Details of the Target

General Information of Target

Target ID LDTP00619
Target Name Eukaryotic translation initiation factor 3 subunit D (EIF3D)
Gene Name EIF3D
Gene ID 8664
Synonyms
EIF3S7; Eukaryotic translation initiation factor 3 subunit D; eIF3d; Eukaryotic translation initiation factor 3 subunit 7; eIF-3-zeta; eIF3 p66
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKFMTPVIQDNPSGWGPCAVPEQFRDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYS
SQFGGGSQYAYFHEEDESSFQLVDTARTQKTAYQRNRMRFAQRNLRRDKDRRNMLQFNLQ
ILPKSAKQKERERIRLQKKFQKQFGVRQKWDQKSQKPRDSSVEVRSDWEVKEEMDFPQLM
KMRYLEVSEPQDIECCGALEYYDKAFDRITTRSEKPLRSIKRIFHTVTTTDDPVIRKLAK
TQGNVFATDAILATLMSCTRSVYSWDIVVQRVGSKLFFDKRDNSDFDLLTVSETANEPPQ
DEGNSFNSPRNLAMEATYINHNFSQQCLRMGKERYNFPNPNPFVEDDMDKNEIASVAYRY
RRWKLGDDIDLIVRCEHDGVMTGANGEVSFINIKTLNEWDSRHCNGVDWRQKLDSQRGAV
IATELKNNSYKLARWTCCALLAGSEYLKLGYVSRYHVKDSSRHVILGTQQFKPNEFASQI
NLSVENAWGILRCVIDICMKLEEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEEEE
EEEEEEET
Target Bioclass
Other
Family
EIF-3 subunit D family
Subcellular location
Cytoplasm
Function
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
Uniprot ID
O15371
Ensemble ID
ENST00000216190.13
HGNC ID
HGNC:3278

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.G386R DBIA    Probe Info 
AN3CA SNV: p.D108G DBIA    Probe Info 
EFO27 SNV: p.R97Q DBIA    Probe Info 
FUOV1 SNV: p.Y202H DBIA    Probe Info 
HEC1 SNV: p.R106C; p.A205S DBIA    Probe Info 
HT115 SNV: p.F323L .
IGR1 SNV: p.R133H DBIA    Probe Info 
IGROV1 SNV: p.E545Ter DBIA    Probe Info 
JURKAT SNV: p.R417Ter Compound 10    Probe Info 
KMCH1 SNV: p.Q128K DBIA    Probe Info 
MDAMB157 SNV: p.G379S DBIA    Probe Info 
MOLT4 SNV: p.A253V IA-alkyne    Probe Info 
YSCCC SNV: p.D108H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.15  LDD0402  [1]
P2
 Probe Info  		3.97  LDD0449  [2]
P3
 Probe Info  		4.71  LDD0450  [2]
P8
 Probe Info  		1.87  LDD0451  [2]
A-EBA
 Probe Info  		2.66  LDD0215  [3]
11RK73
 Probe Info  		2.02  LDD0328  [4]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
TH211
 Probe Info  		Y50(9.40)  LDD0257  [6]
TH214
 Probe Info  		Y50(10.42)  LDD0258  [6]
TH216
 Probe Info  		Y50(12.84)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
ONAyne
 Probe Info  		K215(0.00); K412(0.00)  LDD0273  [8]
Probe 1
 Probe Info  		Y30(20.15); Y335(7.02); Y451(14.58)  LDD3495  [9]
BTD
 Probe Info  		C404(1.03)  LDD2089  [10]
AHL-Pu-1
 Probe Info  		C196(2.99)  LDD0168  [11]
EA-probe
 Probe Info  		C19(0.87)  LDD2210  [12]
HHS-475
 Probe Info  		Y50(0.45); Y318(0.83)  LDD0264  [13]
DBIA
 Probe Info  		C19(0.97)  LDD0078  [14]
ATP probe
 Probe Info  		K426(0.00); K53(0.00); K204(0.00); K364(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C375(0.00); C19(0.00); C404(0.00); C327(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C375(0.00); C258(0.00); C19(0.00); C404(0.00)  LDD0032  [17]
IPIAA_L
 Probe Info  		C404(0.00); C195(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C375(0.00); C19(0.00); C404(0.00); C327(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [19]
NAIA_4
 Probe Info  		C19(0.00); C258(0.00); C327(0.00); C375(0.00)  LDD2226  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
IPM
 Probe Info  		N.A.  LDD0147  [23]
NHS
 Probe Info  		K41(0.00); K53(0.00); K505(0.00)  LDD0010  [21]
PF-06672131
 Probe Info  		N.A.  LDD0017  [24]
SF
 Probe Info  		Y50(0.00); K458(0.00); K90(0.00)  LDD0028  [25]
STPyne
 Probe Info  		N.A.  LDD0009  [21]
TFBX
 Probe Info  		C258(0.00); C493(0.00)  LDD0148  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
Ox-W18
 Probe Info  		W45(0.00); W150(0.00); W168(0.00); W265(0.00)  LDD2175  [27]
1c-yne
 Probe Info  		N.A.  LDD0228  [28]
Acrolein
 Probe Info  		C19(0.00); H225(0.00); C404(0.00); C195(0.00)  LDD0217  [29]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [29]
Methacrolein
 Probe Info  		C404(0.00); H225(0.00)  LDD0218  [29]
W1
 Probe Info  		N.A.  LDD0236  [30]
NAIA_5
 Probe Info  		C19(0.00); C404(0.00); C327(0.00); C258(0.00)  LDD2223  [20]
HHS-465
 Probe Info  		K53(0.00); Y50(0.00)  LDD2240  [31]
HHS-482
 Probe Info  		Y318(1.34); Y50(1.06)  LDD2239  [32]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		10.35  LDD0475  [33]
FFF probe3
 Probe Info  		5.46  LDD0465  [33]
STS-2
 Probe Info  		1.00  LDD0139  [34]
VE-P
 Probe Info  		N.A.  LDD0396  [35]
STS-1
 Probe Info  		N.A.  LDD0068  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C404(0.47)  LDD2132  [10]
 LDCM0025  4SU-RNA HEK-293T C196(2.99)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C196(3.54); C19(2.58)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C196(1.26); C19(1.11); C195(1.28); C258(0.99)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C196(0.78); C19(1.00); C195(0.66); C258(0.97)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C196(0.55); C19(0.90); C195(0.75); C258(0.71)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C196(0.48); C19(1.01); C195(0.97); C258(0.57)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C196(0.52); C19(0.96); C195(0.76); C258(0.57)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C196(0.09); C19(1.02); C195(0.56); C258(0.16)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C196(0.15); C19(0.93); C195(0.52); C258(0.20)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C196(0.15); C19(1.00); C195(0.52); C258(0.21)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C196(0.15); C19(1.09); C195(0.52); C258(0.19)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C196(0.14); C19(1.02); C195(0.62); C258(0.18)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C196(0.55); C19(1.00); C195(0.69); C258(0.53)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C196(0.73); C19(0.94); C195(0.73); C258(0.50)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C196(1.01); C19(0.97); C195(0.76); C258(0.85)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C196(0.40); C19(1.06); C195(0.68); C258(0.54)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C196(0.40); C19(1.13); C195(0.75); C258(0.68)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C196(0.23); C19(1.15); C195(0.83); C258(0.30)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C196(1.27); C19(1.31); C195(1.11); C327(0.94)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C196(0.77); C19(1.87); C195(0.89); C327(1.02)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C196(0.50); C19(1.31); C195(0.67); C327(0.45)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C196(0.52); C19(1.21); C195(0.68); C327(0.42)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C196(0.79); C19(1.36); C195(0.86); C327(1.14)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C196(0.86); C19(1.08); C195(0.94); C327(0.80)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C196(0.79); C19(1.36); C195(0.86); C327(0.73)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C196(0.94); C19(1.00); C195(0.79); C258(0.91)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C196(0.76); C19(1.30); C195(0.89); C327(0.48)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C196(0.87); C19(1.40); C195(0.89); C327(0.96)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C196(1.03); C19(1.73); C195(0.99); C327(0.88)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C196(1.15); C19(1.23); C195(1.08); C327(0.97)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C196(0.87); C19(1.11); C195(0.92); C327(1.06)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C196(0.85); C19(1.67); C195(0.92); C327(0.97)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C196(0.58); C19(1.46); C195(0.67); C327(0.52)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C196(0.60); C19(1.31); C195(0.71); C327(0.64)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C196(0.53); C19(0.57); C195(0.53); C327(0.49)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C196(1.37); C19(0.50); C195(1.39); C327(3.24)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C196(0.65); C19(0.51); C195(0.66); C327(0.87)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C196(1.21); C19(0.56); C195(1.28); C327(2.48)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C196(1.54); C19(0.58); C195(1.64); C327(1.97)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C196(0.80); C19(0.61); C195(0.83); C327(0.94)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C196(0.46); C19(0.64); C195(0.60); C327(0.76)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C196(0.47); C19(0.65); C195(0.61); C327(0.62)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C196(0.71); C19(0.71); C195(0.81); C327(0.82)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C196(0.95); C19(0.62); C195(1.05); C327(1.52)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C196(0.50); C19(0.56); C195(0.76); C327(0.87)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C196(0.66); C19(0.59); C195(0.86); C327(0.90)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C196(1.23); C19(0.83); C195(0.98); C258(0.83)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C196(0.37); C19(0.55); C195(0.65); C327(0.65)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C196(0.58); C19(0.62); C195(0.83); C327(1.19)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C196(1.83); C19(0.63); C195(1.99); C327(1.96)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C196(0.91); C19(1.10); C195(0.83); C327(1.17)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C437(0.17); C375(0.30); C404(0.36); C493(0.41)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C437(0.59); C438(0.76); C195(0.84); C493(0.85)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C437(0.41); C438(0.68); C375(0.69); C493(0.73)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C437(0.14); C404(0.28); C375(0.30); C498(0.30)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C437(0.13); C404(0.23); C375(0.23); C327(0.27)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C437(0.12); C375(0.23); C404(0.26); C498(0.28)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C375(0.73); C195(0.77); C196(0.78); C258(0.84)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C437(0.66); C375(0.74); C438(0.78); C195(0.94)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C437(0.68); C19(0.82); C438(0.83); C375(0.87)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C437(0.11); C404(0.19); C375(0.26); C493(0.27)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C437(0.16); C404(0.25); C375(0.26); C493(0.30)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C196(0.58); C19(0.83); C195(0.56); C327(0.70)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C196(0.74); C19(0.83); C195(0.57); C327(0.69)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C196(1.01); C19(1.02); C195(0.92); C327(1.94)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C196(1.11); C19(0.87); C195(0.96); C327(1.48)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C498(0.89); C19(0.90); C196(0.92); C327(0.93)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C498(0.39); C327(0.42); C196(0.61); C437(0.68)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C327(0.77); C498(0.81); C196(0.84); C195(0.87)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C258(0.79); C196(0.79); C195(1.04); C438(1.15)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C498(0.76); C493(0.90); C19(0.91); C196(0.91)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C327(0.64); C498(0.75); C19(0.89); C437(0.90)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C498(0.90); C327(0.97); C493(1.02); C19(1.03)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C327(0.82); C19(0.83); C498(0.86); C493(0.91)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C437(0.94); C438(0.94); C498(0.94); C19(0.95)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C195(0.71); C258(0.71); C196(0.74); C493(0.89)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C196(0.55); C195(0.57); C498(0.82); C438(0.85)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C196(0.50); C195(0.55); C438(0.64); C498(0.65)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C196(0.51); C195(0.55); C498(0.61); C493(0.69)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C196(0.50); C195(0.63); C493(0.71); C404(0.71)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C258(0.71); C196(0.83); C195(0.89); C19(1.24)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C196(0.40); C195(0.52); C493(0.69); C437(0.73)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C196(0.59); C195(0.69); C258(0.76); C498(0.83)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C196(0.21); C498(0.28); C438(0.30); C493(0.40)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C498(0.39); C196(0.42); C438(0.45); C195(0.48)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C498(0.17); C438(0.20); C195(0.34); C196(0.35)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C327(1.20); C19(1.20); C404(1.26); C375(1.54)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C404(1.03); C19(1.03); C375(1.40); C327(1.81)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C19(1.03); C404(1.27); C327(1.32); C375(1.54)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C404(1.00); C375(1.17); C19(1.26); C327(1.48)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C375(0.79); C327(0.81); C19(1.02); C404(1.03)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C258(0.51); C196(0.58); C195(0.76); C19(1.05)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C327(0.43); C196(0.49); C375(0.54); C438(0.56)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C404(0.98); C327(1.04); C19(1.19); C375(1.31)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C327(0.64); C196(0.72); C195(0.77); C375(0.78)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C404(0.81); C375(1.01); C327(1.11); C19(1.17)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C327(0.62); C196(0.70); C195(0.72); C375(0.73)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C327(0.44); C375(0.48); C196(0.50); C438(0.55)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C375(0.92); C404(0.96); C327(1.18); C493(1.26)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C375(0.54); C258(0.77); C438(0.78); C498(0.82)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C404(0.88); C375(1.31); C327(1.57); C19(1.63)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C375(0.34); C258(0.35); C196(0.38); C498(0.39)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C258(0.43); C196(0.57); C195(0.86); C437(1.22)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C375(0.29); C498(0.35); C196(0.36); C438(0.36)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C404(0.82); C19(1.31); C493(1.61); C327(2.06)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C375(0.55); C258(0.69); C438(0.70); C196(0.70)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C375(0.29); C498(0.35); C438(0.36); C258(0.36)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C375(0.25); C258(0.32); C438(0.35); C437(0.36)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C375(0.27); C498(0.37); C258(0.38); C438(0.39)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C375(0.37); C498(0.43); C258(0.46); C327(0.50)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C258(0.25); C493(0.44); C498(0.46); C196(0.58)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C493(0.38); C498(0.42); C196(0.42); C258(0.45)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C258(0.13); C493(0.26); C498(0.26); C438(0.47)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C196(0.63); C195(0.66); C375(0.71); C438(0.74)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C258(0.43); C196(0.74); C493(0.75); C498(0.75)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C258(0.86); C196(0.97); C19(1.18); C438(1.28)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C258(0.17); C493(0.24); C498(0.26); C437(0.51)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C258(0.33); C493(0.50); C498(0.56); C438(0.63)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C258(0.13); C498(0.26); C493(0.27); C438(0.63)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C258(0.12); C498(0.36); C493(0.36); C438(0.48)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C258(0.23); C498(0.54); C196(0.56); C493(0.56)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C258(0.11); C493(0.31); C498(0.33); C438(0.48)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C498(0.36); C493(0.37); C196(0.38); C258(0.40)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C498(0.28); C493(0.32); C196(0.34); C258(0.40)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C195(0.76); C19(0.82); C196(0.86); C327(0.88)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C498(0.16); C493(0.21); C258(0.21); C196(0.27)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C498(0.84); C437(0.87); C438(0.87); C493(0.91)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C498(0.20); C493(0.23); C196(0.26); C258(0.32)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C498(0.21); C493(0.27); C196(0.29); C258(0.33)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C498(0.23); C493(0.29); C196(0.29); C258(0.34)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C498(0.27); C196(0.32); C493(0.34); C258(0.39)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C498(0.18); C493(0.22); C196(0.23); C258(0.27)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C498(0.19); C493(0.23); C196(0.25); C258(0.29)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C437(1.10); C438(1.10); C195(1.13); C19(1.17)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C498(0.31); C493(0.38); C196(0.43); C258(0.47)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C375(0.68); C195(0.73); C196(0.73); C327(0.76)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C498(0.18); C493(0.21); C196(0.25); C258(0.27)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C327(0.64); C258(0.74); C196(0.97); C498(0.99)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C498(0.26); C258(0.31); C493(0.33); C196(0.36)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C498(0.14); C196(0.14); C438(0.19); C327(0.20)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C196(0.14); C498(0.14); C438(0.19); C375(0.20)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C258(0.69); C438(0.73); C375(0.73); C498(0.77)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C438(0.60); C498(0.60); C375(0.68); C437(0.69)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C493(0.95); C258(1.01); C19(1.06); C437(1.06)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C498(0.53); C196(0.65); C437(0.67); C375(0.67)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C498(0.19); C196(0.21); C438(0.23); C437(0.25)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C19(0.95); C493(1.14); C498(1.37); C437(1.45)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C498(0.13); C196(0.13); C438(0.15); C437(0.18)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C196(0.11); C498(0.12); C438(0.15); C437(0.15)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C196(0.49); C498(0.51); C438(0.55); C437(0.55)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C375(0.87); C498(1.08); C327(1.08); C437(1.18)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C493(1.00); C498(1.07); C19(1.21); C438(1.21)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C498(0.33); C196(0.41); C438(0.46); C437(0.48)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C498(0.13); C196(0.14); C438(0.16); C437(0.19)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C196(0.09); C327(0.11); C258(0.11); C375(0.16)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C327(0.53); C493(0.58); C196(0.64); C258(0.73)  LDD0683  [14]
 LDCM0248  AKOS034007472 HCT 116 C196(1.16); C19(0.92); C195(0.99); C258(1.01)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C195(0.81); C19(0.89); C327(0.94); C196(0.94)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C375(0.17); C327(0.23); C258(0.24); C493(0.34)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 11.63  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C19(0.97)  LDD0078  [14]
 LDCM0630  CCW28-3 231MFP C19(1.38)  LDD2214  [37]
 LDCM0108  Chloroacetamide HeLa C19(0.00); H225(0.00); C327(0.00); C438(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C19(2.36)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C19(0.85); C493(1.03); C258(1.04); C195(1.04)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C196(0.28); C437(0.30); C258(0.36); C498(0.39)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C258(0.60); C196(0.73); C195(0.89); C438(1.04)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C195(0.61); C375(0.61); C327(0.69); C196(0.69)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C195(0.79); C375(0.81); C196(0.89); C258(0.90)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C493(0.84); C498(0.84); C195(0.85); C19(0.90)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C195(0.84); C19(0.91); C196(0.95); C493(0.98)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C327(0.52); C498(0.63); C437(0.70); C438(0.70)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C498(0.37); C327(0.48); C437(0.55); C438(0.55)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C498(0.22); C327(0.32); C437(0.47); C438(0.47)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C498(0.14); C327(0.22); C437(0.37); C438(0.37)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C498(0.62); C327(0.62); C196(0.81); C493(0.81)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C196(0.20); C258(0.23); C437(0.23); C498(0.28)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C498(0.45); C196(0.53); C493(0.61); C327(0.61)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C498(0.67); C196(0.73); C327(0.77); C195(0.84)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C196(0.63); C195(0.73); C327(0.74); C404(0.79)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C196(0.31); C498(0.39); C493(0.46); C195(0.47)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C196(0.51); C195(0.70); C404(0.71); C493(0.75)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C196(0.52); C195(0.63); C493(0.73); C498(0.78)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C196(0.59); C195(0.62); C493(0.79); C438(0.83)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C327(0.46); C196(0.56); C375(0.64); C195(0.65)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C327(0.63); C195(0.79); C196(0.79); C375(0.88)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C327(0.60); C438(0.64); C375(0.65); C196(0.65)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C196(0.16); C437(0.21); C258(0.22); C498(0.25)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C327(0.85); C375(0.87); C404(0.94); C19(1.05)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C375(0.43); C327(0.61); C258(0.65); C196(0.77)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C375(0.69); C196(0.77); C327(0.80); C498(0.84)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C375(0.22); C438(0.30); C498(0.31); C437(0.31)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C375(0.26); C498(0.31); C258(0.33); C437(0.35)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C258(0.49); C196(0.84); C195(1.00); C437(1.04)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C258(0.57); C196(0.76); C437(0.86); C438(0.89)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C258(0.55); C196(0.75); C195(0.84); C438(0.93)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C258(0.18); C493(0.26); C498(0.30); C196(0.53)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C196(0.43); C437(0.45); C493(0.48); C498(0.52)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C493(0.72); C438(0.72); C437(0.73); C196(0.73)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C258(0.67); C196(0.74); C195(0.76); C438(0.77)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C498(0.64); C493(0.80); C327(0.82); C258(0.85)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C498(0.67); C195(0.79); C437(0.89); C493(0.90)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C195(0.79); C437(0.98); C438(1.03); C498(1.03)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C498(0.72); C327(0.84); C404(0.86); C195(0.92)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C19(0.90); C438(1.02); C195(1.03); C493(1.08)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C437(0.24); C404(0.26); C258(0.31); C493(0.35)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C404(0.18); C437(0.19); C258(0.24); C493(0.26)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C404(0.23); C258(0.29); C437(0.31); C493(0.33)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C437(0.31); C404(0.39); C493(0.44); C498(0.46)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C404(0.20); C437(0.22); C258(0.24); C493(0.29)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C19(0.94); C195(0.72); C258(0.22); C327(0.31)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C19(1.11); C195(0.98); C258(0.52); C327(0.63)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C19(1.21); C195(0.86); C258(0.55); C327(0.69)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C19(0.95); C195(1.08); C258(0.44); C327(0.62)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C19(1.02); C195(0.86); C258(0.35); C327(0.46)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C196(1.17); C19(1.01); C195(1.08); C258(1.25)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C19(1.22); C195(0.85); C258(0.81); C327(0.88)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C196(0.64); C19(1.85); C195(0.72); C258(0.83)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C196(1.47); C19(1.33); C195(1.23); C258(1.18)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C196(0.89); C19(1.16); C195(0.86); C258(1.32)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C196(0.14); C19(0.88); C195(0.41); C258(0.25)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C196(0.11); C19(1.02); C195(0.38); C258(0.28)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C196(0.13); C19(0.86); C195(0.37); C258(0.32)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C196(0.12); C19(0.94); C195(0.39); C258(0.34)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C196(0.12); C19(0.84); C195(0.33); C258(0.25)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C196(0.88); C19(1.11); C195(0.88); C258(1.09)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C196(0.15); C19(0.85); C195(0.32); C258(0.29)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C196(0.20); C19(0.99); C195(0.38); C258(0.45)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C196(0.14); C19(0.94); C195(0.39); C258(0.27)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C196(0.13); C19(0.96); C195(0.32); C258(0.35)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C196(0.35); C19(1.12); C195(0.47); C258(0.76)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C196(0.16); C19(0.85); C195(0.35); C258(0.28)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C196(1.32); C19(0.93); C195(1.10); C404(1.26)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C196(1.09); C19(0.95); C195(1.04); C404(1.13)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C196(1.48); C19(0.96); C195(1.18); C404(1.18)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C196(1.06); C19(0.99); C195(0.91); C404(0.98)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C196(0.71); C19(1.12); C195(0.76); C258(0.89)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C196(1.65); C19(0.88); C195(1.21); C404(1.16)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C196(1.66); C19(0.90); C195(1.26); C404(1.16)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C196(1.48); C19(1.02); C195(1.16); C404(1.25)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C196(1.42); C19(1.07); C195(1.47); C404(1.18)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C196(1.55); C19(1.08); C195(1.27); C404(1.16)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C196(1.06); C19(1.09); C195(0.94); C404(1.21)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C196(0.96); C19(1.08); C195(0.90); C404(0.98)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C196(1.52); C19(1.04); C195(1.16); C404(1.14)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C196(1.28); C19(1.19); C195(1.08); C404(1.21)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C196(0.91); C19(1.13); C195(0.89); C404(1.01)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C196(1.03); C19(1.20); C195(1.00); C258(0.88)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C196(1.09); C19(1.33); C195(1.00); C404(1.06)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C196(0.96); C19(1.07); C195(0.93); C258(1.10)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C196(0.95); C19(1.12); C195(0.89); C258(1.06)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C196(0.84); C19(1.11); C195(0.80); C258(0.62)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C196(0.68); C19(1.17); C195(0.58); C258(0.41)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C196(0.97); C19(1.08); C195(0.88); C258(0.72)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C196(0.57); C19(0.95); C195(0.46); C258(0.14)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C196(0.67); C19(1.02); C195(0.55); C258(0.35)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C196(0.87); C19(1.24); C195(0.88); C258(0.74)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C196(1.66); C19(1.10); C195(1.60); C258(1.80)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C196(0.19); C19(0.84); C195(0.47); C258(0.19)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C196(0.89); C19(1.25); C195(0.84); C258(0.90)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C196(0.68); C19(1.13); C195(0.65); C258(0.48)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C196(1.00); C19(1.31); C195(0.94); C258(0.94)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C196(0.81); C19(1.13); C195(0.72); C258(1.00)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C196(0.70); C19(1.17); C195(0.64); C258(0.70)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C196(0.96); C19(1.02); C195(1.27); C258(1.43)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C196(0.63); C19(0.87); C195(0.90); C258(2.54)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C196(0.66); C19(0.99); C195(0.98); C258(0.93)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C196(0.55); C19(0.78); C195(0.97); C258(0.43)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C196(0.16); C19(0.82); C195(0.40); C258(0.23)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C196(1.16); C19(1.03); C195(1.20); C258(1.47)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C196(0.70); C19(1.08); C195(1.05); C258(0.76)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C196(0.46); C19(0.82); C195(0.91); C258(0.38)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C196(0.47); C19(0.78); C195(0.86); C258(0.39)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C196(0.54); C19(0.84); C195(0.86); C258(0.40)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C196(0.70); C19(1.02); C195(1.08); C258(0.95)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C196(0.84); C19(0.93); C195(1.66); C258(0.93)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C196(0.65); C19(0.99); C195(1.04); C258(0.84)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C196(0.56); C19(0.79); C195(0.80); C258(0.33)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C196(0.53); C19(0.97); C195(0.83); C258(0.38)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C196(0.32); C19(1.07); C195(0.49); C258(0.46)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C196(0.77); C19(0.82); C195(1.21); C258(1.17)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C196(0.86); C19(1.11); C195(1.14); C258(0.84)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C196(1.06); C19(1.31); C195(1.14); C258(0.66)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C196(1.10); C19(1.13); C195(0.98); C258(0.91)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C196(0.65); C19(1.19); C195(0.93); C258(0.59)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C196(0.75); C19(1.10); C195(0.94); C258(0.54)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C196(0.87); C19(1.22); C195(1.09); C258(0.65)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C196(0.69); C19(1.16); C195(0.87); C258(0.64)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C196(0.58); C19(1.13); C195(0.89); C258(0.50)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C196(0.71); C19(1.19); C195(0.91); C258(0.58)  LDD0811  [14]
 LDCM0634  CY-0357 Hep-G2 C19(1.37)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C404(0.99); C375(0.88); C19(0.95); C258(0.81)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C19(1.03); C327(0.90)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa C19(0.87)  LDD2210  [12]
 LDCM0625  F8 Ramos C327(0.60); C19(0.81)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C327(0.41); C19(1.57)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C327(3.51); C19(0.20)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C327(0.59); C19(1.12)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C327(0.70); C19(1.69)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C327(1.11); C19(0.81)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C327(0.50); C19(1.17)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C327(1.57); C19(0.98)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C19(0.56)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C327(0.57); C19(1.07)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C327(1.03); C19(0.20)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C327(0.29); C19(1.87)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C19(0.58)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C327(0.53); C19(1.57)  LDD2201  [39]
 LDCM0468  Fragment33 HCT 116 C196(0.83); C19(1.15); C195(0.77); C258(0.57)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C327(0.43); C19(1.05)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C327(0.51); C19(0.73)  LDD2184  [39]
 LDCM0427  Fragment51 HCT 116 C196(0.14); C19(1.26); C195(0.34); C258(0.28)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C19(1.14)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C327(0.27); C19(1.14)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C327(0.45); C19(0.77)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C327(0.25); C19(0.94)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y50(0.45); Y318(0.83)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y50(0.18); Y335(0.93); Y318(0.94)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y50(0.18); Y318(1.02)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y50(0.69); Y318(0.90)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y50(0.22); Y318(1.09)  LDD0268  [13]
 LDCM0107  IAA HeLa H225(0.00); H321(0.00); C438(0.00); C196(0.00)  LDD0221  [29]
 LDCM0022  KB02 HCT 116 C19(1.22); C195(0.97)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C19(1.27); C195(0.97)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C19(1.30); C195(0.83)  LDD0082  [14]
 LDCM0109  NEM HeLa H225(0.00); H321(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C404(1.03)  LDD2089  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C498(0.39)  LDD2120  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C498(0.77)  LDD2128  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C498(0.31)  LDD2143  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C19(0.88)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C258(1.50); C19(1.42); C195(1.00); C196(1.00)  LDD0304  [41]
 LDCM0021  THZ1 HCT 116 C19(0.98); C437(0.92); C438(0.92); C195(0.88)  LDD2173  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Eukaryotic translation initiation factor 3 subunit E (EIF3E) EIF-3 subunit E family P60228
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
BEN domain-containing protein 5 (BEND5) . Q7L4P6
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Heat shock factor 2-binding protein (HSF2BP) . O75031
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Pleckstrin homology-like domain family A member 1 (PHLDA1) . Q8WV24
PRKCA-binding protein (PICK1) . Q9NRD5
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28) . O15084

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
28 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
31 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
32 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
33 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
34 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
35 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
36 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
37 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
41 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.