Details of the Target

General Information of Target

Target ID LDTP04249
Target Name T-complex protein 1 subunit gamma (CCT3)
Gene Name CCT3
Gene ID 7203
Synonyms
CCTG; TRIC5; T-complex protein 1 subunit gamma; TCP-1-gamma; CCT-gamma; hTRiC5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMT
NDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPT
VVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAV
KMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVL
LDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLA
QHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYF
TFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAH
ALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGV
NGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAP
DAGQE
Target Bioclass
Other
Family
TCP-1 chaperonin family
Subcellular location
Cytoplasm
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Uniprot ID
P49368
Ensemble ID
ENST00000295688.8
HGNC ID
HGNC:1616

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 SNV: p.R231H DBIA    Probe Info 
IM95 SNV: p.F264L; p.Y274N DBIA    Probe Info 
JURKAT SNV: p.D520N Compound 10    Probe Info 
SKMEL2 SNV: p.R306W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 59 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.21  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		4.14  LDD0215  [3]
11RK72
 Probe Info  		5.16  LDD0327  [4]
11RK73
 Probe Info  		4.85  LDD0328  [4]
CHEMBL5175495
 Probe Info  		6.42  LDD0196  [5]
CY4
 Probe Info  		3.48  LDD0244  [6]
N1
 Probe Info  		7.08  LDD0242  [6]
TH211
 Probe Info  		Y232(20.00); Y247(20.00); Y274(7.40); Y359(5.25)  LDD0257  [7]
TH214
 Probe Info  		Y303(11.78); Y247(9.83); Y232(7.36)  LDD0258  [7]
TH216
 Probe Info  		Y232(20.00); Y247(20.00); Y437(20.00); Y359(13.25)  LDD0259  [7]
YN-4
 Probe Info  		100.00  LDD0445  [8]
BTD
 Probe Info  		C40(1.62)  LDD1699  [9]
ONAyne
 Probe Info  		K234(0.00); K78(0.00); K353(0.00); K249(0.00)  LDD0273  [10]
OPA-S-S-alkyne
 Probe Info  		K427(0.77); K249(1.76); K222(2.19); K381(2.81)  LDD3494  [11]
Probe 1
 Probe Info  		Y303(9.06); Y437(14.18)  LDD3495  [12]
THZ1-DTB
 Probe Info  		C182(1.12); C366(1.12); C213(1.06); C455(1.08)  LDD0460  [13]
AHL-Pu-1
 Probe Info  		C455(2.26); C213(2.79)  LDD0168  [14]
EA-probe
 Probe Info  		C455(0.92)  LDD2210  [15]
HHS-482
 Probe Info  		Y247(0.82); Y359(0.72)  LDD0285  [16]
HHS-475
 Probe Info  		Y359(1.67); Y247(1.77)  LDD0264  [17]
HHS-465
 Probe Info  		Y232(10.00); Y303(7.91); Y359(10.00)  LDD2237  [18]
DBIA
 Probe Info  		C173(1.02); C455(1.00); C213(0.92); C475(0.90)  LDD0078  [19]
5E-2FA
 Probe Info  		H302(0.00); H526(0.00); H4(0.00); H420(0.00)  LDD2235  [20]
AMP probe
 Probe Info  		K249(0.00); K381(0.00); K15(0.00); K138(0.00)  LDD0200  [21]
ATP probe
 Probe Info  		K249(0.00); K381(0.00); K15(0.00); K138(0.00)  LDD0199  [21]
4-Iodoacetamidophenylacetylene
 Probe Info  		C372(0.00); C475(0.00); C366(0.00); C279(0.00)  LDD0038  [22]
IA-alkyne
 Probe Info  		C213(0.00); C279(0.00); C455(0.00); C366(0.00)  LDD0032  [23]
IPIAA_H
 Probe Info  		C213(0.00); C279(0.00); C173(0.00); C366(0.00)  LDD0030  [24]
IPIAA_L
 Probe Info  		C455(0.00); C213(0.00); C173(0.00); C366(0.00)  LDD0031  [24]
Lodoacetamide azide
 Probe Info  		C372(0.00); C475(0.00); C366(0.00); C279(0.00)  LDD0037  [22]
2PCA
 Probe Info  		N.A.  LDD0034  [25]
ATP probe
 Probe Info  		K502(0.00); K163(0.00); K138(0.00)  LDD0035  [26]
JW-RF-010
 Probe Info  		C173(0.00); C455(0.00); C213(0.00); C398(0.00)  LDD0026  [27]
NAIA_4
 Probe Info  		C213(0.00); C279(0.00); C366(0.00); C398(0.00)  LDD2226  [28]
TFBX
 Probe Info  		C213(0.00); C173(0.00); C398(0.00); C455(0.00)  LDD0027  [27]
WYneN
 Probe Info  		C372(0.00); C40(0.00); C455(0.00); C398(0.00)  LDD0021  [29]
WYneO
 Probe Info  		C455(0.00); C213(0.00)  LDD0022  [29]
1d-yne
 Probe Info  		N.A.  LDD0356  [30]
Compound 10
 Probe Info  		C173(0.00); C213(0.00); C366(0.00); C372(0.00)  LDD2216  [31]
Compound 11
 Probe Info  		C213(0.00); C455(0.00)  LDD2213  [31]
ENE
 Probe Info  		C455(0.00); C398(0.00); C213(0.00)  LDD0006  [29]
IPM
 Probe Info  		C213(0.00); C366(0.00); C455(0.00); C173(0.00)  LDD0005  [29]
NHS
 Probe Info  		K248(0.00); K527(0.00); K21(0.00); K353(0.00)  LDD0010  [29]
PF-06672131
 Probe Info  		C173(0.00); C213(0.00); C366(0.00); C398(0.00)  LDD0017  [32]
PPMS
 Probe Info  		C455(0.00); C213(0.00)  LDD0008  [29]
SF
 Probe Info  		K138(0.00); K234(0.00); K381(0.00); K527(0.00)  LDD0028  [33]
STPyne
 Probe Info  		K353(0.00); K248(0.00); K354(0.00); K249(0.00)  LDD0009  [29]
Phosphinate-6
 Probe Info  		C213(0.00); C398(0.00); C40(0.00); C327(0.00)  LDD0018  [34]
Ox-W18
 Probe Info  		W478(0.00); W168(0.00); W435(0.00)  LDD2175  [35]
1c-yne
 Probe Info  		K78(0.00); K469(0.00); K203(0.00); K354(0.00)  LDD0228  [30]
Acrolein
 Probe Info  		C475(0.00); C173(0.00); C213(0.00); H420(0.00)  LDD0217  [36]
Cinnamaldehyde
 Probe Info  		C455(0.00); C398(0.00)  LDD0220  [36]
Crotonaldehyde
 Probe Info  		C455(0.00); C398(0.00); C475(0.00); C213(0.00)  LDD0219  [36]
Methacrolein
 Probe Info  		C173(0.00); C213(0.00); C398(0.00); C475(0.00)  LDD0218  [36]
W1
 Probe Info  		C213(0.00); C398(0.00); C173(0.00); C366(0.00)  LDD0236  [37]
AOyne
 Probe Info  		6.40  LDD0443  [38]
NAIA_5
 Probe Info  		C372(0.00); C475(0.00); C398(0.00); C366(0.00)  LDD2223  [28]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C317
 Probe Info  		5.86  LDD1983  [39]
FFF probe12
 Probe Info  		5.47  LDD0473  [40]
FFF probe13
 Probe Info  		7.61  LDD0475  [40]
FFF probe14
 Probe Info  		12.66  LDD0477  [40]
FFF probe2
 Probe Info  		5.03  LDD0463  [40]
FFF probe3
 Probe Info  		5.70  LDD0464  [40]
JN0003
 Probe Info  		5.51  LDD0469  [40]
STS-2
 Probe Info  		N.A.  LDD0138  [41]
VE-P
 Probe Info  		N.A.  LDD0396  [42]
DA-2
 Probe Info  		N.A.  LDD0073  [43]
STS-1
 Probe Info  		N.A.  LDD0069  [44]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C372(0.67); C398(0.52); C455(0.62); C40(0.46)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C372(0.69); C398(0.81); C455(0.58); C40(0.79)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C372(1.35); C398(0.80); C455(0.50); C40(0.47)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C372(0.98); C398(1.13); C455(0.96); C40(0.79)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C372(0.94); C398(1.63); C455(0.93); C40(1.28)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C372(1.16); C398(1.71); C455(1.31); C40(1.40)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C372(1.12); C455(1.51)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C372(0.62); C398(0.66); C455(0.42); C40(0.47)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C398(0.89); C455(0.61); C40(0.73); C213(0.59)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C455(2.26); C213(2.79)  LDD0168  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C213(2.11)  LDD0169  [14]
 LDCM0214  AC1 HCT 116 C173(0.99); C213(1.03); C366(0.95); C372(1.34)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C173(0.83); C213(1.01); C366(0.73); C372(1.07)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C173(0.71); C213(0.70); C366(0.63); C372(1.02)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C173(0.67); C213(0.66); C366(0.63); C372(0.90)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C173(0.78); C213(0.82); C366(0.67); C372(1.05)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C173(0.60); C213(0.68); C366(0.57); C372(0.95)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C173(0.67); C213(0.69); C366(0.62); C372(0.99)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C173(0.78); C213(0.73); C366(0.66); C372(0.92)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C173(0.73); C213(0.79); C366(0.70); C372(0.93)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C173(0.74); C213(0.75); C366(0.64); C372(0.98)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C173(0.64); C213(0.74); C366(0.76); C372(0.93)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C173(0.76); C213(0.80); C366(0.81); C372(1.07)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C173(0.80); C213(1.00); C366(0.61); C372(0.86)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C173(0.71); C213(0.82); C366(0.64); C372(0.90)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C173(0.73); C213(0.78); C366(0.64); C372(0.87)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C173(0.65); C213(0.71); C366(0.60); C372(1.00)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C173(1.20); C213(1.01); C366(1.02); C372(1.11)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C173(1.01); C213(1.02); C366(0.91); C372(0.99)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C173(1.11); C213(1.05); C366(0.92); C372(1.09)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C173(0.87); C213(0.94); C366(0.73); C372(1.02)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C173(0.90); C213(1.31); C366(0.80); C372(1.27)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C173(0.87); C213(1.02); C366(0.81); C372(1.37)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C173(0.88); C213(1.09); C366(0.79); C372(1.04)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C173(0.88); C213(1.03); C366(0.80); C372(1.08)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C173(0.89); C213(0.95); C366(0.68); C372(1.17)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C173(0.93); C213(1.35); C366(0.76); C372(1.14)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C173(0.94); C213(1.12); C366(0.97); C372(1.25)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C173(0.99); C213(1.26); C366(1.22); C372(1.24)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C173(1.08); C213(1.20); C366(1.05); C372(1.19)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C173(0.88); C213(1.11); C366(0.90); C372(1.15)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C173(0.90); C213(1.03); C366(0.87); C372(1.34)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C173(0.91); C213(1.14); C366(0.91); C372(1.19)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C213(1.17); C366(0.99); C372(0.72); C398(0.90)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C213(1.03); C366(1.17); C372(0.93); C398(1.12)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C213(1.07); C366(1.10); C372(1.08); C398(0.92)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C213(0.98); C366(1.03); C372(0.93); C398(1.11)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C213(1.39); C366(1.54); C372(1.11); C398(1.12)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C213(1.13); C366(1.03); C372(1.00); C398(0.94)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C213(1.32); C366(1.07); C372(1.05); C398(0.92)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C213(1.15); C366(1.06); C372(0.96); C398(0.88)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C213(0.97); C366(0.96); C372(1.19); C398(0.81)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C213(1.22); C366(1.16); C372(1.04); C398(0.99)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C213(1.19); C366(0.93); C372(1.04); C398(0.74)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C213(1.11); C366(1.08); C372(1.56); C398(0.90)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C173(0.84); C213(0.97); C366(0.66); C372(1.01)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C213(1.30); C366(1.03); C372(1.16); C398(0.91)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C213(1.08); C366(1.00); C372(1.16); C398(0.92)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C213(1.27); C366(0.98); C372(1.42); C398(0.83)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C173(0.59); C213(1.00); C366(0.63); C372(1.10)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C366(0.61); C173(0.65); C475(0.74); C372(0.83)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C173(0.62); C372(0.70); C366(0.71); C475(0.72)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C173(0.56); C372(0.67); C366(0.69); C475(0.73)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C173(0.81); C366(0.82); C475(0.89); C372(0.93)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C173(0.61); C372(0.69); C475(0.70); C455(0.86)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C173(0.49); C475(0.64); C366(0.66); C372(0.72)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C366(0.71); C475(0.84); C455(0.87); C173(0.88)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C366(0.67); C173(0.69); C475(0.76); C455(0.77)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C173(0.59); C366(0.64); C475(0.68); C372(0.78)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C173(0.63); C366(0.68); C475(0.71); C372(0.73)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C173(0.51); C366(0.64); C475(0.64); C372(0.75)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C173(0.73); C213(1.28); C366(0.82); C372(0.79)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C173(0.59); C213(1.29); C366(0.71); C372(0.75)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C173(0.87); C213(1.21); C366(0.80); C372(0.90)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C173(0.81); C213(1.25); C366(0.82); C372(0.78)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C475(0.73); C366(0.84); C173(0.91); C398(0.93)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C398(0.88); C475(0.90); C366(0.97); C213(0.98)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C475(0.90); C366(0.93); C213(0.96); C372(0.96)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C372(0.89); C366(0.96); C173(1.00); C213(1.05)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C475(0.69); C366(0.82); C455(0.88); C398(0.89)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C475(0.75); C173(0.84); C366(0.93); C398(0.97)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C475(0.73); C366(0.89); C173(0.90); C455(0.92)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C475(0.76); C366(0.87); C173(0.91); C398(1.00)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C366(0.99); C372(1.03); C173(1.03); C213(1.06)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C475(0.73); C173(0.76); C366(0.84); C398(0.91)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C173(0.89); C366(0.91); C455(0.96); C475(0.98)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C475(0.74); C366(0.75); C173(0.75); C455(0.80)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C455(0.87); C475(0.92); C173(0.94); C398(0.99)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C173(0.85); C455(0.90); C366(0.99); C398(1.05)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C372(1.06); C173(1.17); C366(1.26); C398(1.34)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C455(0.64); C173(0.72); C366(0.76); C475(0.76)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C366(0.77); C173(0.80); C455(0.85); C475(0.87)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C173(0.79); C455(0.80); C366(0.85); C398(0.97)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C173(0.82); C366(0.82); C475(0.85); C455(0.89)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C173(0.77); C366(0.79); C475(0.81); C455(0.88)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C213(0.91); C366(0.92); C398(0.98); C475(1.06)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C455(0.87); C213(0.87); C366(0.90); C372(1.04)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C366(0.70); C475(0.88); C398(1.01); C455(1.02)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C455(0.91); C213(0.92); C366(0.93); C475(1.01)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C366(0.79); C475(0.85); C398(0.87); C455(0.95)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C372(0.90); C366(1.07); C173(1.12); C455(1.24)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C366(0.74); C475(0.78); C213(0.89); C398(0.91)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C366(0.92); C455(0.94); C213(0.95); C398(1.03)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C455(0.97); C213(1.01); C475(1.05); C398(1.05)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C475(0.78); C366(0.79); C398(0.84); C455(0.86)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C475(1.02); C366(1.02); C213(1.03); C398(1.07)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C366(0.81); C475(0.83); C398(0.93); C213(1.00)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C213(0.89); C173(1.04); C455(1.06); C398(1.08)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C455(0.80); C366(0.96); C173(0.97); C398(1.00)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C455(0.86); C475(0.95); C173(0.96); C366(1.04)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C455(0.69); C475(0.82); C366(0.82); C173(0.88)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C372(0.91); C366(1.02); C173(1.12); C455(1.18)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C455(0.81); C475(0.85); C173(0.86); C366(0.87)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C213(0.98); C173(1.17); C475(1.21); C372(1.36)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C455(0.76); C475(0.78); C173(0.91); C366(0.95)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C455(0.86); C475(0.89); C173(0.94); C366(0.95)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C475(0.80); C455(0.81); C398(0.82); C366(0.83)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C455(0.65); C475(0.69); C173(0.78); C366(0.82)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C475(0.64); C455(0.65); C173(0.71); C366(0.74)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C366(0.55); C475(0.69); C173(0.77); C455(0.81)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C366(0.56); C455(0.71); C475(0.73); C173(0.76)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C366(0.53); C475(0.66); C398(0.75); C173(0.80)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C366(0.69); C475(0.71); C455(0.79); C173(0.87)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C366(0.56); C475(0.68); C455(0.68); C173(0.79)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C366(0.61); C475(0.67); C173(0.75); C455(0.83)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C366(0.66); C475(0.75); C455(0.86); C173(0.89)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C366(0.49); C475(0.66); C173(0.70); C398(0.86)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C366(0.55); C475(0.71); C173(0.81); C398(0.94)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C366(0.55); C475(0.64); C398(0.81); C372(0.82)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C366(0.54); C475(0.65); C398(0.76); C173(0.78)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C366(0.41); C475(0.52); C398(0.59); C173(0.67)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C366(0.96); C213(0.96); C475(0.98); C173(0.99)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C173(0.91); C475(0.92); C455(0.97); C366(0.99)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C366(0.61); C475(0.68); C455(0.69); C173(0.78)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C173(0.84); C475(0.87); C366(0.91); C398(0.94)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C173(1.05); C366(1.16); C475(1.20); C455(1.26)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C475(0.84); C173(0.89); C455(0.92); C366(0.99)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C173(0.77); C475(0.79); C366(0.82); C398(0.92)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C475(0.69); C455(0.73); C366(0.75); C173(0.75)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C475(0.66); C366(0.73); C173(0.74); C455(0.83)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C173(0.92); C366(0.98); C475(1.05); C455(1.11)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C475(0.81); C366(0.83); C173(0.85); C455(0.90)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C475(0.79); C173(0.83); C366(0.86); C455(0.92)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C455(0.85); C366(0.85); C475(0.86); C173(0.87)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C366(0.68); C475(0.74); C455(0.75); C398(0.84)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C475(0.81); C366(0.96); C173(0.96); C398(1.13)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C366(0.84); C173(0.84); C475(1.01); C455(1.04)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C475(0.57); C455(0.69); C398(0.73); C366(0.74)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C366(0.76); C372(0.83); C173(0.84); C475(0.85)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C366(0.78); C173(0.79); C372(0.82); C398(1.00)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C372(0.77); C173(0.78); C366(0.87); C398(0.98)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C372(0.76); C173(0.83); C366(1.05); C455(1.10)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C173(0.90); C372(1.04); C213(1.21); C366(1.22)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C173(0.94); C372(1.02); C366(1.28); C213(1.42)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C173(0.82); C372(0.89); C366(1.02); C455(1.07)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C173(0.99); C372(1.00); C475(1.16); C398(1.20)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C173(0.73); C366(0.96); C475(1.05); C372(1.09)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C173(0.76); C372(0.93); C366(1.00); C475(1.22)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C173(0.78); C372(0.86); C366(1.08); C398(1.17)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C173(0.77); C372(0.86); C366(1.14); C398(1.37)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C173(0.81); C372(0.96); C366(1.13); C455(1.15)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C372(0.76); C173(0.77); C366(0.96); C213(1.17)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C173(0.73); C372(0.77); C475(0.99); C366(1.00)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C455(0.31); C475(0.41); C366(0.43); C173(0.46)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C455(0.69); C213(0.73); C173(0.78); C366(0.80)  LDD0683  [19]
 LDCM0545  Acetamide MDA-MB-231 C372(0.81); C398(0.94); C455(0.48); C40(0.63)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C372(0.63); C398(0.88); C455(0.77); C40(0.75)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C173(0.78); C213(0.94); C366(0.71); C372(1.04)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C475(0.54); C366(0.58); C173(0.68); C455(0.81)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C366(0.54); C475(0.61); C455(0.64); C173(0.71)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C173(1.02); C455(1.00); C213(0.92); C475(0.90)  LDD0078  [19]
 LDCM0498  BS-3668 MDA-MB-231 C398(1.11); C455(0.60); C40(0.78); C213(0.95)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C366(0.00); C173(0.00); C213(0.00); C475(0.00)  LDD0222  [36]
 LDCM0632  CL-Sc Hep-G2 C398(20.00); C366(2.13); C213(2.06); C173(1.13)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C372(0.92); C398(1.01); C475(1.02); C213(1.06)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C173(0.92); C475(0.95); C398(0.95); C366(0.96)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C366(1.06); C173(1.15); C398(1.16); C372(1.19)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C366(0.51); C475(0.55); C455(0.68); C173(0.70)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C366(0.66); C475(0.67); C173(0.81); C455(0.81)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C475(0.65); C455(0.71); C366(0.73); C173(0.75)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C366(0.61); C475(0.64); C455(0.74); C173(0.76)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C475(0.74); C366(0.75); C398(0.84); C455(0.86)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C475(0.76); C398(0.86); C173(0.89); C455(0.93)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C455(0.88); C475(0.93); C398(0.94); C366(0.95)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C398(0.87); C366(0.92); C475(0.95); C173(0.98)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C475(0.80); C366(0.81); C173(0.91); C372(0.91)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C173(0.84); C475(0.86); C366(0.87); C398(0.95)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C366(0.82); C475(0.92); C398(0.95); C173(0.97)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C366(0.74); C372(0.79); C475(0.82); C213(0.83)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C173(0.86); C398(0.95); C455(0.96); C213(1.00)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C455(0.72); C366(0.74); C173(0.81); C475(0.89)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C366(0.71); C475(0.76); C173(0.79); C455(0.81)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C455(0.66); C366(0.67); C475(0.70); C173(0.70)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C173(0.74); C475(0.76); C366(0.79); C455(0.84)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C475(0.69); C366(0.80); C398(0.82); C455(0.95)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C366(0.82); C398(0.93); C455(0.97); C213(0.98)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C366(0.67); C475(0.77); C398(0.83); C455(0.91)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C173(0.81); C475(0.91); C372(0.93); C455(0.99)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C366(0.77); C455(0.78); C475(0.78); C398(0.85)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C455(0.55); C366(0.74); C475(0.90); C398(0.91)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C455(0.52); C475(0.70); C366(0.78); C173(0.79)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C455(0.76); C366(0.85); C173(0.90); C398(0.93)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C455(0.67); C475(0.70); C366(0.78); C173(0.84)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C366(0.58); C475(0.64); C455(0.77); C173(0.82)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C366(0.63); C455(0.77); C372(0.79); C398(0.83)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C366(0.65); C475(0.74); C455(0.77); C372(0.82)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C366(0.61); C475(0.69); C455(0.75); C173(0.80)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C173(0.81); C366(0.89); C455(0.89); C475(0.90)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C372(0.94); C173(1.00); C455(1.07); C475(1.13)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C173(0.80); C475(0.88); C366(0.89); C455(0.93)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C475(0.70); C398(0.78); C455(0.78); C366(0.82)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C475(0.56); C398(0.72); C366(0.74); C173(0.81)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C475(0.54); C366(0.69); C173(0.71); C398(0.75)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C475(0.69); C366(0.77); C173(0.79); C455(0.85)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C372(0.88); C475(1.04); C173(1.07); C398(1.10)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C475(0.71); C455(0.78); C173(0.81); C372(0.84)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C475(0.63); C173(0.74); C366(0.75); C455(0.85)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C475(0.59); C366(0.72); C173(0.75); C398(0.78)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C398(0.90); C475(0.91); C372(0.93); C173(0.95)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C475(0.65); C173(0.89); C366(0.90); C398(0.92)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C173(0.84); C213(1.40); C366(0.82); C372(0.83)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C173(0.94); C213(1.28); C366(1.01); C372(0.79)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C173(0.84); C213(1.33); C366(0.92); C372(0.90)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C173(0.76); C213(1.04); C366(0.89); C372(0.73)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C173(0.76); C213(1.05); C366(0.75); C372(0.86)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C173(1.10); C213(1.23); C366(1.24); C372(0.95)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C173(0.79); C213(0.90); C366(0.89); C372(0.93)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C173(0.95); C213(1.20); C366(0.98); C372(0.85)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C173(0.86); C213(1.02); C366(0.84); C372(0.94)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C173(0.85); C213(1.01); C366(0.85); C372(1.05)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C173(0.79); C213(1.20); C366(0.71); C372(1.02)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C173(0.96); C213(1.22); C366(0.87); C372(1.14)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C173(0.95); C213(1.14); C366(0.89); C372(0.93)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C173(0.85); C213(1.19); C366(0.82); C372(0.95)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C173(0.85); C213(0.97); C366(0.81); C372(0.91)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C173(0.96); C213(1.11); C366(1.23); C372(0.86)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C173(0.89); C213(1.16); C366(0.77); C372(0.94)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C173(0.98); C213(1.17); C366(0.97); C372(1.07)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C173(0.80); C213(1.17); C366(0.70); C372(1.47)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C173(0.85); C213(1.10); C366(0.86); C372(0.96)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C173(0.73); C213(1.31); C366(0.78); C372(0.99)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C173(0.77); C213(1.30); C366(0.76); C372(1.06)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C173(0.98); C213(0.96); C366(0.95); C372(0.85)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C173(1.10); C213(0.94); C366(0.78); C372(0.87)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C173(1.15); C213(1.18); C366(1.05); C372(0.93)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C173(0.88); C213(0.99); C366(1.05); C372(1.21)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C173(0.99); C213(1.09); C366(1.16); C372(0.90)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C173(1.04); C213(1.05); C366(1.20); C372(1.18)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C173(1.07); C213(1.05); C366(1.06); C372(0.84)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C173(0.98); C213(0.93); C366(1.02); C372(0.94)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C173(0.93); C213(0.93); C366(0.91); C372(0.75)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C173(1.19); C213(1.15); C366(1.07); C372(1.06)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C173(1.34); C213(1.01); C366(1.02); C372(1.19)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C173(0.96); C213(0.92); C366(0.85); C372(1.04)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C173(0.92); C213(1.01); C366(0.92); C372(0.88)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C173(0.95); C213(1.00); C366(0.98); C372(0.90)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C173(1.14); C213(1.12); C366(1.03); C372(0.86)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C173(0.84); C213(0.99); C366(0.95); C372(0.92)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C173(1.13); C213(1.09); C366(1.09); C372(0.96)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C173(1.06); C213(1.04); C366(0.94); C372(0.92)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C173(1.27); C213(1.03); C366(1.18); C372(0.90)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C173(1.23); C213(1.02); C366(0.96); C372(0.86)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C173(0.98); C213(1.00); C366(0.83); C372(1.12)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C173(1.07); C213(1.09); C366(0.92); C372(1.04)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C173(1.07); C213(1.09); C366(0.85); C372(1.04)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C173(1.03); C213(1.02); C366(0.86); C372(0.99)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C173(1.09); C213(0.91); C366(0.79); C372(1.06)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C173(0.89); C213(0.93); C366(0.85); C372(0.83)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C173(0.97); C213(1.26); C366(1.16); C372(1.12)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C173(1.05); C213(1.01); C366(0.89); C372(0.94)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C173(1.09); C213(1.00); C366(0.90); C372(0.88)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C173(0.96); C213(0.90); C366(0.81); C372(0.80)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C173(0.95); C213(0.91); C366(0.80); C372(0.89)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C173(1.07); C213(0.95); C366(0.97); C372(0.93)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C173(0.66); C213(0.72); C366(0.68); C372(1.00)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C173(0.65); C213(0.80); C366(0.62); C372(1.13)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C173(0.70); C213(0.82); C366(0.71); C372(0.88)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C173(0.72); C213(0.92); C366(0.75); C372(1.17)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C173(0.82); C213(1.00); C366(0.76); C372(0.85)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C173(0.64); C213(0.75); C366(0.77); C372(1.18)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C173(0.75); C213(0.97); C366(0.84); C372(1.07)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C173(0.67); C213(0.93); C366(0.71); C372(1.10)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C173(0.66); C213(0.82); C366(0.69); C372(1.08)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C173(0.60); C213(0.73); C366(0.64); C372(1.04)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C173(0.74); C213(0.82); C366(0.72); C372(1.08)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C173(0.75); C213(0.79); C366(0.67); C372(0.93)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C173(0.68); C213(0.82); C366(0.69); C372(1.04)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C173(0.74); C213(0.94); C366(0.76); C372(1.12)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C173(0.61); C213(0.72); C366(0.66); C372(0.89)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C173(0.94); C213(1.22); C366(1.05); C372(0.88)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C173(0.80); C213(0.84); C366(0.97); C372(0.88)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C173(1.00); C213(1.15); C366(0.96); C372(0.75)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C173(1.00); C213(1.07); C366(0.97); C372(0.99)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C173(0.99); C213(1.00); C366(0.95); C372(0.95)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C173(0.98); C213(1.15); C366(1.00); C372(0.90)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C173(0.96); C213(1.10); C366(0.87); C372(0.80)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C173(0.94); C213(1.00); C366(0.81); C372(0.90)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C173(0.99); C213(1.09); C366(0.86); C372(0.91)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C173(1.06); C213(1.27); C366(1.06); C372(0.85)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C173(1.13); C213(1.16); C366(0.95); C372(1.11)  LDD0811  [19]
 LDCM0634  CY-0357 Hep-G2 C455(1.58); C398(0.89); C213(0.72)  LDD2228  [28]
 LDCM0495  E2913 HEK-293T C398(0.87); C372(0.65); C475(0.95); C213(0.95)  LDD1698  [45]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C455(3.23); C372(2.26); C40(2.06); C366(1.26)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa C455(0.92)  LDD2210  [15]
 LDCM0625  F8 Ramos C372(1.11); C398(1.61); C213(1.07); C173(0.62)  LDD2187  [46]
 LDCM0572  Fragment10 Ramos C372(0.95); C398(1.12); C213(1.48); C173(1.68)  LDD2189  [46]
 LDCM0573  Fragment11 Ramos C372(0.02); C398(0.05); C213(0.03); C173(1.74)  LDD2190  [46]
 LDCM0574  Fragment12 Ramos C372(1.13); C398(0.79); C213(2.16); C173(2.55)  LDD2191  [46]
 LDCM0575  Fragment13 Ramos C372(1.03); C398(0.89); C213(1.23); C173(2.10)  LDD2192  [46]
 LDCM0576  Fragment14 Ramos C372(1.99); C398(1.53); C213(2.13); C173(0.99)  LDD2193  [46]
 LDCM0579  Fragment20 Ramos C372(1.21); C398(1.23); C213(2.50); C173(3.15)  LDD2194  [46]
 LDCM0580  Fragment21 Ramos C372(1.01); C398(0.74); C213(1.08); C173(1.17)  LDD2195  [46]
 LDCM0582  Fragment23 Ramos C372(0.57); C398(0.70); C213(0.80); C173(0.78)  LDD2196  [46]
 LDCM0578  Fragment27 Ramos C372(0.95); C398(0.85); C213(0.97); C173(1.93)  LDD2197  [46]
 LDCM0586  Fragment28 Ramos C372(1.24); C398(0.90); C213(0.88); C173(0.95)  LDD2198  [46]
 LDCM0588  Fragment30 Ramos C372(1.02); C398(0.84); C213(1.18); C173(1.80)  LDD2199  [46]
 LDCM0589  Fragment31 Ramos C372(1.42); C398(0.82); C213(1.39); C173(2.15)  LDD2200  [46]
 LDCM0590  Fragment32 Ramos C372(0.92); C398(0.53); C213(1.92); C173(1.44)  LDD2201  [46]
 LDCM0468  Fragment33 HCT 116 C173(1.13); C213(0.95); C366(0.81); C372(0.81)  LDD0785  [19]
 LDCM0596  Fragment38 Ramos C372(0.99); C398(0.66); C213(1.10); C173(1.50)  LDD2203  [46]
 LDCM0566  Fragment4 Ramos C372(1.57); C398(1.61); C213(1.88); C173(1.25)  LDD2184  [46]
 LDCM0427  Fragment51 HCT 116 C173(0.73); C213(1.07); C366(0.63); C372(0.98)  LDD0744  [19]
 LDCM0610  Fragment52 Ramos C372(4.00); C398(1.09); C213(1.34); C173(1.36)  LDD2204  [46]
 LDCM0614  Fragment56 Ramos C372(1.19); C398(1.22); C213(1.18); C173(0.99)  LDD2205  [46]
 LDCM0569  Fragment7 Ramos C372(1.48); C398(1.08); C213(1.89); C173(0.80)  LDD2186  [46]
 LDCM0571  Fragment9 Ramos C372(1.22); C398(1.16); C213(2.23); C173(2.92)  LDD2188  [46]
 LDCM0116  HHS-0101 DM93 Y359(1.67); Y247(1.77)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y359(0.88); Y247(1.55)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y359(0.42); Y247(0.63)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y247(0.63); Y359(0.73)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y359(0.37); Y247(0.53)  LDD0268  [17]
 LDCM0015  HNE MDA-MB-231 C455(0.99)  LDD0346  [46]
 LDCM0107  IAA HeLa C173(0.00); C475(0.00); H420(0.00); C213(0.00)  LDD0221  [36]
 LDCM0123  JWB131 DM93 Y247(0.82); Y359(0.72)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y247(1.13); Y359(0.66)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y247(1.07); Y359(0.85)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y247(3.60); Y359(2.46)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y247(1.84); Y359(1.96)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y247(0.74); Y359(0.62)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y247(0.46); Y359(0.53)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y247(0.75); Y359(0.87)  LDD0292  [16]
 LDCM0022  KB02 HCT 116 C372(2.12); C475(1.48); C366(1.51); C213(1.36)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C372(2.78); C475(1.44); C366(2.01); C213(1.68)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C372(3.46); C475(2.41); C366(1.92); C213(1.47)  LDD0082  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C372(1.01); C455(1.27); C40(1.94)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C372(1.03); C398(1.07); C455(0.73); C40(1.04)  LDD2121  [9]
 LDCM0109  NEM HeLa H420(0.00); H302(0.00); C455(0.00); H526(0.00)  LDD0223  [36]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C372(1.02); C398(1.15); C455(0.76); C40(1.09)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C398(1.26); C455(1.11)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C372(1.22); C455(1.16); C40(1.46); C213(1.06)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C372(1.16); C398(1.41); C455(1.10); C40(1.51)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C372(1.98)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C372(0.28); C398(0.70); C40(0.14); C475(0.25)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C372(0.65); C398(0.93); C455(0.68); C40(0.98)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C372(0.91); C455(0.56); C40(0.81)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C372(1.16); C398(1.67); C455(1.13); C40(1.64)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C398(0.30); C455(0.25); C213(0.63)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C398(0.97); C455(1.05); C40(0.83)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C398(0.43); C455(0.48); C213(0.67)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C372(1.49); C455(1.88); C40(1.10); C213(1.08)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C372(0.49); C398(0.53); C455(0.98); C40(0.41)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C372(0.80); C398(1.26); C455(0.91); C40(0.97)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C398(0.53); C455(0.23); C40(0.55); C213(0.76)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C372(0.72); C398(0.66); C455(0.56); C40(0.66)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C372(0.61); C398(0.73); C40(0.39); C213(0.67)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C372(0.93); C398(1.46); C455(1.03); C40(1.13)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C398(0.53); C40(0.39); C213(0.59)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C398(0.47); C455(0.47); C40(0.39)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C372(0.43); C40(0.30)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C372(0.56); C40(0.58)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C372(1.60); C398(1.79); C455(2.37); C40(1.60)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C372(0.73); C455(0.87); C40(0.51); C213(0.91)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C372(0.46); C398(0.11); C40(0.28)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C372(0.95); C398(1.19); C455(0.84); C40(1.01)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C372(0.47); C40(0.19); C366(0.73)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C372(0.86); C398(1.10); C455(0.78); C40(1.04)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C372(0.39); C455(0.03); C40(0.19)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C372(1.05); C398(1.68); C455(0.96); C40(1.16)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C455(0.75); C40(0.69); C213(0.83)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C372(1.27); C398(1.77); C455(1.30); C40(1.39)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C372(0.58); C398(0.55); C455(0.64); C40(0.46)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C372(0.40); C398(0.44); C455(0.45); C40(0.46)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C372(1.39); C398(2.24); C455(1.40); C40(1.51)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C372(1.21); C398(1.67); C455(1.25); C40(1.48)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C372(0.94); C398(1.24); C455(0.95); C40(0.99)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C398(4.47); C455(2.85); C372(2.55)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C372(1.01); C398(1.18); C455(0.81); C40(1.22)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C455(0.16); C40(0.51); C213(0.52)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C455(0.90); C40(0.43)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C372(1.98); C398(2.26); C455(2.50); C40(1.90)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C372(2.68); C455(0.40); C40(0.55)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C372(0.86); C398(1.11); C455(0.91); C40(1.07)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C455(2.19); C40(1.04)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C398(0.40); C455(0.46)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C372(0.40); C398(0.48); C455(0.05); C40(0.23)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C398(0.76); C455(0.53); C40(0.64); C213(0.89)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C372(0.46); C398(0.61); C455(0.10); C40(0.21)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C40(1.44)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C398(1.81); C213(1.00); C372(0.77); C475(0.53)  LDD2206  [47]
 LDCM0628  OTUB2-COV-1 HEK-293T C173(1.35); C398(1.22); C213(1.09); C455(1.00)  LDD2207  [47]
 LDCM0131  RA190 MM1.R C398(1.49); C213(1.48); C455(1.41); C173(1.35)  LDD0304  [48]
 LDCM0021  THZ1 HeLa S3 C182(1.12); C366(1.12); C213(1.06); C455(1.08)  LDD0460  [13]
 LDCM0111  W14 Hep-G2 S297(1.42)  LDD0238  [37]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Ubiquitin-conjugating enzyme E2 Z (UBE2Z) Ubiquitin-conjugating enzyme family Q9H832
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosducin-like protein (PDCL) Phosducin family Q13371
Polycomb protein EED (EED) WD repeat ESC family O75530
Gem-associated protein 4 (GEMIN4) . P57678
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Protein ZNRD2 (ZNRD2) . O60232

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphoaminophosphonic Acid-adenylate Ester . DB04395

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
22 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
23 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
24 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
25 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
26 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
27 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
31 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
32 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
33 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
34 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
35 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
36 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
37 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
38 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
39 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
40 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
41 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
42 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
43 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
44 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
45 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
46 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
47 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
48 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.