T C103(1.14); C92(1.40)  LDD0968  [10]
 LDCM0371  CL102 HEK-293T C103(1.78); C92(1.37)  LDD0969  [10]
 LDCM0372  CL103 HEK-293T C103(0.98); C92(1.09)  LDD0970  [10]
 LDCM0373  CL104 HEK-293T C103(1.47); C92(1.07)  LDD0971  [10]
 LDCM0374  CL105 HCT 116 C92(0.92)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C92(0.69)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C92(0.77)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C92(0.66)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C92(1.12)  LDD0695  [10]
 LDCM0379  CL11 HEK-293T C103(1.98); C107(0.10); C116(0.28); C92(3.21)  LDD0977  [10]
 LDCM0380  CL110 HCT 116 C92(1.09)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C92(0.77)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C92(1.18)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C92(1.27)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C92(1.59)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C92(1.32)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C92(1.11)  LDD0703  [10]
 LDCM0387  CL117 HEK-293T C116(0.96); C128(0.96); C92(0.86)  LDD0985  [10]
 LDCM0388  CL118 HEK-293T C116(0.83); C128(0.83); C92(0.96)  LDD0986  [10]
 LDCM0389  CL119 HEK-293T C116(1.62); C128(1.62); C92(0.91)  LDD0987  [10]
 LDCM0390  CL12 HEK-293T C103(0.79); C107(1.38); C116(1.33); C92(1.67)  LDD0988  [10]
 LDCM0391  CL120 HEK-293T C116(0.86); C128(0.86); C92(0.82)  LDD0989  [10]
 LDCM0392  CL121 HEK-293T C103(1.45); C116(1.74); C128(1.26); C92(1.64)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C103(1.15); C116(0.75); C128(0.71); C92(1.41)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C103(1.03); C116(1.73); C128(1.16); C92(1.17)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C103(1.42); C116(1.20); C128(0.94); C92(1.45)  LDD0993  [10]
 LDCM0396  CL125 HCT 116 C92(0.77)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C92(1.02)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C92(0.67)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C92(0.70)  LDD0716  [10]
 LDCM0400  CL13 HEK-293T C103(0.92); C107(1.61); C116(1.02); C92(1.65)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C103(0.89); C107(1.00); C116(1.10); C92(2.21)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C103(0.86); C107(0.48); C116(0.84); C92(3.25)  LDD1000  [10]
 LDCM0403  CL16 HEK-293T C92(1.11)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C92(1.14)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C92(1.03)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C92(0.96)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C103(0.90); C107(0.81); C116(1.01); C92(1.57)  LDD1005  [10]
 LDCM0408  CL20 HEK-293T C92(1.48)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C92(1.69)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C92(1.17)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C92(0.96)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C92(1.28)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C92(1.52)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C92(0.86)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C92(1.19)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C92(1.14)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C92(1.40)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C103(0.86); C107(0.84); C116(1.04); C92(1.54)  LDD1016  [10]
 LDCM0419  CL30 HEK-293T C92(1.93)  LDD1017  [10]
 LDCM0420  CL31 HCT 116 C92(2.04)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C92(0.73)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C92(1.03)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C92(1.56)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C92(1.06)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C92(0.88)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C92(1.39)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C92(0.92)  LDD0745  [10]
 LDCM0429  CL4 HEK-293T C103(0.99); C107(0.67); C116(1.24); C92(1.75)  LDD1027  [10]
 LDCM0430  CL40 HCT 116 C92(0.77)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C92(1.10)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C92(1.12)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C92(0.96)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C92(0.84)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C92(2.50)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C92(1.16)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C92(0.94)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C92(0.94)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C92(0.90)  LDD0756  [10]
 LDCM0440  CL5 HEK-293T C103(0.88); C107(1.15); C116(1.25); C92(1.89)  LDD1038  [10]
 LDCM0441  CL50 HCT 116 C92(0.96)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C92(1.07)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C92(1.25)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C92(1.13)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C92(0.97)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C92(0.77)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C92(0.92)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C92(0.89)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C92(0.92)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C92(0.91)  LDD0767  [10]
 LDCM0451  CL6 HEK-293T C103(0.86); C107(1.23); C116(0.88); C92(1.73)  LDD1049  [10]
 LDCM0452  CL60 HCT 116 C92(1.11)  LDD0769  [10]
 LDCM0453  CL61 HEK-293T C103(0.92); C107(1.23); C116(1.03); C128(0.94)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C103(1.00); C107(0.90); C116(1.14); C128(0.91)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C103(1.05); C107(0.85); C116(0.94); C128(0.88)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C103(1.26); C107(0.68); C116(1.44); C128(1.02)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C103(1.36); C107(1.10); C116(0.91); C128(0.97)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C103(0.99); C107(0.95); C116(1.02); C128(0.84)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C103(1.37); C107(1.14); C116(0.96); C128(0.96)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C103(1.04); C107(0.66); C116(0.62); C128(0.62)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C103(1.06); C107(0.50); C116(1.00); C128(0.79)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C103(1.00); C107(0.73); C116(1.20); C92(2.68)  LDD1060  [10]
 LDCM0463  CL70 HEK-293T C103(1.10); C107(0.88); C116(0.82); C128(0.78)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C103(1.07); C107(0.68); C116(0.79); C128(0.77)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C103(1.09); C107(0.93); C116(0.95); C128(0.92)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C103(0.99); C107(0.57); C116(0.40); C128(0.51)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C103(1.28); C107(0.11); C116(1.08); C128(0.59)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C92(1.27)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C92(2.20)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C92(1.01)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C92(1.13)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C103(1.31); C107(0.12); C116(0.70); C92(0.80)  LDD1071  [10]
 LDCM0474  CL80 HEK-293T C92(1.39)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C92(0.95)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C92(0.84)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C92(1.21)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C92(1.30)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C92(1.00)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C92(0.95)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C92(1.12)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C92(1.78)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C92(0.85)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C103(1.18); C107(0.98); C116(0.65); C92(0.88)  LDD1082  [10]
 LDCM0485  CL90 HEK-293T C92(0.90)  LDD1083  [10]
 LDCM0486  CL91 HCT 116 C92(1.18)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C92(1.07)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C92(0.84)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C92(1.28)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C92(1.07)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C92(1.06)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C92(0.83)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C92(0.89)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C92(0.68)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C287(0.90); C92(0.92); C128(1.07); C103(1.03)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C92(0.81)  LDD1702  [9]
 LDCM0625  F8 Ramos C179(1.65); C287(3.12)  LDD2187  [27]
 LDCM0572  Fragment10 MDA-MB-231 C92(1.00)  LDD1389  [28]
 LDCM0573  Fragment11 MDA-MB-231 C92(1.17)  LDD1391  [28]
 LDCM0574  Fragment12 MDA-MB-231 C92(1.05)  LDD1393  [28]
 LDCM0575  Fragment13 MDA-MB-231 C92(1.80)  LDD1395  [28]
 LDCM0576  Fragment14 MDA-MB-231 C92(0.98)  LDD1397  [28]
 LDCM0577  Fragment15 MDA-MB-231 C92(0.70)  LDD1399  [28]
 LDCM0579  Fragment20 MDA-MB-231 C92(1.52)  LDD1402  [28]
 LDCM0580  Fragment21 MDA-MB-231 C92(1.11)  LDD1404  [28]
 LDCM0581  Fragment22 Ramos C92(1.00)  LDD1407  [28]
 LDCM0582  Fragment23 MDA-MB-231 C92(0.94)  LDD1408  [28]
 LDCM0583  Fragment24 Ramos C92(1.04)  LDD1410  [28]
 LDCM0584  Fragment25 MDA-MB-231 C92(1.02)  LDD1411  [28]
 LDCM0585  Fragment26 Ramos C92(1.01)  LDD1412  [28]
 LDCM0578  Fragment27 MDA-MB-231 C92(0.48)  LDD1401  [28]
 LDCM0586  Fragment28 MDA-MB-231 C92(1.76)  LDD1415  [28]
 LDCM0587  Fragment29 MDA-MB-231 C92(0.94)  LDD1417  [28]
 LDCM0588  Fragment30 MDA-MB-231 C92(0.93)  LDD1419  [28]
 LDCM0589  Fragment31 MDA-MB-231 C92(0.90)  LDD1421  [28]
 LDCM0590  Fragment32 Ramos C92(1.48)  LDD1424  [28]
 LDCM0468  Fragment33 HEK-293T C103(1.13); C107(0.85); C116(1.58); C128(1.14)  LDD1066  [10]
 LDCM0592  Fragment34 MDA-MB-231 C92(0.82)  LDD1427  [28]
 LDCM0593  Fragment35 MDA-MB-231 C92(0.74)  LDD1429  [28]
 LDCM0594  Fragment36 MDA-MB-231 C92(1.11)  LDD1431  [28]
 LDCM0595  Fragment37 Ramos C92(1.16)  LDD1432  [28]
 LDCM0596  Fragment38 MDA-MB-231 C92(1.07)  LDD1433  [28]
 LDCM0597  Fragment39 MDA-MB-231 C92(1.12)  LDD1435  [28]
 LDCM0566  Fragment4 MDA-MB-231 C92(1.16)  LDD1378  [28]
 LDCM0598  Fragment40 Ramos C92(1.55)  LDD1437  [28]
 LDCM0599  Fragment41 MDA-MB-231 C92(0.86)  LDD1438  [28]
 LDCM0600  Fragment42 Ramos C92(0.84)  LDD1440  [28]
 LDCM0601  Fragment43 Ramos C92(0.95)  LDD1442  [28]
 LDCM0602  Fragment44 MDA-MB-231 C92(0.96)  LDD1443  [28]
 LDCM0603  Fragment45 MDA-MB-231 C92(15.09)  LDD1482  [28]
 LDCM0604  Fragment46 MDA-MB-231 C92(0.74)  LDD1445  [28]
 LDCM0606  Fragment48 MDA-MB-231 C92(1.00)  LDD1447  [28]
 LDCM0608  Fragment50 MDA-MB-231 C92(20.00)  LDD1449  [28]
 LDCM0427  Fragment51 HCT 116 C92(1.63)  LDD0744  [10]
 LDCM0610  Fragment52 MDA-MB-231 C92(1.28)  LDD1452  [28]
 LDCM0611  Fragment53 MDA-MB-231 C92(0.72)  LDD1454  [28]
 LDCM0612  Fragment54 MDA-MB-231 C92(0.73)  LDD1456  [28]
 LDCM0614  Fragment56 MDA-MB-231 C92(0.92)  LDD1458  [28]
 LDCM0568  Fragment6 MDA-MB-231 C92(1.14)  LDD1382  [28]
 LDCM0569  Fragment7 Ramos C92(5.07)  LDD1384  [28]
 LDCM0570  Fragment8 MDA-MB-231 C92(14.30)  LDD1385  [28]
 LDCM0571  Fragment9 MDA-MB-231 C92(1.26)  LDD1387  [28]
 LDCM0107  IAA HeLa H364(0.00); H367(0.00); C103(0.00); C179(0.00)  LDD0221  [21]
 LDCM0022  KB02 HCT 116 C92(15.97); C107(15.97)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C92(1.71); C107(1.71)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C92(1.95); C107(1.95)  LDD0082  [10]
 LDCM0109  NEM HeLa H352(0.00); H364(0.00); H367(0.00); H271(0.00)  LDD0223  [21]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C179(1.05)  LDD2099  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C179(1.01)  LDD2107  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C179(0.85)  LDD2111  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C179(0.63)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C179(0.57)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C179(0.95)  LDD2118  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C179(0.64)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C179(1.01)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C179(0.81)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C179(0.91)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C179(0.83)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C179(1.11)  LDD2127  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C179(0.38)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C179(0.53)  LDD2134  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C179(1.18)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C179(1.03)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C179(2.84)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C179(0.78)  LDD2140  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C179(0.50)  LDD2151  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C92(0.36); C287(0.28)  LDD2206  [29]
 LDCM0628  OTUB2-COV-1 HEK-293T C92(1.08); C287(0.40)  LDD2207  [29]
 LDCM0159  P28 BxPC-3 1.61  LDD0409  [8]
 LDCM0131  RA190 MM1.R C287(1.18); C92(1.12); C116(1.06); C128(1.06)  LDD0304  [30]
 LDCM0021  THZ1 HCT 116 C116(1.19); C128(1.19); C103(1.17); C107(1.17)  LDD2173  [10]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Trimetazidine Small molecular drug DB09069

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD039908 , PXD029761
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