Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment32  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 86 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 20.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 20.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 12.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 8.6
 LDTP13147  Cathepsin Z (CTSZ) C92 6.4
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 6.4
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 5.0
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 4.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 4.1
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 4.0
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 3.8
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 3.7
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 3.5
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 3.4
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.9
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.9
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.8
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 2.7
 LDTP02502  Thioredoxin (TXN) C32 2.6
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 2.5
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.3
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 2.3
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 2.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 2.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.9
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.8
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.8
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.7
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.7
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.6
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.5
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 1.5
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.5
 LDTP04424  Galactokinase (GALK1) C182 1.5
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.5
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.4
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.4
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.4
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.3
 LDTP12190  NmrA-like family domain-containing protein 1 (NMRAL1) C154 1.3
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.3
 LDTP04689  Adenosine kinase (ADK) C353 1.3
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C358 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.2
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.1
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.1
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.1
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.1
 LDTP02672  Elongation factor 2 (EEF2) C136 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.1
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.0
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.0
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.0
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.9
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.9
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.8
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.8
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.7
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.7
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 0.7
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 0.6
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 20.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 13.6
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 12.2
 LDTP04662  Exportin-2 (CSE1L) C842 3.2
 LDTP04801  Gasdermin-D (GSDMD) C268 2.0
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.5
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.3
 LDTP00501  Exportin-1 (XPO1) C528 1.2
 LDTP00501  Exportin-1 (XPO1) C34 1.0
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.7
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 20.0
 LDTP05284  Transcription factor RelB (RELB) C109 20.0
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 8.2
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.4
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.1
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 72 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 20.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 20.0
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 20.0
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 19.0
 LDTP04092  Crk-like protein (CRKL) C249 17.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 16.5
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 10.0
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 9.9
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 8.4
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 7.1
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 7.0
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 5.9
 LDTP04902  Actin-related protein 3 (ACTR3) C235 5.4
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 4.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 4.1
 LDTP12571  LanC-like protein 2 (LANCL2) C187 3.4
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 3.2
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 3.1
 LDTP11718  Cleavage stimulation factor subunit 2 tau variant (CSTF2T) C150 3.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.9
 LDTP05867  Treacle protein (TCOF1) C1298 2.6
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 2.5
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 2.4
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 2.4
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 2.3
 LDTP01532  ZW10 interactor (ZWINT) C54 2.3
 LDTP13580  Coronin-1C (CORO1C) C420 2.2
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 2.1
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 2.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.9
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.9
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.8
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.8
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.7
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.7
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.7
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.7
 LDTP05867  Treacle protein (TCOF1) C38 1.7
 LDTP10864  Calponin-2 (CNN2) C164 1.6
 LDTP02205  Tubulin beta chain (TUBB) C354 1.6
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.6
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 1.5
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.5
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.5
 LDTP10864  Calponin-2 (CNN2) C215 1.5
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.5
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.4
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.4
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.4
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.4
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.4
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.3
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.3
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.2
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.2
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.1
 LDTP02205  Tubulin beta chain (TUBB) C239 1.1
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.0
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.9
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.8
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7
 LDTP03244  Cofilin-1 (CFL1) C80 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.