Details of the Target

General Information of Target

Target ID LDTP10774
Target Name Elongation factor G, mitochondrial (GFM1)
Gene Name GFM1
Gene ID 85476
Synonyms
EFG; EFG1; GFM; Elongation factor G, mitochondrial; EF-Gmt; Elongation factor G 1, mitochondrial; mEF-G 1; Elongation factor G1; hEFG1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPLSPARTLRLWGPRSLGVALGVFMTIGFALQLLGGPFQRRLPGLQLRQPSAPSLRPAL
PSCPPRQRLVFLKTHKSGSSSVLSLLHRYGDQHGLRFALPARYQFGYPKLFQASRVKGYR
PQGGGTQLPFHILCHHMRFNLKEVLQVMPSDSFFFSIVRDPAALARSAFSYYKSTSSAFR
KSPSLAAFLANPRGFYRPGARGDHYARNLLWFDFGLPFPPEKRAKRGNIHPPRDPNPPQL
QVLPSGAGPRAQTLNPNALIHPVSTVTDHRSQISSPASFDLGSSSFIQWGLAWLDSVFDL
VMVAEYFDESLVLLADALCWGLDDVVGFMHNAQAGHKQGLSTVSNSGLTAEDRQLTARAR
AWNNLDWALYVHFNRSLWARIEKYGQGRLQTAVAELRARREALAKHCLVGGEASDPKYIT
DRRFRPFQFGSAKVLGYILRSGLSPQDQEECERLATPELQYKDKLDAKQFPPTVSLPLKT
SRPLSP
Target Bioclass
Enzyme
Family
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Subcellular location
Mitochondrion
Function
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. {|HAMAP-Rule:MF_03061}.
Uniprot ID
Q96RP9
Ensemble ID
ENST00000264263.9
HGNC ID
HGNC:13780

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.G667R DBIA    Probe Info 
COLO800 SNV: p.I732T DBIA    Probe Info 
HCT15 SNV: p.E266D DBIA    Probe Info 
HT115 SNV: p.T369A DBIA    Probe Info 
KARPAS299 Deletion: p.T369CfsTer12 .
KASUMI2 SNV: p.M92V DBIA    Probe Info 
MDAMB468 SNV: p.M190I DBIA    Probe Info 
MELJUSO SNV: p.G422C DBIA    Probe Info 
NUGC3 SNV: p.I529S DBIA    Probe Info 
RPMI8226 SNV: p.L463M DBIA    Probe Info 
SNU869 SNV: p.F590V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.55  LDD0402  [1]
TH211
 Probe Info  		Y713(13.23); Y235(7.82)  LDD0257  [2]
STPyne
 Probe Info  		K280(7.69); K340(0.87); K468(3.84); K540(7.69)  LDD0277  [3]
AZ-9
 Probe Info  		E712(10.00)  LDD2209  [4]
Probe 1
 Probe Info  		Y68(19.38); Y69(32.87); Y235(66.60); Y385(86.22)  LDD3495  [5]
DBIA
 Probe Info  		C742(1.32)  LDD3310  [6]
BTD
 Probe Info  		C516(1.58); C514(1.37)  LDD2090  [7]
AHL-Pu-1
 Probe Info  		C516(2.23); C514(2.30)  LDD0170  [8]
5E-2FA
 Probe Info  		H445(0.00); H500(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K596(0.00); K603(0.00); K541(0.00); K520(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C594(0.00); C723(0.00); C706(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C594(0.00); C723(0.00); C706(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C594(0.00); C723(0.00); C256(0.00); C706(0.00)  LDD0037  [11]
Alkyne tyramide
 Probe Info  		Y549(0.00); Y235(0.00)  LDD0003  [13]
IPM
 Probe Info  		N.A.  LDD0147  [14]
NHS
 Probe Info  		N.A.  LDD0010  [13]
PF-06672131
 Probe Info  		N.A.  LDD0152  [15]
TFBX
 Probe Info  		C706(0.00); C516(0.00)  LDD0148  [14]
Phosphinate-6
 Probe Info  		C153(0.00); C514(0.00); C146(0.00)  LDD0018  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [17]
Acrolein
 Probe Info  		H602(0.00); C723(0.00); C594(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		C594(0.00); C723(0.00); C516(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C516(0.00); C594(0.00); C723(0.00)  LDD0218  [18]
AOyne
 Probe Info  		7.30  LDD0443  [19]
NAIA_5
 Probe Info  		C644(0.00); C594(0.00); C706(0.00); C723(0.00)  LDD2223  [20]
HHS-482
 Probe Info  		Y713(0.61)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe2
 Probe Info  		5.69  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe9
 Probe Info  		12.35  LDD0470  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C516(0.73)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C516(1.03)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C594(1.57)  LDD2117  [7]
 LDCM0025  4SU-RNA DM93 C516(2.23); C514(2.30)  LDD0170  [8]
 LDCM0214  AC1 HEK-293T C594(0.98); C723(1.06); C256(1.03); C153(0.98)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C594(0.91); C256(1.06); C153(1.08); C516(0.99)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C594(0.97); C723(1.02); C256(1.01); C153(1.08)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C594(1.02); C723(1.05); C256(1.18); C153(0.94)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C594(0.98); C723(1.02); C256(0.87); C153(1.21)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C594(0.93); C723(0.93); C256(1.07); C153(1.02)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C594(0.91); C723(1.05); C256(0.93); C153(0.99)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C594(0.93); C256(1.02); C153(1.02); C516(0.95)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C594(0.93); C723(0.85); C256(0.79); C153(0.79)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C594(0.96); C256(1.01); C153(0.96); C516(1.07)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C594(0.98); C723(1.06); C256(1.06); C153(0.96)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C594(0.95); C723(0.95); C256(1.02); C153(1.03)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C594(0.98); C723(1.05); C256(0.89); C153(1.27)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C594(0.93); C723(0.93); C256(0.93); C153(0.93)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C594(0.94); C256(1.00); C153(1.03); C516(0.96)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C594(0.98); C723(1.04); C256(0.98); C153(1.01)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C594(1.01); C256(1.07); C153(1.00); C516(1.08)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C594(0.98); C723(1.00); C256(0.95); C153(0.99)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C594(0.93); C723(1.09); C256(1.16); C153(1.02)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C594(0.99); C723(1.11); C256(0.96); C153(0.99)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C594(1.04); C723(0.98); C256(0.96); C153(1.03)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C594(0.99); C723(0.98); C256(1.04); C153(0.95)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C594(0.97); C723(1.00); C256(1.00); C153(1.04)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C594(0.93); C256(0.97); C153(0.97); C516(0.94)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C594(0.93); C723(0.97); C256(0.85); C153(1.07)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C594(0.88); C256(1.04); C153(1.09); C516(1.05)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C594(0.92); C723(0.81); C256(0.91); C153(0.98)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C594(1.04); C723(1.08); C256(1.16); C153(0.94)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C594(0.98); C723(0.99); C256(1.11); C153(0.90)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C594(0.91); C723(1.00); C256(1.10); C153(0.87)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C594(0.90); C723(1.08); C256(0.95); C153(1.08)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C594(0.99); C723(1.27); C256(1.17); C153(1.01)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C594(0.92); C256(1.02); C153(1.07); C516(1.00)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C594(0.96); C723(0.94); C256(0.94); C153(1.13)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C594(0.96); C256(1.01); C153(1.17); C516(0.95)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C594(0.97); C723(1.00); C256(1.21); C153(1.00)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C594(1.00); C723(1.05); C256(1.05); C153(1.00)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C594(0.95); C723(1.11); C256(1.07); C153(0.96)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C594(0.96); C723(0.94); C256(1.06); C153(1.13)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C594(0.93); C723(1.06); C256(1.05); C153(1.13)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C594(0.94); C256(1.00); C153(1.14); C516(1.02)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C594(0.90); C723(1.00); C256(0.90); C153(1.08)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C594(1.02); C723(1.09); C256(1.09); C153(1.02)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C594(0.94); C256(1.01); C153(1.04); C516(1.05)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C594(0.98); C723(1.01); C256(1.18); C153(0.85)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C594(1.01); C723(1.10); C256(1.10); C153(1.03)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C594(0.92); C723(1.01); C256(1.01); C153(1.09)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C594(0.92); C723(0.92); C256(0.96); C153(1.12)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C594(0.86); C723(0.99); C256(1.08); C153(1.21)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C594(0.92); C256(1.03); C153(1.01); C516(0.99)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C594(0.92); C723(1.01); C256(1.07); C153(1.12)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C594(0.90); C256(1.16); C153(1.21); C516(1.04)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C594(0.96); C723(0.93); C256(0.97); C153(1.06)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C594(0.98); C723(1.07); C256(0.80); C153(0.97)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C594(0.96); C723(0.98); C256(1.04); C153(1.08)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C594(0.93); C723(1.06); C256(1.08); C153(1.15)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C594(0.89); C723(0.90); C256(0.96); C153(1.12)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C594(0.85); C723(0.96); C256(0.97); C153(0.94)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C594(0.95); C256(1.02); C153(1.17); C516(1.03)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C594(1.01); C723(0.92); C256(0.99); C153(1.02)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C594(0.98); C256(1.06); C153(1.12); C516(1.05)  LDD1569  [24]
 LDCM0248  AKOS034007472 HEK-293T C594(0.99); C723(0.99); C256(1.06); C153(1.01)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C594(0.98); C723(1.09); C256(1.05); C153(1.05)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C594(0.96); C256(0.98); C153(1.14); C516(1.03)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0108  Chloroacetamide HeLa C723(0.00); C594(0.00); H54(0.00); C516(0.00)  LDD0222  [18]
 LDCM0367  CL1 HEK-293T C594(0.90); C723(0.98); C256(1.18); C153(0.93)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C594(0.98); C723(0.96); C256(1.01); C153(0.88)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C594(0.85); C723(1.08); C256(0.94); C153(0.99)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C594(0.90); C723(0.99); C256(1.11); C153(1.00)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C594(1.03); C723(1.11); C256(0.92); C153(0.92)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C594(0.94); C723(1.09); C256(0.85); C153(0.93)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C594(1.02); C723(1.07); C256(0.91); C153(1.08)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C594(0.93); C723(0.96); C256(1.01); C153(1.03)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C594(0.91); C723(1.08); C256(1.08); C153(1.02)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C594(0.93); C723(1.09); C256(0.95); C153(1.05)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C594(0.92); C723(0.96); C256(0.84); C153(0.91)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C594(0.90); C723(1.13); C256(1.17); C153(0.91)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C594(1.02); C723(0.98); C256(0.83); C153(0.93)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C594(0.95); C723(1.01); C256(1.06); C153(0.96)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C594(0.97); C723(1.03); C256(1.14); C153(1.05)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C594(0.87); C723(1.01); C256(1.01); C153(1.12)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C594(0.90); C723(0.99); C256(1.07); C153(0.95)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C594(0.90); C723(0.96); C256(0.97); C153(0.80)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C594(1.03); C723(0.98); C256(0.98); C153(0.99)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C594(0.84); C723(0.95); C256(0.98); C153(0.93)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C594(0.91); C723(1.05); C256(1.08); C153(0.97)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C594(0.96); C723(1.01); C256(1.17); C153(0.90)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C594(0.97); C723(1.02); C256(0.86); C153(0.92)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C594(0.89); C256(0.98); C153(1.38); C516(0.96)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C594(0.90); C723(1.01); C256(0.87); C153(1.10)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C594(0.91); C723(1.12); C256(1.20); C153(0.99)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C594(0.93); C723(1.00); C256(1.11); C153(0.93)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C594(0.94); C723(1.11); C256(1.03); C153(0.86)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C594(0.88); C723(1.05); C256(0.85); C153(0.99)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C594(0.90); C723(0.98); C256(1.13); C153(1.08)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C594(0.87); C723(0.96); C256(1.08); C153(0.94)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C594(0.93); C723(1.02); C256(0.94); C153(1.05)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C594(0.88); C723(0.98); C256(0.92); C153(1.19)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C594(0.88); C723(1.08); C256(1.19); C153(0.93)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C594(0.95); C723(0.99); C256(1.14); C153(1.00)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C594(0.93); C723(1.29); C256(0.81); C153(0.89)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C594(0.81); C723(0.92); C256(1.02); C153(1.02)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C594(0.96); C723(1.07); C256(0.92); C153(1.06)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C594(0.89); C256(1.11); C153(1.17); C516(0.94)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C594(1.01); C723(0.92); C256(0.94); C153(0.99)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C594(0.95); C723(1.02); C256(1.02); C153(0.93)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C594(1.11); C723(1.15); C256(1.09); C153(1.00)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C594(0.91); C723(0.89); C256(1.01); C153(0.55)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C594(0.96); C723(1.22); C256(0.91); C153(1.13)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C594(0.99); C723(1.05); C256(1.01); C153(1.14)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C594(0.95); C256(1.01); C153(1.28); C516(0.95)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C594(0.93); C723(1.08); C256(1.27); C153(1.00)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C594(0.96); C723(1.01); C256(1.36); C153(1.00)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C594(0.94); C723(1.04); C256(0.95); C153(0.98)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C594(1.01); C723(1.14); C256(0.98); C153(1.07)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C594(0.93); C723(0.99); C256(1.04); C153(0.99)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C594(0.98); C723(1.04); C256(0.83); C153(1.06)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C594(0.91); C256(0.94); C153(1.02); C516(0.99)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C594(0.98); C723(0.96); C256(1.27); C153(1.05)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C594(1.02); C723(1.10); C256(1.14); C153(0.97)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C594(1.05); C723(0.92); C256(0.88); C153(0.54)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C594(1.01); C723(0.97); C256(0.75); C153(1.05)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C594(0.99); C723(0.98); C256(1.09); C153(1.10)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C594(1.00); C256(1.06); C153(1.22); C516(0.99)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C594(0.87); C723(0.98); C256(1.24); C153(0.95)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C594(0.97); C723(1.07); C256(0.94); C153(1.15)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C594(0.82); C723(1.04); C256(0.86); C153(1.14)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C594(0.94); C723(0.88); C256(0.86); C153(1.10)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C594(0.94); C723(0.97); C256(0.96); C153(1.03)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C594(0.99); C256(1.17); C153(0.98); C516(0.95)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C594(1.03); C723(1.00); C256(0.99); C153(0.85)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C594(1.01); C723(1.07); C256(1.11); C153(1.04)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C594(1.02); C723(1.06); C256(0.99); C153(0.60)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C594(1.06); C723(1.08); C256(0.87); C153(1.07)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C594(1.02); C723(0.99); C256(0.87); C153(1.04)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C594(1.00); C256(1.02); C153(1.32); C516(0.95)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C594(0.97); C723(1.10); C256(1.28); C153(1.01)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C594(1.00); C723(1.08); C256(0.91); C153(1.09)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C594(0.91); C723(1.09); C256(1.27); C153(0.91)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C594(0.84); C723(1.04); C256(0.88); C153(1.01)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C594(1.02); C723(1.27); C256(1.01); C153(0.94)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C594(0.98); C256(1.06); C153(0.51); C516(0.81)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C594(1.04); C723(1.04); C256(1.06); C153(1.01)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C594(1.18); C723(1.23); C256(1.21); C153(1.16)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C594(0.99); C723(0.97); C256(0.91); C153(0.70)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C594(0.95); C723(1.02); C256(0.95); C153(1.04)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C594(0.96); C723(1.02); C256(0.96); C153(0.99)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C594(0.90); C256(0.99); C153(1.12); C516(0.81)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C594(1.05); C256(1.01); C153(1.24); C516(0.95)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C594(0.84); C723(1.11); C256(1.17); C153(1.07)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C594(0.95); C723(1.10); C256(1.31); C153(1.02)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C594(0.96); C723(1.06); C256(0.92); C153(0.99)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C594(0.99); C723(0.99); C256(1.05); C153(1.13)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C594(0.96); C723(1.07); C256(1.02); C153(1.02)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C594(0.93); C256(1.03); C153(1.09); C516(0.94)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C594(1.00); C723(1.08); C256(1.13); C153(1.15)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C594(1.09); C723(1.22); C256(1.23); C153(0.95)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C594(0.98); C723(1.18); C256(1.01); C153(0.67)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C594(0.99); C723(0.97); C256(0.93); C153(1.24)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C594(0.97); C723(1.01); C256(1.01); C153(1.31)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C594(0.93); C723(1.00); C256(1.03); C153(0.96)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C594(0.94); C256(0.93); C153(1.26); C516(0.95)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C594(0.98); C723(1.00); C256(1.27); C153(0.99)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C594(0.98); C723(0.97); C256(1.10); C153(1.00)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C594(0.91); C723(0.99); C256(0.98); C153(1.02)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C594(1.05); C723(1.04); C256(1.01); C153(1.07)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C594(0.90); C256(1.15); C153(1.18); C516(0.97)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C594(1.05); C723(0.95); C256(1.05); C153(0.94)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C594(0.93); C723(1.83); C256(1.04); C153(0.88)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C594(1.05); C723(1.07); C256(1.26); C153(0.97)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C594(0.98); C723(1.00); C256(1.02); C153(0.64)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C594(1.02); C723(1.07); C256(0.85); C153(1.21)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C594(1.01); C723(1.06); C256(0.92); C153(1.10)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C594(1.07); C256(1.04); C153(1.19); C516(1.00)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C594(0.89); C723(1.04); C256(1.14); C153(1.10)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C594(0.86); C723(0.98); C256(1.33); C153(1.02)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C594(0.95); C723(1.02); C256(1.07); C153(1.01)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C594(0.85); C723(1.00); C256(0.92); C153(1.26)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C594(0.95); C723(0.97); C256(0.84); C153(1.00)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C594(0.96); C723(1.17); C256(0.98); C153(0.65)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C594(0.92); C256(1.41); C153(1.03); C516(0.80)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C594(1.03); C723(0.99); C256(0.94); C153(0.88)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C594(1.01); C723(1.06); C256(1.21); C153(1.05)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C594(0.98); C723(1.00); C256(1.02); C153(0.77)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C594(0.95); C723(1.01); C256(0.91); C153(1.13)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C594(1.02); C723(1.57); C256(0.82); C153(0.70)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C594(0.97); C256(0.93); C153(1.29); C516(0.97)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C594(0.93); C723(1.24); C256(1.17); C153(0.96)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C594(1.02); C723(1.08); C256(0.99); C153(1.01)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C594(0.95); C723(1.04); C256(0.88); C153(1.00)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C594(0.97); C723(1.06); C256(1.02); C153(1.01)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C514(1.26); C516(1.19)  LDD1702  [7]
 LDCM0572  Fragment10 MDA-MB-231 C153(14.75)  LDD1465  [25]
 LDCM0573  Fragment11 Ramos C153(3.26)  LDD1392  [25]
 LDCM0574  Fragment12 MDA-MB-231 C153(20.00)  LDD1468  [25]
 LDCM0575  Fragment13 Ramos C153(0.79)  LDD1470  [25]
 LDCM0576  Fragment14 MDA-MB-231 C153(1.26)  LDD1397  [25]
 LDCM0577  Fragment15 MDA-MB-231 C153(0.88)  LDD1399  [25]
 LDCM0580  Fragment21 MDA-MB-231 C153(1.38)  LDD1473  [25]
 LDCM0582  Fragment23 Ramos C153(1.73)  LDD1409  [25]
 LDCM0583  Fragment24 Ramos C153(1.48)  LDD1410  [25]
 LDCM0578  Fragment27 MDA-MB-231 C153(0.98)  LDD1401  [25]
 LDCM0586  Fragment28 MDA-MB-231 C153(0.74)  LDD1415  [25]
 LDCM0587  Fragment29 Ramos C153(1.15)  LDD1476  [25]
 LDCM0468  Fragment33 HEK-293T C594(1.00); C723(1.06); C256(1.00); C153(1.03)  LDD1671  [24]
 LDCM0596  Fragment38 MDA-MB-231 C153(1.34)  LDD1433  [25]
 LDCM0566  Fragment4 MDA-MB-231 C153(0.98)  LDD1461  [25]
 LDCM0599  Fragment41 MDA-MB-231 C153(1.45)  LDD1438  [25]
 LDCM0600  Fragment42 Ramos C153(0.52)  LDD1440  [25]
 LDCM0601  Fragment43 Ramos C153(2.33)  LDD1442  [25]
 LDCM0427  Fragment51 Ramos C153(1.22)  LDD1451  [25]
 LDCM0614  Fragment56 MDA-MB-231 C153(0.88)  LDD1458  [25]
 LDCM0568  Fragment6 MDA-MB-231 C153(1.19)  LDD1382  [25]
 LDCM0570  Fragment8 Ramos C153(1.85)  LDD1386  [25]
 LDCM0571  Fragment9 Ramos C153(2.78)  LDD1464  [25]
 LDCM0107  IAA HeLa H54(0.00); C594(0.00); C723(0.00)  LDD0221  [18]
 LDCM0022  KB02 MDA-MB-231 C153(20.00)  LDD1374  [25]
 LDCM0023  KB03 MDA-MB-231 C153(20.00)  LDD1376  [25]
 LDCM0024  KB05 COLO792 C742(1.32)  LDD3310  [6]
 LDCM0109  NEM HeLa H616(0.00); H54(0.00)  LDD0223  [18]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C516(1.58); C514(1.37)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C516(1.09)  LDD2092  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C516(1.03)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C516(0.83)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C516(1.35)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C516(0.68); C514(0.85)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C594(1.24)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C516(0.60); C514(0.76)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C594(1.00)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C516(0.88)  LDD2110  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C594(1.93)  LDD2123  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C594(1.51)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C594(2.10)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C594(1.42)  LDD2137  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C516(0.58); C514(1.06)  LDD2141  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C594(1.37)  LDD2146  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C516(1.47); C514(2.81)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C153(1.16)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C153(1.56)  LDD2207  [26]
 LDCM0131  RA190 MM1.R C153(1.17)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM63 (TRIM63) . Q969Q1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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