Details of the Target

General Information of Target

Target ID LDTP10990
Target Name T-complex protein 1 subunit eta (CCT7)
Gene Name CCT7
Gene ID 10574
Synonyms
CCTH; NIP7-1; T-complex protein 1 subunit eta; TCP-1-eta; CCT-eta; HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSK
TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGK
PAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEV
IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE
FECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPS
SPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFN
PSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLL
TDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARDI
VQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA
Target Bioclass
Other
Family
TCP-1 chaperonin family
Subcellular location
Cytoplasm
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Uniprot ID
Q99832
Ensemble ID
ENST00000258091.10
HGNC ID
HGNC:1622

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.A124V DBIA    Probe Info 
HT SNV: p.I168V DBIA    Probe Info 
HT3 SNV: p.P229L DBIA    Probe Info 
ICC12 SNV: p.D456N DBIA    Probe Info 
JURKAT SNV: p.A248V Compound 10    Probe Info 
KNS42 SNV: p.P542R DBIA    Probe Info 
MEWO Substitution: p.P523L DBIA    Probe Info 
NCIH196 SNV: p.G54S DBIA    Probe Info 
SW948 SNV: p.E114A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 57 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.35  LDD0402  [1]
A-EBA
 Probe Info  		3.28  LDD0215  [2]
11RK72
 Probe Info  		5.66  LDD0327  [3]
11RK73
 Probe Info  		5.22  LDD0328  [3]
CHEMBL5175495
 Probe Info  		7.20  LDD0196  [4]
CY4
 Probe Info  		5.91  LDD0244  [5]
N1
 Probe Info  		4.64  LDD0242  [5]
TH211
 Probe Info  		Y111(20.00); Y438(14.85); Y232(11.59); Y263(10.39)  LDD0257  [6]
TH214
 Probe Info  		Y111(20.00); Y358(20.00)  LDD0258  [6]
TH216
 Probe Info  		Y111(20.00); Y438(16.50); Y358(12.28)  LDD0259  [6]
YN-1
 Probe Info  		2.02  LDD0444  [7]
BTD
 Probe Info  		C370(3.86)  LDD1699  [8]
ONAyne
 Probe Info  		K320(0.00); K47(0.00); K55(0.00); K292(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K250(1.57); K320(2.53)  LDD3494  [10]
Probe 1
 Probe Info  		Y232(31.53); Y438(14.48)  LDD3495  [11]
JZ128-DTB
 Probe Info  		C450(0.00); C29(0.00)  LDD0462  [12]
THZ1-DTB
 Probe Info  		C326(1.18); C450(1.07); C345(1.07); C29(0.97)  LDD0460  [12]
AHL-Pu-1
 Probe Info  		C310(2.87)  LDD0168  [13]
EA-probe
 Probe Info  		C29(5.04); C450(1.10); C29(15.00); C511(1.05)  LDD2210  [14]
HHS-482
 Probe Info  		Y222(0.21)  LDD0285  [15]
HHS-475
 Probe Info  		Y111(0.81); Y302(0.86); Y222(0.94)  LDD0264  [16]
HHS-465
 Probe Info  		Y222(10.00); Y232(10.00); Y263(10.00); Y475(2.70)  LDD2237  [17]
DBIA
 Probe Info  		C158(0.98); C370(0.90); C29(0.89)  LDD0078  [18]
5E-2FA
 Probe Info  		H283(0.00); H117(0.00); H390(0.00)  LDD2235  [19]
AMP probe
 Probe Info  		K366(0.00); K368(0.00)  LDD0200  [20]
ATP probe
 Probe Info  		K366(0.00); K368(0.00); K55(0.00); K292(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C158(0.00); C345(0.00); C310(0.00); C29(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C310(0.00); C326(0.00); C158(0.00); C345(0.00)  LDD0032  [22]
IPIAA_H
 Probe Info  		C450(0.00); C511(0.00); C310(0.00); C345(0.00)  LDD0030  [23]
IPIAA_L
 Probe Info  		C450(0.00); C511(0.00); C29(0.00); C345(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C158(0.00); C345(0.00); C310(0.00); C29(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		K67(0.00); K463(0.00)  LDD0035  [24]
JW-RF-010
 Probe Info  		C158(0.00); C29(0.00); C345(0.00)  LDD0026  [25]
NAIA_4
 Probe Info  		C29(0.00); C158(0.00); C326(0.00); C345(0.00)  LDD2226  [26]
TFBX
 Probe Info  		C370(0.00); C345(0.00); C450(0.00); C29(0.00)  LDD0027  [25]
WYneN
 Probe Info  		C158(0.00); C345(0.00)  LDD0021  [27]
KY-26
 Probe Info  		N.A.  LDD0301  [28]
1d-yne
 Probe Info  		K106(0.00); K292(0.00); K109(0.00)  LDD0356  [29]
Compound 10
 Probe Info  		C158(0.00); C345(0.00); C364(0.00); C450(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		C364(0.00); C450(0.00)  LDD2213  [30]
ENE
 Probe Info  		N.A.  LDD0006  [27]
IPM
 Probe Info  		C29(0.00); C364(0.00)  LDD0005  [27]
NHS
 Probe Info  		K292(0.00); K135(0.00); K172(0.00)  LDD0010  [27]
NPM
 Probe Info  		N.A.  LDD0016  [27]
PF-06672131
 Probe Info  		C364(0.00); C450(0.00)  LDD0017  [31]
SF
 Probe Info  		K67(0.00); K137(0.00); K144(0.00); K77(0.00)  LDD0028  [32]
STPyne
 Probe Info  		K67(0.00); K157(0.00); K292(0.00); K172(0.00)  LDD0009  [27]
VSF
 Probe Info  		C158(0.00); C29(0.00)  LDD0007  [27]
Phosphinate-6
 Probe Info  		C450(0.00); C158(0.00); C511(0.00); C29(0.00)  LDD0018  [33]
Ox-W18
 Probe Info  		W271(0.00); W474(0.00)  LDD2175  [34]
1c-yne
 Probe Info  		K109(0.00); K401(0.00); K77(0.00); K292(0.00)  LDD0228  [29]
Acrolein
 Probe Info  		C326(0.00); C29(0.00); C450(0.00); H390(0.00)  LDD0217  [35]
Crotonaldehyde
 Probe Info  		C450(0.00); C364(0.00); H73(0.00)  LDD0219  [35]
Methacrolein
 Probe Info  		C450(0.00); H390(0.00); C364(0.00); C345(0.00)  LDD0218  [35]
W1
 Probe Info  		C364(0.00); C310(0.00); C370(0.00); C450(0.00)  LDD0236  [36]
AOyne
 Probe Info  		7.60  LDD0443  [37]
NAIA_5
 Probe Info  		C370(0.00); C158(0.00); C345(0.00); C310(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		11.79  LDD1868  [38]
C293
 Probe Info  		19.97  LDD1963  [38]
FFF probe13
 Probe Info  		8.09  LDD0475  [39]
FFF probe2
 Probe Info  		5.39  LDD0463  [39]
JN0003
 Probe Info  		6.50  LDD0469  [39]
STS-2
 Probe Info  		N.A.  LDD0138  [40]
VE-P
 Probe Info  		N.A.  LDD0396  [41]
BD-F
 Probe Info  		P110(0.00); Y111(0.00)  LDD0024  [42]
LD-F
 Probe Info  		Y111(0.00); K109(0.00); Q107(0.00)  LDD0015  [42]
STS-1
 Probe Info  		N.A.  LDD0068  [43]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C158(0.47); C450(0.73); C310(0.59); C370(0.65)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C158(0.71); C450(0.97); C310(0.74); C370(0.96)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C158(0.69); C450(0.58); C310(0.51); C370(0.48)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C158(0.98); C450(1.00); C310(1.00); C370(0.93)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C158(1.03); C310(1.03); C370(1.15); C364(1.31)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C158(1.19); C310(1.31); C370(1.11)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C158(2.33); C310(0.92); C370(1.33)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C158(0.64); C310(0.47); C370(0.55); C364(0.70)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C158(0.79); C450(1.09); C370(0.52); C364(0.72)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C310(2.87)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C511(2.73); C326(2.31)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C370(1.28); C158(1.03); C29(0.70); C310(1.26)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C370(1.30); C158(0.93); C29(0.57); C310(0.72)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C370(0.68); C158(0.74); C29(0.60); C310(0.54)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C370(0.64); C158(0.69); C29(0.47); C310(0.43)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C370(0.80); C158(0.74); C29(0.64); C310(0.61)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C370(0.47); C158(0.66); C29(0.58); C310(0.44)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C370(0.55); C158(0.66); C29(0.51); C310(0.58)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C370(0.59); C158(0.69); C29(0.49); C310(0.54)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C370(0.72); C158(0.76); C29(0.61); C310(0.46)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C370(0.69); C158(0.95); C29(0.47); C310(0.62)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C370(0.88); C158(0.88); C29(0.47); C310(0.66)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C370(1.13); C158(0.76); C29(0.66); C310(0.69)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C370(1.26); C158(0.93); C29(0.54); C310(0.67)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C370(0.61); C158(0.80); C29(0.72); C310(0.45)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C370(0.64); C158(0.90); C29(0.87); C310(0.50)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C370(0.50); C158(0.87); C29(0.42); C310(0.42)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C370(1.09); C158(1.11); C310(1.01); C326(1.16)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C370(0.98); C158(1.06); C310(1.07); C326(0.93)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C370(0.87); C158(1.09); C310(1.01); C326(0.78)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C370(0.88); C158(0.90); C310(1.06); C326(0.54)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C370(0.82); C158(1.01); C310(1.13); C326(0.76)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C370(0.92); C158(0.94); C310(1.52); C326(0.92)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C370(0.67); C158(0.90); C310(1.13); C326(0.67)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C370(1.25); C158(0.93); C29(0.62); C310(0.86)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C370(0.84); C158(0.89); C310(1.27); C326(0.65)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C370(1.03); C158(0.93); C310(1.20); C326(1.14)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C370(1.02); C158(1.10); C310(1.23); C326(0.97)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C370(1.46); C158(1.16); C310(1.25); C326(0.95)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C370(4.31); C158(1.10); C310(1.07); C326(1.18)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C370(0.87); C158(0.96); C310(1.33); C326(0.64)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C370(0.98); C158(1.03); C310(1.40); C326(0.75)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C370(0.87); C158(0.99); C310(1.30); C326(0.71)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C370(0.78); C158(1.09); C310(0.80); C326(0.57)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C370(1.40); C158(1.40); C310(1.10); C326(1.14)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C370(1.38); C158(1.14); C310(0.81); C326(0.77)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C370(1.36); C158(1.21); C310(0.92); C326(1.20)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C370(2.01); C158(1.56); C310(1.58); C326(3.06)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C370(0.94); C158(1.10); C310(1.09); C326(1.04)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C370(1.13); C158(1.21); C310(0.76); C326(0.83)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C370(1.16); C158(1.09); C310(0.80); C326(0.59)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C370(1.13); C158(1.10); C310(0.83); C326(0.66)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C370(1.28); C158(1.39); C310(1.31); C326(1.38)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C370(0.89); C158(1.07); C310(0.67); C326(0.68)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C370(1.21); C158(1.22); C310(0.86); C326(0.97)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C370(1.48); C158(0.96); C29(0.50); C310(0.78)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C370(1.13); C158(1.23); C310(0.77); C326(0.77)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C370(1.06); C158(1.15); C310(0.84); C326(1.05)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C370(1.29); C158(1.16); C310(1.06); C326(1.08)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C370(1.11); C158(0.82); C310(0.71); C326(0.61)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C326(0.45); C364(0.54); C310(0.55); C345(0.65)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C326(0.54); C364(0.66); C345(0.78); C310(0.82)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C364(0.52); C326(0.54); C310(0.58); C345(0.65)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C345(0.55); C326(0.56); C310(0.67); C364(0.67)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C326(0.44); C364(0.47); C345(0.50); C450(0.72)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C364(0.41); C326(0.45); C345(0.54); C310(0.58)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C326(0.43); C29(0.70); C364(0.81); C310(0.83)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C326(0.58); C345(0.62); C310(0.66); C364(0.69)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C364(0.50); C310(0.53); C326(0.53); C345(0.67)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C310(0.41); C345(0.42); C326(0.47); C364(0.57)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C326(0.37); C345(0.50); C364(0.53); C310(0.56)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C370(1.59); C158(0.96); C310(0.58); C326(0.72)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C370(1.74); C158(0.81); C310(0.50); C326(0.68)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C370(1.44); C158(1.02); C310(0.83); C326(1.06)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C370(2.00); C158(1.05); C310(0.94); C326(1.29)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C345(0.76); C364(0.77); C158(0.91); C370(0.94)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C326(0.56); C345(0.61); C158(0.76); C364(0.80)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C364(0.77); C345(0.83); C158(0.83); C326(0.91)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C326(0.78); C29(0.83); C345(0.85); C364(0.94)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C370(0.67); C364(0.68); C345(0.70); C326(0.70)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C345(0.69); C364(0.69); C158(0.75); C370(0.75)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C158(0.80); C364(0.85); C345(0.85); C370(0.91)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C345(0.80); C158(0.86); C370(0.88); C364(0.94)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C158(0.92); C310(1.10); C450(1.15); C364(1.17)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C370(0.74); C345(0.75); C310(0.79); C364(0.80)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C345(0.75); C450(0.78); C326(0.79); C310(0.82)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C345(0.52); C310(0.53); C370(0.55); C450(0.61)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C345(0.58); C450(0.71); C310(0.78); C364(0.78)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C326(0.68); C345(0.68); C450(0.72); C158(0.75)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C370(1.11); C326(1.21); C345(1.23); C29(1.25)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C345(0.48); C310(0.54); C450(0.55); C364(0.56)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C345(0.55); C450(0.60); C326(0.71); C310(0.72)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C326(0.54); C345(0.55); C450(0.60); C310(0.60)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C310(0.56); C345(0.57); C364(0.57); C370(0.62)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C345(0.51); C310(0.55); C364(0.55); C370(0.59)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C158(0.92); C326(0.97); C450(1.08); C370(1.16)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C450(0.84); C158(0.85); C370(1.26); C326(1.30)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C370(0.96); C158(1.00); C326(1.04); C450(1.08)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C158(0.86); C370(0.89); C450(0.89); C310(1.00)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C370(0.71); C326(0.76); C310(0.78); C364(0.84)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C326(0.84); C29(0.90); C345(0.98); C364(1.16)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C370(0.71); C364(0.73); C310(0.75); C326(0.79)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C450(0.91); C158(0.94); C370(0.96); C326(1.01)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C450(0.82); C370(0.87); C310(0.89); C158(0.91)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C370(0.64); C158(0.78); C364(0.78); C450(0.79)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C450(0.99); C158(1.03); C370(1.10); C364(1.10)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C370(0.87); C364(0.93); C158(1.00); C310(1.01)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C370(0.55); C450(0.73); C158(0.79); C310(1.11)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C370(0.69); C158(0.81); C310(0.85); C450(0.92)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C370(0.72); C158(0.93); C450(0.94); C310(0.97)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C370(0.65); C364(0.73); C450(0.73); C310(0.76)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C29(0.67); C326(0.75); C345(1.01); C364(1.15)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C370(0.71); C310(0.74); C364(0.75); C450(0.83)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C370(0.70); C158(0.87); C450(0.92); C345(1.82)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C370(0.71); C310(0.79); C158(0.85); C364(0.86)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C370(0.73); C364(0.83); C310(0.84); C158(0.90)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C310(0.66); C364(0.69); C345(0.70); C370(0.71)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C364(0.65); C370(0.76); C310(0.76); C345(0.80)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C364(0.57); C310(0.60); C370(0.67); C158(0.69)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C326(0.36); C364(0.52); C345(0.56); C450(0.69)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C326(0.41); C364(0.52); C345(0.58); C450(0.64)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C326(0.36); C364(0.56); C345(0.59); C450(0.77)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C326(0.50); C310(0.54); C29(0.62); C364(0.63)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C326(0.43); C364(0.53); C345(0.59); C310(0.65)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C326(0.42); C364(0.58); C345(0.60); C450(0.69)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C326(0.40); C345(0.53); C364(0.57); C310(0.76)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C326(0.32); C364(0.59); C310(0.68); C370(0.71)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C326(0.32); C364(0.51); C345(0.61); C310(0.62)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C326(0.31); C364(0.47); C345(0.54); C450(0.63)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C326(0.30); C364(0.50); C345(0.57); C450(0.64)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C326(0.19); C364(0.44); C345(0.53); C370(0.55)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C345(0.89); C364(0.99); C310(1.07); C158(1.09)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C326(0.87); C310(0.89); C364(0.90); C158(0.96)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C326(0.40); C29(0.47); C310(0.64); C364(0.70)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C326(0.78); C364(0.82); C158(1.00); C450(1.02)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C310(0.99); C370(1.18); C345(1.27); C158(1.30)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C364(0.79); C370(0.85); C326(0.91); C345(0.92)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C364(0.62); C326(0.70); C370(0.75); C345(0.85)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C326(0.55); C364(0.59); C450(0.76); C345(0.89)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C364(0.59); C326(0.63); C450(0.81); C158(0.90)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C450(0.82); C364(0.85); C326(0.95); C158(1.00)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C364(0.70); C326(0.79); C450(0.83); C310(0.99)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C364(0.87); C326(0.95); C450(1.02); C158(1.11)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C364(0.80); C370(0.86); C326(0.96); C450(0.98)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C326(0.39); C310(0.60); C29(0.63); C364(0.67)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C364(0.82); C326(0.94); C310(0.98); C450(1.07)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C326(0.62); C310(1.00); C370(1.03); C345(1.03)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C326(0.41); C364(0.56); C450(0.72); C158(0.90)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C326(0.50); C364(0.55); C370(0.66); C345(0.66)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C326(0.56); C345(0.58); C370(0.62); C364(0.67)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C370(0.66); C326(0.74); C310(0.81); C364(0.86)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C364(0.85); C326(0.86); C310(0.90); C450(0.97)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C310(1.08); C450(1.20); C158(1.24); C345(1.25)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C370(0.95); C345(1.04); C310(1.10); C158(1.13)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C364(0.73); C345(0.76); C326(0.79); C310(0.81)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C310(0.93); C370(1.03); C450(1.07); C158(1.19)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C326(0.63); C364(0.65); C370(0.66); C310(0.91)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C326(0.60); C370(0.61); C364(0.79); C310(0.89)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C370(0.68); C310(0.79); C326(0.95); C345(1.00)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C370(0.80); C310(0.88); C158(0.98); C326(1.17)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C370(0.93); C158(1.10); C310(1.12); C364(1.18)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C370(0.68); C326(0.77); C364(0.81); C310(0.87)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C370(0.66); C364(0.67); C326(0.68); C345(0.71)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C29(0.21); C450(0.22); C364(0.24); C345(0.30)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C450(0.57); C345(0.59); C310(0.67); C326(0.80)  LDD0683  [18]
 LDCM0545  Acetamide MDA-MB-231 C158(0.77); C450(0.62); C310(0.55); C370(0.86)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C450(0.77); C310(0.97); C370(0.65); C364(0.97)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C370(1.24); C158(0.89); C29(0.45); C310(0.69)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C326(0.26); C29(0.40); C364(0.58); C310(0.62)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C326(0.15); C29(0.48); C364(0.50); C345(0.54)  LDD0592  [18]
 LDCM0156  Aniline NCI-H1299 C158(0.00); C29(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C158(0.98); C370(0.90); C29(0.89)  LDD0078  [18]
 LDCM0498  BS-3668 MDA-MB-231 C158(0.70); C450(0.86); C310(0.69); C370(0.99)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C29(1.30)  LDD2214  [44]
 LDCM0108  Chloroacetamide HeLa C326(0.00); C450(0.00); H390(0.00); C345(0.00)  LDD0222  [35]
 LDCM0632  CL-Sc Hep-G2 C29(20.00); C364(1.84); C450(1.77); C158(1.21)  LDD2227  [26]
 LDCM0367  CL1 HCT 116 C29(0.63); C158(0.80); C450(0.85); C310(0.89)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C29(0.45); C345(0.75); C310(0.83); C450(0.85)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C326(0.86); C370(0.93); C345(0.96); C158(1.08)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C326(0.20); C29(0.36); C364(0.47); C310(0.57)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C326(0.54); C29(0.56); C364(0.70); C310(0.75)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C326(0.43); C29(0.58); C364(0.79); C158(0.85)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C326(0.34); C29(0.55); C364(0.67); C310(0.73)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C345(0.51); C364(0.60); C370(0.61); C326(0.78)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C345(0.47); C326(0.55); C370(0.66); C364(0.69)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C345(0.58); C326(0.69); C364(0.72); C370(0.76)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C345(0.60); C364(0.68); C370(0.69); C326(0.82)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C364(0.65); C345(0.67); C310(0.85); C370(0.85)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C29(0.61); C326(0.69); C158(0.86); C310(0.92)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C326(0.70); C364(0.71); C345(0.77); C370(0.78)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C345(0.63); C364(0.65); C370(0.76); C450(0.76)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C345(0.87); C450(0.91); C158(0.97); C326(0.98)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C345(0.47); C326(0.56); C450(0.58); C310(0.60)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C450(0.58); C345(0.61); C326(0.63); C310(0.71)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C345(0.42); C310(0.48); C450(0.50); C364(0.53)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C310(0.61); C364(0.66); C370(0.66); C450(0.67)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C370(0.58); C364(0.62); C310(0.68); C326(0.68)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C310(0.89); C370(0.92); C450(0.94); C158(0.95)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C370(0.63); C364(0.76); C326(0.76); C310(0.80)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C29(0.69); C370(0.73); C450(0.84); C326(0.86)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C370(0.73); C326(0.82); C310(0.86); C364(0.87)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C364(0.54); C370(0.62); C450(0.75); C158(0.83)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C364(0.69); C310(0.71); C370(0.73); C345(0.83)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C370(0.63); C310(0.70); C364(0.75); C158(0.79)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C370(0.55); C364(0.63); C158(0.68); C310(0.71)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C326(0.63); C364(0.67); C450(0.74); C310(0.77)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C326(0.54); C345(0.76); C364(0.77); C450(0.79)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C326(0.64); C364(0.65); C450(0.76); C345(0.83)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C326(0.30); C364(0.45); C345(0.57); C450(0.69)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C29(0.49); C326(0.82); C158(0.86); C450(0.93)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C29(0.81); C370(0.94); C450(1.04); C310(1.05)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C29(0.31); C326(0.74); C158(0.89); C450(0.94)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C364(0.56); C450(0.57); C345(0.67); C29(0.68)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C29(0.69); C364(0.77); C450(0.81); C326(0.82)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C29(0.55); C326(0.60); C450(0.62); C345(0.67)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C326(0.52); C364(0.58); C345(0.65); C29(0.68)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C29(0.70); C370(0.83); C310(1.03); C158(1.07)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C326(0.46); C364(0.55); C345(0.62); C450(0.64)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C326(0.45); C29(0.59); C364(0.61); C345(0.65)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C326(0.43); C345(0.60); C364(0.65); C450(0.67)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C364(0.73); C345(0.80); C450(0.95); C326(0.96)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C326(0.56); C364(0.60); C450(0.62); C345(0.64)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C370(0.82); C158(0.85); C29(0.75); C310(0.91)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C370(0.99); C158(0.98); C29(1.23); C310(0.80)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C370(1.09); C158(0.95); C29(0.84); C310(0.94)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C370(0.87); C158(0.92); C29(0.79); C310(0.93)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C370(0.79); C158(0.89); C29(0.67); C310(1.03)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C370(1.14); C158(1.20); C29(0.88); C310(0.95)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C370(0.98); C158(0.89); C29(0.67); C310(1.22)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C370(1.22); C158(1.10); C310(1.44); C326(0.88)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C370(0.96); C158(1.08); C310(0.78); C326(0.64)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C370(0.75); C158(1.00); C310(0.86); C326(0.55)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C370(0.83); C158(0.88); C310(0.93); C326(0.44)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C370(0.98); C158(1.16); C310(0.90); C326(0.74)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C370(1.04); C158(1.07); C310(0.84); C326(0.73)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C370(0.91); C158(1.04); C310(1.11); C326(0.58)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C370(0.84); C158(1.04); C310(0.79); C326(0.39)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C370(1.26); C158(1.03); C29(1.03); C310(0.89)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C370(0.82); C158(0.96); C310(0.75); C326(0.43)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C370(0.97); C158(1.21); C310(1.10); C326(0.84)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C370(1.17); C158(1.04); C310(1.02); C326(0.40)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C370(0.94); C158(1.02); C310(0.96); C326(0.46)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C370(0.95); C158(0.92); C310(1.05); C326(0.43)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C370(1.00); C158(0.99); C310(0.95); C326(0.34)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C370(0.84); C158(1.05); C310(1.10); C326(1.99)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C370(1.11); C158(1.07); C310(0.94); C326(1.42)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C370(1.09); C158(1.50); C310(1.73); C326(2.60)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C370(0.78); C158(1.06); C310(1.04); C326(1.23)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C370(1.85); C158(1.01); C29(0.65); C310(1.13)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C370(1.24); C158(1.23); C310(1.49); C326(1.81)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C370(1.25); C158(1.11); C310(1.25); C326(2.11)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C370(1.01); C158(1.00); C310(1.12); C326(1.70)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C370(0.98); C158(1.06); C310(1.24); C326(1.71)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C370(1.05); C158(1.31); C310(1.61); C326(2.81)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C370(1.13); C158(1.18); C310(1.32); C326(2.57)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C370(1.29); C158(1.03); C310(0.87); C326(0.90)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C370(1.14); C158(1.19); C310(1.21); C326(2.05)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C370(0.86); C158(1.05); C310(1.18); C326(1.64)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C370(1.07); C158(1.30); C310(1.42); C326(1.77)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C370(1.24); C158(0.96); C29(0.71); C310(1.13)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C370(1.08); C158(1.29); C310(1.27); C326(1.48)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C370(1.42); C158(1.02); C29(0.84); C310(1.04)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C370(1.29); C158(1.21); C29(1.32); C310(1.33)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C370(1.17); C158(1.19); C29(0.84); C310(0.99)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C370(2.17); C158(0.96); C29(0.79); C310(0.80)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C370(1.77); C158(1.04); C29(0.82); C310(1.14)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C370(1.35); C158(1.03); C29(0.86); C310(0.81)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C370(1.79); C158(1.01); C29(1.01); C310(0.91)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C370(2.60); C158(1.17); C29(0.92); C310(1.08)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C370(1.29); C158(0.95); C29(0.87); C310(1.03)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C370(1.15); C158(0.96); C29(0.72); C310(1.01)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C370(1.02); C158(1.13); C29(1.32); C310(1.04)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C370(1.61); C158(1.12); C29(0.87); C310(0.91)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C370(1.58); C158(0.97); C29(0.84); C310(1.00)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C370(1.41); C158(1.00); C29(0.75); C310(0.87)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C370(1.25); C158(1.07); C29(1.05); C310(1.01)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C370(0.86); C158(0.77); C29(0.43); C310(0.64)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C370(1.18); C158(0.80); C29(0.62); C310(0.74)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C370(1.05); C158(0.82); C29(0.38); C310(0.57)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C370(0.84); C158(0.97); C29(0.72); C310(0.60)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C370(0.66); C158(0.86); C29(0.80); C310(0.87)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C370(1.01); C158(0.84); C29(0.43); C310(0.66)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C370(1.10); C158(0.86); C29(0.59); C310(0.74)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C370(1.17); C158(0.91); C29(0.59); C310(0.74)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C370(0.82); C158(0.75); C29(0.45); C310(0.77)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C370(0.77); C158(0.73); C29(0.43); C310(0.60)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C370(0.74); C158(0.78); C29(0.51); C310(0.72)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C370(0.79); C158(0.75); C29(0.44); C310(0.72)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C370(0.81); C158(0.72); C29(0.45); C310(0.78)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C370(0.97); C158(0.84); C29(0.52); C310(0.82)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C370(0.92); C158(0.72); C29(0.32); C310(0.55)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C370(1.61); C158(0.96); C29(0.76); C310(1.06)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C370(0.92); C158(0.91); C29(0.79); C310(1.08)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C370(0.84); C158(1.03); C29(0.71); C310(1.05)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C370(1.31); C158(0.93); C29(0.59); C310(1.10)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C370(1.44); C158(0.93); C29(0.62); C310(1.27)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C370(1.11); C158(1.11); C29(0.87); C310(1.18)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C370(1.20); C158(0.95); C29(0.67); C310(1.16)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C370(1.08); C158(0.91); C29(0.56); C310(0.98)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C370(0.94); C158(1.08); C29(0.56); C310(1.13)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C370(0.90); C158(1.14); C29(0.96); C310(1.03)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C370(0.92); C158(1.07); C29(0.88); C310(1.13)  LDD0811  [18]
 LDCM0634  CY-0357 Hep-G2 C450(2.82); C158(1.18); C345(0.90); C29(0.83)  LDD2228  [26]
 LDCM0495  E2913 HEK-293T C310(0.98); C158(0.99); C345(0.99); C370(0.96)  LDD1698  [45]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C370(3.31); C450(3.30); C364(2.73); C158(2.10)  LDD1702  [8]
 LDCM0175  Ethacrynic acid HeLa C29(5.04); C450(1.10); C29(15.00); C511(1.05)  LDD2210  [14]
 LDCM0625  F8 Ramos C364(0.83); C158(1.60); C345(1.16); C310(0.78)  LDD2187  [46]
 LDCM0572  Fragment10 MDA-MB-231 C29(2.38)  LDD1389  [47]
 LDCM0573  Fragment11 MDA-MB-231 C29(1.78)  LDD1391  [47]
 LDCM0574  Fragment12 MDA-MB-231 C29(2.19)  LDD1393  [47]
 LDCM0575  Fragment13 MDA-MB-231 C29(1.20)  LDD1395  [47]
 LDCM0576  Fragment14 MDA-MB-231 C29(2.27)  LDD1397  [47]
 LDCM0577  Fragment15 Ramos C29(3.81)  LDD1400  [47]
 LDCM0579  Fragment20 MDA-MB-231 C29(3.53)  LDD1402  [47]
 LDCM0580  Fragment21 MDA-MB-231 C29(1.38)  LDD1404  [47]
 LDCM0581  Fragment22 MDA-MB-231 C29(1.08)  LDD1406  [47]
 LDCM0582  Fragment23 MDA-MB-231 C29(3.45)  LDD1408  [47]
 LDCM0583  Fragment24 Ramos C29(1.92)  LDD1410  [47]
 LDCM0584  Fragment25 MDA-MB-231 C29(1.03)  LDD1411  [47]
 LDCM0585  Fragment26 Ramos C29(1.05)  LDD1412  [47]
 LDCM0578  Fragment27 MDA-MB-231 C29(0.97)  LDD1401  [47]
 LDCM0586  Fragment28 MDA-MB-231 C29(1.05)  LDD1415  [47]
 LDCM0587  Fragment29 MDA-MB-231 C29(1.04)  LDD1417  [47]
 LDCM0588  Fragment30 MDA-MB-231 C29(0.95)  LDD1419  [47]
 LDCM0589  Fragment31 MDA-MB-231 C29(3.50)  LDD1421  [47]
 LDCM0590  Fragment32 MDA-MB-231 C29(3.77)  LDD1423  [47]
 LDCM0468  Fragment33 HCT 116 C370(1.44); C158(1.10); C29(1.08); C310(0.99)  LDD0785  [18]
 LDCM0592  Fragment34 MDA-MB-231 C29(0.90)  LDD1427  [47]
 LDCM0593  Fragment35 Ramos C29(1.06)  LDD1430  [47]
 LDCM0594  Fragment36 MDA-MB-231 C29(1.86)  LDD1431  [47]
 LDCM0595  Fragment37 Ramos C29(0.98)  LDD1432  [47]
 LDCM0596  Fragment38 MDA-MB-231 C29(1.38)  LDD1433  [47]
 LDCM0597  Fragment39 MDA-MB-231 C29(1.70)  LDD1435  [47]
 LDCM0566  Fragment4 MDA-MB-231 C29(5.03)  LDD1378  [47]
 LDCM0598  Fragment40 MDA-MB-231 C29(0.90)  LDD1436  [47]
 LDCM0599  Fragment41 MDA-MB-231 C29(1.41)  LDD1438  [47]
 LDCM0600  Fragment42 Ramos C29(1.08)  LDD1440  [47]
 LDCM0601  Fragment43 MDA-MB-231 C29(1.49)  LDD1441  [47]
 LDCM0602  Fragment44 MDA-MB-231 C29(0.81)  LDD1443  [47]
 LDCM0603  Fragment45 MDA-MB-231 C29(1.96)  LDD1444  [47]
 LDCM0604  Fragment46 MDA-MB-231 C29(0.86)  LDD1445  [47]
 LDCM0605  Fragment47 MDA-MB-231 C29(1.18)  LDD1446  [47]
 LDCM0606  Fragment48 MDA-MB-231 C29(1.12)  LDD1447  [47]
 LDCM0607  Fragment49 MDA-MB-231 C29(10.91)  LDD1448  [47]
 LDCM0608  Fragment50 MDA-MB-231 C29(2.06)  LDD1449  [47]
 LDCM0427  Fragment51 HCT 116 C370(0.86); C158(1.04); C310(0.77); C326(0.42)  LDD0744  [18]
 LDCM0610  Fragment52 MDA-MB-231 C29(1.36)  LDD1452  [47]
 LDCM0611  Fragment53 MDA-MB-231 C29(1.04)  LDD1454  [47]
 LDCM0612  Fragment54 MDA-MB-231 C29(1.09)  LDD1456  [47]
 LDCM0613  Fragment55 MDA-MB-231 C29(1.07)  LDD1457  [47]
 LDCM0614  Fragment56 MDA-MB-231 C29(1.06)  LDD1458  [47]
 LDCM0568  Fragment6 MDA-MB-231 C29(1.90)  LDD1382  [47]
 LDCM0569  Fragment7 MDA-MB-231 C29(2.19)  LDD1383  [47]
 LDCM0570  Fragment8 MDA-MB-231 C29(1.90)  LDD1385  [47]
 LDCM0571  Fragment9 MDA-MB-231 C29(2.08)  LDD1387  [47]
 LDCM0116  HHS-0101 DM93 Y111(0.81); Y302(0.86); Y222(0.94)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y302(0.80); Y111(0.84); Y222(1.11)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y302(0.78); Y222(1.11); Y111(1.31)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y111(0.56); Y302(0.83); Y222(0.98)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y302(0.79); Y222(0.90); Y111(1.00)  LDD0268  [16]
 LDCM0015  HNE MDA-MB-231 C450(0.96); C511(1.04)  LDD0346  [46]
 LDCM0107  IAA HeLa H390(0.00); C364(0.00); C450(0.00); H233(0.00)  LDD0221  [35]
 LDCM0123  JWB131 DM93 Y222(0.21)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y222(0.45)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y222(0.38)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y222(0.65)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y222(0.39)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y222(1.39)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y222(0.69)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y222(0.39)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 C450(0.00); C29(0.00)  LDD0462  [12]
 LDCM0022  KB02 HCT 116 C345(2.15); C370(2.26); C364(2.42); C158(1.28)  LDD0080  [18]
 LDCM0023  KB03 HCT 116 C345(2.20); C370(1.85); C364(2.68); C158(1.94)  LDD0081  [18]
 LDCM0024  KB05 HCT 116 C345(3.04); C370(2.69); C364(2.30); C158(1.81)  LDD0082  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C158(1.58); C310(0.74); C370(1.10)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C158(0.79); C310(0.81); C370(1.13); C364(1.03)  LDD2121  [8]
 LDCM0109  NEM HeLa C450(0.00); H390(0.00); H73(0.00); C364(0.00)  LDD0223  [35]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C158(1.04); C450(0.86); C310(0.76); C370(1.08)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C158(2.33); C310(1.05); C370(0.95)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C158(1.61); C370(1.26)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C158(1.21); C310(1.19); C370(1.09); C364(1.61)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C158(2.70); C370(1.54)  LDD2094  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C158(0.74); C310(0.53); C370(0.71); C364(1.05)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C158(1.35); C370(1.06)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C158(0.81); C310(1.04); C370(1.21); C364(1.13)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C158(0.37); C310(0.41); C370(0.55)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C450(1.12); C310(1.91); C370(0.65); C364(1.18)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C158(0.58); C310(0.63); C370(0.64)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C310(1.73)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C310(0.56); C29(0.80)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C158(0.71); C310(0.90); C370(0.73); C364(1.04)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C158(0.41); C450(1.05); C310(0.61); C370(0.90)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C158(0.63); C450(0.61); C310(0.61)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C158(0.93); C310(0.92); C370(0.69)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C158(0.71); C450(1.32); C310(1.04); C364(1.49)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C158(1.10); C450(0.64); C310(0.92); C370(0.64)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C158(0.60); C450(0.49); C310(0.73); C370(0.44)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C158(0.30)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C158(0.24); C364(0.85); C29(1.21)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C158(1.82); C310(1.83); C370(1.31); C364(1.86)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C158(0.85); C310(0.82); C370(0.78); C364(0.99)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C364(0.96)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C158(0.62); C310(0.89); C370(1.08); C364(1.26)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C29(0.98)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C158(0.90); C450(1.00); C310(0.87); C370(1.08)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C158(0.21); C29(1.06)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C158(0.79); C450(1.00); C310(1.08); C364(1.50)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C158(0.54); C310(0.89)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C158(1.26); C450(1.11); C310(1.19); C364(1.40)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C158(0.92); C310(0.73); C370(0.55); C364(0.97)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C310(0.33); C370(0.49); C364(0.82)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C158(0.84); C450(1.64); C310(1.38); C370(1.37)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C158(1.10); C310(1.31); C370(1.32); C364(1.16)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C158(0.84); C450(1.05); C310(0.97); C370(1.02)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C310(2.00)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C158(0.62); C310(0.79); C370(0.10); C364(0.94)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C158(0.44); C310(0.49); C370(0.46)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C158(0.81); C310(0.98); C370(0.66)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C450(2.47); C310(2.47); C370(1.30); C364(1.92)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C310(1.01); C370(1.64); C29(1.41)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C158(0.79); C310(0.86); C370(0.94); C364(1.03)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C310(1.52); C370(0.63)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C450(0.41); C310(0.46); C370(0.51); C364(0.74)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C158(0.16)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C158(0.47); C310(0.52); C370(0.83)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C158(0.21); C370(0.29)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C158(3.49); C310(1.69); C370(1.55)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C511(0.98); C450(0.95); C29(0.67)  LDD2206  [48]
 LDCM0628  OTUB2-COV-1 HEK-293T C158(6.61); C450(0.91); C450(0.80); C29(0.77)  LDD2207  [48]
 LDCM0131  RA190 MM1.R C345(2.02); C450(1.58); C29(1.33); C326(1.27)  LDD0304  [49]
 LDCM0021  THZ1 HeLa S3 C326(1.18); C450(1.07); C345(1.07); C29(0.97)  LDD0460  [12]
 LDCM0113  W17 Hep-G2 S221(0.54); K218(0.56)  LDD0240  [36]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Helix-loop-helix protein 1 (NHLH1) . Q02575
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-complex protein 1 subunit beta (CCT2) TCP-1 chaperonin family P78371
Period circadian protein homolog 1 (PER1) . O15534
Protein ZNRD2 (ZNRD2) . O60232
WW domain-binding protein 2 (WBP2) . Q969T9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
4 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
25 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
28 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
32 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
33 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
34 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
35 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
36 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
37 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
38 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
39 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
40 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
41 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
42 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
43 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
44 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
45 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
46 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
47 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
48 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
49 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.