Details of the Target

General Information of Target

Target ID LDTP13393
Target Name Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)
Gene Name SLC25A13
Gene ID 10165
Synonyms
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial; Calcium-binding mitochondrial carrier protein Aralar2; ARALAR-related gene 2; ARALAR2; Citrin; Mitochondrial aspartate glutamate carrier 2; Solute carrier family 25 member 13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRKQAKPQHINSEEDQGEQQPQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDE
ATVKRLRREETHVCEKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVL
SHQPTSPGSKDCHRENGGSSEDMKEKPDAESVVYLKTETALPPTPQDISYLAKGKVANTN
VTLQALRGTKVAVNQRSADALPAPVPGANSIPWVLEQILCLQQQQLQQIQLTEQIRIQVN
MWASHALHSSGAGADTLKTLGSHMSQQVSAAVALLSQKAGSQGLSLDALKQAKLPHANIP
SATSSLSPGLAPFTLKPDGTRVLPNVMSRLPSALLPQAPGSVLFQSPFSTVALDTSKKGK
GKPPNISAVDVKPKDEAALYKHKCKYCSKVFGTDSSLQIHLRSHTGERPFVCSVCGHRFT
TKGNLKVHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVPDPIDEPSLSLDSKPVLVT
TSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGGPTLPGVGPNYNSPRAGGFQGSG
TPEPGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTHTGERPFQCKICG
RAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMGGQIPNTPLPE
NPCDFTGSEPMTVGENGSTGAICHDDVIESIDVEEVSSQEAPSSSSKVPTPLPSIHSASP
TLGFAMMASLDAPGKVGPAPFNLQRQGSRENGSVESDGLTNDSSSLMGDQEYQSRSPDIL
ETTSFQALSPANSQAESIKSKSPDAGSKAESSENSRTEMEGRSSLPSTFIRAPPTYVKVE
VPGTFVGPSTLSPGMTPLLAAQPRRQAKQHGCTRCGKNFSSASALQIHERTHTGEKPFVC
NICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENTMALLGTDGKRVSEIFPKEILAP
SVNVDPVVWNQYTSMLNGGLAVKTNEISVIQSGGVPTLPVSLGATSVVNNATVSKMDGSQ
SGISADVEKPSATDGVPKHQFPHFLEENKIAVS
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation.
Uniprot ID
Q9UJS0
Ensemble ID
ENST00000265631.10
HGNC ID
HGNC:10983

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G361 SNV: p.G439E DBIA    Probe Info 
IM95 Deletion: p.E141KfsTer6 .
JURKAT Deletion: p.F480LfsTer28 .
KMS12BM SNV: p.K260Ter .
RPMI7951 SNV: p.P403L DBIA    Probe Info 
SW756 SNV: p.E297K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.42  LDD0402  [1]
11RK72
 Probe Info  		3.54  LDD0327  [2]
11RK73
 Probe Info  		3.31  LDD0328  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
W1
 Probe Info  		13.46  LDD0235  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K418(1.58); K484(4.48); K568(10.00); K576(9.92)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K235(2.24); K408(2.67); K487(4.12)  LDD3494  [7]
DBIA
 Probe Info  		C504(2.62)  LDD3310  [8]
BTD
 Probe Info  		C377(0.98)  LDD2089  [9]
EA-probe
 Probe Info  		N.A.  LDD0440  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
TFBX
 Probe Info  		C503(0.00); C565(0.00)  LDD0027  [13]
IPM
 Probe Info  		C565(0.00); C377(0.00); C503(0.00)  LDD0005  [14]
NHS
 Probe Info  		K235(0.00); K5(0.00)  LDD0010  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
1d-yne
 Probe Info  		K653(0.00); K641(0.00)  LDD0357  [15]
Acrolein
 Probe Info  		C503(0.00); C377(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C565(0.00); C377(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C565(0.00); C377(0.00)  LDD0218  [16]
AOyne
 Probe Info  		8.60  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		11.16  LDD1728  [19]
C107
 Probe Info  		6.36  LDD1794  [19]
C112
 Probe Info  		18.38  LDD1799  [19]
C134
 Probe Info  		22.47  LDD1816  [19]
C143
 Probe Info  		13.00  LDD1825  [19]
C158
 Probe Info  		9.25  LDD1838  [19]
C161
 Probe Info  		12.82  LDD1841  [19]
C187
 Probe Info  		15.56  LDD1865  [19]
C201
 Probe Info  		32.45  LDD1877  [19]
C218
 Probe Info  		12.04  LDD1892  [19]
C220
 Probe Info  		17.03  LDD1894  [19]
C246
 Probe Info  		13.09  LDD1919  [19]
C277
 Probe Info  		7.84  LDD1947  [19]
C376
 Probe Info  		7.73  LDD2036  [19]
C390
 Probe Info  		24.42  LDD2049  [19]
C413
 Probe Info  		11.16  LDD2069  [19]
FFF probe11
 Probe Info  		20.00  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe15
 Probe Info  		11.84  LDD0478  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
FFF probe4
 Probe Info  		6.94  LDD0466  [20]
FFF probe6
 Probe Info  		13.41  LDD0467  [20]
FFF probe7
 Probe Info  		12.29  LDD0483  [20]
FFF probe9
 Probe Info  		8.18  LDD0470  [20]
JN0003
 Probe Info  		20.00  LDD0469  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
BD-F
 Probe Info  		N.A.  LDD0024  [22]
LD-F
 Probe Info  		T265(0.00); M267(0.00); I271(0.00); L272(0.00)  LDD0015  [22]
DA-2
 Probe Info  		N.A.  LDD0070  [23]
OEA-DA
 Probe Info  		8.54  LDD0046  [24]
STS-1
 Probe Info  		N.A.  LDD0068  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C565(1.40)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C377(2.07)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C377(1.40)  LDD2132  [9]
 LDCM0214  AC1 HEK-293T C377(0.93); C503(1.07); C437(1.01); C202(1.24)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C377(0.97); C503(0.95); C437(1.17); C202(1.10)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C377(0.97); C503(0.97); C437(0.99); C489(0.86)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C377(1.02); C503(0.96); C437(1.04); C489(1.22)  LDD1510  [26]
 LDCM0259  AC14 HEK-293T C377(0.93); C503(0.89); C437(0.97); C489(1.26)  LDD1512  [26]
 LDCM0270  AC15 HEK-293T C377(0.98); C503(0.98); C437(0.99); C489(0.99)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C377(1.01); C503(1.00); C437(1.11); C202(1.73)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C377(0.94); C503(1.05); C437(1.20); C202(1.04)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C377(0.99); C503(0.93); C437(1.04); C489(0.89)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C377(0.89); C503(0.94); C437(1.02); C202(0.95)  LDD1518  [26]
 LDCM0280  AC20 HEK-293T C377(1.04); C503(0.98); C437(1.09); C489(0.96)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C377(0.99); C503(1.09); C437(1.06); C202(0.86)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C377(0.97); C503(0.97); C437(0.88); C489(1.05)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C377(0.94); C503(0.96); C437(0.93); C489(0.91)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C377(0.98); C503(0.91); C437(0.98); C202(0.98)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C377(0.98); C503(1.06); C437(0.99); C202(1.03)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C377(1.09); C503(0.96); C437(1.01); C202(0.88)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C377(0.98); C503(0.96); C437(1.01); C489(0.75)  LDD1526  [26]
 LDCM0288  AC28 HEK-293T C377(0.99); C503(1.09); C437(0.94); C489(0.96)  LDD1527  [26]
 LDCM0289  AC29 HEK-293T C377(0.97); C503(1.05); C437(0.97); C202(1.16)  LDD1528  [26]
 LDCM0290  AC3 HEK-293T C377(0.88); C503(1.03); C437(1.04); C489(0.71)  LDD1529  [26]
 LDCM0291  AC30 HEK-293T C377(0.98); C503(1.03); C437(1.14); C489(1.03)  LDD1530  [26]
 LDCM0292  AC31 HEK-293T C377(0.99); C503(1.05); C437(0.98); C489(0.97)  LDD1531  [26]
 LDCM0293  AC32 HEK-293T C377(1.01); C503(1.07); C437(1.03); C202(1.27)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C377(0.87); C503(1.01); C437(1.05); C202(1.01)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C377(0.89); C503(0.90); C437(0.98); C202(0.98)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C377(0.87); C503(0.93); C437(0.97); C489(0.82)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C377(1.00); C503(1.00); C437(1.06); C489(1.05)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C377(0.93); C503(0.90); C437(0.90); C202(0.80)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C377(0.87); C503(1.07); C437(1.17); C489(1.06)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C377(1.01); C503(1.02); C437(1.09); C489(1.01)  LDD1539  [26]
 LDCM0301  AC4 HEK-293T C377(1.04); C503(1.04); C437(0.93); C489(1.05)  LDD1540  [26]
 LDCM0302  AC40 HEK-293T C377(0.89); C503(0.96); C437(0.88); C202(1.43)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C377(0.92); C503(1.06); C437(1.03); C202(0.99)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C377(0.84); C503(0.95); C437(1.14); C202(1.26)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C377(0.90); C503(0.90); C437(1.03); C489(0.90)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C377(0.99); C503(0.98); C437(0.94); C489(0.92)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C377(0.94); C503(1.00); C437(1.14); C202(0.99)  LDD1546  [26]
 LDCM0308  AC46 HEK-293T C377(0.92); C503(0.96); C437(1.10); C489(1.14)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C377(1.02); C503(0.97); C437(1.00); C489(0.88)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C377(0.86); C503(1.00); C437(1.09); C202(0.99)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C377(1.03); C503(1.07); C437(1.10); C202(1.12)  LDD1550  [26]
 LDCM0312  AC5 HEK-293T C377(1.12); C503(1.03); C437(1.07); C202(1.07)  LDD1551  [26]
 LDCM0313  AC50 HEK-293T C377(0.95); C503(0.95); C437(1.03); C202(1.47)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C377(0.89); C503(0.99); C437(0.98); C489(0.90)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C377(1.01); C503(0.97); C437(0.94); C489(1.12)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C377(0.96); C503(0.90); C437(1.09); C202(0.92)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C377(0.92); C503(0.94); C437(0.96); C489(1.23)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C377(1.04); C503(0.93); C437(0.96); C489(0.97)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C377(0.84); C503(0.95); C437(1.16); C202(0.96)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C377(0.90); C503(1.11); C437(1.00); C202(1.56)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C377(0.94); C503(0.99); C437(1.05); C202(0.90)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C377(0.87); C503(0.99); C437(0.99); C489(0.82)  LDD1561  [26]
 LDCM0323  AC6 HEK-293T C377(0.99); C503(0.96); C437(1.06); C489(0.99)  LDD1562  [26]
 LDCM0324  AC60 HEK-293T C377(1.02); C503(1.06); C437(0.95); C489(0.94)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C377(1.07); C503(1.03); C437(1.17); C202(0.88)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C377(0.97); C503(1.03); C437(1.08); C489(1.04)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C377(1.04); C503(1.04); C437(0.97); C489(0.83)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C377(0.87); C503(1.07); C437(0.97); C202(1.28)  LDD1567  [26]
 LDCM0334  AC7 HEK-293T C377(0.97); C503(1.04); C437(0.99); C489(0.90)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C377(0.91); C503(1.04); C437(0.88); C202(1.26)  LDD1569  [26]
 LDCM0545  Acetamide MDA-MB-231 C377(0.40)  LDD2138  [9]
 LDCM0248  AKOS034007472 HEK-293T C377(0.93); C503(0.91); C437(1.12); C202(0.93)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C377(1.01); C503(1.03); C437(1.13); C202(1.24)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C377(1.00); C503(0.95); C437(1.08); C202(1.11)  LDD1514  [26]
 LDCM0498  BS-3668 MDA-MB-231 C377(0.66)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C503(0.00); C377(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C377(0.98); C503(1.16); C437(0.99)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C377(0.50); C503(1.05); C437(1.56); C489(1.15)  LDD1572  [26]
 LDCM0369  CL100 HEK-293T C377(0.97); C503(1.15); C437(1.09)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C377(0.95); C503(1.13); C437(1.07)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C377(1.02); C503(1.15); C437(0.89); C489(1.18)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C377(0.96); C503(0.94); C437(0.98)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C377(0.97); C503(1.09); C437(0.99)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C377(1.01); C503(1.01); C437(0.94)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C377(1.08); C503(1.00); C437(1.08); C489(0.98)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C377(0.98); C503(1.08); C437(0.98)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C377(0.99); C503(1.09); C437(0.94)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C377(1.00); C503(1.11); C437(1.00)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C377(0.41); C503(0.85); C437(1.36); C489(1.07)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C377(1.08); C503(1.27); C437(0.72); C489(1.21)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C377(1.00); C503(1.13); C437(1.06)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C377(0.99); C503(1.09); C437(0.94)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C377(0.87); C503(1.03); C437(0.93)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C377(0.99); C503(1.16); C437(1.00); C489(0.94)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C377(0.88); C503(1.06); C437(1.02)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C377(0.94); C503(1.05); C437(0.90)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C377(0.90); C503(0.95); C437(0.96)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C377(1.03); C503(0.94); C437(1.17); C489(0.94)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C377(0.93); C503(0.99); C437(1.07)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C377(1.08); C503(0.79); C437(1.18); C202(2.95)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C377(0.90); C503(1.07); C437(1.02)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C377(0.96); C503(0.99); C437(0.96)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C377(1.00); C503(0.93); C437(1.03); C489(1.15)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C377(0.95); C503(1.15); C437(1.18)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C377(1.11); C503(1.12); C437(1.06)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C377(0.92); C503(1.13); C437(0.93)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C377(0.98); C503(1.01); C437(0.98); C489(1.00)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C377(0.86); C503(1.05); C437(1.07)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C377(0.92); C503(1.11); C437(0.99)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C377(0.90); C503(0.99); C437(1.20)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C377(0.95); C503(0.98); C437(1.20); C489(0.93)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C377(1.00); C503(1.17); C437(1.23)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C377(1.04); C503(1.01); C437(0.94)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C377(1.11); C503(1.07); C437(1.11); C202(0.84)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C377(0.99); C503(0.85); C437(1.12); C202(1.44)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C377(1.05); C503(0.80); C437(1.03); C489(0.89)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C377(0.97); C503(0.94); C437(1.13); C489(1.03)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C377(0.69); C503(0.80); C437(1.11); C489(1.06)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C377(0.42); C503(0.86); C437(1.29); C202(1.02)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C377(0.40); C503(0.74); C437(1.13); C489(1.23)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C377(0.38); C503(0.75); C437(1.38); C489(0.92)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C377(1.13); C503(0.75); C437(0.99); C202(1.72)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C377(1.15); C503(1.32); C437(1.12)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C377(1.13); C503(0.94); C437(0.96); C489(0.82)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C377(1.05); C503(1.08); C437(0.99)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C377(1.10); C503(1.05); C437(1.13)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C377(1.16); C503(0.97); C437(1.18); C202(1.07)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C377(0.90); C503(1.02); C437(1.24)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C377(1.23); C503(0.89); C437(1.05); C202(1.56)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C377(1.23); C503(0.85); C437(0.98); C489(0.89)  LDD1624  [26]
 LDCM0421  CL32 HEK-293T C377(0.82); C503(0.83); C437(1.08); C489(1.01)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C377(0.46); C503(0.91); C437(1.15); C202(0.98)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C377(0.46); C503(0.73); C437(1.20); C489(1.30)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C377(0.36); C503(0.73); C437(1.36); C489(1.03)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C377(1.28); C503(0.76); C437(0.94); C202(1.79)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C377(1.03); C503(1.17); C437(1.03)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C377(0.98); C503(1.12); C437(0.95)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C377(0.98); C503(1.10); C437(1.01)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C377(1.02); C503(0.97); C437(0.99)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C377(1.08); C503(1.00); C437(1.12); C202(1.26)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C377(1.19); C503(0.83); C437(1.01); C202(0.87)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C377(1.10); C503(0.83); C437(1.04); C489(0.93)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C377(0.77); C503(0.79); C437(1.05); C489(0.87)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C377(0.44); C503(0.83); C437(1.25); C202(1.22)  LDD1639  [26]
 LDCM0436  CL46 HEK-293T C377(0.44); C503(0.71); C437(1.05); C489(1.03)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C377(0.38); C503(0.77); C437(1.24); C489(0.97)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C377(1.13); C503(0.86); C437(0.85); C202(1.22)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C377(0.94); C503(1.22); C437(0.98)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C377(0.98); C503(0.98); C437(1.06); C202(1.19)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C377(1.02); C503(0.99); C437(1.27); C489(1.21)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C377(1.04); C503(1.06); C437(1.02)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C377(1.03); C503(1.02); C437(0.96); C202(1.38)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C377(1.02); C503(0.93); C437(1.09); C202(1.21)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C377(1.10); C503(0.76); C437(1.11); C489(0.75)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C377(0.76); C503(0.80); C437(1.10); C489(1.09)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C377(0.46); C503(0.86); C437(1.28); C202(1.01)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C377(0.49); C503(0.77); C437(1.32); C489(1.22)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C377(0.44); C503(0.76); C437(1.31); C489(0.95)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C377(1.13); C503(1.07); C437(1.05); C202(1.55)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C377(1.06); C503(0.81); C437(0.98); C202(1.50)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C377(0.94); C503(1.04); C437(1.00)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C377(0.99); C503(1.01); C437(1.05); C489(0.92)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C377(0.98); C503(0.97); C437(1.24)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C377(1.00); C503(1.20); C437(1.09)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C377(0.94); C503(0.94); C437(1.12); C202(1.54)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C377(1.04); C503(0.87); C437(1.04); C202(1.62)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C377(1.04); C503(0.82); C437(1.08); C489(0.85)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C377(0.75); C503(0.88); C437(1.05); C489(0.88)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C377(0.50); C503(0.80); C437(1.04); C202(0.90)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C377(0.93); C503(0.82); C437(1.07); C489(0.77)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C377(0.49); C503(0.76); C437(1.11); C489(1.18)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C377(0.49); C503(0.73); C437(1.16); C489(1.12)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C377(1.10); C503(0.80); C437(0.96); C202(1.33)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C377(0.96); C503(1.14); C437(0.99)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C377(0.95); C503(1.03); C437(1.07); C489(0.76)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C377(0.95); C503(1.01); C437(1.00)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C377(1.03); C503(1.17); C437(1.08); C202(1.25)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C377(1.02); C503(0.86); C437(1.08); C202(1.02)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C377(1.05); C503(0.89); C437(0.95); C489(0.83)  LDD1675  [26]
 LDCM0473  CL8 HEK-293T C377(1.06); C503(1.42); C437(1.23); C489(1.24)  LDD1676  [26]
 LDCM0474  CL80 HEK-293T C377(0.83); C503(0.86); C437(1.06); C489(0.98)  LDD1677  [26]
 LDCM0475  CL81 HEK-293T C377(0.52); C503(0.74); C437(1.10); C202(1.14)  LDD1678  [26]
 LDCM0476  CL82 HEK-293T C377(0.58); C503(0.81); C437(1.08); C489(1.12)  LDD1679  [26]
 LDCM0477  CL83 HEK-293T C377(0.56); C503(0.85); C437(1.26); C489(0.96)  LDD1680  [26]
 LDCM0478  CL84 HEK-293T C377(1.03); C503(0.89); C437(1.15); C202(1.19)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C377(0.94); C503(1.06); C437(0.96)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C377(0.95); C503(1.09); C437(1.00); C489(1.03)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C377(0.88); C503(1.26); C437(1.25)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C377(0.88); C503(1.05); C437(0.94)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C377(0.87); C503(1.00); C437(1.08); C202(1.11)  LDD1686  [26]
 LDCM0484  CL9 HEK-293T C377(0.48); C503(0.85); C437(1.37); C202(1.29)  LDD1687  [26]
 LDCM0485  CL90 HEK-293T C377(1.11); C503(1.25); C437(0.99); C202(0.87)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C377(1.00); C503(0.89); C437(0.93); C489(0.75)  LDD1689  [26]
 LDCM0487  CL92 HEK-293T C377(0.91); C503(0.88); C437(1.04); C489(1.05)  LDD1690  [26]
 LDCM0488  CL93 HEK-293T C377(0.67); C503(0.86); C437(1.30); C202(1.27)  LDD1691  [26]
 LDCM0489  CL94 HEK-293T C377(0.65); C503(0.75); C437(1.18); C489(1.00)  LDD1692  [26]
 LDCM0490  CL95 HEK-293T C377(0.72); C503(0.90); C437(1.31); C489(0.84)  LDD1693  [26]
 LDCM0491  CL96 HEK-293T C377(0.88); C503(1.07); C437(1.14); C202(1.42)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C377(0.93); C503(1.19); C437(0.95)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C377(0.92); C503(1.11); C437(0.92); C489(0.94)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C377(0.96); C503(1.18); C437(1.20)  LDD1697  [26]
 LDCM0495  E2913 HEK-293T C377(0.99); C503(1.11); C437(1.28)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C377(9.11)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [10]
 LDCM0625  F8 Ramos C565(1.13); C503(1.50); C377(1.24)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C565(2.77); C503(1.47); C377(3.01)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C565(0.06); C503(0.12); C377(0.61)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C565(4.09); C503(1.78); C377(1.85)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C565(1.08); C503(2.53); C377(1.32)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C565(5.36); C503(2.31); C377(5.11)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C565(6.39); C503(1.70)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C565(1.38); C503(1.55); C377(1.32)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C565(0.96); C503(1.49); C377(0.87)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C565(0.94); C503(1.69); C377(0.95)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C565(1.27); C503(0.46); C377(0.86)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C565(1.38); C503(1.90); C377(1.43)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C565(1.55); C503(1.95); C377(1.23)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C565(2.17); C503(2.47)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C377(1.01); C503(1.05); C437(1.20)  LDD1671  [26]
 LDCM0596  Fragment38 Ramos C565(1.23); C503(1.43); C377(1.22)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C565(3.58); C503(1.53); C377(2.09)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C377(1.07); C503(1.01); C437(1.14); C489(0.97)  LDD1631  [26]
 LDCM0610  Fragment52 Ramos C565(1.13); C503(1.35); C377(1.44)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C565(1.07); C503(2.46); C377(1.20)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C565(3.24); C503(1.27); C377(3.21)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C565(10.80); C503(2.09); C377(3.09)  LDD2188  [27]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C377(0.95); C503(1.04); C437(0.95)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C377(1.03); C503(1.06); C437(1.10)  LDD1497  [26]
 LDCM0024  KB05 COLO792 C504(2.62)  LDD3310  [8]
 LDCM0109  NEM HeLa N.A.  LDD0227  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C377(0.98)  LDD2089  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C377(1.28)  LDD2107  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C377(1.04)  LDD2111  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C377(0.17)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C377(0.19); C565(1.00)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C377(3.37)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C377(0.95)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C377(0.09)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C377(1.14); C565(1.00)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C377(0.13); C565(0.97)  LDD2124  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C377(0.09); C565(1.04)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C377(2.26)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C377(0.90)  LDD2128  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C377(2.30); C565(1.15)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C377(1.15)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C377(0.93)  LDD2137  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C377(1.10)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C377(0.83)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C377(1.54)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C377(1.60)  LDD2146  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C565(0.73)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C377(0.38)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C377(0.11)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C377(2.29)  LDD2153  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C377(0.86); C503(0.74)  LDD2207  [28]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aspartic Acid Small molecular drug DB00128

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
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