Details of the Target

General Information of Target

Target ID LDTP02534
Target Name Endoplasmic reticulum chaperone BiP (HSPA5)
Gene Name HSPA5
Gene ID 3309
Synonyms
GRP78; Endoplasmic reticulum chaperone BiP; EC 3.6.4.10; 78 kDa glucose-regulated protein; GRP-78; Binding-immunoglobulin protein; BiP; Heat shock protein 70 family protein 5; HSP70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Heat shock protein 70 family
Subcellular location
Endoplasmic reticulum lumen
Function
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1. Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation.; (Microbial infection) Plays an important role in viral binding to the host cell membrane and entry for several flaviruses such as Dengue virus, Zika virus and Japanese encephalitis virus. Acts as a component of the cellular receptor for Dengue virus serotype 2/DENV-2 on human liver cells.; (Microbial infection) Acts as a receptor for CotH proteins expressed by fungi of the order mucorales, the causative agent of mucormycosis, which plays an important role in epithelial cell invasion by the fungi. Acts as a receptor for R.delemar CotH3 in nasal epithelial cells, which may be an early step in rhinoorbital/cerebral mucormycosis (RCM) disease progression.
TTD ID
T77594
Uniprot ID
P11021
DrugMap ID
TTW26OG
Ensemble ID
ENST00000324460.7
HGNC ID
HGNC:5238
ChEMBL ID
CHEMBL1781865

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [2]
P3
 Probe Info  		10.00  LDD0454  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		4.17  LDD0215  [3]
11RK72
 Probe Info  		3.76  LDD0327  [4]
11RK73
 Probe Info  		3.60  LDD0328  [4]
CY4
 Probe Info  		7.77  LDD0244  [5]
N1
 Probe Info  		4.60  LDD0242  [5]
C-Sul
 Probe Info  		6.74  LDD0066  [6]
TH211
 Probe Info  		Y635(20.00)  LDD0257  [7]
TH214
 Probe Info  		Y65(19.18)  LDD0258  [7]
TH216
 Probe Info  		Y65(20.00); Y160(8.92)  LDD0259  [7]
YN-4
 Probe Info  		100.00  LDD0445  [8]
ONAyne
 Probe Info  		K340(0.00); K446(0.00); K287(0.00); K523(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K326(0.36); K164(0.99); K382(1.18); K96(1.44)  LDD3494  [10]
Probe 1
 Probe Info  		Y65(37.85); Y127(32.88); Y160(52.22); Y175(7.85)  LDD3495  [11]
THZ1-DTB
 Probe Info  		C420(1.01)  LDD0460  [12]
BTD
 Probe Info  		C41(0.51)  LDD2100  [13]
HHS-482
 Probe Info  		Y127(8.51); Y160(0.97); Y175(1.46); Y568(0.84)  LDD0285  [14]
HHS-475
 Probe Info  		Y209(0.98); Y127(1.12); Y635(1.13); Y65(1.18)  LDD0264  [15]
IPM
 Probe Info  		C41(1.95)  LDD1701  [13]
HHS-465
 Probe Info  		Y160(10.00); Y635(6.11)  LDD2237  [16]
DBIA
 Probe Info  		C41(0.98)  LDD0533  [17]
5E-2FA
 Probe Info  		H303(0.00); H477(0.00); H167(0.00)  LDD2235  [18]
AMP probe
 Probe Info  		K268(0.00); K523(0.00)  LDD0200  [19]
ATP probe
 Probe Info  		K268(0.00); K523(0.00); K123(0.00); K125(0.00)  LDD0199  [19]
m-APA
 Probe Info  		H303(0.00); H477(0.00); H167(0.00)  LDD2231  [18]
ATP probe
 Probe Info  		K81(0.00); K138(0.00); K547(0.00); K268(0.00)  LDD0035  [20]
NHS
 Probe Info  		K81(0.00); K113(0.00); K370(0.00); K447(0.00)  LDD0010  [21]
SF
 Probe Info  		K523(0.00); K521(0.00); K370(0.00); Y635(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K447(0.00); K376(0.00); K326(0.00); K353(0.00)  LDD0009  [21]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
Acrolein
 Probe Info  		H608(0.00); H167(0.00); H477(0.00); H303(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		H303(0.00); H167(0.00); C41(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		H167(0.00); C41(0.00); H303(0.00); H608(0.00)  LDD0218  [24]
W1
 Probe Info  		D475(0.00); D483(0.00); N476(0.00); N522(0.00)  LDD0236  [25]
MPP-AC
 Probe Info  		N.A.  LDD0428  [26]
TER-AC
 Probe Info  		N.A.  LDD0426  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [26]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C282
 Probe Info  		15.78  LDD1952  [27]
FFF probe12
 Probe Info  		11.18  LDD0473  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe14
 Probe Info  		20.00  LDD0477  [28]
FFF probe2
 Probe Info  		7.93  LDD0463  [28]
FFF probe3
 Probe Info  		7.83  LDD0464  [28]
FFF probe6
 Probe Info  		5.58  LDD0467  [28]
FFF probe9
 Probe Info  		13.58  LDD0470  [28]
JN0003
 Probe Info  		12.90  LDD0469  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
Diazir
 Probe Info  		N.A.  LDD0011  [21]
OEA-DA
 Probe Info  		11.65  LDD0046  [30]
STS-1
 Probe Info  		N.A.  LDD0068  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C41(0.81)  LDD2142  [13]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C41(0.82)  LDD2112  [13]
 LDCM0214  AC1 PaTu 8988t C41(0.39)  LDD1093  [17]
 LDCM0215  AC10 PaTu 8988t C41(0.60)  LDD1094  [17]
 LDCM0216  AC100 HCT 116 C41(0.98)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C41(0.69)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C41(0.69)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C41(0.67)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C41(0.73)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C41(0.71)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C41(0.78)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C41(0.59)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C41(1.05)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C41(0.74)  LDD0542  [17]
 LDCM0226  AC11 PaTu 8988t C41(0.38)  LDD1105  [17]
 LDCM0227  AC110 HCT 116 C41(0.81)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C41(0.78)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C41(0.83)  LDD0546  [17]
 LDCM0230  AC113 HEK-293T C41(0.85)  LDD0828  [17]
 LDCM0231  AC114 HEK-293T C41(0.82)  LDD0829  [17]
 LDCM0232  AC115 HEK-293T C41(1.01)  LDD0830  [17]
 LDCM0233  AC116 HEK-293T C41(0.75)  LDD0831  [17]
 LDCM0234  AC117 HEK-293T C41(0.99)  LDD0832  [17]
 LDCM0235  AC118 HEK-293T C41(0.94)  LDD0833  [17]
 LDCM0236  AC119 HEK-293T C41(0.89)  LDD0834  [17]
 LDCM0237  AC12 PaTu 8988t C41(0.59)  LDD1116  [17]
 LDCM0238  AC120 HEK-293T C41(1.00)  LDD0836  [17]
 LDCM0239  AC121 HEK-293T C41(1.10)  LDD0837  [17]
 LDCM0240  AC122 HEK-293T C41(1.04)  LDD0838  [17]
 LDCM0241  AC123 HEK-293T C41(0.87)  LDD0839  [17]
 LDCM0242  AC124 HEK-293T C41(1.00)  LDD0840  [17]
 LDCM0243  AC125 HEK-293T C41(0.91)  LDD0841  [17]
 LDCM0244  AC126 HEK-293T C41(0.56)  LDD0842  [17]
 LDCM0245  AC127 HEK-293T C41(0.48)  LDD0843  [17]
 LDCM0246  AC128 HEK-293T C41(1.12)  LDD0844  [17]
 LDCM0247  AC129 HEK-293T C41(1.02)  LDD0845  [17]
 LDCM0249  AC130 HEK-293T C41(1.07)  LDD0847  [17]
 LDCM0250  AC131 HEK-293T C41(1.03)  LDD0848  [17]
 LDCM0251  AC132 HEK-293T C41(1.01)  LDD0849  [17]
 LDCM0252  AC133 HEK-293T C41(1.03)  LDD0850  [17]
 LDCM0253  AC134 HEK-293T C41(1.02)  LDD0851  [17]
 LDCM0254  AC135 HEK-293T C41(1.22)  LDD0852  [17]
 LDCM0255  AC136 HEK-293T C41(1.31)  LDD0853  [17]
 LDCM0256  AC137 HEK-293T C41(1.04)  LDD0854  [17]
 LDCM0257  AC138 HEK-293T C41(0.90)  LDD0855  [17]
 LDCM0258  AC139 HEK-293T C41(1.23)  LDD0856  [17]
 LDCM0259  AC14 PaTu 8988t C41(0.59)  LDD1138  [17]
 LDCM0260  AC140 HEK-293T C41(1.04)  LDD0858  [17]
 LDCM0261  AC141 HEK-293T C41(1.01)  LDD0859  [17]
 LDCM0262  AC142 HEK-293T C41(1.07)  LDD0860  [17]
 LDCM0263  AC143 HEK-293T C41(1.40)  LDD0861  [17]
 LDCM0264  AC144 HEK-293T C41(1.02)  LDD0862  [17]
 LDCM0265  AC145 HEK-293T C41(1.04)  LDD0863  [17]
 LDCM0266  AC146 HEK-293T C41(1.02)  LDD0864  [17]
 LDCM0267  AC147 HEK-293T C41(0.89)  LDD0865  [17]
 LDCM0268  AC148 HEK-293T C41(1.00)  LDD0866  [17]
 LDCM0269  AC149 HEK-293T C41(0.98)  LDD0867  [17]
 LDCM0270  AC15 PaTu 8988t C41(0.78)  LDD1149  [17]
 LDCM0271  AC150 HEK-293T C41(0.97)  LDD0869  [17]
 LDCM0272  AC151 HEK-293T C41(1.01)  LDD0870  [17]
 LDCM0273  AC152 HEK-293T C41(1.22)  LDD0871  [17]
 LDCM0274  AC153 HEK-293T C41(0.94)  LDD0872  [17]
 LDCM0621  AC154 HEK-293T C41(1.23)  LDD2162  [17]
 LDCM0622  AC155 HEK-293T C41(1.26)  LDD2163  [17]
 LDCM0623  AC156 HEK-293T C41(0.84)  LDD2164  [17]
 LDCM0624  AC157 HEK-293T C41(0.55)  LDD2165  [17]
 LDCM0276  AC17 PaTu 8988t C41(1.13)  LDD1155  [17]
 LDCM0277  AC18 PaTu 8988t C41(0.84)  LDD1156  [17]
 LDCM0278  AC19 PaTu 8988t C41(0.92)  LDD1157  [17]
 LDCM0279  AC2 PaTu 8988t C41(0.82)  LDD1158  [17]
 LDCM0280  AC20 PaTu 8988t C41(0.84)  LDD1159  [17]
 LDCM0281  AC21 PaTu 8988t C41(0.66)  LDD1160  [17]
 LDCM0282  AC22 PaTu 8988t C41(0.62)  LDD1161  [17]
 LDCM0283  AC23 PaTu 8988t C41(0.45)  LDD1162  [17]
 LDCM0284  AC24 PaTu 8988t C41(1.21)  LDD1163  [17]
 LDCM0285  AC25 HEK-293T C41(0.98)  LDD1524  [32]
 LDCM0286  AC26 HEK-293T C41(1.06)  LDD1525  [32]
 LDCM0287  AC27 HEK-293T C41(1.05)  LDD1526  [32]
 LDCM0288  AC28 HEK-293T C41(1.09)  LDD1527  [32]
 LDCM0289  AC29 HEK-293T C41(0.99)  LDD1528  [32]
 LDCM0290  AC3 PaTu 8988t C41(0.99)  LDD1169  [17]
 LDCM0291  AC30 HEK-293T C41(1.13)  LDD1530  [32]
 LDCM0292  AC31 HEK-293T C41(1.09)  LDD1531  [32]
 LDCM0293  AC32 HEK-293T C41(1.05)  LDD1532  [32]
 LDCM0294  AC33 HEK-293T C41(0.94)  LDD1533  [32]
 LDCM0295  AC34 HEK-293T C41(1.04)  LDD1534  [32]
 LDCM0296  AC35 HEK-293T C41(1.04)  LDD1535  [32]
 LDCM0297  AC36 HEK-293T C41(1.01)  LDD1536  [32]
 LDCM0298  AC37 HEK-293T C41(0.99)  LDD1537  [32]
 LDCM0299  AC38 HEK-293T C41(1.08)  LDD1538  [32]
 LDCM0300  AC39 HEK-293T C41(1.02)  LDD1539  [32]
 LDCM0301  AC4 PaTu 8988t C41(1.18)  LDD1180  [17]
 LDCM0302  AC40 HEK-293T C41(0.99)  LDD1541  [32]
 LDCM0303  AC41 HEK-293T C41(0.88)  LDD1542  [32]
 LDCM0304  AC42 HEK-293T C41(1.06)  LDD1543  [32]
 LDCM0305  AC43 HEK-293T C41(1.00)  LDD1544  [32]
 LDCM0306  AC44 HEK-293T C41(1.02)  LDD1545  [32]
 LDCM0307  AC45 HEK-293T C41(0.98)  LDD1546  [32]
 LDCM0308  AC46 HCT 116 C41(1.22)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C41(0.98)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C41(1.47)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C41(0.36)  LDD0628  [17]
 LDCM0312  AC5 PaTu 8988t C41(0.47)  LDD1191  [17]
 LDCM0313  AC50 HCT 116 C41(0.40)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C41(0.94)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C41(1.00)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C41(0.80)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C41(0.57)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C41(0.34)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C41(0.22)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C41(0.86)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C41(1.02)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C41(0.47)  LDD0639  [17]
 LDCM0323  AC6 PaTu 8988t C41(0.86)  LDD1202  [17]
 LDCM0324  AC60 HCT 116 C41(0.98)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C41(1.16)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C41(0.36)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C41(0.64)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C41(0.42)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C41(0.64)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C41(0.70)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C41(0.14)  LDD0648  [17]
 LDCM0332  AC68 HEK-293T C41(1.10)  LDD0930  [17]
 LDCM0333  AC69 HEK-293T C41(0.98)  LDD0931  [17]
 LDCM0334  AC7 PaTu 8988t C41(0.79)  LDD1213  [17]
 LDCM0335  AC70 HEK-293T C41(0.90)  LDD0933  [17]
 LDCM0336  AC71 HEK-293T C41(1.08)  LDD0934  [17]
 LDCM0337  AC72 HEK-293T C41(1.16)  LDD0935  [17]
 LDCM0338  AC73 HEK-293T C41(1.16)  LDD0936  [17]
 LDCM0339  AC74 HEK-293T C41(1.22)  LDD0937  [17]
 LDCM0340  AC75 HEK-293T C41(1.02)  LDD0938  [17]
 LDCM0341  AC76 HEK-293T C41(1.08)  LDD0939  [17]
 LDCM0342  AC77 HEK-293T C41(1.02)  LDD0940  [17]
 LDCM0343  AC78 HEK-293T C41(1.13)  LDD0941  [17]
 LDCM0344  AC79 HEK-293T C41(1.07)  LDD0942  [17]
 LDCM0345  AC8 PaTu 8988t C41(1.04)  LDD1224  [17]
 LDCM0346  AC80 HEK-293T C41(1.15)  LDD0944  [17]
 LDCM0347  AC81 HEK-293T C41(1.03)  LDD0945  [17]
 LDCM0348  AC82 HEK-293T C41(1.13)  LDD0946  [17]
 LDCM0365  AC98 HCT 116 C41(0.11)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C41(0.99)  LDD0683  [17]
 LDCM0248  AKOS034007472 PaTu 8988t C41(0.78)  LDD1127  [17]
 LDCM0356  AKOS034007680 PaTu 8988t C41(0.61)  LDD1235  [17]
 LDCM0275  AKOS034007705 PaTu 8988t C41(0.69)  LDD1154  [17]
 LDCM0108  Chloroacetamide HeLa H167(0.00); H608(0.00); H303(0.00); H477(0.00)  LDD0222  [24]
 LDCM0367  CL1 HCT 116 C41(1.24)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C41(0.88)  LDD0685  [17]
 LDCM0369  CL100 PaTu 8988t C41(0.90)  LDD1248  [17]
 LDCM0370  CL101 PaTu 8988t C41(0.80)  LDD1249  [17]
 LDCM0371  CL102 PaTu 8988t C41(0.57)  LDD1250  [17]
 LDCM0372  CL103 PaTu 8988t C41(0.41)  LDD1251  [17]
 LDCM0373  CL104 PaTu 8988t C41(0.71)  LDD1252  [17]
 LDCM0374  CL105 PaTu 8988t C41(1.04)  LDD1253  [17]
 LDCM0375  CL106 PaTu 8988t C41(1.06)  LDD1254  [17]
 LDCM0376  CL107 PaTu 8988t C41(0.84)  LDD1255  [17]
 LDCM0377  CL108 PaTu 8988t C41(1.20)  LDD1256  [17]
 LDCM0378  CL109 PaTu 8988t C41(0.99)  LDD1257  [17]
 LDCM0379  CL11 HCT 116 C41(0.64)  LDD0696  [17]
 LDCM0380  CL110 PaTu 8988t C41(0.75)  LDD1259  [17]
 LDCM0381  CL111 PaTu 8988t C41(0.51)  LDD1260  [17]
 LDCM0382  CL112 HEK-293T C41(0.96)  LDD1586  [32]
 LDCM0383  CL113 HEK-293T C41(0.96)  LDD1587  [32]
 LDCM0384  CL114 HEK-293T C41(0.98)  LDD1588  [32]
 LDCM0385  CL115 HEK-293T C41(1.09)  LDD1589  [32]
 LDCM0386  CL116 HEK-293T C41(0.98)  LDD1590  [32]
 LDCM0387  CL117 HEK-293T C41(0.96)  LDD1591  [32]
 LDCM0388  CL118 HEK-293T C41(1.01)  LDD1592  [32]
 LDCM0389  CL119 HEK-293T C41(1.07)  LDD1593  [32]
 LDCM0390  CL12 HCT 116 C41(0.45)  LDD0707  [17]
 LDCM0391  CL120 HEK-293T C41(0.98)  LDD1595  [32]
 LDCM0392  CL121 HCT 116 C41(1.03)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C41(1.04)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C41(0.69)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C41(0.48)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C41(0.66)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C41(0.74)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C41(0.65)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C41(0.63)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C41(1.35)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C41(1.33)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C41(0.56)  LDD0719  [17]
 LDCM0403  CL16 PaTu 8988t C41(0.70)  LDD1282  [17]
 LDCM0404  CL17 PaTu 8988t C41(0.69)  LDD1283  [17]
 LDCM0405  CL18 PaTu 8988t C41(0.56)  LDD1284  [17]
 LDCM0406  CL19 PaTu 8988t C41(0.59)  LDD1285  [17]
 LDCM0407  CL2 HCT 116 C41(1.52)  LDD0724  [17]
 LDCM0408  CL20 PaTu 8988t C41(0.52)  LDD1287  [17]
 LDCM0409  CL21 PaTu 8988t C41(0.72)  LDD1288  [17]
 LDCM0410  CL22 PaTu 8988t C41(0.60)  LDD1289  [17]
 LDCM0411  CL23 PaTu 8988t C41(0.59)  LDD1290  [17]
 LDCM0412  CL24 PaTu 8988t C41(0.82)  LDD1291  [17]
 LDCM0413  CL25 PaTu 8988t C41(0.91)  LDD1292  [17]
 LDCM0414  CL26 PaTu 8988t C41(0.50)  LDD1293  [17]
 LDCM0415  CL27 PaTu 8988t C41(0.71)  LDD1294  [17]
 LDCM0416  CL28 PaTu 8988t C41(0.49)  LDD1295  [17]
 LDCM0417  CL29 PaTu 8988t C41(0.62)  LDD1296  [17]
 LDCM0418  CL3 HCT 116 C41(1.37)  LDD0735  [17]
 LDCM0419  CL30 PaTu 8988t C41(1.12)  LDD1298  [17]
 LDCM0420  CL31 HEK-293T C41(1.08)  LDD1624  [32]
 LDCM0421  CL32 HEK-293T C41(1.18)  LDD1625  [32]
 LDCM0422  CL33 HEK-293T C41(1.20)  LDD1626  [32]
 LDCM0423  CL34 HEK-293T C41(1.35)  LDD1627  [32]
 LDCM0424  CL35 HEK-293T C41(1.56)  LDD1628  [32]
 LDCM0425  CL36 HEK-293T C41(1.32)  LDD1629  [32]
 LDCM0426  CL37 HEK-293T C41(0.98)  LDD1630  [32]
 LDCM0428  CL39 HEK-293T C41(1.05)  LDD1632  [32]
 LDCM0429  CL4 HCT 116 C41(1.54)  LDD0746  [17]
 LDCM0430  CL40 HEK-293T C41(1.01)  LDD1634  [32]
 LDCM0431  CL41 HEK-293T C41(0.95)  LDD1635  [32]
 LDCM0432  CL42 HEK-293T C41(1.28)  LDD1636  [32]
 LDCM0433  CL43 HEK-293T C41(1.21)  LDD1637  [32]
 LDCM0434  CL44 HEK-293T C41(1.13)  LDD1638  [32]
 LDCM0435  CL45 HEK-293T C41(1.27)  LDD1639  [32]
 LDCM0436  CL46 PaTu 8988t C41(1.02)  LDD1315  [17]
 LDCM0437  CL47 PaTu 8988t C41(0.91)  LDD1316  [17]
 LDCM0438  CL48 PaTu 8988t C41(0.76)  LDD1317  [17]
 LDCM0439  CL49 PaTu 8988t C41(0.70)  LDD1318  [17]
 LDCM0440  CL5 HCT 116 C41(1.25)  LDD0757  [17]
 LDCM0441  CL50 PaTu 8988t C41(0.61)  LDD1320  [17]
 LDCM0442  CL51 PaTu 8988t C41(0.97)  LDD1321  [17]
 LDCM0443  CL52 PaTu 8988t C41(0.82)  LDD1322  [17]
 LDCM0444  CL53 PaTu 8988t C41(0.63)  LDD1323  [17]
 LDCM0445  CL54 PaTu 8988t C41(1.43)  LDD1324  [17]
 LDCM0446  CL55 PaTu 8988t C41(0.97)  LDD1325  [17]
 LDCM0447  CL56 PaTu 8988t C41(0.18)  LDD1326  [17]
 LDCM0448  CL57 PaTu 8988t C41(0.17)  LDD1327  [17]
 LDCM0449  CL58 PaTu 8988t C41(0.62)  LDD1328  [17]
 LDCM0450  CL59 PaTu 8988t C41(0.19)  LDD1329  [17]
 LDCM0451  CL6 HCT 116 C41(1.68)  LDD0768  [17]
 LDCM0452  CL60 PaTu 8988t C41(0.22)  LDD1331  [17]
 LDCM0453  CL61 PaTu 8988t C41(1.47)  LDD1332  [17]
 LDCM0454  CL62 PaTu 8988t C41(1.17)  LDD1333  [17]
 LDCM0455  CL63 PaTu 8988t C41(1.16)  LDD1334  [17]
 LDCM0456  CL64 PaTu 8988t C41(1.00)  LDD1335  [17]
 LDCM0457  CL65 PaTu 8988t C41(1.03)  LDD1336  [17]
 LDCM0458  CL66 PaTu 8988t C41(1.04)  LDD1337  [17]
 LDCM0459  CL67 PaTu 8988t C41(0.35)  LDD1338  [17]
 LDCM0460  CL68 PaTu 8988t C41(0.26)  LDD1339  [17]
 LDCM0461  CL69 PaTu 8988t C41(0.29)  LDD1340  [17]
 LDCM0462  CL7 HCT 116 C41(0.89)  LDD0779  [17]
 LDCM0463  CL70 PaTu 8988t C41(0.44)  LDD1342  [17]
 LDCM0464  CL71 PaTu 8988t C41(1.48)  LDD1343  [17]
 LDCM0465  CL72 PaTu 8988t C41(0.79)  LDD1344  [17]
 LDCM0466  CL73 PaTu 8988t C41(0.36)  LDD1345  [17]
 LDCM0467  CL74 PaTu 8988t C41(0.96)  LDD1346  [17]
 LDCM0469  CL76 HCT 116 C41(1.47)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C41(3.09)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C41(0.98)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C41(0.91)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C41(0.43)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C41(5.55)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C41(1.25)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C41(0.45)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C41(0.67)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C41(0.27)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C41(1.19)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C41(1.07)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C41(1.23)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C41(0.75)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C41(0.20)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C41(1.23)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C41(1.20)  LDD0802  [17]
 LDCM0486  CL91 PaTu 8988t C41(1.30)  LDD1365  [17]
 LDCM0487  CL92 PaTu 8988t C41(0.89)  LDD1366  [17]
 LDCM0488  CL93 PaTu 8988t C41(0.95)  LDD1367  [17]
 LDCM0489  CL94 PaTu 8988t C41(1.28)  LDD1368  [17]
 LDCM0490  CL95 PaTu 8988t C41(0.70)  LDD1369  [17]
 LDCM0491  CL96 PaTu 8988t C41(1.10)  LDD1370  [17]
 LDCM0492  CL97 PaTu 8988t C41(0.86)  LDD1371  [17]
 LDCM0493  CL98 PaTu 8988t C41(0.71)  LDD1372  [17]
 LDCM0494  CL99 PaTu 8988t C41(0.87)  LDD1373  [17]
 LDCM0495  E2913 HEK-293T C41(1.13)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C41(1.45)  LDD1702  [13]
 LDCM0468  Fragment33 PaTu 8988t C41(0.73)  LDD1347  [17]
 LDCM0427  Fragment51 HEK-293T C41(1.01)  LDD1631  [32]
 LDCM0116  HHS-0101 DM93 Y209(0.98); Y127(1.12); Y635(1.13); Y65(1.18)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y313(0.40); Y65(0.72); Y635(0.82); Y127(0.91)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y313(0.39); Y635(0.81); Y65(1.04); Y127(1.09)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y160(0.63); Y635(0.77); Y127(1.10); Y65(1.12)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y313(0.26); Y127(0.45); Y160(0.67); Y65(0.67)  LDD0268  [15]
 LDCM0107  IAA HeLa H608(0.00); H167(0.00); H477(0.00); H303(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y127(8.51); Y160(0.97); Y175(1.46); Y568(0.84)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y127(4.78); Y160(1.12); Y175(2.80); Y313(0.49)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y127(5.08); Y160(0.65); Y175(0.59); Y568(0.72)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y127(20.00); Y160(1.67); Y175(1.80); Y313(7.73)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y127(20.00); Y160(2.90); Y175(4.71); Y313(3.91)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y127(8.54); Y160(1.15); Y568(0.56); Y635(0.25)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y127(9.46); Y160(0.69); Y175(0.76); Y313(1.52)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y127(6.49); Y160(0.58); Y175(1.02); Y568(0.90)  LDD0292  [14]
 LDCM0022  KB02 HEK-293T C41(0.97)  LDD1492  [32]
 LDCM0023  KB03 HEK-293T C41(0.96)  LDD1497  [32]
 LDCM0024  KB05 NCI-H1975 C41(1.46)  LDD3352  [33]
 LDCM0109  NEM HeLa H608(0.00); H477(0.00); H167(0.00); H303(0.00)  LDD0223  [24]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C41(0.51)  LDD2100  [13]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C41(0.99)  LDD2104  [13]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C41(0.80)  LDD2110  [13]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C41(0.55)  LDD2114  [13]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C41(1.85)  LDD2135  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C41(1.72)  LDD2136  [13]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C41(0.89)  LDD2141  [13]
 LDCM0021  THZ1 HeLa S3 C420(1.01)  LDD0460  [12]
 LDCM0110  W12 Hep-G2 D186(0.76)  LDD0237  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Putative inactive beta-glucuronidase-like protein SMA3 (GUSBP1) Glycosyl hydrolase 2 family Q15486
Angiotensin-converting enzyme 2 (ACE2) Peptidase M2 family Q9BYF1
Protein disulfide-isomerase A6 (PDIA6) Protein disulfide isomerase family Q15084
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) Ser/Thr protein kinase family Q9NZJ5
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) Ubiquitin-conjugating enzyme family Q13404
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Amyloid-beta precursor protein (APP) APP family P05067
Hypoxia up-regulated protein 1 (HYOU1) Heat shock protein 70 family Q9Y4L1
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) Ser/Thr protein kinase family O75460
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) SecY/SEC61-alpha family P61619
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) BZIP family P18850
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dermokine (DMKN) Dermokine family Q6E0U4
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Endoplasmin (HSP90B1) Heat shock protein 90 family P14625
Nucleotide exchange factor SIL1 (SIL1) SIL1 family Q9H173
SNW domain-containing protein 1 (SNW1) SNW family Q13573
DnaJ homolog subfamily B member 11 (DNAJB11) . Q9UBS4
PRKC apoptosis WT1 regulator protein (PAWR) . Q96IZ0
Tetratricopeptide repeat protein 23-like (TTC23L) . Q6PF05

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Acetylsalicylic Acid Small molecular drug DB00945
Copper . DB09130
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sam-6 Antibody D06PZC
Nkp-1339 Small molecular drug D08SIT
It-139 . D0Q4LG

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840