Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment23  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 99 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 20.0
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 13.2
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 10.1
 LDTP03400  Deoxycytidine kinase (DCK) C45 9.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 6.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 4.7
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 3.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 3.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 3.4
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 3.3
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 3.2
 LDTP04374  Dynamin-2 (DNM2) C27 3.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 3.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 3.1
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 2.9
 LDTP02502  Thioredoxin (TXN) C32 2.9
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 2.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 2.6
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 2.4
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 2.3
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 2.3
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 2.2
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 2.2
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.1
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 2.1
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 2.1
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 2.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.9
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.8
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 1.7
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.7
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C4367 1.5
 LDTP02672  Elongation factor 2 (EEF2) C136 1.5
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.5
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.5
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.5
 LDTP03496  Protein PML (PML) C389 1.5
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.5
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.5
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.4
 LDTP02672  Elongation factor 2 (EEF2) C41 1.4
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.4
 LDTP06211  Caspase-8 (CASP8) C360 1.4
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.4
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 1.4
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.3
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.3
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.3
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 1.3
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 1.3
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.3
 LDTP04424  Galactokinase (GALK1) C182 1.3
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.3
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.2
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.2
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.2
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 1.2
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.2
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.2
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.1
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.1
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.1
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.1
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.1
 LDTP12190  NmrA-like family domain-containing protein 1 (NMRAL1) C154 1.1
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.1
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 1.1
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.0
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.0
 LDTP13147  Cathepsin Z (CTSZ) C92 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 1.0
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 0.9
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 0.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.8
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 0.8
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.7
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 0.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.7
Transporter and channel
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01574  Importin-7 (IPO7) C757 5.4
 LDTP00501  Exportin-1 (XPO1) C34 5.3
 LDTP00501  Exportin-1 (XPO1) C528 2.9
 LDTP13661  Sorting nexin-6 (SNX6) C264 2.7
 LDTP04707  Protein SEC13 homolog (SEC13) C187 2.6
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 2.2
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 2.1
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.8
 LDTP04801  Gasdermin-D (GSDMD) C268 1.8
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 1.7
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.9
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 0.8
 LDTP04662  Exportin-2 (CSE1L) C842 0.2
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 6.9
 LDTP02016  Glucocorticoid receptor (NR3C1) C302 4.7
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.5
 LDTP05284  Transcription factor RelB (RELB) C109 1.3
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.1
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 0.8
Other
Click to Show/Hide to Show 84 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03244  Cofilin-1 (CFL1) C80 20.0
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1059 20.0
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 10.9
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 10.4
 LDTP02205  Tubulin beta chain (TUBB) C239 6.8
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 6.7
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 6.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 4.8
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 4.2
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 4.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 3.7
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 3.5
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 3.5
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 3.4
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 3.2
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 3.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 3.1
 LDTP02205  Tubulin beta chain (TUBB) C354 3.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 2.9
 LDTP13964  MOB-like protein phocein (MOB4) C134 2.9
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 2.8
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 2.8
 LDTP05867  Treacle protein (TCOF1) C1298 2.8
 LDTP13580  Coronin-1C (CORO1C) C456 2.6
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 2.5
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 2.4
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.4
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 2.4
 LDTP18494  Tropomodulin-3 (TMOD3) C132 2.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 2.2
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 2.2
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 2.2
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 2.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 2.2
 LDTP05867  Treacle protein (TCOF1) C38 2.2
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C660 2.1
 LDTP10864  Calponin-2 (CNN2) C164 2.1
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.0
 LDTP10864  Calponin-2 (CNN2) C215 2.0
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 2.0
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.9
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.8
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.8
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.8
 LDTP12443  Anillin (ANLN) C712 1.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.7
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.7
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.6
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.5
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 1.5
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.5
 LDTP13580  Coronin-1C (CORO1C) C420 1.5
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.5
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.5
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.5
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.4
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.4
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.4
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.4
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 1.4
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 1.4
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 1.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.3
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.3
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.3
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.3
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.3
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.2
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.2
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.2
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.2
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.2
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.1
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.1
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 1.0
 LDTP04092  Crk-like protein (CRKL) C249 1.0
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.