Details of the Probe

General Information of Probe

Probe ID
LDPC0189
Probe Name
11RK73
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 3 Molecular Weight (mw) 817.996
Lipid-water partition coefficient (xlogp) 0.46938
Rotatable Bond Count (rotbonds) 23
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 16
Chemical Identifiers
Formula
C35H51N11O8S2
Canonical SMILES
[H]C12CSC(CCCCC(=O)NCCOCCOCCOCCOCc3cn(CC(=O)N4CCc5nc(NC(=O)C6CCN(C#N)C6)sc5C4)nn3)C1([H])NC(=O)N2
InChI
InChI=1S/C35H51N11O8S2/c36-23-44-8-5-24(17-44)33(49)41-35-39-26-6-9-45(19-29(26)56-35)31(48)20-46-18-25(42-43-46)21-54-16-15-53-14-13-52-12-11-51-10-7-37-30(47)4-2-1-3-28-32-27(22-55-28)38-34(50)40-32/h18,24,27-28,32H,1-17,19-22H2,(H,37,47)(H2,38,40,50)(H,39,41,49)/t24-,27+,28+,32+/m0/s1
InChIKey
OZMRLFGFDFLQTD-BCZYHNNCSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

46 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 2.00  LDD0328 
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 2.00  LDD0328 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 5.31  LDD0328 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 5.31  LDD0328 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 2.51  LDD0328 
Actin, cytoplasmic 2 (ACTG1) LDTP05059 2.51  LDD0328 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 3.32  LDD0328 
Apoptosis-inducing factor 1, mitochondrial (AIFM1) LDTP01687 3.32  LDD0328 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 2.27  LDD0328 
Arginine--tRNA ligase, cytoplasmic (RARS1) LDTP04601 2.27  LDD0328 
ATP-dependent RNA helicase DDX3X (DDX3X) LDTP00314 2.60  LDD0328 
ATP-dependent RNA helicase DDX3X (DDX3X) LDTP00314 2.60  LDD0328 
ATP-dependent RNA helicase DHX15 (DHX15) LDTP00684 2.80  LDD0328 
ATP-dependent RNA helicase DHX15 (DHX15) LDTP00684 2.80  LDD0328 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 2.63  LDD0328 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 2.63  LDD0328 
DNA replication licensing factor MCM3 (MCM3) LDTP03316 6.53  LDD0328 
DNA replication licensing factor MCM3 (MCM3) LDTP03316 6.53  LDD0328 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 7.08  LDD0328 
DNA-dependent protein kinase catalytic subunit (PRKDC) LDTP05136 7.08  LDD0328 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 2.58  LDD0328 
Elongation factor 1-alpha 1 (EEF1A1) LDTP05071 2.58  LDD0328 
Elongation factor 2 (EEF2) LDTP02672 6.04  LDD0328 
Elongation factor 2 (EEF2) LDTP02672 6.04  LDD0328 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 3.60  LDD0328 
Endoplasmic reticulum chaperone BiP (HSPA5) LDTP02534 3.60  LDD0328 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 2.48  LDD0328 
Heat shock cognate 71 kDa protein (HSPA8) LDTP02541 2.48  LDD0328 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 6.17  LDD0328 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 6.17  LDD0328 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 6.53  LDD0328 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 6.53  LDD0328 
Isoleucine--tRNA ligase, cytoplasmic (IARS1) LDTP03947 2.71  LDD0328 
Isoleucine--tRNA ligase, cytoplasmic (IARS1) LDTP03947 2.71  LDD0328 
Methionine--tRNA ligase, cytoplasmic (MARS1) LDTP04730 3.37  LDD0328 
Methionine--tRNA ligase, cytoplasmic (MARS1) LDTP04730 3.37  LDD0328 
Multifunctional protein CAD (CAD) LDTP03401 7.13  LDD0328 
Multifunctional protein CAD (CAD) LDTP03401 7.13  LDD0328 
Parkinson disease protein 7 (PARK7) LDTP10878 14.71  LDD0328 
Parkinson disease protein 7 (PARK7) LDTP10878 14.71  LDD0328 
Poly [ADP-ribose] polymerase 1 (PARP1) LDTP02375 2.23  LDD0328 
Poly [ADP-ribose] polymerase 1 (PARP1) LDTP02375 2.23  LDD0328 
Probable ATP-dependent RNA helicase DDX17 (DDX17) LDTP09899 2.34  LDD0328 
Probable ATP-dependent RNA helicase DDX17 (DDX17) LDTP09899 2.34  LDD0328 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 3.76  LDD0328 
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) LDTP02067 3.76  LDD0328 
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⏷ Show the Full List of 46 Enzyme
20 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ADP/ATP translocase 2 (SLC25A5) LDTP02087 3.54  LDD0328 
ADP/ATP translocase 2 (SLC25A5) LDTP02087 3.54  LDD0328 
Amino acid transporter heavy chain SLC3A2 (SLC3A2) LDTP02256 4.79  LDD0328 
Amino acid transporter heavy chain SLC3A2 (SLC3A2) LDTP02256 4.79  LDD0328 
BOS complex subunit NCLN (NCLN) LDTP10036 2.10  LDD0328 
BOS complex subunit NCLN (NCLN) LDTP10036 2.10  LDD0328 
Desmoplakin (DSP) LDTP02815 3.44  LDD0328 
Desmoplakin (DSP) LDTP02815 3.44  LDD0328 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 5.36  LDD0328 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) LDTP02057 5.36  LDD0328 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 3.31  LDD0328 
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) LDTP13393 3.31  LDD0328 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 4.40  LDD0328 
Heat shock protein HSP 90-beta (HSP90AB1) LDTP02262 4.40  LDD0328 
Importin subunit beta-1 (KPNB1) LDTP06242 4.77  LDD0328 
Importin subunit beta-1 (KPNB1) LDTP06242 4.77  LDD0328 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 4.25  LDD0328 
Nuclear pore complex protein Nup93 (NUP93) LDTP08769 4.25  LDD0328 
T-complex protein 1 subunit delta (CCT4) LDTP04391 5.19  LDD0328 
T-complex protein 1 subunit delta (CCT4) LDTP04391 5.19  LDD0328 
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⏷ Show the Full List of 20 Transporter and channel
44 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 4.19  LDD0328 
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) LDTP06083 4.19  LDD0328 
DNA mismatch repair protein Msh6 (MSH6) LDTP04518 4.85  LDD0328 
DNA mismatch repair protein Msh6 (MSH6) LDTP04518 4.85  LDD0328 
Eukaryotic translation initiation factor 3 subunit A (EIF3A) LDTP06055 2.66  LDD0328 
Eukaryotic translation initiation factor 3 subunit A (EIF3A) LDTP06055 2.66  LDD0328 
Eukaryotic translation initiation factor 3 subunit B (EIF3B) LDTP04718 2.67  LDD0328 
Eukaryotic translation initiation factor 3 subunit B (EIF3B) LDTP04718 2.67  LDD0328 
Eukaryotic translation initiation factor 3 subunit D (EIF3D) LDTP00619 2.02  LDD0328 
Eukaryotic translation initiation factor 3 subunit D (EIF3D) LDTP00619 2.02  LDD0328 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 3.93  LDD0328 
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) LDTP05421 3.93  LDD0328 
F-box only protein 22 (FBXO22) LDTP09187 2.56  LDD0328 
F-box only protein 22 (FBXO22) LDTP09187 2.56  LDD0328 
Far upstream element-binding protein 2 (KHSRP) LDTP09938 6.74  LDD0328 
Far upstream element-binding protein 2 (KHSRP) LDTP09938 6.74  LDD0328 
Heat shock 70 kDa protein 1B (HSPA1B) LDTP02435 3.11  LDD0328 
Heat shock 70 kDa protein 1B (HSPA1B) LDTP02435 3.11  LDD0328 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 3.42  LDD0328 
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) LDTP04514 3.42  LDD0328 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 2.86  LDD0328 
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) LDTP04952 2.86  LDD0328 
Keratin, type I cuticular Ha1 (KRT31) LDTP06357 7.67  LDD0328 
Keratin, type I cuticular Ha1 (KRT31) LDTP06357 7.67  LDD0328 
Keratin, type II cuticular Hb3 (KRT83) LDTP05118 5.95  LDD0328 
Keratin, type II cuticular Hb3 (KRT83) LDTP05118 5.95  LDD0328 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 2.97  LDD0328 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 2.97  LDD0328 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 3.14  LDD0328 
Poly(rC)-binding protein 2 (PCBP2) LDTP06367 3.14  LDD0328 
Protein RCC2 (RCC2) LDTP13020 3.67  LDD0328 
Protein RCC2 (RCC2) LDTP13020 3.67  LDD0328 
Small ribosomal subunit protein eS1 (RPS3A) LDTP04913 2.09  LDD0328 
Small ribosomal subunit protein eS1 (RPS3A) LDTP04913 2.09  LDD0328 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 7.42  LDD0328 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 7.42  LDD0328 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 3.41  LDD0328 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 3.41  LDD0328 
T-complex protein 1 subunit eta (CCT7) LDTP10990 5.22  LDD0328 
T-complex protein 1 subunit eta (CCT7) LDTP10990 5.22  LDD0328 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 4.85  LDD0328 
T-complex protein 1 subunit gamma (CCT3) LDTP04249 4.85  LDD0328 
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) LDTP05034 3.96  LDD0328 
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) LDTP05034 3.96  LDD0328 
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⏷ Show the Full List of 44 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
5 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Interaction Atlas ID
 LDD0328 
Download The Altas

References

1 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828