Details of the Target

General Information of Target

Target ID LDTP06367
Target Name Poly(rC)-binding protein 2 (PCBP2)
Gene Name PCBP2
Gene ID 5094
Synonyms
Poly(rC)-binding protein 2; Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2; hnRNP E2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIIT
LAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKI
KEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLETLSQSPPKGVTI
PYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQ
PDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWGLDASAQTTSHELTIPNDLIG
CIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETG
GMGSS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Acts as a negative regulator of antiviral signaling. Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated. Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing.; (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD.
Uniprot ID
Q15366
Ensemble ID
ENST00000359282.9
HGNC ID
HGNC:8648
ChEMBL ID
CHEMBL4295826

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
11RK72
 Probe Info  		3.49  LDD0327  [2]
11RK73
 Probe Info  		3.14  LDD0328  [2]
CHEMBL5175495
 Probe Info  		6.78  LDD0196  [3]
CY-1
 Probe Info  		14.21  LDD0243  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y182(20.00); Y278(5.05)  LDD0257  [5]
TH214
 Probe Info  		Y182(20.00)  LDD0258  [5]
TH216
 Probe Info  		Y182(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
AZ-9
 Probe Info  		E56(1.00)  LDD2208  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K309(3.28); K322(4.37)  LDD3494  [9]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [10]
THZ1-DTB
 Probe Info  		C109(1.08); C217(1.12)  LDD0460  [10]
Sulforaphane-probe2
 Probe Info  		2.22  LDD0042  [11]
AHL-Pu-1
 Probe Info  		C217(10.66)  LDD0170  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
DBIA
 Probe Info  		C301(9.42); C158(142.17)  LDD0209  [14]
HHS-482
 Probe Info  		Y182(0.86)  LDD0285  [15]
HHS-475
 Probe Info  		Y349(0.75); Y236(0.90); Y278(1.00); Y200(1.09)  LDD0264  [16]
HHS-465
 Probe Info  		Y182(10.00); Y278(5.34); Y349(2.90)  LDD2237  [17]
5E-2FA
 Probe Info  		H260(0.00); H255(0.00)  LDD2235  [18]
AMP probe
 Probe Info  		K115(0.00); K119(0.00)  LDD0200  [19]
ATP probe
 Probe Info  		K115(0.00); K119(0.00); K185(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C158(0.00); C301(0.00); C109(0.00); C163(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		C54(0.00); C109(0.00); C158(0.00)  LDD0032  [21]
IPIAA_H
 Probe Info  		C54(0.00); C158(0.00)  LDD0030  [22]
IPIAA_L
 Probe Info  		C301(0.00); C109(0.00); C158(0.00); C54(0.00)  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		C158(0.00); C301(0.00); C109(0.00); C163(0.00)  LDD0037  [20]
ATP probe
 Probe Info  		N.A.  LDD0035  [23]
BTD
 Probe Info  		N.A.  LDD0004  [24]
JW-RF-010
 Probe Info  		C109(0.00); C217(0.00); C118(0.00); C163(0.00)  LDD0026  [25]
NAIA_4
 Probe Info  		C301(0.00); C158(0.00); C54(0.00); C109(0.00)  LDD2226  [26]
TFBX
 Probe Info  		C158(0.00); C54(0.00); C163(0.00); C118(0.00)  LDD0027  [25]
WYneN
 Probe Info  		C54(0.00); C158(0.00); C109(0.00)  LDD0021  [24]
Compound 10
 Probe Info  		C109(0.00); C158(0.00)  LDD2216  [27]
Compound 11
 Probe Info  		N.A.  LDD2213  [27]
IPM
 Probe Info  		C54(0.00); C158(0.00); C109(0.00)  LDD0005  [24]
NHS
 Probe Info  		K322(0.00); K185(0.00); K23(0.00); K309(0.00)  LDD0010  [24]
PF-06672131
 Probe Info  		C109(0.00); C158(0.00)  LDD0017  [28]
SF
 Probe Info  		Y182(0.00); K37(0.00); K31(0.00); K185(0.00)  LDD0028  [29]
STPyne
 Probe Info  		N.A.  LDD0009  [24]
VSF
 Probe Info  		C54(0.00); C158(0.00); C109(0.00)  LDD0007  [24]
Phosphinate-6
 Probe Info  		C217(0.00); C54(0.00); C118(0.00); C109(0.00)  LDD0018  [30]
1c-yne
 Probe Info  		K322(0.00); K185(0.00); K78(0.00)  LDD0228  [31]
Acrolein
 Probe Info  		H247(0.00); H260(0.00); C158(0.00); H255(0.00)  LDD0217  [32]
Methacrolein
 Probe Info  		C158(0.00); K119(0.00)  LDD0218  [32]
W1
 Probe Info  		N.A.  LDD0236  [33]
AOyne
 Probe Info  		5.00  LDD0443  [34]
NAIA_5
 Probe Info  		C158(0.00); C118(0.00); C109(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.54  LDD0475  [35]
FFF probe2
 Probe Info  		7.52  LDD0463  [35]
FFF probe3
 Probe Info  		7.76  LDD0464  [35]
STS-2
 Probe Info  		3.90  LDD0138  [36]
VE-P
 Probe Info  		N.A.  LDD0396  [37]
DA-2
 Probe Info  		N.A.  LDD0073  [38]
OEA-DA
 Probe Info  		3.37  LDD0046  [39]
STS-1
 Probe Info  		N.A.  LDD0068  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C217(10.66)  LDD0170  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C217(2.29)  LDD0372  [12]
 LDCM0214  AC1 HEK-293T C301(1.15)  LDD0812  [41]
 LDCM0215  AC10 HEK-293T C301(0.82)  LDD0813  [41]
 LDCM0216  AC100 HEK-293T C301(0.98)  LDD0814  [41]
 LDCM0217  AC101 HEK-293T C301(0.96)  LDD0815  [41]
 LDCM0218  AC102 HEK-293T C301(1.09)  LDD0816  [41]
 LDCM0219  AC103 HEK-293T C301(0.96)  LDD0817  [41]
 LDCM0220  AC104 HEK-293T C301(0.84)  LDD0818  [41]
 LDCM0221  AC105 HEK-293T C301(1.13)  LDD0819  [41]
 LDCM0222  AC106 HEK-293T C301(1.25)  LDD0820  [41]
 LDCM0223  AC107 HEK-293T C301(1.24)  LDD0821  [41]
 LDCM0224  AC108 HEK-293T C301(1.19)  LDD0822  [41]
 LDCM0225  AC109 HEK-293T C301(1.00)  LDD0823  [41]
 LDCM0226  AC11 HEK-293T C301(1.00)  LDD0824  [41]
 LDCM0227  AC110 HEK-293T C301(0.88)  LDD0825  [41]
 LDCM0228  AC111 HEK-293T C301(0.80)  LDD0826  [41]
 LDCM0229  AC112 HEK-293T C301(0.83)  LDD0827  [41]
 LDCM0230  AC113 HEK-293T C301(1.08)  LDD0828  [41]
 LDCM0231  AC114 HEK-293T C301(0.93)  LDD0829  [41]
 LDCM0232  AC115 HEK-293T C301(1.07)  LDD0830  [41]
 LDCM0233  AC116 HEK-293T C301(0.83)  LDD0831  [41]
 LDCM0234  AC117 HEK-293T C301(0.84)  LDD0832  [41]
 LDCM0235  AC118 HEK-293T C301(0.80)  LDD0833  [41]
 LDCM0236  AC119 HEK-293T C301(0.74)  LDD0834  [41]
 LDCM0237  AC12 HEK-293T C301(1.10)  LDD0835  [41]
 LDCM0238  AC120 HEK-293T C301(0.76)  LDD0836  [41]
 LDCM0239  AC121 HEK-293T C301(0.83)  LDD0837  [41]
 LDCM0240  AC122 HEK-293T C301(0.89)  LDD0838  [41]
 LDCM0241  AC123 HEK-293T C301(0.89)  LDD0839  [41]
 LDCM0242  AC124 HEK-293T C301(0.82)  LDD0840  [41]
 LDCM0243  AC125 HEK-293T C301(0.92)  LDD0841  [41]
 LDCM0244  AC126 HEK-293T C301(0.77)  LDD0842  [41]
 LDCM0245  AC127 HEK-293T C301(0.79)  LDD0843  [41]
 LDCM0246  AC128 HEK-293T C301(1.53)  LDD0844  [41]
 LDCM0247  AC129 HEK-293T C301(0.89)  LDD0845  [41]
 LDCM0249  AC130 HEK-293T C301(0.85)  LDD0847  [41]
 LDCM0250  AC131 HEK-293T C301(1.05)  LDD0848  [41]
 LDCM0251  AC132 HEK-293T C301(1.25)  LDD0849  [41]
 LDCM0252  AC133 HEK-293T C301(0.85)  LDD0850  [41]
 LDCM0253  AC134 HEK-293T C301(0.89)  LDD0851  [41]
 LDCM0254  AC135 HEK-293T C301(1.18)  LDD0852  [41]
 LDCM0255  AC136 HEK-293T C301(0.91)  LDD0853  [41]
 LDCM0256  AC137 HEK-293T C301(1.04)  LDD0854  [41]
 LDCM0257  AC138 HEK-293T C301(0.96)  LDD0855  [41]
 LDCM0258  AC139 HEK-293T C301(0.95)  LDD0856  [41]
 LDCM0259  AC14 HEK-293T C301(0.83)  LDD0857  [41]
 LDCM0260  AC140 HEK-293T C301(0.97)  LDD0858  [41]
 LDCM0261  AC141 HEK-293T C301(1.11)  LDD0859  [41]
 LDCM0262  AC142 HEK-293T C301(1.06)  LDD0860  [41]
 LDCM0263  AC143 HEK-293T C301(1.77)  LDD0861  [41]
 LDCM0264  AC144 HEK-293T C301(0.98)  LDD0862  [41]
 LDCM0265  AC145 HEK-293T C301(1.14)  LDD0863  [41]
 LDCM0266  AC146 HEK-293T C301(1.00)  LDD0864  [41]
 LDCM0267  AC147 HEK-293T C301(1.10)  LDD0865  [41]
 LDCM0268  AC148 HEK-293T C301(1.52)  LDD0866  [41]
 LDCM0269  AC149 HEK-293T C301(1.48)  LDD0867  [41]
 LDCM0270  AC15 HEK-293T C301(0.80)  LDD0868  [41]
 LDCM0271  AC150 HEK-293T C301(1.33)  LDD0869  [41]
 LDCM0272  AC151 HEK-293T C301(1.15)  LDD0870  [41]
 LDCM0273  AC152 HEK-293T C301(1.33)  LDD0871  [41]
 LDCM0274  AC153 HEK-293T C301(1.23)  LDD0872  [41]
 LDCM0621  AC154 HEK-293T C301(1.30)  LDD2162  [41]
 LDCM0622  AC155 HEK-293T C301(1.31)  LDD2163  [41]
 LDCM0623  AC156 HEK-293T C301(1.25)  LDD2164  [41]
 LDCM0624  AC157 HEK-293T C301(1.25)  LDD2165  [41]
 LDCM0276  AC17 HEK-293T C301(0.47)  LDD0874  [41]
 LDCM0277  AC18 HEK-293T C301(0.74)  LDD0875  [41]
 LDCM0278  AC19 HEK-293T C301(0.67)  LDD0876  [41]
 LDCM0279  AC2 HEK-293T C301(0.85)  LDD0877  [41]
 LDCM0280  AC20 HEK-293T C301(0.58)  LDD0878  [41]
 LDCM0281  AC21 HEK-293T C301(0.54)  LDD0879  [41]
 LDCM0282  AC22 HEK-293T C301(0.63)  LDD0880  [41]
 LDCM0283  AC23 HEK-293T C301(0.52)  LDD0881  [41]
 LDCM0284  AC24 HEK-293T C301(0.67)  LDD0882  [41]
 LDCM0285  AC25 HEK-293T C301(0.75)  LDD0883  [41]
 LDCM0286  AC26 HEK-293T C301(0.72)  LDD0884  [41]
 LDCM0287  AC27 HEK-293T C301(0.69)  LDD0885  [41]
 LDCM0288  AC28 HEK-293T C301(1.10)  LDD0886  [41]
 LDCM0289  AC29 HEK-293T C301(0.73)  LDD0887  [41]
 LDCM0290  AC3 HEK-293T C301(1.08)  LDD0888  [41]
 LDCM0291  AC30 HEK-293T C301(0.66)  LDD0889  [41]
 LDCM0292  AC31 HEK-293T C301(0.72)  LDD0890  [41]
 LDCM0293  AC32 HEK-293T C301(0.65)  LDD0891  [41]
 LDCM0294  AC33 HEK-293T C301(0.74)  LDD0892  [41]
 LDCM0295  AC34 HEK-293T C301(0.68)  LDD0893  [41]
 LDCM0296  AC35 HEK-293T C301(1.33)  LDD0894  [41]
 LDCM0297  AC36 HEK-293T C301(1.10)  LDD0895  [41]
 LDCM0298  AC37 HEK-293T C301(1.12)  LDD0896  [41]
 LDCM0299  AC38 HEK-293T C301(0.98)  LDD0897  [41]
 LDCM0300  AC39 HEK-293T C301(1.16)  LDD0898  [41]
 LDCM0301  AC4 HEK-293T C301(0.97)  LDD0899  [41]
 LDCM0302  AC40 HEK-293T C301(1.10)  LDD0900  [41]
 LDCM0303  AC41 HEK-293T C301(1.01)  LDD0901  [41]
 LDCM0304  AC42 HEK-293T C301(0.91)  LDD0902  [41]
 LDCM0305  AC43 HEK-293T C301(1.23)  LDD0903  [41]
 LDCM0306  AC44 HEK-293T C301(1.00)  LDD0904  [41]
 LDCM0307  AC45 HEK-293T C301(1.00)  LDD0905  [41]
 LDCM0308  AC46 PaTu 8988t C301(1.49)  LDD1187  [41]
 LDCM0309  AC47 PaTu 8988t C301(1.44)  LDD1188  [41]
 LDCM0310  AC48 PaTu 8988t C301(1.03)  LDD1189  [41]
 LDCM0311  AC49 PaTu 8988t C301(1.36)  LDD1190  [41]
 LDCM0312  AC5 HEK-293T C301(0.86)  LDD0910  [41]
 LDCM0313  AC50 PaTu 8988t C301(1.77)  LDD1192  [41]
 LDCM0314  AC51 PaTu 8988t C301(1.25)  LDD1193  [41]
 LDCM0315  AC52 PaTu 8988t C301(1.31)  LDD1194  [41]
 LDCM0316  AC53 PaTu 8988t C301(1.20)  LDD1195  [41]
 LDCM0317  AC54 PaTu 8988t C301(1.55)  LDD1196  [41]
 LDCM0318  AC55 PaTu 8988t C301(1.10)  LDD1197  [41]
 LDCM0319  AC56 PaTu 8988t C301(1.46)  LDD1198  [41]
 LDCM0320  AC57 HEK-293T C301(0.82)  LDD0918  [41]
 LDCM0321  AC58 HEK-293T C301(0.77)  LDD0919  [41]
 LDCM0322  AC59 HEK-293T C301(0.78)  LDD0920  [41]
 LDCM0323  AC6 HEK-293T C301(0.90)  LDD0921  [41]
 LDCM0324  AC60 HEK-293T C301(1.34)  LDD0922  [41]
 LDCM0325  AC61 HEK-293T C301(0.87)  LDD0923  [41]
 LDCM0326  AC62 HEK-293T C301(0.85)  LDD0924  [41]
 LDCM0327  AC63 HEK-293T C301(0.81)  LDD0925  [41]
 LDCM0328  AC64 HEK-293T C301(0.68)  LDD0926  [41]
 LDCM0329  AC65 HEK-293T C301(0.82)  LDD0927  [41]
 LDCM0330  AC66 HEK-293T C301(0.80)  LDD0928  [41]
 LDCM0331  AC67 HEK-293T C301(0.67)  LDD0929  [41]
 LDCM0332  AC68 HEK-293T C301(1.21)  LDD0930  [41]
 LDCM0333  AC69 HEK-293T C301(0.90)  LDD0931  [41]
 LDCM0334  AC7 HEK-293T C301(0.78)  LDD0932  [41]
 LDCM0335  AC70 HEK-293T C301(1.11)  LDD0933  [41]
 LDCM0336  AC71 HEK-293T C301(1.08)  LDD0934  [41]
 LDCM0337  AC72 HEK-293T C301(1.08)  LDD0935  [41]
 LDCM0338  AC73 HEK-293T C301(1.05)  LDD0936  [41]
 LDCM0339  AC74 HEK-293T C301(1.13)  LDD0937  [41]
 LDCM0340  AC75 HEK-293T C301(1.08)  LDD0938  [41]
 LDCM0341  AC76 HEK-293T C301(1.16)  LDD0939  [41]
 LDCM0342  AC77 HEK-293T C301(1.13)  LDD0940  [41]
 LDCM0343  AC78 HEK-293T C301(1.11)  LDD0941  [41]
 LDCM0344  AC79 HEK-293T C301(1.06)  LDD0942  [41]
 LDCM0345  AC8 HEK-293T C301(0.78)  LDD0943  [41]
 LDCM0346  AC80 HEK-293T C301(0.99)  LDD0944  [41]
 LDCM0347  AC81 HEK-293T C301(1.06)  LDD0945  [41]
 LDCM0348  AC82 HEK-293T C301(0.98)  LDD0946  [41]
 LDCM0349  AC83 HEK-293T C301(0.53)  LDD0947  [41]
 LDCM0350  AC84 HEK-293T C301(0.45)  LDD0948  [41]
 LDCM0351  AC85 HEK-293T C301(0.53)  LDD0949  [41]
 LDCM0352  AC86 HEK-293T C301(0.57)  LDD0950  [41]
 LDCM0353  AC87 HEK-293T C301(0.62)  LDD0951  [41]
 LDCM0354  AC88 HEK-293T C301(0.47)  LDD0952  [41]
 LDCM0355  AC89 HEK-293T C301(0.47)  LDD0953  [41]
 LDCM0357  AC90 HEK-293T C301(0.44)  LDD0955  [41]
 LDCM0358  AC91 HEK-293T C301(0.44)  LDD0956  [41]
 LDCM0359  AC92 HEK-293T C301(0.48)  LDD0957  [41]
 LDCM0360  AC93 HEK-293T C301(0.59)  LDD0958  [41]
 LDCM0361  AC94 HEK-293T C301(0.56)  LDD0959  [41]
 LDCM0362  AC95 HEK-293T C301(0.38)  LDD0960  [41]
 LDCM0363  AC96 HEK-293T C301(0.60)  LDD0961  [41]
 LDCM0364  AC97 HEK-293T C301(0.37)  LDD0962  [41]
 LDCM0365  AC98 HEK-293T C301(1.23)  LDD0963  [41]
 LDCM0366  AC99 HEK-293T C301(0.94)  LDD0964  [41]
 LDCM0520  AKOS000195272 MDA-MB-231 C109(0.62)  LDD2113  [42]
 LDCM0248  AKOS034007472 HEK-293T C301(0.81)  LDD0846  [41]
 LDCM0356  AKOS034007680 HEK-293T C301(0.70)  LDD0954  [41]
 LDCM0275  AKOS034007705 HEK-293T C301(0.72)  LDD0873  [41]
 LDCM0156  Aniline NCI-H1299 12.04  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C301(2.06); C217(1.38); C54(1.25)  LDD2214  [43]
 LDCM0108  Chloroacetamide HeLa H247(0.00); H255(0.00); C158(0.00); C163(0.00)  LDD0222  [32]
 LDCM0632  CL-Sc Hep-G2 C109(1.19); C158(0.93); C109(0.72)  LDD2227  [26]
 LDCM0367  CL1 HEK-293T C301(0.81)  LDD0965  [41]
 LDCM0368  CL10 HEK-293T C301(0.81)  LDD0966  [41]
 LDCM0369  CL100 HEK-293T C301(0.88)  LDD0967  [41]
 LDCM0370  CL101 HEK-293T C301(0.63)  LDD0968  [41]
 LDCM0371  CL102 HEK-293T C301(0.67)  LDD0969  [41]
 LDCM0372  CL103 HEK-293T C301(0.73)  LDD0970  [41]
 LDCM0373  CL104 HEK-293T C301(0.72)  LDD0971  [41]
 LDCM0374  CL105 HEK-293T C301(0.69)  LDD0972  [41]
 LDCM0375  CL106 HEK-293T C301(0.66)  LDD0973  [41]
 LDCM0376  CL107 HEK-293T C301(0.57)  LDD0974  [41]
 LDCM0377  CL108 HEK-293T C301(0.68)  LDD0975  [41]
 LDCM0378  CL109 HEK-293T C301(0.59)  LDD0976  [41]
 LDCM0379  CL11 HEK-293T C301(0.77)  LDD0977  [41]
 LDCM0380  CL110 HEK-293T C301(0.57)  LDD0978  [41]
 LDCM0381  CL111 HEK-293T C301(0.56)  LDD0979  [41]
 LDCM0382  CL112 HEK-293T C301(0.68)  LDD0980  [41]
 LDCM0383  CL113 HEK-293T C301(0.74)  LDD0981  [41]
 LDCM0384  CL114 HEK-293T C301(0.65)  LDD0982  [41]
 LDCM0385  CL115 HEK-293T C301(0.58)  LDD0983  [41]
 LDCM0386  CL116 HEK-293T C301(0.61)  LDD0984  [41]
 LDCM0387  CL117 HEK-293T C301(1.55)  LDD0985  [41]
 LDCM0388  CL118 HEK-293T C301(1.15)  LDD0986  [41]
 LDCM0389  CL119 HEK-293T C301(1.03)  LDD0987  [41]
 LDCM0390  CL12 HEK-293T C301(0.88)  LDD0988  [41]
 LDCM0391  CL120 HEK-293T C301(1.24)  LDD0989  [41]
 LDCM0392  CL121 PaTu 8988t C301(1.13)  LDD1271  [41]
 LDCM0393  CL122 PaTu 8988t C301(1.42)  LDD1272  [41]
 LDCM0394  CL123 PaTu 8988t C301(1.23)  LDD1273  [41]
 LDCM0395  CL124 PaTu 8988t C301(1.54)  LDD1274  [41]
 LDCM0396  CL125 HEK-293T C301(0.93)  LDD0994  [41]
 LDCM0397  CL126 HEK-293T C301(0.87)  LDD0995  [41]
 LDCM0398  CL127 HEK-293T C301(0.94)  LDD0996  [41]
 LDCM0399  CL128 HEK-293T C301(1.11)  LDD0997  [41]
 LDCM0400  CL13 HEK-293T C301(0.89)  LDD0998  [41]
 LDCM0401  CL14 HEK-293T C301(0.90)  LDD0999  [41]
 LDCM0402  CL15 HEK-293T C301(0.85)  LDD1000  [41]
 LDCM0403  CL16 HEK-293T C301(1.09)  LDD1001  [41]
 LDCM0404  CL17 HEK-293T C301(1.08)  LDD1002  [41]
 LDCM0405  CL18 HEK-293T C301(1.10)  LDD1003  [41]
 LDCM0406  CL19 HEK-293T C301(0.92)  LDD1004  [41]
 LDCM0407  CL2 HEK-293T C301(0.89)  LDD1005  [41]
 LDCM0408  CL20 HEK-293T C301(1.06)  LDD1006  [41]
 LDCM0409  CL21 HEK-293T C301(1.01)  LDD1007  [41]
 LDCM0410  CL22 HEK-293T C301(0.98)  LDD1008  [41]
 LDCM0411  CL23 HEK-293T C301(1.33)  LDD1009  [41]
 LDCM0412  CL24 HEK-293T C301(1.17)  LDD1010  [41]
 LDCM0413  CL25 HEK-293T C301(1.15)  LDD1011  [41]
 LDCM0414  CL26 HEK-293T C301(1.82)  LDD1012  [41]
 LDCM0415  CL27 HEK-293T C301(1.08)  LDD1013  [41]
 LDCM0416  CL28 HEK-293T C301(1.21)  LDD1014  [41]
 LDCM0417  CL29 HEK-293T C301(1.16)  LDD1015  [41]
 LDCM0418  CL3 HEK-293T C301(0.77)  LDD1016  [41]
 LDCM0419  CL30 HEK-293T C301(1.28)  LDD1017  [41]
 LDCM0420  CL31 HEK-293T C301(0.75)  LDD1018  [41]
 LDCM0421  CL32 HEK-293T C301(0.81)  LDD1019  [41]
 LDCM0422  CL33 HEK-293T C301(0.68)  LDD1020  [41]
 LDCM0423  CL34 HEK-293T C301(0.92)  LDD1021  [41]
 LDCM0424  CL35 HEK-293T C301(0.78)  LDD1022  [41]
 LDCM0425  CL36 HEK-293T C301(1.00)  LDD1023  [41]
 LDCM0426  CL37 HEK-293T C301(0.95)  LDD1024  [41]
 LDCM0428  CL39 HEK-293T C301(0.71)  LDD1026  [41]
 LDCM0429  CL4 HEK-293T C301(0.91)  LDD1027  [41]
 LDCM0430  CL40 HEK-293T C301(0.74)  LDD1028  [41]
 LDCM0431  CL41 HEK-293T C301(0.65)  LDD1029  [41]
 LDCM0432  CL42 HEK-293T C301(0.79)  LDD1030  [41]
 LDCM0433  CL43 HEK-293T C301(0.85)  LDD1031  [41]
 LDCM0434  CL44 HEK-293T C301(0.86)  LDD1032  [41]
 LDCM0435  CL45 HEK-293T C301(0.74)  LDD1033  [41]
 LDCM0436  CL46 HEK-293T C301(0.84)  LDD1034  [41]
 LDCM0437  CL47 HEK-293T C301(1.00)  LDD1035  [41]
 LDCM0438  CL48 HEK-293T C301(0.93)  LDD1036  [41]
 LDCM0439  CL49 HEK-293T C301(0.88)  LDD1037  [41]
 LDCM0440  CL5 HEK-293T C301(0.89)  LDD1038  [41]
 LDCM0441  CL50 HEK-293T C301(1.04)  LDD1039  [41]
 LDCM0442  CL51 HEK-293T C301(1.11)  LDD1040  [41]
 LDCM0443  CL52 HEK-293T C301(1.12)  LDD1041  [41]
 LDCM0444  CL53 HEK-293T C301(1.07)  LDD1042  [41]
 LDCM0445  CL54 HEK-293T C301(1.12)  LDD1043  [41]
 LDCM0446  CL55 HEK-293T C301(1.00)  LDD1044  [41]
 LDCM0447  CL56 HEK-293T C301(1.05)  LDD1045  [41]
 LDCM0448  CL57 HEK-293T C301(0.89)  LDD1046  [41]
 LDCM0449  CL58 HEK-293T C301(0.94)  LDD1047  [41]
 LDCM0450  CL59 HEK-293T C301(0.90)  LDD1048  [41]
 LDCM0451  CL6 HEK-293T C301(0.94)  LDD1049  [41]
 LDCM0452  CL60 HEK-293T C301(0.87)  LDD1050  [41]
 LDCM0453  CL61 HEK-293T C301(1.19)  LDD1051  [41]
 LDCM0454  CL62 HEK-293T C301(0.81)  LDD1052  [41]
 LDCM0455  CL63 HEK-293T C301(0.81)  LDD1053  [41]
 LDCM0456  CL64 HEK-293T C301(1.00)  LDD1054  [41]
 LDCM0457  CL65 HEK-293T C301(0.81)  LDD1055  [41]
 LDCM0458  CL66 HEK-293T C301(0.79)  LDD1056  [41]
 LDCM0459  CL67 HEK-293T C301(0.88)  LDD1057  [41]
 LDCM0460  CL68 HEK-293T C301(0.97)  LDD1058  [41]
 LDCM0461  CL69 HEK-293T C301(1.46)  LDD1059  [41]
 LDCM0462  CL7 HEK-293T C301(0.85)  LDD1060  [41]
 LDCM0463  CL70 HEK-293T C301(0.87)  LDD1061  [41]
 LDCM0464  CL71 HEK-293T C301(0.92)  LDD1062  [41]
 LDCM0465  CL72 HEK-293T C301(1.04)  LDD1063  [41]
 LDCM0466  CL73 HEK-293T C301(0.93)  LDD1064  [41]
 LDCM0467  CL74 HEK-293T C301(0.64)  LDD1065  [41]
 LDCM0469  CL76 HEK-293T C301(0.96)  LDD1067  [41]
 LDCM0470  CL77 HEK-293T C301(0.85)  LDD1068  [41]
 LDCM0471  CL78 HEK-293T C301(0.72)  LDD1069  [41]
 LDCM0472  CL79 HEK-293T C301(0.69)  LDD1070  [41]
 LDCM0473  CL8 HEK-293T C301(0.69)  LDD1071  [41]
 LDCM0474  CL80 HEK-293T C301(0.81)  LDD1072  [41]
 LDCM0475  CL81 HEK-293T C301(0.77)  LDD1073  [41]
 LDCM0476  CL82 HEK-293T C301(1.16)  LDD1074  [41]
 LDCM0477  CL83 HEK-293T C301(1.11)  LDD1075  [41]
 LDCM0478  CL84 HEK-293T C301(0.77)  LDD1076  [41]
 LDCM0479  CL85 HEK-293T C301(0.93)  LDD1077  [41]
 LDCM0480  CL86 HEK-293T C301(0.80)  LDD1078  [41]
 LDCM0481  CL87 HEK-293T C301(0.86)  LDD1079  [41]
 LDCM0482  CL88 HEK-293T C301(0.96)  LDD1080  [41]
 LDCM0483  CL89 HEK-293T C301(0.84)  LDD1081  [41]
 LDCM0484  CL9 HEK-293T C301(0.69)  LDD1082  [41]
 LDCM0485  CL90 HEK-293T C301(0.87)  LDD1083  [41]
 LDCM0486  CL91 HEK-293T C301(0.83)  LDD1084  [41]
 LDCM0487  CL92 HEK-293T C301(0.80)  LDD1085  [41]
 LDCM0488  CL93 HEK-293T C301(0.78)  LDD1086  [41]
 LDCM0489  CL94 HEK-293T C301(0.66)  LDD1087  [41]
 LDCM0490  CL95 HEK-293T C301(0.61)  LDD1088  [41]
 LDCM0491  CL96 HEK-293T C301(0.76)  LDD1089  [41]
 LDCM0492  CL97 HEK-293T C301(0.77)  LDD1090  [41]
 LDCM0493  CL98 HEK-293T C301(0.84)  LDD1091  [41]
 LDCM0494  CL99 HEK-293T C301(0.82)  LDD1092  [41]
 LDCM0634  CY-0357 Hep-G2 C109(1.37); C158(1.01)  LDD2228  [26]
 LDCM0495  E2913 HEK-293T C54(1.06); C109(0.96); C163(1.06); C158(0.93)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C109(0.89); C158(0.85)  LDD1702  [42]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C54(1.11); C109(1.16); C158(0.72); C217(0.51)  LDD2187  [45]
 LDCM0572  Fragment10 Ramos C54(2.47); C109(0.26); C158(0.38); 3.84  LDD2189  [45]
 LDCM0573  Fragment11 Ramos C54(0.00); C109(0.01); C158(0.01); 0.97  LDD2190  [45]
 LDCM0574  Fragment12 Ramos C54(0.77); C109(0.42); C158(0.39); 1.15  LDD2191  [45]
 LDCM0575  Fragment13 Ramos C54(0.85); C109(0.86); C158(1.05); 1.71  LDD2192  [45]
 LDCM0576  Fragment14 Ramos C54(0.86); C109(0.67); C158(0.43); 0.79  LDD2193  [45]
 LDCM0579  Fragment20 Ramos C54(1.04); C109(0.34); C158(0.44); 0.92  LDD2194  [45]
 LDCM0580  Fragment21 Ramos C54(0.82); C109(0.84); C158(0.70); 0.61  LDD2195  [45]
 LDCM0582  Fragment23 Ramos C54(1.22); C109(0.55); C158(0.88); 1.04  LDD2196  [45]
 LDCM0578  Fragment27 Ramos C54(0.79); C109(1.15); C158(0.97); 0.76  LDD2197  [45]
 LDCM0586  Fragment28 Ramos C54(0.80); C109(0.60); C158(0.46); 0.77  LDD2198  [45]
 LDCM0588  Fragment30 Ramos C54(1.17); C109(0.68); C158(0.90); C217(1.04)  LDD2199  [45]
 LDCM0589  Fragment31 Ramos C54(0.74); C109(1.04); C158(0.92); 0.92  LDD2200  [45]
 LDCM0590  Fragment32 Ramos C54(1.27); C109(0.44); C158(0.31); C217(0.74)  LDD2201  [45]
 LDCM0468  Fragment33 HEK-293T C301(0.90)  LDD1066  [41]
 LDCM0596  Fragment38 Ramos C54(0.79); C109(0.45); C158(0.66); 0.38  LDD2203  [45]
 LDCM0566  Fragment4 Ramos C54(0.83); C109(1.50); C158(0.62); 5.22  LDD2184  [45]
 LDCM0427  Fragment51 HEK-293T C301(1.33)  LDD1025  [41]
 LDCM0610  Fragment52 Ramos C54(1.00); C109(0.53); C158(1.07); C217(0.66)  LDD2204  [45]
 LDCM0614  Fragment56 Ramos C54(0.89); C109(1.33); C158(1.18); C217(1.74)  LDD2205  [45]
 LDCM0569  Fragment7 Ramos C54(2.03); C109(0.72); C158(0.44); 1.52  LDD2186  [45]
 LDCM0571  Fragment9 Ramos C54(1.27); C109(0.40); C158(0.53); C217(1.44)  LDD2188  [45]
 LDCM0116  HHS-0101 DM93 Y349(0.75); Y236(0.90); Y278(1.00); Y200(1.09)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y182(0.88); Y349(0.94); Y200(0.96); Y230(1.05)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y182(0.64); Y230(0.70); Y278(0.80); Y236(0.82)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y182(0.83); Y236(0.95); Y230(1.10); Y200(1.11)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y200(0.96); Y349(1.28); Y278(1.33); Y236(1.35)  LDD0268  [16]
 LDCM0107  IAA HeLa H255(0.00); C158(0.00); H260(0.00); C163(0.00)  LDD0221  [32]
 LDCM0123  JWB131 DM93 Y182(0.86)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y182(0.56); Y349(1.17)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y182(0.69); Y236(0.73); Y349(0.93)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y182(3.43); Y349(1.52)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y182(1.92); Y236(1.04); Y349(1.97)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y182(1.28); Y349(0.13)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y182(0.42); Y349(0.90)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y182(1.16); Y349(0.80)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [10]
 LDCM0022  KB02 HEK-293T C54(0.59); C109(0.99); C163(0.96); C217(1.07)  LDD1492  [44]
 LDCM0023  KB03 Jurkat C301(9.42); C158(142.17)  LDD0209  [14]
 LDCM0024  KB05 COLO792 C86(1.55); C163(1.24)  LDD3310  [46]
 LDCM0109  NEM HeLa H255(0.00); H247(0.00); H260(0.00)  LDD0223  [32]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C109(0.45)  LDD2115  [42]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C163(0.85)  LDD2136  [42]
 LDCM0627  NUDT7-COV-1 HEK-293T C217(3.43)  LDD2206  [47]
 LDCM0628  OTUB2-COV-1 HEK-293T C118(1.07); C109(0.79); C217(0.67); C158(0.62)  LDD2207  [47]
 LDCM0131  RA190 MM1.R C217(1.85); C158(1.18)  LDD0304  [48]
 LDCM0003  Sulforaphane MCF-7 2.22  LDD0042  [11]
 LDCM0021  THZ1 HeLa S3 C109(1.08); C217(1.12)  LDD0460  [10]
 LDCM0110  W12 Hep-G2 C109(1.64); C54(15.42)  LDD0237  [33]
 LDCM0111  W14 Hep-G2 C54(12.19)  LDD0238  [33]
 LDCM0113  W17 Hep-G2 C54(3.31)  LDD0240  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Poly(rC)-binding protein 1 (PCBP1) . Q15365

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
23 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
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