Details of the Target

General Information of Target

Target ID LDTP12737
Target Name BRISC and BRCA1-A complex member 1 (BABAM1)
Gene Name BABAM1
Gene ID 29086
Synonyms
C19orf62; MERIT40; NBA1; BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAVLGQLGALWIHNLRSRGKLALGVLPQSYIHTSASLDISRKWEKKNKIVYPPQLPGE
PRRPAEIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQD
MAVRDHNVEFRSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKVYCHYFVKLVEGPPPPP
EPPKTAVAHAKEYIQQLRSRTIVHTL
Target Bioclass
Other
Family
BABAM1 family
Subcellular location
Cytoplasm
Function
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
Uniprot ID
Q9NWV8
Ensemble ID
ENST00000359435.8
HGNC ID
HGNC:25008

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.I138N .
HEC1 SNV: p.R26S DBIA    Probe Info 
HEC1B SNV: p.S72Y .
HT115 SNV: p.S112L .
KARPAS422 SNV: p.Y217D DBIA    Probe Info 
MCC13 SNV: p.A154T DBIA    Probe Info 
MEWO SNV: p.P76A DBIA    Probe Info 
NCIH1793 SNV: p.R24L DBIA    Probe Info 
PF382 SNV: p.A300S DBIA    Probe Info 
RKO SNV: p.S66P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K135(5.88)  LDD0277  [2]
Probe 1
 Probe Info  		Y209(9.85)  LDD3495  [3]
BTD
 Probe Info  		C91(0.88)  LDD2099  [4]
DA-P3
 Probe Info  		4.27  LDD0181  [5]
DBIA
 Probe Info  		C222(6.92)  LDD0209  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
NAIA_4
 Probe Info  		C222(0.00); C294(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		14.80  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		10.78  LDD1868  [13]
C193
 Probe Info  		5.28  LDD1869  [13]
C286
 Probe Info  		6.87  LDD1956  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C294(1.11)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C294(1.03)  LDD0532  [14]
 LDCM0226  AC11 HCT 116 C294(1.09)  LDD0543  [14]
 LDCM0230  AC113 PaTu 8988t C294(1.19)  LDD1109  [14]
 LDCM0231  AC114 PaTu 8988t C294(1.19)  LDD1110  [14]
 LDCM0232  AC115 PaTu 8988t C294(0.97)  LDD1111  [14]
 LDCM0233  AC116 PaTu 8988t C294(1.24)  LDD1112  [14]
 LDCM0234  AC117 PaTu 8988t C294(1.32)  LDD1113  [14]
 LDCM0235  AC118 PaTu 8988t C294(1.19)  LDD1114  [14]
 LDCM0236  AC119 PaTu 8988t C294(1.13)  LDD1115  [14]
 LDCM0237  AC12 HCT 116 C294(1.20)  LDD0554  [14]
 LDCM0238  AC120 PaTu 8988t C294(1.11)  LDD1117  [14]
 LDCM0239  AC121 PaTu 8988t C294(1.29)  LDD1118  [14]
 LDCM0240  AC122 PaTu 8988t C294(1.26)  LDD1119  [14]
 LDCM0241  AC123 PaTu 8988t C294(1.26)  LDD1120  [14]
 LDCM0242  AC124 PaTu 8988t C294(1.34)  LDD1121  [14]
 LDCM0243  AC125 PaTu 8988t C294(0.90)  LDD1122  [14]
 LDCM0244  AC126 PaTu 8988t C294(1.03)  LDD1123  [14]
 LDCM0245  AC127 PaTu 8988t C294(1.41)  LDD1124  [14]
 LDCM0259  AC14 HCT 116 C294(0.95)  LDD0576  [14]
 LDCM0270  AC15 HCT 116 C294(0.75)  LDD0587  [14]
 LDCM0276  AC17 HEK-293T C294(1.03); C222(0.92); C238(0.96)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C294(1.03); C222(0.98); C238(0.83)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C222(0.84); C238(0.82)  LDD1517  [15]
 LDCM0279  AC2 HCT 116 C294(0.78)  LDD0596  [14]
 LDCM0280  AC20 HEK-293T C294(1.10); C222(1.09); C238(0.97)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C294(0.97); C222(0.96); C238(0.94)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C294(0.87); C222(0.90); C238(0.91)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C294(0.92); C222(0.90); C238(0.85)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C294(0.97); C222(0.92); C238(1.04); C98(0.99)  LDD1523  [15]
 LDCM0285  AC25 HCT 116 C294(1.09)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C294(1.09)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C294(1.17)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C294(1.44)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C294(1.11)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C294(1.08)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C294(1.13)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C294(1.08)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C294(1.09)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C294(0.84)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C294(0.53)  LDD0612  [14]
 LDCM0296  AC35 PaTu 8988t C294(0.83)  LDD1175  [14]
 LDCM0297  AC36 PaTu 8988t C294(0.84)  LDD1176  [14]
 LDCM0298  AC37 PaTu 8988t C294(0.77)  LDD1177  [14]
 LDCM0299  AC38 PaTu 8988t C294(0.65)  LDD1178  [14]
 LDCM0300  AC39 PaTu 8988t C294(0.76)  LDD1179  [14]
 LDCM0301  AC4 HCT 116 C294(1.09)  LDD0618  [14]
 LDCM0302  AC40 PaTu 8988t C294(0.75)  LDD1181  [14]
 LDCM0303  AC41 PaTu 8988t C294(1.04)  LDD1182  [14]
 LDCM0304  AC42 PaTu 8988t C294(0.88)  LDD1183  [14]
 LDCM0305  AC43 PaTu 8988t C294(0.88)  LDD1184  [14]
 LDCM0306  AC44 PaTu 8988t C294(0.87)  LDD1185  [14]
 LDCM0307  AC45 PaTu 8988t C294(0.96)  LDD1186  [14]
 LDCM0308  AC46 HEK-293T C294(0.99); C222(0.89); C238(1.02)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C294(1.01); C222(1.00); C238(0.94)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C294(0.95); C222(1.05); C238(1.01); C98(0.96)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C294(1.01); C222(0.92); C238(1.01)  LDD1550  [15]
 LDCM0312  AC5 HCT 116 C294(1.03)  LDD0629  [14]
 LDCM0313  AC50 HEK-293T C294(1.02); C222(1.05); C238(0.89)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C222(1.09); C238(1.01)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C294(0.97); C222(1.10); C238(0.98)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C294(1.04); C222(1.03); C238(0.99)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C294(0.96); C222(0.87); C238(0.99)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C294(0.98); C222(0.89); C238(0.93)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C294(0.94); C222(0.96); C238(1.00); C98(0.93)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C294(0.98); C222(0.88); C238(0.96)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C294(1.09); C222(0.98); C238(0.99)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C222(1.03); C238(0.95)  LDD1561  [15]
 LDCM0323  AC6 HCT 116 C294(1.19)  LDD0640  [14]
 LDCM0324  AC60 HEK-293T C294(1.02); C222(1.31); C238(0.98)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C294(1.03); C222(0.96); C238(1.12)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C294(0.89); C222(0.95); C238(0.90)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C294(0.95); C222(0.88); C238(0.90)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C294(1.01); C222(1.17); C238(1.17); C98(0.97)  LDD1567  [15]
 LDCM0334  AC7 HCT 116 C294(1.11)  LDD0651  [14]
 LDCM0345  AC8 HCT 116 C294(1.07)  LDD0662  [14]
 LDCM0248  AKOS034007472 HCT 116 C294(1.10)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C294(1.20)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C294(1.32)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 14.08  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C294(0.96); C238(1.20)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C294(0.98); C222(0.50); C238(1.29)  LDD1572  [15]
 LDCM0369  CL100 HCT 116 C294(1.30)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C294(1.06)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C294(1.09)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C294(1.03)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C294(1.35)  LDD0690  [14]
 LDCM0374  CL105 HEK-293T C294(0.94); C238(1.00)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C294(0.97); C222(0.93); C238(0.96)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C294(0.99); C238(0.84)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C294(0.96); C222(0.98); C238(0.98)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C294(0.95); C238(1.43)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C294(0.84); C222(0.31); C238(1.01)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C294(0.89); C222(0.92); C238(1.01)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C294(0.88); C238(0.89)  LDD1585  [15]
 LDCM0382  CL112 HCT 116 C294(1.08)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C294(0.92)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C294(0.93)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C294(0.77)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C294(0.55)  LDD0703  [14]
 LDCM0387  CL117 PaTu 8988t C294(0.96)  LDD1266  [14]
 LDCM0388  CL118 PaTu 8988t C294(1.00)  LDD1267  [14]
 LDCM0389  CL119 PaTu 8988t C294(0.82)  LDD1268  [14]
 LDCM0390  CL12 HEK-293T C294(0.97); C222(0.36); C238(1.17); C98(0.91)  LDD1594  [15]
 LDCM0391  CL120 PaTu 8988t C294(0.85)  LDD1270  [14]
 LDCM0392  CL121 HEK-293T C294(0.90); C238(1.09)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C294(1.09); C222(1.18); C238(0.98)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C294(0.83); C238(1.15)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C294(0.99); C222(1.01); C238(1.02)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C294(0.95); C238(0.92)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C294(0.99); C222(1.09); C238(0.96)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C294(0.90); C238(1.00)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C294(0.95); C222(1.19); C238(0.98)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C294(0.87); C238(1.91)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C294(1.14); C222(0.89); C238(1.18)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C294(0.90); C238(0.80)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C294(1.04); C222(0.63); C238(0.88)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C294(0.96); C222(0.54); C238(0.89)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C294(0.97); C222(0.53); C238(0.90)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C222(0.45); C238(0.96)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C294(1.20); C222(0.89); C238(1.08)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C294(1.01); C222(0.37); C238(0.93)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C294(0.99); C222(0.35); C238(0.99)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C294(1.03); C222(0.39); C238(1.11)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C294(1.02); C222(0.31); C238(1.04)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C294(1.11); C222(0.36); C238(1.12); C98(0.91)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C294(0.91); C238(1.06)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C294(0.98); C222(0.88); C238(0.92)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C294(0.95); C238(0.90)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C294(0.94); C222(0.69); C238(0.90)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C294(0.92); C222(0.52); C238(0.99)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C294(1.04); C238(0.89)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C294(1.03); C222(0.53); C238(0.85)  LDD1623  [15]
 LDCM0420  CL31 HCT 116 C294(1.10)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C294(0.90)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C294(1.02)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C294(0.78)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C294(0.86)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C294(0.87)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C294(0.75)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C294(0.85)  LDD0745  [14]
 LDCM0429  CL4 HEK-293T C294(1.04); C222(0.71); C238(0.95)  LDD1633  [15]
 LDCM0430  CL40 HCT 116 C294(1.03)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C294(0.83)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C294(0.50)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C294(0.78)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C294(0.79)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C294(1.27)  LDD0752  [14]
 LDCM0436  CL46 HEK-293T C294(0.98); C222(0.39); C238(1.02)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C294(0.90); C222(0.29); C238(1.15)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C294(1.07); C222(0.38); C238(1.41); C98(1.00)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C294(0.99); C238(1.11)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C294(0.99); C222(0.56); C238(0.95)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C294(0.90); C222(0.90); C238(1.12)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C294(1.03); C222(0.76); C238(0.93)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C294(0.99); C222(0.81); C238(0.93)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C294(0.93); C222(2.39); C238(1.15)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C222(0.43); C238(0.84)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C294(1.03); C222(0.42); C238(1.40)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C294(0.93); C222(0.46); C238(1.26)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C294(0.94); C222(0.41); C238(0.94)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C294(1.08); C222(0.30); C238(0.98)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C294(0.95); C222(0.54); C238(0.82)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C294(0.96); C222(0.37); C238(1.05); C98(1.07)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C294(0.88); C238(0.98)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C294(1.04); C222(1.08); C238(1.24)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C294(0.90); C238(0.96)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C294(1.03); C222(0.74); C238(0.92)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C294(1.02); C222(0.59); C238(0.93)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C294(0.99); C222(0.60); C238(1.00)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C222(0.52); C238(0.94)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C294(0.93); C222(0.53); C238(1.05)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C294(0.97); C222(0.48); C238(1.06)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C222(0.49); C238(0.88)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C294(0.98); C222(0.44); C238(0.88)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C294(1.01); C222(0.33); C238(0.98)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C294(1.01); C222(0.39); C238(1.30); C98(0.98)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C294(1.01); C238(1.16)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C294(0.96); C222(1.03); C238(0.97)  LDD1670  [15]
 LDCM0469  CL76 PaTu 8988t C294(0.95)  LDD1348  [14]
 LDCM0470  CL77 PaTu 8988t C294(1.17)  LDD1349  [14]
 LDCM0471  CL78 PaTu 8988t C294(1.13)  LDD1350  [14]
 LDCM0472  CL79 PaTu 8988t C294(1.30)  LDD1351  [14]
 LDCM0473  CL8 HEK-293T C294(1.10); C222(1.21); C238(1.37)  LDD1676  [15]
 LDCM0474  CL80 PaTu 8988t C294(1.08)  LDD1353  [14]
 LDCM0475  CL81 PaTu 8988t C294(1.14)  LDD1354  [14]
 LDCM0476  CL82 PaTu 8988t C294(1.02)  LDD1355  [14]
 LDCM0477  CL83 PaTu 8988t C294(1.13)  LDD1356  [14]
 LDCM0478  CL84 PaTu 8988t C294(1.13)  LDD1357  [14]
 LDCM0479  CL85 PaTu 8988t C294(1.17)  LDD1358  [14]
 LDCM0480  CL86 PaTu 8988t C294(0.92)  LDD1359  [14]
 LDCM0481  CL87 PaTu 8988t C294(1.28)  LDD1360  [14]
 LDCM0482  CL88 PaTu 8988t C294(1.17)  LDD1361  [14]
 LDCM0483  CL89 PaTu 8988t C294(1.13)  LDD1362  [14]
 LDCM0484  CL9 HEK-293T C294(1.10); C222(0.40); C238(1.09)  LDD1687  [15]
 LDCM0485  CL90 PaTu 8988t C294(1.20)  LDD1364  [14]
 LDCM0486  CL91 HCT 116 C294(0.97)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C294(0.77)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C294(0.94)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C294(0.88)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C294(1.16)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C294(1.00)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C294(1.60)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C294(1.45)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C294(1.22)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C294(0.95); C238(1.18)  LDD1698  [15]
 LDCM0625  F8 Ramos C294(1.35); C222(2.28)  LDD2187  [16]
 LDCM0572  Fragment10 MDA-MB-231 C222(1.60)  LDD1389  [17]
 LDCM0573  Fragment11 Ramos C222(1.15)  LDD1392  [17]
 LDCM0575  Fragment13 Ramos C222(0.72)  LDD1396  [17]
 LDCM0576  Fragment14 MDA-MB-231 C222(1.08)  LDD1397  [17]
 LDCM0577  Fragment15 Ramos C222(1.41)  LDD1400  [17]
 LDCM0579  Fragment20 Ramos C222(1.93)  LDD1403  [17]
 LDCM0580  Fragment21 Ramos C294(0.82); C222(1.07)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C222(3.52)  LDD1409  [17]
 LDCM0583  Fragment24 Ramos C222(20.00)  LDD1410  [17]
 LDCM0584  Fragment25 MDA-MB-231 C222(1.42)  LDD1411  [17]
 LDCM0585  Fragment26 Ramos C222(0.84)  LDD1412  [17]
 LDCM0578  Fragment27 MDA-MB-231 C222(0.79)  LDD1401  [17]
 LDCM0586  Fragment28 Ramos C222(0.92)  LDD1416  [17]
 LDCM0587  Fragment29 MDA-MB-231 C222(1.21)  LDD1417  [17]
 LDCM0588  Fragment30 MDA-MB-231 C222(0.40)  LDD1419  [17]
 LDCM0589  Fragment31 MDA-MB-231 C222(1.26)  LDD1421  [17]
 LDCM0590  Fragment32 Ramos C222(2.34)  LDD1424  [17]
 LDCM0468  Fragment33 HEK-293T C294(0.90); C238(1.13)  LDD1671  [15]
 LDCM0592  Fragment34 MDA-MB-231 C222(0.82)  LDD1427  [17]
 LDCM0596  Fragment38 MDA-MB-231 C222(1.00)  LDD1433  [17]
 LDCM0566  Fragment4 Ramos C222(2.27)  LDD1379  [17]
 LDCM0598  Fragment40 Ramos C222(1.13)  LDD1437  [17]
 LDCM0599  Fragment41 MDA-MB-231 C222(1.74)  LDD1438  [17]
 LDCM0601  Fragment43 MDA-MB-231 C222(20.00)  LDD1441  [17]
 LDCM0604  Fragment46 MDA-MB-231 C222(1.04)  LDD1445  [17]
 LDCM0605  Fragment47 MDA-MB-231 C222(1.37)  LDD1446  [17]
 LDCM0427  Fragment51 HCT 116 C294(1.10)  LDD0744  [14]
 LDCM0610  Fragment52 MDA-MB-231 C222(1.74)  LDD1452  [17]
 LDCM0611  Fragment53 Ramos C222(0.88)  LDD1455  [17]
 LDCM0614  Fragment56 MDA-MB-231 C222(0.81)  LDD1458  [17]
 LDCM0569  Fragment7 Ramos C222(0.95)  LDD2186  [16]
 LDCM0570  Fragment8 MDA-MB-231 C222(1.27)  LDD1385  [17]
 LDCM0571  Fragment9 MDA-MB-231 C222(20.00)  LDD1387  [17]
 LDCM0022  KB02 MDA-MB-231 C222(2.70)  LDD1374  [17]
 LDCM0023  KB03 Jurkat C222(6.92)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C294(2.39)  LDD3310  [18]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C91(0.88)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C91(1.15)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C91(0.51); C294(0.82)  LDD2109  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C91(1.05)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C91(0.62)  LDD2140  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C222(1.23)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C222(0.82)  LDD2207  [19]
 LDCM0029  Quercetin HEK-293T 4.27  LDD0181  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) ARTD/PARP family Q9H2K2
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BRISC and BRCA1-A complex member 2 (BABAM2) BABAM2 family Q9NXR7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.