Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment11					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	20.0
LDTP05992	Bleomycin hydrolase (BLMH)				C73	20.0
LDTP06211	Caspase-8 (CASP8)				C360	20.0
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	20.0
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	20.0
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	20.0
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	20.0
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	20.0
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	20.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	20.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	20.0
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	20.0
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	20.0
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	12.6
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	12.5
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	10.9
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	10.8
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	10.6
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	9.2
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	8.9
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	8.8
LDTP14888	Pre-rRNA-processing protein TSR1 homolog (TSR1)				C126	7.3
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	5.8
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	5.7
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	4.7
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	4.4
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	4.1
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	4.0
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	3.6
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	3.5
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	3.3
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	3.3
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	3.3
LDTP15311	Deaminated glutathione amidase (NIT1)				C203	3.2
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	3.1
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	2.8
LDTP10002	Ribonuclease P/MRP protein subunit POP5 (POP5)				C146	2.7
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	2.7
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	2.5
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	2.4
LDTP13147	Cathepsin Z (CTSZ)				C92	2.3
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	2.2
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	2.0
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	1.9
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.9
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	1.9
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.9
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.8
LDTP02502	Thioredoxin (TXN)				C32	1.8
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.8
LDTP07110	Putative transferase CAF17, mitochondrial (IBA57)				C170	1.7
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.7
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.7
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.7
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.7
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C377	1.6
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	1.6
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.6
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.5
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	1.5
LDTP03000	General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)				C342	1.5
LDTP02672	Elongation factor 2 (EEF2)				C41	1.4
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.3
LDTP03806	ADP-ribosylation factor-like protein 3 (ARL3)				C174	1.3
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.2
LDTP04424	Galactokinase (GALK1)				C182	1.2
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.1
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.1
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.1
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	1.0
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.0
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.0
LDTP09912	DNA repair protein RAD50 (RAD50)				C1302	1.0
LDTP13663	Dual specificity protein phosphatase 12 (DUSP12)				C265	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.9
LDTP04689	Adenosine kinase (ADK)				C353	0.9
LDTP09446	Ribonuclease H2 subunit C (RNASEH2C)				C34	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.8
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.8
LDTP04374	Dynamin-2 (DNM2)				C27	0.8
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.8
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.8
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C170	0.8
LDTP02733	Pyruvate kinase PKM (PKM)				C423	0.8
LDTP02672	Elongation factor 2 (EEF2)				C136	0.8
LDTP09912	DNA repair protein RAD50 (RAD50)				C1296	0.7
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)				C269	0.7
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.7
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.7
LDTP10801	ATPase WRNIP1 (WRNIP1)				C272	0.6
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.6
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	0.5
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	0.5
LDTP04251	Elongation factor Tu, mitochondrial (TUFM)				C147	0.4

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	20.0
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	20.0
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	15.2
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	4.2
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	3.2
LDTP04801	Gasdermin-D (GSDMD)				C268	2.2
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	2.2
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.5
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	1.1
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.1
LDTP00501	Exportin-1 (XPO1)				C34	1.0
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.0
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.9
LDTP01574	Importin-7 (IPO7)				C757	0.8
LDTP00501	Exportin-1 (XPO1)				C528	0.7

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05485	Recombining binding protein suppressor of hairless (RBPJ)				C313	20.0
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	18.5
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	7.9
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	6.0
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	1.9
LDTP02016	Glucocorticoid receptor (NR3C1)				C302	1.5
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	1.2
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04092	Crk-like protein (CRKL)				C249	20.0
LDTP07755	Dynamin-binding protein (DNMBP)				C691	20.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	20.0
LDTP07037	WD repeat domain phosphoinositide-interacting protein 3 (WDR45B)				C63	19.3
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	17.7
LDTP13837	Trafficking protein particle complex subunit 4 (TRAPPC4)				C195	10.0
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	8.3
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	8.2
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	7.8
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	7.5
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	6.9
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	5.7
LDTP04902	Actin-related protein 3 (ACTR3)				C235	4.6
LDTP13964	MOB-like protein phocein (MOB4)				C134	4.3
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	4.2
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	4.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	3.5
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	3.4
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	3.4
LDTP10284	Multivesicular body subunit 12A (MVB12A)				C231	2.9
LDTP00202	AH receptor-interacting protein (AIP)				C122	2.8
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	2.8
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	2.7
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	2.7
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	2.7
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1059	2.6
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	2.4
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	2.3
LDTP11212	Tubulin-specific chaperone D (TBCD)				C850	2.3
LDTP13580	Coronin-1C (CORO1C)				C420	2.3
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	2.2
LDTP01532	ZW10 interactor (ZWINT)				C54	2.2
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	2.1
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	2.1
LDTP10864	Calponin-2 (CNN2)				C215	2.0
LDTP05867	Treacle protein (TCOF1)				C1298	2.0
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.9
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.9
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.9
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.9
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.8
LDTP10864	Calponin-2 (CNN2)				C164	1.8
LDTP05867	Treacle protein (TCOF1)				C38	1.7
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.7
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.7
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.7
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	1.7
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	1.6
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.6
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	1.5
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	1.5
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	1.4
LDTP02205	Tubulin beta chain (TUBB)				C354	1.4
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.4
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.4
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C684	1.3
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.3
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.3
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	1.3
LDTP14337	Protein strawberry notch homolog 1 (SBNO1)				C445	1.3
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C280	1.3
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	1.3
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	1.2
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	1.2
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	1.1
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	1.1
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	1.1
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.0
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.0
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.0
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	1.0
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.0
LDTP02205	Tubulin beta chain (TUBB)				C239	1.0
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	0.9
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	0.9
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	0.9
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	0.9
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.9
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	0.9
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	0.8
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	0.8
LDTP13580	Coronin-1C (CORO1C)				C456	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.8
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	0.7
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	0.7
LDTP18494	Tropomodulin-3 (TMOD3)				C132	0.7
LDTP03244	Cofilin-1 (CFL1)				C80	0.7
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	0.6

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.