Details of the Target

General Information of Target

Target ID LDTP05421
Target Name Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)
Gene Name EIF4G1
Gene ID 1981
Synonyms
EIF4F; EIF4G; EIF4GI; Eukaryotic translation initiation factor 4 gamma 1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; p220
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
Target Bioclass
Other
Family
Eukaryotic initiation factor 4G family
Subcellular location
Cytoplasm
Function
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive). Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon. Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation.
Uniprot ID
Q04637
Ensemble ID
ENST00000342981.8
HGNC ID
HGNC:3296
ChEMBL ID
CHEMBL4523621

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS Substitution: p.T161A DBIA    Probe Info 
CMK SNV: p.R1197Q DBIA    Probe Info 
COLO678 SNV: p.D613N DBIA    Probe Info 
HCT15 SNV: p.Q37Ter; p.Y958C DBIA    Probe Info 
HT115 SNV: p.R183Ter DBIA    Probe Info 
JHH1 SNV: p.Q778K DBIA    Probe Info 
JURKAT SNV: p.P24T Compound 10    Probe Info 
LNCaP clone FGC SNV: p.E591K DBIA    Probe Info 
MOLT4 SNV: p.R894H IA-alkyne    Probe Info 
NB1 SNV: p.P16T DBIA    Probe Info 
NCIH1793 SNV: p.D1003Y DBIA    Probe Info 
NCIH2122 SNV: p.R516G DBIA    Probe Info 
NCIH23 SNV: p.E1295D DBIA    Probe Info 
OVISE SNV: p.E631Q DBIA    Probe Info 
P31FUJ SNV: p.S1246P DBIA    Probe Info 
RKO SNV: p.E591Ter DBIA    Probe Info 
SKMEL24 SNV: p.S255L DBIA    Probe Info 
SNGM SNV: p.G189R DBIA    Probe Info 
SNU1 Deletion: p.P11HfsTer31 DBIA    Probe Info 
TE10 SNV: p.L1256F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 53 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.60  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		3.04  LDD0215  [3]
11RK72
 Probe Info  		3.73  LDD0327  [4]
11RK73
 Probe Info  		3.93  LDD0328  [4]
CHEMBL5175495
 Probe Info  		7.38  LDD0196  [5]
CY-1
 Probe Info  		100.00  LDD0243  [6]
CY4
 Probe Info  		100.00  LDD0244  [6]
N1
 Probe Info  		100.00  LDD0242  [6]
TH211
 Probe Info  		Y958(20.00); Y1253(5.70)  LDD0260  [7]
YN-1
 Probe Info  		100.00  LDD0444  [8]
ONAyne
 Probe Info  		K1188(5.56); K881(10.00)  LDD0274  [9]
STPyne
 Probe Info  		K1000(10.00); K1019(10.00); K1026(3.94); K1059(3.82)  LDD0277  [9]
Probe 1
 Probe Info  		Y311(21.20); Y815(9.82); Y1424(16.64); Y1514(27.45)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C662(0.00); C934(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C662(0.95)  LDD0460  [11]
BTD
 Probe Info  		C1516(1.68)  LDD1700  [12]
AHL-Pu-1
 Probe Info  		C821(2.08); C819(2.07); C662(2.12)  LDD0169  [13]
DBIA
 Probe Info  		C662(13.37); C821(840.93)  LDD0209  [14]
HHS-475
 Probe Info  		Y103(5.74)  LDD0265  [15]
ATP probe
 Probe Info  		K1071(0.00); K832(0.00); K190(0.00); K1244(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C819(0.00); C1265(0.00); C662(0.00); C1516(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C819(0.00); C919(0.00)  LDD0032  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C819(0.00); C1487(0.00); C1265(0.00); C662(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		K1059(0.00); K907(0.00); K1587(0.00); K1026(0.00)  LDD0035  [20]
JW-RF-010
 Probe Info  		C936(0.00); C662(0.00)  LDD0026  [21]
NAIA_4
 Probe Info  		C662(0.00); C1265(0.00); C1384(0.00)  LDD2226  [22]
TFBX
 Probe Info  		C919(0.00); C662(0.00); C819(0.00); C936(0.00)  LDD0027  [21]
WYneN
 Probe Info  		C1516(0.00); C662(0.00); C934(0.00)  LDD0021  [23]
WYneO
 Probe Info  		N.A.  LDD0022  [23]
1d-yne
 Probe Info  		N.A.  LDD0356  [24]
Compound 10
 Probe Info  		N.A.  LDD2216  [25]
Compound 11
 Probe Info  		N.A.  LDD2213  [25]
IPM
 Probe Info  		C1516(0.00); C662(0.00)  LDD0005  [23]
NHS
 Probe Info  		K1026(0.00); K1071(0.00); K524(0.00); K593(0.00)  LDD0010  [23]
NPM
 Probe Info  		N.A.  LDD0016  [23]
PF-06672131
 Probe Info  		C662(0.00); C919(0.00); C1516(0.00)  LDD0017  [26]
SF
 Probe Info  		K597(0.00); Y596(0.00)  LDD0028  [27]
VSF
 Probe Info  		N.A.  LDD0007  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [28]
Ox-W18
 Probe Info  		W1463(0.00); W1588(0.00)  LDD2175  [29]
1c-yne
 Probe Info  		K1074(0.00); K714(0.00); K1059(0.00); K1404(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		C662(0.00); C934(0.00); C919(0.00); H582(0.00)  LDD0217  [30]
Cinnamaldehyde
 Probe Info  		C934(0.00); C936(0.00)  LDD0220  [30]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [30]
Methacrolein
 Probe Info  		C919(0.00); C662(0.00); C934(0.00); C936(0.00)  LDD0218  [30]
W1
 Probe Info  		N.A.  LDD0236  [31]
NAIA_5
 Probe Info  		C1384(0.00); C1487(0.00); C821(0.00); C1265(0.00)  LDD2223  [22]
HHS-465
 Probe Info  		Y52(0.00); Y103(0.00); Y104(0.00)  LDD2240  [32]
HHS-482
 Probe Info  		Y103(1.09); Y104(1.09)  LDD2239  [33]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.02  LDD0471  [34]
FFF probe13
 Probe Info  		12.64  LDD0475  [34]
FFF probe14
 Probe Info  		20.00  LDD0477  [34]
FFF probe2
 Probe Info  		5.36  LDD0463  [34]
FFF probe3
 Probe Info  		12.48  LDD0464  [34]
STS-1
 Probe Info  		N.A.  LDD0136  [35]
STS-2
 Probe Info  		N.A.  LDD0138  [35]
DA-2
 Probe Info  		N.A.  LDD0072  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C919(1.46)  LDD2117  [12]
 LDCM0025  4SU-RNA DM93 C821(2.48)  LDD0170  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C821(2.08); C819(2.07); C662(2.12)  LDD0169  [13]
 LDCM0561  Abegg_cp(-)-10 HeLa C919(2.46)  LDD0312  [21]
 LDCM0214  AC1 HEK-293T C819(1.12); C662(0.74); C1487(0.81); C1265(0.91)  LDD1507  [37]
 LDCM0215  AC10 HEK-293T C819(0.88); C662(0.94); C1487(0.94); C1265(0.92)  LDD1508  [37]
 LDCM0226  AC11 HEK-293T C819(1.14); C662(0.77); C1487(1.08); C1265(0.98)  LDD1509  [37]
 LDCM0237  AC12 HEK-293T C819(0.89); C662(0.91); C1487(0.98); C1265(0.93)  LDD1510  [37]
 LDCM0259  AC14 HEK-293T C819(0.97); C662(0.95); C1487(1.06); C1265(1.05)  LDD1512  [37]
 LDCM0270  AC15 HEK-293T C819(1.02); C662(0.96); C1487(1.13); C1265(1.14)  LDD1513  [37]
 LDCM0276  AC17 HEK-293T C819(1.07); C662(0.80); C1487(0.89); C1265(0.93)  LDD1515  [37]
 LDCM0277  AC18 HEK-293T C819(0.94); C662(1.00); C1487(1.03); C1265(0.93)  LDD1516  [37]
 LDCM0278  AC19 HEK-293T C819(1.01); C662(0.72); C1487(1.03); C1265(0.98)  LDD1517  [37]
 LDCM0279  AC2 HEK-293T C819(0.90); C662(0.73); C1487(1.13); C1265(1.06)  LDD1518  [37]
 LDCM0280  AC20 HEK-293T C819(1.02); C662(1.00); C1487(0.93); C1265(1.23)  LDD1519  [37]
 LDCM0281  AC21 HEK-293T C662(1.06); C1487(1.04); C1265(0.92); C1384(0.93)  LDD1520  [37]
 LDCM0282  AC22 HEK-293T C819(1.13); C662(0.86); C1487(1.09); C1265(1.23)  LDD1521  [37]
 LDCM0283  AC23 HEK-293T C819(0.86); C662(1.01); C1487(1.08); C1265(1.28)  LDD1522  [37]
 LDCM0284  AC24 HEK-293T C819(1.05); C662(0.89); C1487(0.97); C1265(1.09)  LDD1523  [37]
 LDCM0285  AC25 HEK-293T C819(0.92); C662(1.09); C1487(0.94); C1265(0.91)  LDD1524  [37]
 LDCM0286  AC26 HEK-293T C819(0.96); C662(0.97); C1487(1.06); C1265(0.94)  LDD1525  [37]
 LDCM0287  AC27 HEK-293T C819(0.98); C662(0.86); C1487(1.02); C1265(0.94)  LDD1526  [37]
 LDCM0288  AC28 HEK-293T C819(1.02); C662(0.97); C1487(0.94); C1265(1.34)  LDD1527  [37]
 LDCM0289  AC29 HEK-293T C662(1.00); C1487(1.03); C1265(0.87); C1384(0.99)  LDD1528  [37]
 LDCM0290  AC3 HEK-293T C819(1.36); C662(0.59); C1487(1.12); C1265(1.11)  LDD1529  [37]
 LDCM0291  AC30 HEK-293T C819(1.17); C662(0.96); C1487(1.21); C1265(1.13)  LDD1530  [37]
 LDCM0292  AC31 HEK-293T C819(1.03); C662(1.01); C1487(1.00); C1265(1.21)  LDD1531  [37]
 LDCM0293  AC32 HEK-293T C819(0.99); C662(0.87); C1487(0.99); C1265(1.13)  LDD1532  [37]
 LDCM0294  AC33 HEK-293T C819(1.12); C662(1.06); C1487(1.02); C1265(0.92)  LDD1533  [37]
 LDCM0295  AC34 HEK-293T C819(1.02); C662(0.97); C1487(1.16); C1265(1.01)  LDD1534  [37]
 LDCM0296  AC35 HEK-293T C819(1.00); C662(0.84); C1487(1.13); C1265(1.02)  LDD1535  [37]
 LDCM0297  AC36 HEK-293T C819(1.01); C662(0.97); C1487(0.95); C1265(1.11)  LDD1536  [37]
 LDCM0298  AC37 HEK-293T C662(0.78); C1487(0.95); C1265(0.90); C1384(1.00)  LDD1537  [37]
 LDCM0299  AC38 HEK-293T C819(1.15); C662(0.86); C1487(1.10); C1265(1.26)  LDD1538  [37]
 LDCM0300  AC39 HEK-293T C819(0.97); C662(1.00); C1487(1.04); C1265(1.01)  LDD1539  [37]
 LDCM0301  AC4 HEK-293T C819(1.02); C662(0.94); C1487(1.13); C1265(1.18)  LDD1540  [37]
 LDCM0302  AC40 HEK-293T C819(1.06); C662(0.86); C1487(0.90); C1265(1.03)  LDD1541  [37]
 LDCM0303  AC41 HEK-293T C819(0.96); C662(1.05); C1487(0.95); C1265(0.92)  LDD1542  [37]
 LDCM0304  AC42 HEK-293T C819(0.95); C662(1.06); C1487(1.09); C1265(0.95)  LDD1543  [37]
 LDCM0305  AC43 HEK-293T C819(0.92); C662(0.85); C1487(0.96); C1265(1.01)  LDD1544  [37]
 LDCM0306  AC44 HEK-293T C819(1.04); C662(1.01); C1487(1.03); C1265(1.12)  LDD1545  [37]
 LDCM0307  AC45 HEK-293T C662(0.90); C1487(1.08); C1265(0.88); C1384(0.90)  LDD1546  [37]
 LDCM0308  AC46 HEK-293T C819(1.00); C662(1.06); C1487(1.11); C1265(1.12)  LDD1547  [37]
 LDCM0309  AC47 HEK-293T C819(0.82); C662(0.99); C1487(1.08); C1265(1.37)  LDD1548  [37]
 LDCM0310  AC48 HEK-293T C819(1.13); C662(0.78); C1487(1.07); C1265(1.01)  LDD1549  [37]
 LDCM0311  AC49 HEK-293T C819(1.27); C662(0.98); C1487(0.96); C1265(0.99)  LDD1550  [37]
 LDCM0312  AC5 HEK-293T C662(0.92); C1487(1.08); C1265(0.83); C1384(1.00)  LDD1551  [37]
 LDCM0313  AC50 HEK-293T C819(0.95); C662(1.00); C1487(1.03); C1265(1.04)  LDD1552  [37]
 LDCM0314  AC51 HEK-293T C819(1.11); C662(0.73); C1487(1.00); C1265(1.08)  LDD1553  [37]
 LDCM0315  AC52 HEK-293T C819(0.96); C662(0.97); C1487(0.94); C1265(1.08)  LDD1554  [37]
 LDCM0316  AC53 HEK-293T C662(0.90); C1487(0.98); C1265(0.86); C1384(1.02)  LDD1555  [37]
 LDCM0317  AC54 HEK-293T C819(1.23); C662(0.86); C1487(1.13); C1265(1.13)  LDD1556  [37]
 LDCM0318  AC55 HEK-293T C819(1.05); C662(0.99); C1487(0.99); C1265(1.18)  LDD1557  [37]
 LDCM0319  AC56 HEK-293T C819(1.12); C662(0.81); C1487(0.99); C1265(1.05)  LDD1558  [37]
 LDCM0320  AC57 HEK-293T C819(1.04); C662(0.95); C1487(0.95); C1265(0.88)  LDD1559  [37]
 LDCM0321  AC58 HEK-293T C819(0.96); C662(0.87); C1487(1.06); C1265(0.89)  LDD1560  [37]
 LDCM0322  AC59 HEK-293T C819(1.03); C662(0.86); C1487(1.16); C1265(1.13)  LDD1561  [37]
 LDCM0323  AC6 HEK-293T C819(0.98); C662(0.88); C1487(1.12); C1265(1.03)  LDD1562  [37]
 LDCM0324  AC60 HEK-293T C819(1.19); C662(0.97); C1487(0.92); C1265(1.18)  LDD1563  [37]
 LDCM0325  AC61 HEK-293T C662(0.91); C1487(0.98); C1265(0.92); C1384(0.98)  LDD1564  [37]
 LDCM0326  AC62 HEK-293T C819(1.09); C662(0.86); C1487(1.04); C1265(1.04)  LDD1565  [37]
 LDCM0327  AC63 HEK-293T C819(1.23); C662(1.01); C1487(1.08); C1265(1.09)  LDD1566  [37]
 LDCM0328  AC64 HEK-293T C819(1.04); C662(0.87); C1487(1.04); C1265(1.04)  LDD1567  [37]
 LDCM0334  AC7 HEK-293T C819(1.40); C662(1.02); C1487(1.03); C1265(1.18)  LDD1568  [37]
 LDCM0345  AC8 HEK-293T C819(1.06); C662(0.82); C1487(0.94); C1265(1.00)  LDD1569  [37]
 LDCM0248  AKOS034007472 HEK-293T C662(0.91); C1487(1.07); C1265(0.94); C1384(0.99)  LDD1511  [37]
 LDCM0356  AKOS034007680 HEK-293T C819(1.14); C662(0.88); C1487(0.99); C1265(0.93)  LDD1570  [37]
 LDCM0275  AKOS034007705 HEK-293T C819(1.13); C662(0.78); C1487(1.00); C1265(1.07)  LDD1514  [37]
 LDCM0156  Aniline NCI-H1299 11.51  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C1516(1.68); C662(1.47)  LDD2214  [38]
 LDCM0108  Chloroacetamide HeLa C662(0.00); C919(0.00); H582(0.00); H1255(0.00)  LDD0222  [30]
 LDCM0632  CL-Sc Hep-G2 C919(1.55); C662(0.91); C821(0.84); C821(0.74)  LDD2227  [22]
 LDCM0367  CL1 HEK-293T C819(1.14); C662(1.09); C1487(0.94); C1265(0.83)  LDD1571  [37]
 LDCM0368  CL10 HEK-293T C819(0.81); C662(0.76); C1487(1.10); C1265(0.98)  LDD1572  [37]
 LDCM0369  CL100 HEK-293T C662(0.78); C1487(1.03); C1265(1.00); C1384(1.02)  LDD1573  [37]
 LDCM0370  CL101 HEK-293T C819(1.11); C662(1.01); C1487(0.93); C1265(0.84)  LDD1574  [37]
 LDCM0371  CL102 HEK-293T C819(0.94); C662(0.78); C1487(1.09); C1265(0.90)  LDD1575  [37]
 LDCM0372  CL103 HEK-293T C819(0.86); C662(0.98); C1487(0.96); C1265(0.94)  LDD1576  [37]
 LDCM0373  CL104 HEK-293T C662(0.87); C1487(1.11); C1265(1.05); C1384(1.06)  LDD1577  [37]
 LDCM0374  CL105 HEK-293T C819(1.01); C662(0.98); C1487(0.92); C1265(0.93)  LDD1578  [37]
 LDCM0375  CL106 HEK-293T C819(0.98); C662(1.05); C1487(0.89); C1265(0.98)  LDD1579  [37]
 LDCM0376  CL107 HEK-293T C819(0.92); C662(0.91); C1487(0.84); C1265(0.99)  LDD1580  [37]
 LDCM0377  CL108 HEK-293T C662(0.96); C1487(1.01); C1265(1.00); C1384(1.01)  LDD1581  [37]
 LDCM0378  CL109 HEK-293T C819(1.03); C662(0.92); C1487(0.82); C1265(0.84)  LDD1582  [37]
 LDCM0379  CL11 HEK-293T C819(0.90); C662(0.93); C1487(1.05); C1265(1.15)  LDD1583  [37]
 LDCM0380  CL110 HEK-293T C819(0.83); C662(0.89); C1487(0.93); C1265(0.82)  LDD1584  [37]
 LDCM0381  CL111 HEK-293T C819(0.90); C662(0.96); C1487(0.96); C1265(0.90)  LDD1585  [37]
 LDCM0382  CL112 HEK-293T C662(0.93); C1487(0.98); C1265(1.06); C1384(0.99)  LDD1586  [37]
 LDCM0383  CL113 HEK-293T C819(1.18); C662(0.91); C1487(0.91); C1265(0.86)  LDD1587  [37]
 LDCM0384  CL114 HEK-293T C819(0.92); C662(0.80); C1487(0.90); C1265(0.88)  LDD1588  [37]
 LDCM0385  CL115 HEK-293T C819(0.90); C662(0.93); C1487(0.96); C1265(1.01)  LDD1589  [37]
 LDCM0386  CL116 HEK-293T C662(0.88); C1487(1.08); C1265(1.00); C1384(1.05)  LDD1590  [37]
 LDCM0387  CL117 HEK-293T C819(1.19); C662(0.99); C1487(1.08); C1265(1.05)  LDD1591  [37]
 LDCM0388  CL118 HEK-293T C819(0.95); C662(0.88); C1487(0.97); C1265(0.96)  LDD1592  [37]
 LDCM0389  CL119 HEK-293T C819(0.92); C662(0.91); C1487(0.83); C1265(0.90)  LDD1593  [37]
 LDCM0390  CL12 HEK-293T C819(1.07); C662(0.97); C1487(1.15); C1265(1.05)  LDD1594  [37]
 LDCM0391  CL120 HEK-293T C662(0.95); C1487(1.11); C1265(1.08); C1384(1.07)  LDD1595  [37]
 LDCM0392  CL121 HEK-293T C819(1.12); C662(1.09); C1487(0.90); C1265(0.91)  LDD1596  [37]
 LDCM0393  CL122 HEK-293T C819(0.97); C662(0.97); C1487(1.19); C1265(0.99)  LDD1597  [37]
 LDCM0394  CL123 HEK-293T C819(0.89); C662(0.79); C1487(1.00); C1265(0.97)  LDD1598  [37]
 LDCM0395  CL124 HEK-293T C662(0.98); C1487(1.01); C1265(1.01); C1384(1.01)  LDD1599  [37]
 LDCM0396  CL125 HEK-293T C819(1.11); C662(1.03); C1487(0.86); C1265(0.87)  LDD1600  [37]
 LDCM0397  CL126 HEK-293T C819(1.08); C662(0.97); C1487(1.25); C1265(1.02)  LDD1601  [37]
 LDCM0398  CL127 HEK-293T C819(0.95); C662(1.05); C1487(0.90); C1265(0.98)  LDD1602  [37]
 LDCM0399  CL128 HEK-293T C662(0.91); C1487(1.17); C1265(1.02); C1384(1.09)  LDD1603  [37]
 LDCM0400  CL13 HEK-293T C819(1.18); C662(1.14); C1487(0.93); C1265(0.90)  LDD1604  [37]
 LDCM0401  CL14 HEK-293T C819(1.02); C662(0.92); C1487(0.96); C1265(0.96)  LDD1605  [37]
 LDCM0402  CL15 HEK-293T C819(0.92); C662(0.78); C1487(0.92); C1265(0.84)  LDD1606  [37]
 LDCM0403  CL16 HEK-293T C662(1.01); C1487(1.16); C1265(1.13); C1384(1.17)  LDD1607  [37]
 LDCM0404  CL17 HEK-293T C819(0.78); C662(0.90); C1487(0.79); C1265(0.85)  LDD1608  [37]
 LDCM0405  CL18 HEK-293T C819(0.94); C662(1.02); C1487(1.10); C1265(0.84)  LDD1609  [37]
 LDCM0406  CL19 HEK-293T C819(0.95); C662(0.74); C1487(0.99); C1265(1.04)  LDD1610  [37]
 LDCM0407  CL2 HEK-293T C819(1.03); C662(1.26); C1487(0.89); C1265(1.00)  LDD1611  [37]
 LDCM0408  CL20 HEK-293T C819(1.01); C662(0.97); C1487(1.03); C1265(1.13)  LDD1612  [37]
 LDCM0409  CL21 HEK-293T C662(0.85); C1487(0.98); C1265(1.20); C1384(1.02)  LDD1613  [37]
 LDCM0410  CL22 HEK-293T C819(0.99); C662(0.92); C1487(1.24); C1265(1.19)  LDD1614  [37]
 LDCM0411  CL23 HEK-293T C819(1.12); C662(0.98); C1487(1.09); C1265(1.08)  LDD1615  [37]
 LDCM0412  CL24 HEK-293T C819(1.00); C662(0.88); C1487(1.08); C1265(1.14)  LDD1616  [37]
 LDCM0413  CL25 HEK-293T C819(1.10); C662(0.82); C1487(0.95); C1265(0.90)  LDD1617  [37]
 LDCM0414  CL26 HEK-293T C819(0.97); C662(0.88); C1487(0.99); C1265(1.00)  LDD1618  [37]
 LDCM0415  CL27 HEK-293T C819(0.96); C662(0.92); C1487(1.14); C1265(0.95)  LDD1619  [37]
 LDCM0416  CL28 HEK-293T C662(1.03); C1487(1.08); C1265(0.99); C1384(1.06)  LDD1620  [37]
 LDCM0417  CL29 HEK-293T C819(1.11); C662(0.93); C1487(0.76); C1265(1.01)  LDD1621  [37]
 LDCM0418  CL3 HEK-293T C819(1.03); C662(1.03); C1487(1.05); C1265(1.07)  LDD1622  [37]
 LDCM0419  CL30 HEK-293T C819(0.99); C662(0.98); C1487(1.06); C1265(0.97)  LDD1623  [37]
 LDCM0420  CL31 HEK-293T C819(0.81); C662(0.71); C1487(1.10); C1265(0.97)  LDD1624  [37]
 LDCM0421  CL32 HEK-293T C819(1.03); C662(0.91); C1487(0.93); C1265(0.98)  LDD1625  [37]
 LDCM0422  CL33 HEK-293T C662(0.72); C1487(1.33); C1265(1.13); C1384(0.87)  LDD1626  [37]
 LDCM0423  CL34 HEK-293T C819(0.98); C662(0.89); C1487(1.17); C1265(1.19)  LDD1627  [37]
 LDCM0424  CL35 HEK-293T C819(1.67); C662(0.99); C1487(1.27); C1265(1.15)  LDD1628  [37]
 LDCM0425  CL36 HEK-293T C819(0.97); C662(0.91); C1487(1.11); C1265(1.12)  LDD1629  [37]
 LDCM0426  CL37 HEK-293T C819(1.09); C662(0.95); C1487(1.18); C1265(1.16)  LDD1630  [37]
 LDCM0428  CL39 HEK-293T C819(0.87); C662(0.96); C1487(0.84); C1265(0.88)  LDD1632  [37]
 LDCM0429  CL4 HEK-293T C662(0.94); C1487(1.17); C1265(0.99); C1384(1.23)  LDD1633  [37]
 LDCM0430  CL40 HEK-293T C662(0.90); C1487(1.17); C1265(1.09); C1384(1.11)  LDD1634  [37]
 LDCM0431  CL41 HEK-293T C819(0.74); C662(0.90); C1487(1.00); C1265(1.01)  LDD1635  [37]
 LDCM0432  CL42 HEK-293T C819(0.95); C662(0.89); C1487(1.11); C1265(0.99)  LDD1636  [37]
 LDCM0433  CL43 HEK-293T C819(1.29); C662(0.71); C1487(1.08); C1265(1.15)  LDD1637  [37]
 LDCM0434  CL44 HEK-293T C819(1.04); C662(1.06); C1487(0.95); C1265(1.13)  LDD1638  [37]
 LDCM0435  CL45 HEK-293T C662(0.98); C1487(0.67); C1265(1.20); C1384(0.91)  LDD1639  [37]
 LDCM0436  CL46 HEK-293T C819(1.00); C662(0.75); C1487(0.95); C1265(1.20)  LDD1640  [37]
 LDCM0437  CL47 HEK-293T C819(0.89); C662(1.01); C1487(1.14); C1265(1.12)  LDD1641  [37]
 LDCM0438  CL48 HEK-293T C819(1.06); C662(0.91); C1487(0.99); C1265(1.26)  LDD1642  [37]
 LDCM0439  CL49 HEK-293T C819(1.11); C662(0.91); C1487(1.11); C1265(0.99)  LDD1643  [37]
 LDCM0440  CL5 HEK-293T C819(1.18); C662(0.99); C1487(0.85); C1265(0.91)  LDD1644  [37]
 LDCM0441  CL50 HEK-293T C819(0.89); C662(0.85); C1487(0.94); C1265(0.88)  LDD1645  [37]
 LDCM0443  CL52 HEK-293T C662(0.81); C1487(1.19); C1265(1.02); C1384(1.08)  LDD1646  [37]
 LDCM0444  CL53 HEK-293T C819(1.06); C662(0.77); C1487(0.92); C1265(0.90)  LDD1647  [37]
 LDCM0445  CL54 HEK-293T C819(0.85); C662(0.73); C1487(0.97); C1265(0.82)  LDD1648  [37]
 LDCM0446  CL55 HEK-293T C819(1.11); C662(0.78); C1487(1.00); C1265(1.04)  LDD1649  [37]
 LDCM0447  CL56 HEK-293T C819(1.03); C662(0.91); C1487(0.84); C1265(1.11)  LDD1650  [37]
 LDCM0448  CL57 HEK-293T C662(0.80); C1487(0.86); C1265(1.04); C1384(0.92)  LDD1651  [37]
 LDCM0449  CL58 HEK-293T C819(0.93); C662(0.76); C1487(1.11); C1265(1.10)  LDD1652  [37]
 LDCM0450  CL59 HEK-293T C819(1.32); C662(0.95); C1487(1.24); C1265(1.09)  LDD1653  [37]
 LDCM0451  CL6 HEK-293T C819(0.99); C662(0.74); C1487(1.21); C1265(0.90)  LDD1654  [37]
 LDCM0452  CL60 HEK-293T C819(0.95); C662(0.90); C1487(1.09); C1265(1.21)  LDD1655  [37]
 LDCM0453  CL61 HEK-293T C819(1.11); C662(0.96); C1487(0.90); C1265(1.02)  LDD1656  [37]
 LDCM0454  CL62 HEK-293T C819(0.83); C662(0.85); C1487(1.01); C1265(0.94)  LDD1657  [37]
 LDCM0455  CL63 HEK-293T C819(0.91); C662(0.96); C1487(0.95); C1265(0.97)  LDD1658  [37]
 LDCM0456  CL64 HEK-293T C662(0.78); C1487(0.96); C1265(1.04); C1384(0.99)  LDD1659  [37]
 LDCM0457  CL65 HEK-293T C819(1.10); C662(0.93); C1487(1.09); C1265(1.00)  LDD1660  [37]
 LDCM0458  CL66 HEK-293T C819(0.97); C662(0.93); C1487(1.11); C1265(0.95)  LDD1661  [37]
 LDCM0459  CL67 HEK-293T C819(0.87); C662(0.84); C1487(1.06); C1265(0.98)  LDD1662  [37]
 LDCM0460  CL68 HEK-293T C819(1.02); C662(0.88); C1487(0.84); C1265(1.18)  LDD1663  [37]
 LDCM0461  CL69 HEK-293T C662(0.79); C1487(1.19); C1265(1.28); C1384(1.01)  LDD1664  [37]
 LDCM0462  CL7 HEK-293T C819(1.17); C662(0.99); C1487(1.12); C1265(1.03)  LDD1665  [37]
 LDCM0463  CL70 HEK-293T C819(1.04); C662(0.98); C1487(1.00); C1265(1.06)  LDD1666  [37]
 LDCM0464  CL71 HEK-293T C819(0.76); C662(1.03); C1487(1.11); C1265(1.26)  LDD1667  [37]
 LDCM0465  CL72 HEK-293T C819(1.06); C662(0.83); C1487(1.05); C1265(1.10)  LDD1668  [37]
 LDCM0466  CL73 HEK-293T C819(1.12); C662(0.94); C1487(0.90); C1265(0.97)  LDD1669  [37]
 LDCM0467  CL74 HEK-293T C819(1.01); C662(0.80); C1487(1.06); C1265(1.09)  LDD1670  [37]
 LDCM0469  CL76 HEK-293T C662(0.84); C1487(0.96); C1265(1.06); C1384(1.11)  LDD1672  [37]
 LDCM0470  CL77 HEK-293T C819(1.20); C662(1.06); C1487(0.84); C1265(0.93)  LDD1673  [37]
 LDCM0471  CL78 HEK-293T C819(0.91); C662(0.92); C1487(0.98); C1265(0.95)  LDD1674  [37]
 LDCM0472  CL79 HEK-293T C819(1.29); C662(0.65); C1487(1.11); C1265(1.23)  LDD1675  [37]
 LDCM0473  CL8 HEK-293T C819(0.82); C662(0.78); C1487(1.08); C1265(0.97)  LDD1676  [37]
 LDCM0474  CL80 HEK-293T C819(0.96); C662(0.96); C1487(0.93); C1265(0.99)  LDD1677  [37]
 LDCM0475  CL81 HEK-293T C662(0.91); C1487(1.11); C1265(1.29); C1384(0.94)  LDD1678  [37]
 LDCM0476  CL82 HEK-293T C819(1.09); C662(0.78); C1487(1.25); C1265(1.33)  LDD1679  [37]
 LDCM0477  CL83 HEK-293T C819(0.75); C662(0.96); C1487(1.15); C1265(1.02)  LDD1680  [37]
 LDCM0478  CL84 HEK-293T C819(0.93); C662(0.78); C1487(1.01); C1265(1.08)  LDD1681  [37]
 LDCM0479  CL85 HEK-293T C819(1.28); C662(0.89); C1487(1.17); C1265(0.98)  LDD1682  [37]
 LDCM0480  CL86 HEK-293T C819(1.11); C662(0.87); C1487(1.15); C1265(0.97)  LDD1683  [37]
 LDCM0481  CL87 HEK-293T C819(1.05); C662(1.04); C1487(1.03); C1265(1.08)  LDD1684  [37]
 LDCM0482  CL88 HEK-293T C662(0.88); C1487(1.06); C1265(1.14); C1384(1.20)  LDD1685  [37]
 LDCM0483  CL89 HEK-293T C819(1.16); C662(0.86); C1487(0.94); C1265(0.93)  LDD1686  [37]
 LDCM0484  CL9 HEK-293T C662(0.91); C1487(1.08); C1265(1.27); C1384(0.97)  LDD1687  [37]
 LDCM0485  CL90 HEK-293T C819(0.77); C662(0.77); C1487(1.01); C1265(0.74)  LDD1688  [37]
 LDCM0486  CL91 HEK-293T C819(0.94); C662(0.71); C1487(1.01); C1265(1.07)  LDD1689  [37]
 LDCM0487  CL92 HEK-293T C819(0.98); C662(0.84); C1487(1.07); C1265(0.98)  LDD1690  [37]
 LDCM0488  CL93 HEK-293T C662(0.80); C1487(0.81); C1265(1.10); C1384(1.02)  LDD1691  [37]
 LDCM0489  CL94 HEK-293T C819(1.04); C662(0.88); C1487(1.17); C1265(1.14)  LDD1692  [37]
 LDCM0490  CL95 HEK-293T C819(0.50); C662(0.91); C1487(1.01); C1265(0.86)  LDD1693  [37]
 LDCM0491  CL96 HEK-293T C819(1.16); C662(0.82); C1487(1.01); C1265(1.03)  LDD1694  [37]
 LDCM0492  CL97 HEK-293T C819(1.04); C662(0.91); C1487(0.85); C1265(0.86)  LDD1695  [37]
 LDCM0493  CL98 HEK-293T C819(0.93); C662(0.55); C1487(0.92); C1265(0.94)  LDD1696  [37]
 LDCM0494  CL99 HEK-293T C819(1.00); C662(0.85); C1487(0.86); C1265(0.89)  LDD1697  [37]
 LDCM0495  E2913 HEK-293T C819(0.86); C662(0.91); C1487(0.90); C1265(1.04)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C662(2.06)  LDD1702  [12]
 LDCM0625  F8 Ramos C819(1.58); C662(1.32); 2.03; C821(4.59)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C819(0.64); C662(1.32); 0.66  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C819(0.09); C662(0.14); 0.10; C1384(6.55)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C819(0.69); C662(0.89); 0.48  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C819(1.15); C662(1.00); 1.73  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C819(0.93); C662(0.98); 1.25; C1384(1.59)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C819(0.52); C662(1.13); 0.55  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C819(1.00); C662(1.02); 0.89  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C819(0.78); C662(1.38); 1.52  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C819(1.31); C662(0.97); 1.17  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C819(1.88); C662(1.00); 0.79; C1384(2.91)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C819(1.12); C662(1.18); 1.21  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C819(1.15); C662(1.00); 1.70  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C819(0.56); C662(1.11); 0.63  LDD2201  [39]
 LDCM0468  Fragment33 HEK-293T C819(0.97); C662(0.92); C1487(1.15); C1265(1.07)  LDD1671  [37]
 LDCM0596  Fragment38 Ramos C819(1.26); C662(0.79); 1.58  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C819(1.15); C662(1.03); C821(2.04)  LDD2184  [39]
 LDCM0427  Fragment51 HEK-293T C819(0.90); C662(0.86); C1487(1.07); C1265(0.99)  LDD1631  [37]
 LDCM0610  Fragment52 Ramos C819(1.06); C662(0.98); 4.80  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C819(1.43); C662(1.03)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C819(1.00); C662(0.95); 0.62; C821(0.95)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C819(0.60); C662(1.19); 0.65  LDD2188  [39]
 LDCM0117  HHS-0201 DM93 Y103(5.74)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y104(7.86); Y103(10.33); Y81(11.85)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y103(8.29)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y103(16.40); Y104(16.85)  LDD0268  [15]
 LDCM0015  HNE MDA-MB-231 C662(0.81); C1384(1.07)  LDD0346  [39]
 LDCM0107  IAA HeLa H927(0.00); C662(0.00); H582(0.00); C934(0.00)  LDD0221  [30]
 LDCM0179  JZ128 PC-3 C662(0.00); C934(0.00)  LDD0462  [11]
 LDCM0022  KB02 HEK-293T C919(1.05); C819(0.94); C1265(0.96); C1384(1.02)  LDD1492  [37]
 LDCM0023  KB03 Jurkat C662(13.37); C821(840.93)  LDD0209  [14]
 LDCM0024  KB05 G361 C826(3.02)  LDD3311  [40]
 LDCM0109  NEM HeLa H582(0.00); H1281(0.00); H1255(0.00); C662(0.00)  LDD0223  [30]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C662(0.55)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1516(1.01)  LDD2107  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1516(0.76)  LDD2109  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C662(0.99)  LDD2110  [12]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C662(0.50)  LDD2114  [12]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1516(1.69); C919(1.46)  LDD2119  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1516(1.06); C919(1.23); C819(1.12)  LDD2125  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1516(0.96); C919(0.83)  LDD2129  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1516(1.05)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1516(1.23); C919(1.58)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1516(1.17); C819(0.86)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1516(1.68)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1516(0.91)  LDD2140  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1516(2.17); C919(1.70)  LDD2144  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1516(1.37)  LDD2146  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C821(1.44); C662(1.23)  LDD2206  [41]
 LDCM0628  OTUB2-COV-1 HEK-293T C662(1.09)  LDD2207  [41]
 LDCM0131  RA190 MM1.R C662(1.57); C1516(1.23)  LDD0304  [42]
 LDCM0021  THZ1 HeLa S3 C662(0.95)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DDX3X (DDX3X) DEAD box helicase family O00571
Eukaryotic initiation factor 4A-I (EIF4A1) DEAD box helicase family P60842
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium and integrin-binding protein 1 (CIB1) . Q99828
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Eukaryotic translation initiation factor 3 subunit J (EIF3J) EIF-3 subunit J family O75822
Eukaryotic translation initiation factor 4E (EIF4E) Eukaryotic initiation factor 4E family P06730
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) Eukaryotic initiation factor 4G family Q04637
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Polyadenylate-binding protein 1 (PABPC1) Polyadenylate-binding protein type-1 family P11940
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
APOBEC1 complementation factor (A1CF) . Q9NQ94
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Peflin (PEF1) . Q9UBV8

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
5 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
29 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
30 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
31 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
32 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
33 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
34 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
35 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
36 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
40 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
41 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
42 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.