Details of the Target

General Information of Target

Target ID LDTP06083
Target Name Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)
Gene Name DYNC1H1
Gene ID 1778
Synonyms
DHC1; DNCH1; DNCL; DNECL; DYHC; KIAA0325; Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE
Target Bioclass
Other
Family
Dynein heavy chain family
Subcellular location
Cytoplasm, cytoskeleton
Function
Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression.
Uniprot ID
Q14204
Ensemble ID
ENST00000360184.10
HGNC ID
HGNC:2961

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 54 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.50  LDD0215  [1]
11RK72
 Probe Info  		4.05  LDD0327  [2]
11RK73
 Probe Info  		4.19  LDD0328  [2]
CY-1
 Probe Info  		4.89  LDD0243  [3]
CY4
 Probe Info  		4.87  LDD0244  [3]
N1
 Probe Info  		17.90  LDD0242  [3]
W1
 Probe Info  		10.79  LDD0235  [4]
TH211
 Probe Info  		Y2641(20.00); Y4196(20.00); Y3051(19.32); Y2265(18.31)  LDD0257  [5]
TH214
 Probe Info  		Y4252(20.00); Y2792(11.82); Y2892(5.23)  LDD0258  [5]
TH216
 Probe Info  		Y1120(20.00); Y146(20.00); Y2638(20.00); Y2765(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K2286(0.00); K3471(0.00); K1610(0.00)  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K2702(0.48); K371(1.14); K3480(1.73); K2286(1.93)  LDD3494  [8]
Probe 1
 Probe Info  		Y604(5.50); Y661(11.42); Y970(4.47); Y1190(27.08)  LDD3495  [9]
JZ128-DTB
 Probe Info  		C4216(0.00); C4438(0.00); C633(0.00)  LDD0462  [10]
THZ1-DTB
 Probe Info  		C4438(1.06)  LDD0460  [10]
AHL-Pu-1
 Probe Info  		C2076(10.10); C633(2.79); C4510(2.73); C4121(2.90)  LDD0168  [11]
HHS-482
 Probe Info  		Y1990(1.01); Y2426(0.73); Y2792(0.92); Y2881(1.14)  LDD0285  [12]
HHS-475
 Probe Info  		Y970(0.45); Y3377(0.68); Y3379(0.82); Y1010(1.92)  LDD0264  [13]
HHS-465
 Probe Info  		Y1990(10.00); Y2350(3.07); Y2426(6.80); Y4196(10.00)  LDD2237  [14]
DBIA
 Probe Info  		C3940(1.03); C633(1.02); C2639(0.96); C2466(0.94)  LDD0078  [15]
5E-2FA
 Probe Info  		H75(0.00); H3200(0.00)  LDD2235  [16]
ATP probe
 Probe Info  		K1912(0.00); K1917(0.00); K2261(0.00); K4283(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C3389(0.00); C3089(0.00); C1888(0.00); C3147(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C2076(0.00); C4216(0.00); C1888(0.00); C3147(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		C4216(0.00); C2594(0.00)  LDD0030  [20]
IPIAA_L
 Probe Info  		C2594(0.00); C2663(0.00); C2076(0.00); C4438(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C3389(0.00); C3089(0.00); C1888(0.00); C3693(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		K36(0.00); K2094(0.00); K4457(0.00)  LDD0035  [21]
BTD
 Probe Info  		C4121(0.00); C2076(0.00)  LDD0004  [22]
JW-RF-010
 Probe Info  		C978(0.00); C633(0.00)  LDD0026  [23]
NAIA_4
 Probe Info  		C633(0.00); C1888(0.00); C1977(0.00); C1999(0.00)  LDD2226  [24]
TFBX
 Probe Info  		C633(0.00); C4644(0.00); C4438(0.00); C978(0.00)  LDD0027  [23]
WYneN
 Probe Info  		C633(0.00); C1977(0.00); C3940(0.00); C2076(0.00)  LDD0021  [22]
WYneO
 Probe Info  		C2712(0.00); C2076(0.00); C867(0.00); C1999(0.00)  LDD0022  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [25]
Compound 10
 Probe Info  		C1999(0.00); C3712(0.00); C633(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C1999(0.00); C633(0.00)  LDD2213  [26]
ENE
 Probe Info  		C1999(0.00); C633(0.00); C3712(0.00); C3940(0.00)  LDD0006  [22]
IPM
 Probe Info  		C4510(0.00); C4121(0.00); C633(0.00); C1888(0.00)  LDD0005  [22]
NHS
 Probe Info  		K1099(0.00); K2094(0.00); K809(0.00); K4089(0.00)  LDD0010  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [27]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
SF
 Probe Info  		Y1990(0.00); Y4205(0.00); Y604(0.00)  LDD0028  [28]
STPyne
 Probe Info  		K4204(0.00); K2094(0.00); K624(0.00); K1584(0.00)  LDD0009  [22]
VSF
 Probe Info  		C4216(0.00); C978(0.00); C1999(0.00); C4570(0.00)  LDD0007  [22]
Ox-W18
 Probe Info  		W546(0.00); W2275(0.00)  LDD2175  [29]
1c-yne
 Probe Info  		K129(0.00); K1228(0.00); K2856(0.00); K2561(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C3573(0.00); C1977(0.00); C4216(0.00); H1500(0.00)  LDD0217  [30]
Crotonaldehyde
 Probe Info  		C4216(0.00); C633(0.00); C2639(0.00); C4570(0.00)  LDD0219  [30]
Methacrolein
 Probe Info  		C4216(0.00); C4438(0.00); C3712(0.00); C1999(0.00)  LDD0218  [30]
m-APA
 Probe Info  		C633(0.00); C4216(0.00)  LDD0404  [31]
NAIA_5
 Probe Info  		C3389(0.00); C3089(0.00); C1888(0.00); C3147(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.40  LDD0476  [32]
FFF probe14
 Probe Info  		20.00  LDD0477  [32]
FFF probe3
 Probe Info  		8.85  LDD0464  [32]
STS-1
 Probe Info  		4.00  LDD0136  [33]
STS-2
 Probe Info  		10.50  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]
DA-2
 Probe Info  		N.A.  LDD0072  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C4570(0.91); C3712(0.79); C3940(0.74); C633(0.71)  LDD2142  [36]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1999(0.95); C4570(0.95); C3940(1.06); C4438(1.15)  LDD2112  [36]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C2712(1.57); C1999(0.70); C4570(0.69); C3712(0.65)  LDD2095  [36]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1999(0.87); C4570(0.83); C4438(1.00); C3389(0.96)  LDD2130  [36]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C2712(0.97); C4570(0.78); C3712(0.99); C3940(1.18)  LDD2117  [36]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1999(1.09); C4570(1.16); C3940(1.18); C3389(1.42)  LDD2152  [36]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1999(1.01); C4570(0.98); C633(0.89); C867(1.10)  LDD2103  [36]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1999(0.55); C4570(0.59); C3712(0.59); C3940(0.82)  LDD2132  [36]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1999(0.65); C4570(0.77); C3712(0.62); C3389(0.86)  LDD2131  [36]
 LDCM0025  4SU-RNA HEK-293T C2076(10.10); C633(2.79); C4510(2.73); C4121(2.90)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2076(10.22); C1059(2.01); C633(2.91); C4510(2.74)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C1059(1.06); C1888(1.29); C1949(1.30); C1956(1.27)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C1059(1.08); C1888(1.25); C1949(1.11); C1956(1.12)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C1059(1.58); C1888(0.82); C1949(0.54); C1956(0.54)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C1059(1.59); C1888(0.98); C1949(0.64); C1956(0.64)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C1059(1.29); C1888(0.93); C1949(0.57); C1956(0.57)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C1059(1.36); C1888(1.03); C1949(0.64); C1956(0.64)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C1059(1.51); C1888(0.94); C1949(0.71); C1956(0.71)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C1059(1.48); C1888(1.09); C1949(0.64); C1956(0.64)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C1059(1.91); C1888(1.00); C1949(0.72); C1956(0.72)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C1059(1.66); C1888(1.22); C1949(0.86); C1956(0.83)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C1059(1.65); C1888(0.99); C1949(0.54); C1956(0.54)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C1059(0.98); C1888(0.90); C1949(0.48); C1956(0.53)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C1059(1.05); C1888(1.17); C1949(1.14); C1956(1.12)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C1059(0.74); C1888(0.77); C1949(0.49); C1956(0.51)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C1059(1.04); C1888(0.83); C1949(0.61); C1956(0.61)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C1059(1.38); C1888(0.94); C1949(0.65); C1956(0.64)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C1059(0.78); C1888(1.01); C1956(1.19); C1999(0.87)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C1059(0.78); C1888(1.19); C1956(1.23); C1999(1.03)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C1059(0.91); C1888(1.20); C1956(1.27); C1999(1.16)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C1059(1.38); C1888(1.18); C1956(1.07); C1999(1.06)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C1059(1.01); C1888(1.10); C1956(1.01); C1999(1.06)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C1059(0.87); C1888(1.12); C1956(1.09); C1999(0.94)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C1059(0.73); C1888(1.01); C1956(1.07); C1999(1.07)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C1059(0.90); C1888(0.97); C1949(1.04); C1956(0.94)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C1059(1.27); C1888(0.92); C1956(0.87); C1999(0.94)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C1059(0.80); C1888(1.08); C1956(1.04); C1999(1.00)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C1059(1.29); C1888(1.04); C1956(0.93); C1999(0.94)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C1059(0.84); C1888(1.10); C1956(1.19); C1999(1.10)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C1059(0.74); C1888(1.04); C1956(1.00); C1999(1.06)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C1059(1.25); C1888(1.21); C1956(1.13); C1999(1.02)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C1059(1.20); C1888(1.12); C1956(1.28); C1999(1.09)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C1059(0.93); C1888(1.25); C1956(1.25); C1999(1.13)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C1059(1.30); C1888(1.44); C1949(1.51); C1956(1.44)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C1059(0.65); C1888(1.31); C1949(0.90); C1956(0.98)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C1059(0.88); C1888(1.42); C1949(1.11); C1956(1.17)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C1059(1.04); C1888(1.26); C1949(1.05); C1956(1.06)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C1059(0.93); C1888(1.27); C1949(1.20); C1956(1.11)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C1059(0.80); C1888(1.36); C1949(1.33); C1956(1.22)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C1059(0.86); C1888(1.77); C1949(1.29); C1956(1.27)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C1059(1.32); C1888(1.49); C1949(1.13); C1956(1.12)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C1059(1.01); C1888(1.09); C1949(1.22); C1956(1.16)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C1059(0.83); C1888(1.26); C1949(1.06); C1956(1.06)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C1059(1.15); C1888(1.47); C1949(1.08); C1956(1.08)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C1059(0.81); C1888(1.52); C1949(1.12); C1956(1.10)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C1059(1.09); C1888(1.34); C1949(1.24); C1956(1.09)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C1059(1.26); C1888(1.42); C1949(1.25); C1956(1.25)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C1059(0.86); C1888(1.40); C1949(1.24); C1956(1.26)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C1059(0.87); C1888(1.37); C1949(1.01); C1956(1.14)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C1059(1.29); C1888(1.08); C1949(0.96); C1956(1.00)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C3712(0.49); C4570(0.56); C3389(0.68); C2639(0.69)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C3712(0.57); C4570(0.60); C2186(0.68); C2639(0.75)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C3712(0.55); C4570(0.70); C2186(0.74); C3693(0.79)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C3712(0.49); C4570(0.57); C3389(0.72); C2639(0.84)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C4570(0.57); C3712(0.63); C3389(0.73); C4121(0.92)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C4570(0.63); C3389(0.71); C3712(0.72); C2186(0.80)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C4438(0.71); C3389(0.76); C4644(0.89); C2594(0.94)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C3712(0.58); C4570(0.68); C3089(0.74); C2186(0.77)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C3712(0.54); C4570(0.62); C3089(0.70); C2639(0.82)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C3712(0.51); C4570(0.57); C3389(0.63); C2594(0.87)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C4570(0.58); C3389(0.71); C3712(0.76); C2142(0.86)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C1059(1.21); C1888(1.20); C1949(0.99); C1956(1.07)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C1059(1.30); C1888(1.09); C1949(1.11); C1956(1.06)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C1059(1.06); C1888(1.06); C1949(1.03); C1956(0.99)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C1059(1.12); C1888(1.10); C1949(0.93); C1956(0.92)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C4438(0.69); C3389(0.76); C2142(0.80); C2639(0.83)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C2142(0.58); C3693(0.75); C3389(0.76); C4570(0.88)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C3712(0.68); C3389(0.70); C2639(0.76); C2594(0.79)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C4121(0.66); C3389(0.87); C2466(0.92); C4216(1.00)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C2594(0.75); C4570(0.77); C3389(0.78); C2712(0.79)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C3712(0.62); C3389(0.71); C4438(0.73); C2594(0.75)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C2142(0.53); C4438(0.58); C3712(0.74); C2639(0.80)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C2142(0.48); C3389(0.80); C3693(0.80); C2594(0.81)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C2142(0.62); C2639(0.82); C3712(0.83); C4121(0.83)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C4121(0.52); C2454(0.75); C3573(0.77); C3389(0.77)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C2454(0.40); C4121(0.55); C4570(0.71); C3389(0.73)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C4121(0.65); C2454(0.66); C4570(0.69); C3389(0.75)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C2454(0.49); C4121(0.53); C4570(0.73); C3573(0.76)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C2454(0.48); C3712(0.61); C4644(0.62); C4570(0.67)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C4121(0.59); C2466(0.81); C3389(0.89); C2454(0.98)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C2454(0.47); C3712(0.57); C4570(0.61); C4644(0.62)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C2454(0.51); C4121(0.59); C4570(0.71); C3712(0.73)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C2454(0.33); C4570(0.60); C3389(0.61); C3712(0.61)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C3389(0.63); C4570(0.72); C3573(0.74); C2454(0.88)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C4644(0.49); C3389(0.61); C4570(0.68); C3712(0.82)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C3693(0.56); C1059(0.76); C1888(0.83); C1956(0.85)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C1059(0.65); C1956(0.78); C978(0.79); C1949(0.81)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C1059(0.68); C3089(0.75); C3693(0.81); C3573(0.82)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C1059(0.77); C4438(0.83); C3693(0.84); C3940(0.86)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C4121(0.89); C2712(0.90); C3089(0.91); C3573(0.95)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C4121(0.67); C3389(0.85); C4438(1.01); C978(1.02)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C3693(0.62); C4644(0.88); C2186(0.95); C3940(0.97)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C3693(0.46); C1059(0.74); C4121(0.90); C3089(0.91)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C3693(0.57); C1059(0.74); C4438(0.82); C1999(0.93)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C3693(0.55); C1059(0.73); C4438(0.83); C3089(0.85)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C3693(0.55); C3089(0.87); C978(0.92); C1059(0.92)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C3693(0.56); C4121(0.94); C3089(0.96); C867(0.97)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C3573(0.58); C4570(0.71); C2594(0.85); C3693(0.89)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C3573(0.66); C4121(0.77); C2454(0.79); C3693(0.82)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C3573(0.65); C2454(0.73); C4570(0.79); C2594(0.79)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C3573(0.58); C4570(0.64); C2594(0.75); C4644(0.85)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C4121(0.74); C3389(0.86); C2142(1.07); C3033(1.08)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C3573(0.60); C4570(0.64); C2594(0.78); C3693(0.81)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C3573(0.61); C2594(0.77); C3693(0.78); C1977(0.91)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C3573(0.63); C4570(0.66); C3693(0.70); C2594(0.79)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C3693(0.75); C4570(0.75); C2594(0.80); C3573(0.82)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C4570(0.61); C3573(0.65); C3693(0.83); C2594(0.89)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C4570(0.81); C3389(0.82); C4121(0.84); C3693(0.85)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C2594(0.68); C3573(0.68); C4570(0.70); C3693(0.81)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C3389(0.73); C4438(0.76); C4121(0.79); C3033(0.88)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C3389(0.69); C4438(0.71); C4570(0.74); C4644(0.77)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C3389(0.67); C4438(0.75); C2454(0.80); C4570(0.89)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C4438(0.56); C2142(0.59); C4644(0.78); C3389(0.83)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C4438(0.80); C3389(0.80); C4570(0.84); C2712(0.86)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C4438(0.73); C4121(0.83); C4570(0.84); C3389(0.90)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C3389(0.65); C4438(0.68); C4570(0.85); C4121(0.86)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C3389(0.73); C4438(0.75); C3033(0.86); C4121(0.88)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C3389(0.74); C4438(0.76); C4121(0.82); C4570(0.97)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C2454(0.71); C4570(0.80); C4121(0.82); C4438(0.88)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C4570(0.83); C4438(0.87); C3389(0.88); C2454(0.96)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C2454(0.64); C4438(0.70); C3389(0.72); C4570(0.80)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C2454(0.57); C1059(0.71); C2466(0.75); C3693(0.76)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C3712(0.70); C2466(0.71); C4644(0.77); C2454(0.77)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C4644(0.79); C3389(0.82); C2142(0.84); C2594(0.87)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C4644(0.61); C2454(0.76); C3033(0.77); C3573(0.84)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C2466(0.71); C1059(0.76); C3940(0.86); C3712(0.90)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C2454(0.68); C4644(0.70); C1059(0.79); C2186(0.86)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C2454(0.63); C4644(0.80); C3693(0.81); C2466(0.82)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C4570(0.82); C2466(0.85); C4644(0.88); C3573(0.91)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C2454(0.57); C4644(0.77); C2466(0.78); C3940(0.90)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C1059(0.76); C2466(0.83); C4570(0.86); C3033(0.87)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C4644(0.68); C2454(0.77); C3693(0.80); C3712(0.84)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C2454(0.57); C1059(0.71); C3693(0.80); C2466(0.81)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C2454(0.73); C4644(0.74); C2466(0.76); C3693(0.87)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C2594(0.73); C4644(0.74); C3389(0.76); C3573(0.83)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C4570(0.72); C3712(0.80); C2186(0.88); C3389(0.91)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C1977(0.29); C2466(0.62); C1059(0.79); C3033(0.80)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C2466(0.69); C3033(0.83); C4644(0.85); C4570(0.95)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C2466(0.58); C2594(0.61); C4438(0.70); C4644(0.73)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C2594(0.57); C2466(0.65); C4438(0.73); C4644(0.73)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C2466(0.54); C2594(0.60); C2454(0.65); C4438(0.72)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C2466(0.52); C2594(0.59); C4644(0.73); C2454(0.75)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C2594(0.79); C4121(0.88); C2712(0.90); C867(0.91)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C2594(0.55); C3389(0.81); C2712(0.81); C4644(0.83)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C2594(0.51); C4438(0.69); C4570(0.70); C4644(0.74)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C2594(0.46); C4121(0.56); C2639(0.75); C2712(0.81)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C2594(0.58); C4438(0.63); C4570(0.79); C4644(0.80)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C2594(0.55); C4438(0.71); C4644(0.76); C2466(0.78)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C2594(0.51); C2466(0.66); C4438(0.75); C4644(0.77)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C2594(0.63); C2466(0.68); C2454(0.73); C4438(0.87)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C1059(0.86); C4121(0.87); C3389(0.89); C867(0.89)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C2594(0.50); C4438(0.73); C2466(0.79); C2454(0.84)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C2594(0.49); C4438(0.63); C4644(0.68); C2712(0.72)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C4570(0.41); C4644(0.43); C4438(0.48); C3033(0.57)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C4644(0.55); C1949(0.59); C1956(0.59); C4438(0.59)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C1999(0.46); C4570(0.28); C3940(0.53); C4438(0.61)  LDD2138  [36]
 LDCM0520  AKOS000195272 MDA-MB-231 C1999(0.70); C4570(0.81); C3940(0.84); C3389(1.11)  LDD2113  [36]
 LDCM0248  AKOS034007472 HCT 116 C1059(1.00); C1888(1.14); C1949(1.09); C1956(1.05)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C2142(0.65); C4644(0.71); C2594(0.72); C3389(0.77)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C3389(0.65); C4438(0.71); C4644(0.83); C2142(0.85)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 C633(0.00); C4216(0.00)  LDD0404  [31]
 LDCM0020  ARS-1620 HCC44 C3940(1.03); C633(1.02); C2639(0.96); C2466(0.94)  LDD0078  [15]
 LDCM0498  BS-3668 MDA-MB-231 C1999(0.55); C4570(0.29); C3712(0.67); C3940(0.73)  LDD2091  [36]
 LDCM0630  CCW28-3 231MFP C1059(1.77); C1888(0.39)  LDD2214  [37]
 LDCM0108  Chloroacetamide HeLa C1977(0.00); C3573(0.00); H1500(0.00); C4216(0.00)  LDD0222  [30]
 LDCM0632  CL-Sc Hep-G2 C3389(20.00); C633(20.00); C4170(2.40); C1888(1.71)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C1977(0.78); C3693(0.80); C4216(0.85); C1949(0.85)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C3389(0.76); C3712(0.89); C4216(0.90); C3573(0.92)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C4121(0.59); C2466(0.71); C3389(0.84); C2454(0.89)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C4438(0.67); C4644(0.67); C3389(0.67); C2594(0.79)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C4644(0.70); C2466(0.72); C2142(0.74); C2594(0.80)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C4438(0.58); C2594(0.69); C2142(0.71); C2466(0.73)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C4438(0.51); C2594(0.72); C3389(0.75); C4644(0.77)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C3712(0.57); C2142(0.63); C3389(0.66); C2639(0.79)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C3389(0.65); C2142(0.74); C4438(0.76); C3712(0.82)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C3389(0.67); C3712(0.69); C2142(0.77); C4570(0.90)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C3389(0.56); C3712(0.70); C4438(0.81); C2142(0.84)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C2142(0.58); C3389(0.62); C3712(0.64); C4438(0.77)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C3389(0.82); C4644(0.95); C3712(0.99); C4216(0.99)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C3389(0.62); C3712(0.64); C2142(0.66); C4438(0.74)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C3712(0.70); C3389(0.75); C4570(0.80); C2594(0.82)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C4216(0.72); C4121(0.79); C3573(0.83); C3389(0.84)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C4644(0.45); C3389(0.59); C3712(0.62); C2454(0.63)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C4644(0.36); C3712(0.61); C4570(0.67); C3089(0.69)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C4644(0.50); C3089(0.55); C4570(0.61); C3712(0.65)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C4644(0.64); C3389(0.70); C4570(0.75); C3573(0.79)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C3693(0.74); C4438(0.91); C4570(0.96); C4644(0.96)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C3693(0.84); C4121(0.86); C3089(0.87); C1059(0.89)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C3693(0.85); C4121(0.85); C3573(0.88); C3089(0.91)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C3389(0.77); C4644(0.91); C3712(1.03); C3693(1.10)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C1059(0.70); C3693(0.73); C2639(0.83); C4438(0.83)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C4570(0.52); C2454(0.59); C3712(0.61); C2594(0.74)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C2594(0.76); C3573(0.77); C3693(0.79); C2454(0.84)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C4570(0.62); C3573(0.67); C3693(0.73); C4644(0.79)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C4570(0.59); C3573(0.66); C2594(0.73); C4644(0.84)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C4438(0.79); C4121(0.85); C2712(0.85); C1956(0.88)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C2712(0.68); C3033(0.77); C4570(0.78); C3389(0.82)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C1956(0.75); C4570(0.81); C4438(0.83); C2712(0.83)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C4438(0.67); C3389(0.72); C4570(0.78); C3033(0.89)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C3389(0.87); C4644(0.92); C4121(0.96); C4216(1.02)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C3389(0.84); C4216(0.89); C1977(0.89); C1956(0.93)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C4121(0.82); C3389(0.92); C3693(0.95); C978(0.97)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C3389(0.72); C4570(0.77); C3573(0.77); C4644(0.79)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C4121(0.73); C3389(0.74); C4570(0.79); C2594(0.86)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C4570(0.77); C4644(0.79); C3389(0.81); C978(0.87)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C3573(0.75); C4570(0.77); C3389(0.78); C4644(0.84)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C2454(0.77); C2466(0.77); C1059(0.87); C3693(0.89)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C3389(0.53); C4570(0.72); C2594(0.73); C4644(0.75)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C3389(0.51); C4570(0.70); C3573(0.71); C4121(0.75)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C3389(0.56); C4570(0.72); C2594(0.78); C4644(0.85)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C3389(0.58); C4570(0.69); C4644(0.76); C1956(0.87)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C3389(0.53); C4644(0.75); C4570(0.83); C4121(0.97)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C1059(1.07); C1888(1.13); C1949(1.14); C1956(0.97)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C1059(1.00); C1888(1.02); C1949(1.18); C1956(1.03)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C1059(0.95); C1888(1.20); C1949(1.11); C1956(0.96)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C1059(1.06); C1888(1.28); C1949(1.24); C1956(1.05)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C1059(1.15); C1888(1.46); C1949(1.10); C1956(0.94)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C1059(1.01); C1888(1.03); C1949(1.05); C1956(1.00)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C1059(0.90); C1888(1.04); C1949(0.97); C1956(0.89)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C1059(1.09); C1888(1.17); C1956(1.05); C1977(0.97)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C1059(1.12); C1888(1.19); C1956(1.29); C1977(0.94)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C1059(1.07); C1888(1.18); C1956(1.05); C1977(0.99)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C1059(1.37); C1888(1.51); C1956(1.18); C1977(0.95)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C1059(1.46); C1888(1.60); C1956(1.19); C1977(0.93)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C1059(1.35); C1888(1.59); C1956(1.20); C1977(0.98)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C1059(1.54); C1888(1.68); C1956(1.21); C1977(1.02)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C1059(1.45); C1888(1.44); C1956(1.11); C1977(1.08)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C1059(1.03); C1888(0.93); C1949(0.96); C1956(0.97)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C1059(1.39); C1888(1.45); C1956(1.26); C1977(0.91)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C1059(1.30); C1888(1.46); C1956(1.28); C1977(1.10)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C1059(1.83); C1888(2.06); C1956(1.76); C1977(1.66)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C1059(1.72); C1888(1.63); C1956(1.37); C1977(1.16)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C1059(1.36); C1888(1.29); C1956(1.11); C1977(0.93)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C1059(1.43); C1888(1.40); C1956(1.26); C1977(0.86)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C1059(0.85); C1888(0.92); C1949(0.97); C1956(0.87)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C1059(0.70); C1888(0.91); C1949(0.95); C1956(0.89)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C1059(0.65); C1888(0.99); C1949(0.99); C1956(0.85)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C1059(0.99); C1888(0.99); C1949(1.00); C1956(0.94)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C1059(0.99); C1888(1.08); C1949(1.15); C1956(1.04)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C1059(0.84); C1888(1.02); C1949(0.87); C1956(0.87)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C1059(0.73); C1888(1.06); C1949(0.94); C1956(0.85)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C1059(0.94); C1888(0.97); C1949(0.84); C1956(0.88)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C1059(0.73); C1888(0.97); C1949(1.00); C1956(0.97)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C1059(0.72); C1888(0.92); C1949(0.89); C1956(0.84)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C1059(0.77); C1888(1.02); C1949(1.03); C1956(0.99)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C1059(0.80); C1888(1.08); C1949(0.89); C1956(0.95)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C1059(0.54); C1888(1.02); C1949(1.10); C1956(0.98)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C1059(0.76); C1888(0.96); C1949(1.01); C1956(1.07)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C1059(0.93); C1888(1.03); C1949(0.80); C1956(0.94)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C1059(1.06); C1888(1.09); C1949(1.39); C1956(1.08)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C1059(0.90); C1888(0.97); C1949(1.16); C1956(1.03)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C1059(1.14); C1888(1.07); C1949(1.04); C1956(1.16)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C1059(1.10); C1888(1.03); C1949(1.15); C1956(0.98)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C1059(1.18); C1888(1.10); C1949(1.28); C1956(1.15)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C1059(1.51); C1888(1.22); C1949(1.37); C1956(1.28)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C1059(1.22); C1888(1.16); C1949(1.26); C1956(1.26)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C1059(1.79); C1888(1.20); C1949(1.91); C1956(1.60)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C1059(1.95); C1888(1.04); C1949(1.57); C1956(1.55)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C1059(1.65); C1888(1.24); C1949(1.37); C1956(1.28)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C1059(1.35); C1888(1.01); C1949(1.27); C1956(1.30)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C1059(1.17); C1888(1.21); C1949(1.59); C1956(1.17)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C1059(1.32); C1888(1.09); C1949(1.27); C1956(1.21)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C1059(1.35); C1888(1.14); C1949(1.29); C1956(1.27)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C1059(1.06); C1888(1.12); C1949(1.16); C1956(1.16)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C1059(1.19); C1888(1.18); C1949(1.22); C1956(1.16)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C1059(1.25); C1888(1.15); C1949(1.40); C1956(1.29)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C1059(0.90); C1888(1.07); C1949(1.05); C1956(1.11)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C1059(0.97); C1888(1.11); C1949(0.90); C1956(0.90)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C1059(0.92); C1888(1.35); C1949(1.00); C1956(0.98)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C1059(1.21); C1888(1.45); C1949(1.33); C1956(1.16)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C1059(1.26); C1888(1.18); C1949(1.10); C1956(1.25)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C1059(0.97); C1888(1.20); C1949(1.28); C1956(1.19)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C1059(0.97); C1888(1.08); C1949(1.11); C1956(1.04)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C1059(1.26); C1888(1.41); C1949(1.60); C1956(1.53)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C1059(1.27); C1888(1.62); C1949(1.55); C1956(1.37)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C1059(1.41); C1888(1.16); C1949(1.74); C1956(1.71)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C1059(1.04); C1888(1.22); C1949(1.16); C1956(1.07)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C1059(1.00); C1888(1.33); C1949(1.15); C1956(0.95)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C1059(1.19); C1888(1.36); C1949(1.15); C1956(1.08)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C1059(1.22); C1888(1.46); C1949(1.43); C1956(1.42)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C1059(1.74); C1888(1.55); C1949(2.02); C1956(2.14)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C1059(1.14); C1888(1.10); C1949(1.13); C1956(1.15)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C1059(0.83); C1888(1.15); C1949(0.95); C1956(0.86)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C1059(1.01); C1888(1.22); C1949(1.12); C1956(1.20)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C1059(0.90); C1888(1.09); C1949(1.01); C1956(1.11)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C1059(1.03); C1888(1.32); C1949(0.91); C1956(0.98)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C1059(0.99); C1888(1.27); C1949(1.04); C1956(1.09)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C1059(1.23); C1888(1.17); C1949(1.12); C1956(1.39)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C1059(1.08); C1888(1.18); C1949(1.20); C1956(1.09)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C1059(1.07); C1888(1.23); C1949(1.18); C1956(1.09)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C1059(0.98); C1888(1.38); C1949(1.10); C1956(1.32)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C1059(1.05); C1888(1.28); C1949(1.20); C1956(1.15)  LDD0811  [15]
 LDCM0634  CY-0357 Hep-G2 C4216(4.29); C633(1.29); C4644(0.94); C2639(0.80)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C2639(0.93); C4570(0.99); C867(0.95); C4121(0.90)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C4438(5.56); C1977(4.81); C867(4.53); C2076(4.14)  LDD1702  [36]
 LDCM0625  F8 Ramos C3940(0.88); C4644(0.68); C633(0.89); C4570(1.21)  LDD2187  [39]
 LDCM0572  Fragment10 MDA-MB-231 C1999(1.42); C1059(1.47)  LDD1389  [40]
 LDCM0573  Fragment11 Ramos C1999(0.74); C1059(2.62)  LDD1392  [40]
 LDCM0574  Fragment12 Ramos C3940(0.56); C4644(0.91); C633(1.49); C4570(1.46)  LDD2191  [39]
 LDCM0575  Fragment13 MDA-MB-231 C1999(0.78)  LDD1395  [40]
 LDCM0576  Fragment14 MDA-MB-231 C1999(1.09)  LDD1397  [40]
 LDCM0577  Fragment15 Ramos C1999(1.17)  LDD1400  [40]
 LDCM0579  Fragment20 MDA-MB-231 C1999(1.11)  LDD1402  [40]
 LDCM0580  Fragment21 MDA-MB-231 C1999(1.11)  LDD1404  [40]
 LDCM0582  Fragment23 Ramos C1999(3.14); C1059(20.00)  LDD1409  [40]
 LDCM0583  Fragment24 Ramos C1999(1.55)  LDD1410  [40]
 LDCM0584  Fragment25 MDA-MB-231 C1999(0.83)  LDD1411  [40]
 LDCM0578  Fragment27 MDA-MB-231 C1999(0.89)  LDD1401  [40]
 LDCM0586  Fragment28 MDA-MB-231 C1059(1.32)  LDD1415  [40]
 LDCM0587  Fragment29 MDA-MB-231 C1999(1.48)  LDD1417  [40]
 LDCM0588  Fragment30 Ramos C3940(1.00); C4644(1.04); C633(2.08); C4570(1.22)  LDD2199  [39]
 LDCM0589  Fragment31 MDA-MB-231 C1999(1.27)  LDD1421  [40]
 LDCM0590  Fragment32 Ramos C3940(0.79); C4644(0.60); C633(3.01); C4570(1.17)  LDD2201  [39]
 LDCM0468  Fragment33 HCT 116 C1059(1.26); C1888(1.00); C1949(1.34); C1956(1.34)  LDD0785  [15]
 LDCM0593  Fragment35 MDA-MB-231 C1059(0.84)  LDD1429  [40]
 LDCM0595  Fragment37 Ramos C1999(0.78)  LDD1432  [40]
 LDCM0596  Fragment38 Ramos C3940(0.79); C4644(1.15); C633(1.46); C4570(1.06)  LDD2203  [39]
 LDCM0566  Fragment4 MDA-MB-231 C1999(1.17)  LDD1378  [40]
 LDCM0598  Fragment40 Ramos C1999(0.78)  LDD1437  [40]
 LDCM0601  Fragment43 MDA-MB-231 C1999(0.99)  LDD1441  [40]
 LDCM0605  Fragment47 MDA-MB-231 C1999(1.26)  LDD1446  [40]
 LDCM0607  Fragment49 MDA-MB-231 C1999(1.20)  LDD1448  [40]
 LDCM0427  Fragment51 HCT 116 C1059(1.76); C1888(2.01); C1956(1.24); C1977(1.27)  LDD0744  [15]
 LDCM0610  Fragment52 MDA-MB-231 C1999(0.99)  LDD1452  [40]
 LDCM0614  Fragment56 Ramos C3940(1.16); C4644(1.14); C633(2.17); C4570(1.44)  LDD2205  [39]
 LDCM0569  Fragment7 MDA-MB-231 C1999(1.60)  LDD1383  [40]
 LDCM0570  Fragment8 MDA-MB-231 C1999(0.94)  LDD1385  [40]
 LDCM0571  Fragment9 MDA-MB-231 C1999(1.07)  LDD1387  [40]
 LDCM0116  HHS-0101 DM93 Y970(0.45); Y3377(0.68); Y3379(0.82); Y1010(1.92)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y970(0.28); Y3377(0.55); Y3379(0.66)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y3377(0.69); Y3379(0.95); Y970(1.88)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y970(0.38); Y1010(0.45); Y3377(0.80); Y3379(1.08)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y970(0.42); Y3377(0.74); Y3379(0.90); Y1010(1.17)  LDD0268  [13]
 LDCM0015  HNE MDA-MB-231 C4438(1.33)  LDD0346  [39]
 LDCM0107  IAA HeLa H3907(0.00); H1817(0.00); C4216(0.00); C2712(0.00)  LDD0221  [30]
 LDCM0123  JWB131 DM93 Y1990(1.01); Y2426(0.73); Y2792(0.92); Y2881(1.14)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y1990(0.85); Y2426(1.23); Y2792(1.10); Y2881(2.57)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y1990(1.52); Y2426(0.44); Y2792(0.74); Y2881(1.69)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y1990(3.49); Y2426(1.67); Y2792(3.19); Y2881(2.63)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y1990(2.78); Y2426(0.83); Y2792(1.78); Y2881(1.73)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y1990(1.36); Y2792(0.13); Y2881(0.16); Y2892(0.13)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y1990(0.55); Y2426(0.81); Y2792(0.92); Y2881(1.64)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y1990(1.12); Y2426(0.56); Y2792(1.02); Y2881(1.19)  LDD0292  [12]
 LDCM0179  JZ128 PC-3 C4216(0.00); C4438(0.00); C633(0.00)  LDD0462  [10]
 LDCM0022  KB02 HCT 116 C978(4.60); C3712(3.31); C4216(1.22); C1999(2.79)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C978(4.47); C3712(3.55); C4216(1.59); C1999(2.17)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C978(4.25); C3712(3.96); C4216(1.58); C1999(1.33)  LDD0082  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1999(1.01); C4570(1.02); C3712(0.91); C3940(1.06)  LDD2102  [36]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1999(0.55); C4570(0.33); C3712(0.57); C3940(0.93)  LDD2121  [36]
 LDCM0109  NEM HeLa H3907(0.00); H2791(0.00); H1695(0.00); H2263(0.00)  LDD0223  [30]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1999(0.68); C3712(0.55); C3940(0.92); C4438(0.91)  LDD2089  [36]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1999(1.46); C4570(1.07); C3712(0.98); C633(1.18)  LDD2090  [36]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1999(0.95); C4570(0.75); C3712(0.95); C3940(1.03)  LDD2092  [36]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1999(1.11); C4570(0.66); C3940(1.21); C3389(0.96)  LDD2093  [36]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1999(1.08); C4570(1.06); C3712(1.10); C3940(1.24)  LDD2094  [36]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C4570(0.54); C3712(0.55); C3389(0.18); C633(0.51)  LDD2096  [36]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1999(0.91); C4570(0.95); C3940(0.82); C3389(0.92)  LDD2097  [36]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1999(1.02); C4570(0.74); C3940(0.80); C3389(0.20)  LDD2098  [36]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C2712(1.02); C4570(0.61); C3712(0.92); C3940(1.94)  LDD2099  [36]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1999(1.12); C4570(1.04); C3712(0.95); C3940(0.58)  LDD2100  [36]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1999(0.90); C4570(0.87); C3940(0.91); C3389(1.35)  LDD2101  [36]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1999(1.03); C4570(0.88); C3712(0.80); C3940(0.77)  LDD2104  [36]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1999(1.45); C4570(1.26); C3712(1.19); C3940(1.23)  LDD2105  [36]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C4570(0.90); C3712(0.76); C633(1.09); C867(0.67)  LDD2106  [36]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C2712(1.05); C1999(0.96); C3712(1.20); C3940(1.07)  LDD2107  [36]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C4570(0.62); C3712(0.71); C3940(0.55); C633(0.39)  LDD2108  [36]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2712(0.80); C3712(0.84); C3940(0.91); C4438(0.92)  LDD2109  [36]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C867(0.93)  LDD2110  [36]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C2712(1.01); C4570(0.54); C3712(0.93); C3940(1.28)  LDD2111  [36]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C4570(0.97); C3940(0.98); C867(0.57)  LDD2114  [36]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1999(0.72); C4570(0.57); C3940(0.52); C3389(0.59)  LDD2115  [36]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C3389(0.43); C633(0.86); C4121(0.59); C2985(0.11)  LDD2116  [36]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C4570(0.51); C3712(0.78); C3389(0.39); C633(0.76)  LDD2118  [36]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1999(2.48); C4570(3.48); C3712(1.94); C3940(1.98)  LDD2119  [36]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1999(1.08); C4570(0.86); C3712(1.00); C3940(0.78)  LDD2120  [36]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C4570(0.40); C3712(0.87); C3389(0.29); C633(0.73)  LDD2122  [36]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1999(0.97); C3712(0.96); C3940(0.97); C4438(0.94)  LDD2123  [36]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1999(0.38); C4570(0.42); C3712(0.68); C3389(0.26)  LDD2124  [36]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2712(1.16); C1999(0.92); C4570(0.81); C3712(0.91)  LDD2125  [36]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C4570(0.38); C3712(0.75); C3389(0.24); C633(0.76)  LDD2126  [36]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1999(1.16); C4570(0.77); C3712(1.02); C3940(1.20)  LDD2127  [36]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1999(1.00); C4570(1.00); C3712(0.86); C3940(0.90)  LDD2128  [36]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C2712(0.93); C4570(0.67); C3712(1.04); C3389(1.16)  LDD2129  [36]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1999(0.74); C4570(0.86); C3389(0.72); C633(0.74)  LDD2133  [36]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1999(0.55); C4570(0.57); C3712(0.45); C3940(0.44)  LDD2134  [36]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C2712(1.21); C1999(1.19); C4570(0.87); C3712(1.24)  LDD2135  [36]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C2712(0.94); C4570(0.86); C3712(1.21); C4438(1.18)  LDD2136  [36]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2712(0.85); C1999(1.13); C4570(0.77); C3712(0.91)  LDD2137  [36]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C867(4.98); C3389(1.88); C1999(1.68); C633(1.28)  LDD1700  [36]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2712(0.71); C4570(0.40); C3712(0.69); C3940(0.68)  LDD2140  [36]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1999(0.71); C4570(0.67); C3712(0.55); C633(0.34)  LDD2141  [36]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1999(1.28); C4570(1.24); C3712(0.98); C3940(0.81)  LDD2143  [36]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C2712(1.56); C1999(2.53); C4570(3.27); C3712(2.19)  LDD2144  [36]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C3712(0.96); C3940(5.30); C633(3.69); C867(1.01)  LDD2145  [36]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1999(0.96); C4570(0.60); C3712(1.03); C3940(1.29)  LDD2146  [36]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1999(2.21); C3940(1.44); C3389(2.08); C633(3.92)  LDD2147  [36]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1999(0.66); C4570(0.50); C3712(0.77); C3940(0.45)  LDD2148  [36]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C4570(0.50); C3712(0.85); C3389(0.25); C633(0.82)  LDD2149  [36]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C3712(0.37); C3940(0.69); C4438(0.67); C3389(0.38)  LDD2150  [36]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C3389(0.32); C633(0.85); C792(0.22); C4121(0.68)  LDD2151  [36]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1999(2.35); C4570(1.50); C3712(1.06); C633(1.17)  LDD2153  [36]
 LDCM0627  NUDT7-COV-1 HEK-293T C4644(1.24); C1888(1.15); C4170(0.37); C633(0.12)  LDD2206  [41]
 LDCM0628  OTUB2-COV-1 HEK-293T C1888(1.52); C1977(1.42); C1888(1.10); C633(0.91)  LDD2207  [41]
 LDCM0021  THZ1 HeLa S3 C4438(1.06)  LDD0460  [10]
 LDCM0110  W12 Hep-G2 C633(6.57)  LDD0237  [4]
 LDCM0113  W17 Hep-G2 C1999(5.47)  LDD0240  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E) Archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family P19388
Presenilin-2 (PSEN2) Peptidase A22A family P49810
Pro-cathepsin H (CTSH) Peptidase C1 family P09668
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
Mitogen-activated protein kinase 11 (MAPK11) CMGC Ser/Thr protein kinase family Q15759
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Dual specificity protein phosphatase 10 (DUSP10) Protein-tyrosine phosphatase family Q9Y6W6
Fatty acid 2-hydroxylase (FA2H) Sterol desaturase family Q7L5A8
DCN1-like protein 5 (DCUN1D5) . Q9BTE7
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Peroxisomal membrane protein PEX14 (PEX14) Peroxin-14 family O75381
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor RXR-gamma (RXRG) Nuclear hormone receptor family P48443
Neurogenin-1 (NEUROG1) . Q92886
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-2 (CFL2) Actin-binding proteins ADF family Q9Y281
Beta-crystallin B3 (CRYBB3) Beta/gamma-crystallin family P26998
Protein BEX2 (BEX2) BEX family Q9BXY8
Translation initiation factor eIF2B subunit epsilon (EIF2B5) EIF-2B gamma/epsilon subunits family Q13144
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) GADD45 family P24522
Receptor-transporting protein 4 (RTP4) TMEM7 family Q96DX8
WD repeat-containing protein 5 (WDR5) WD repeat WDR5/wds family P61964
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Galectin-9C (LGALS9C) . Q6DKI2
PML-RARA-regulated adapter molecule 1 (PRAM1) . Q96QH2
Spermatogenesis-associated protein 46 (SPATA46) . Q5T0L3
Telethonin (TCAP) . O15273
Testis-expressed protein 12 (TEX12) . Q9BXU0
WW domain binding protein 1-like (WBP1L) . Q9NX94

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
29 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
30 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
31 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
34 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
35 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
36 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
37 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
40 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
41 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.