General Information of Target

Target ID LDTP02435
Target Name Heat shock 70 kDa protein 1B (HSPA1B)
Gene Name HSPA1B
Gene ID 3303
Synonyms
HSP72; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; HSP70-2; HSP70.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Target Bioclass
Other
Family
Heat shock protein 70 family
Subcellular location
Cytoplasm
Function
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation.; (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Uniprot ID
P0DMV9
Ensemble ID
ENST00000375650.5
HGNC ID
HGNC:5233
ChEMBL ID
CHEMBL3885585

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info 
7.09  LDD0448  [1]
P2
 Probe Info 
10.00  LDD0449  [1]
P3
 Probe Info 
10.00  LDD0450  [1]
P8
 Probe Info 
5.86  LDD0451  [1]
A-EBA
 Probe Info 
4.46  LDD0215  [2]
11RK72
 Probe Info 
3.40  LDD0327  [3]
11RK73
 Probe Info 
3.11  LDD0328  [3]
CY4
 Probe Info 
100.00  LDD0244  [4]
N1
 Probe Info 
100.00  LDD0242  [4]
C-Sul
 Probe Info 
2.71  LDD0066  [5]
YN-1
 Probe Info 
100.00  LDD0444  [6]
AZ-9
 Probe Info 
E523(0.83); E315(1.00); E521(0.86); D160(0.70)  LDD2208  [7]
ONAyne
 Probe Info 
K524(0.00); K108(0.00); K77(0.00); K71(0.00)  LDD0273  [8]
DBIA
 Probe Info 
C17(1.65)  LDD3311  [9]
HHS-475
 Probe Info 
Y545(0.74); Y15(0.82); Y431(0.87); Y525(0.90)  LDD0264  [10]
AMP probe
 Probe Info 
K507(0.00); K328(0.00); K524(0.00); K526(0.00)  LDD0200  [11]
ATP probe
 Probe Info 
K507(0.00); K328(0.00); K524(0.00); K526(0.00)  LDD0199  [11]
IA-alkyne
 Probe Info 
C306(0.00); C17(0.00); C574(0.00); C267(0.00)  LDD0032  [12]
ATP probe
 Probe Info 
K451(0.00); K348(0.00); K319(0.00); K88(0.00)  LDD0035  [13]
IPM
 Probe Info 
C306(0.00); C603(0.00)  LDD0025  [14]
JW-RF-010
 Probe Info 
N.A.  LDD0026  [14]
NAIA_5
 Probe Info 
C17(0.00); C306(0.00); C308(0.00)  LDD2224  [15]
TFBX
 Probe Info 
C17(0.00); C267(0.00)  LDD0027  [14]
WYneN
 Probe Info 
C603(0.00); C306(0.00)  LDD0021  [16]
WYneO
 Probe Info 
N.A.  LDD0022  [16]
ENE
 Probe Info 
N.A.  LDD0006  [16]
NHS
 Probe Info 
K348(0.00); K451(0.00); K77(0.00); K328(0.00)  LDD0010  [16]
OSF
 Probe Info 
Y525(0.00); Y41(0.00); Y107(0.00)  LDD0029  [17]
PPMS
 Probe Info 
N.A.  LDD0008  [16]
SF
 Probe Info 
K348(0.00); Y41(0.00); K497(0.00); K524(0.00)  LDD0028  [17]
STPyne
 Probe Info 
K159(0.00); K328(0.00); K112(0.00); K319(0.00)  LDD0009  [16]
VSF
 Probe Info 
N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info 
N.A.  LDD0018  [18]
Ox-W18
 Probe Info 
W90(0.00); W580(0.00)  LDD2175  [19]
Acrolein
 Probe Info 
C603(0.00); C306(0.00); H227(0.00); C574(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info 
C306(0.00); H227(0.00); H332(0.00); H240(0.00)  LDD0219  [20]
Methacrolein
 Probe Info 
H332(0.00); C306(0.00); H240(0.00); H227(0.00)  LDD0218  [20]
W1
 Probe Info 
C603(0.00); C306(0.00)  LDD0236  [21]
MPP-AC
 Probe Info 
N.A.  LDD0428  [22]
TPP-AC
 Probe Info 
N.A.  LDD0427  [22]
HHS-465
 Probe Info 
K102(0.00); K108(0.00); K112(0.00); K159(0.00)  LDD2240  [23]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Diazir
 Probe Info 
N.A.  LDD0011  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C17(1.00); C306(0.94); C603(0.85); C574(0.90)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C17(0.91); C306(0.94); C603(0.84); C574(1.10)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C17(0.98); C306(1.02); C603(0.90); C574(1.15)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C17(0.87); C306(0.98); C603(1.03); C574(0.96)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C17(0.99); C306(0.99); C603(0.97); C574(1.00)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C17(0.96); C306(0.89); C603(1.07); C574(1.13)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C17(0.91); C306(0.98); C603(0.83); C574(0.83)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C17(1.06); C306(1.01); C603(0.86); C574(1.03)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C17(0.98); C306(1.02); C603(0.72); C574(0.94)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C17(1.00); C306(0.98); C603(0.88); C574(1.16)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C17(0.98); C306(0.97); C603(0.92); C574(0.95)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C17(1.02); C306(1.02); C603(0.93); C574(0.96)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C17(1.03); C306(0.98); C603(0.98); C574(1.08)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C17(0.93); C306(0.95); C603(1.08); C574(1.13)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C17(0.89); C306(0.99); C603(0.88); C574(1.17)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C17(0.97); C306(0.93); C603(0.93); C574(0.87)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C17(1.01); C306(0.99); C603(1.01); C574(0.97)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C17(1.06); C306(1.06); C603(0.86); C574(1.16)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C17(1.01); C306(1.02); C603(0.98); C574(0.96)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C17(1.09); C306(0.93); C603(0.96); C574(1.03)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C17(1.05); C306(1.00); C603(0.95); C574(1.16)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C17(1.02); C306(0.97); C603(0.93); C574(1.06)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C17(1.01); C306(1.02); C603(1.00); C574(1.12)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C17(0.92); C306(1.02); C603(0.91); C574(1.09)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C17(0.92); C306(0.96); C603(0.81); C574(0.83)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C17(0.86); C306(0.96); C603(0.88); C574(1.01)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C17(1.00); C306(1.08); C603(0.84); C574(1.18)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C17(0.96); C306(0.99); C603(0.99); C574(0.89)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C17(0.99); C306(0.99); C603(1.15); C574(1.16)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C17(0.98); C306(1.03); C603(1.06); C574(1.03)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C17(0.98); C306(0.93); C603(1.04); C574(1.16)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C17(0.97); C306(0.95); C603(0.93); C574(0.96)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C17(1.02); C306(1.02); C603(0.89); C574(1.00)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C17(0.86); C306(0.93); C603(0.79); C574(0.93)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C17(0.93); C306(0.97); C603(1.07); C574(0.99)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C17(1.01); C306(1.00); C603(0.88); C574(1.20)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C17(0.91); C306(1.01); C603(0.94); C574(1.00)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C17(1.02); C306(0.95); C603(0.86); C574(1.00)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C17(1.02); C306(0.96); C603(0.96); C574(1.04)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C17(0.97); C306(0.90); C603(1.14); C574(1.12)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C17(1.01); C306(0.98); C603(1.12); C574(1.12)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C17(0.90); C306(0.97); C603(0.82); C574(0.98)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C17(1.02); C306(0.92); C603(1.02); C574(1.06)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C17(0.96); C306(1.00); C603(0.93); C574(1.09)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C17(0.95); C306(1.02); C603(1.07); C574(1.31)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C17(0.90); C306(1.04); C603(0.91); C574(0.95)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C17(0.94); C306(0.93); C603(0.99); C574(1.08)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C17(0.97); C306(1.01); C603(1.02); C574(1.08)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C17(0.93); C306(0.97); C603(1.08); C574(1.12)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C17(0.95); C306(1.04); C603(0.90); C574(1.13)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C17(0.92); C306(0.94); C603(0.89); C574(0.80)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C17(0.89); C306(0.92); C603(0.95); C574(1.04)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C17(1.01); C306(0.97); C603(0.98); C574(1.22)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C17(0.99); C306(0.99); C603(0.96); C574(0.96)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C17(0.91); C306(0.90); C603(0.94); C574(0.89)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C17(1.00); C306(0.94); C603(0.97); C574(0.92)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C17(0.96); C306(0.97); C603(0.91); C574(0.92)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C17(0.93); C306(0.92); C603(0.91); C574(1.02)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C17(0.97); C306(0.94); C603(1.00); C574(1.01)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C17(1.00); C306(0.94); C603(1.06); C574(1.11)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C17(1.00); C306(1.01); C603(0.91); C574(0.92)  LDD1569  [24]
 LDCM0248  AKOS034007472 HEK-293T C17(1.01); C306(0.96); C603(1.09); C574(1.09)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C17(0.95); C306(0.93); C603(0.89); C574(0.84)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C17(1.03); C306(0.97); C603(1.02); C574(1.03)  LDD1514  [24]
 LDCM0108  Chloroacetamide HeLa C603(0.00); C574(0.00); H227(0.00); H332(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C17(1.05); C306(0.96); C603(1.03); C574(0.96)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C17(1.01); C306(1.16); C603(0.73); C574(0.70)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C17(0.99); C306(0.93); C603(0.79); C574(0.94)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C17(0.96); C306(0.94); C603(0.98); C574(0.88)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C17(0.94); C306(0.95); C603(0.80); C574(0.93)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C17(0.93); C306(0.95); C603(0.96); C574(1.01)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C17(0.98); C306(0.99); C603(0.94); C574(1.00)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C17(0.94); C306(1.04); C603(1.05); C574(0.91)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C17(1.03); C306(1.00); C603(1.10); C574(0.97)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C17(1.03); C306(1.00); C603(0.97); C574(1.11)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C17(0.92); C306(0.97); C603(0.97); C574(0.92)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C17(0.99); C306(0.98); C603(1.03); C574(0.89)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C17(1.06); C306(1.05); C603(1.00); C574(0.62)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C17(0.93); C306(0.91); C603(1.01); C574(0.88)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C17(0.97); C306(1.00); C603(0.94); C574(0.90)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C17(0.95); C306(0.95); C603(0.86); C574(1.02)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C17(0.98); C306(0.92); C603(1.04); C574(0.96)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C17(0.88); C306(1.00); C603(0.84); C574(0.87)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C17(1.02); C306(0.98); C603(1.06); C574(0.97)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C17(0.88); C306(0.98); C603(0.86); C574(0.91)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C17(0.97); C306(0.94); C603(0.92); C574(0.91)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C17(0.93); C306(0.98); C603(0.96); C574(1.00)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C17(1.00); C306(0.94); C603(0.98); C574(1.03)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C17(1.02); C306(1.07); C603(0.89); C574(0.90)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C17(0.90); C306(0.97); C603(0.97); C574(0.93)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C17(0.93); C306(1.01); C603(0.95); C574(0.97)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C17(0.93); C306(1.00); C603(0.98); C574(1.02)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C17(0.90); C306(0.95); C603(0.84); C574(0.89)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C17(0.88); C306(0.97); C603(0.86); C574(0.93)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C17(1.00); C306(0.91); C603(1.05); C574(0.99)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C17(0.97); C306(0.94); C603(0.90); C574(0.89)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C17(1.01); C306(0.93); C603(0.96); C574(0.90)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C17(1.01); C306(0.92); C603(0.89); C574(0.92)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C17(0.95); C306(0.88); C603(1.13); C574(1.03)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C17(1.03); C306(1.02); C603(0.94); C574(1.05)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C17(0.95); C306(0.87); C603(0.95); C574(0.98)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C17(0.91); C306(1.00); C603(0.88); C574(0.96)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C17(0.91); C306(0.96); C603(0.89); C574(0.82)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C17(1.02); C306(1.05); C603(0.87); C574(1.06)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C17(1.04); C306(1.09); C603(1.06); C574(0.96)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C17(1.05); C306(1.08); C603(1.01); C574(1.02)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C17(0.89); C306(1.15); C603(1.05); C574(1.03)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C17(0.94); C306(1.00); C603(0.77); C574(0.74)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C17(1.06); C306(1.18); C603(0.95); C574(0.96)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C17(1.01); C306(1.09); C603(1.16); C574(0.76)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C17(0.98); C306(1.07); C603(0.93); C574(1.04)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C17(1.01); C306(0.93); C603(0.86); C574(0.98)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C17(1.00); C306(1.02); C603(1.06); C574(1.05)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C17(0.99); C306(0.99); C603(1.03); C574(1.07)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C17(0.90); C306(0.97); C603(1.05); C574(1.04)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C17(0.97); C306(0.95); C603(0.99); C574(0.94)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C17(1.09); C306(1.02); C603(1.01); C574(0.98)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C17(1.01); C306(0.99); C603(1.19); C574(1.02)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C17(1.08); C306(1.10); C603(0.87); C574(0.94)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C17(0.98); C306(1.13); C603(0.96); C574(1.03)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C17(0.95); C306(1.04); C603(0.84); C574(0.72)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C17(1.04); C306(1.16); C603(0.98); C574(0.85)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C17(0.98); C306(1.07); C603(0.99); C574(0.72)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C17(1.05); C306(1.07); C603(1.01); C574(1.03)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C17(1.03); C306(0.93); C603(1.06); C574(0.99)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C17(0.98); C306(0.95); C603(1.13); C574(1.04)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C17(0.91); C306(0.95); C603(1.10); C574(0.87)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C17(0.95); C306(0.95); C603(1.00); C574(0.91)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C17(1.02); C306(0.94); C603(0.83); C574(0.85)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C17(0.99); C306(1.00); C603(0.88); C574(0.96)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C17(0.99); C306(1.03); C603(0.92); C574(0.92)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C17(0.91); C306(1.00); C603(1.00); C574(0.92)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C17(1.01); C306(1.04); C603(0.86); C574(0.75)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C17(1.00); C306(1.08); C603(0.89); C574(0.89)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C17(1.05); C306(0.99); C603(1.02); C574(0.70)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C17(1.04); C306(0.97); C603(1.00); C574(1.02)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C17(1.03); C306(0.95); C603(1.19); C574(0.99)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C17(0.94); C306(0.97); C603(0.92); C574(0.94)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C17(0.98); C306(0.99); C603(0.93); C574(1.03)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C17(0.87); C306(1.01); C603(1.05); C574(0.92)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C17(0.95); C306(0.88); C603(0.89); C574(0.77)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C17(0.90); C306(1.01); C603(0.82); C574(0.89)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C17(1.02); C306(1.08); C603(0.87); C574(0.81)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C17(1.00); C306(1.05); C603(0.87); C574(0.93)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C17(0.98); C306(1.03); C603(0.77); C574(0.76)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C17(0.99); C306(1.11); C603(0.83); C574(0.90)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C17(0.95); C306(1.06); C603(1.21); C574(0.62)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C17(0.97); C306(1.11); C603(0.97); C574(0.96)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C17(1.03); C306(1.18); C603(0.85); C574(0.99)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C17(1.03); C306(0.92); C603(1.15); C574(0.99)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C17(0.99); C306(0.96); C603(0.94); C574(1.11)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C17(0.96); C306(0.99); C603(1.04); C574(1.09)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C17(1.02); C306(1.00); C603(0.87); C574(0.83)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C17(0.95); C306(0.95); C603(0.85); C574(0.89)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C17(0.95); C306(0.99); C603(0.99); C574(1.01)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C17(1.00); C306(1.04); C603(0.88); C574(1.00)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C17(0.93); C306(1.03); C603(0.98); C574(0.99)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C17(1.04); C306(0.95); C603(0.93); C574(0.84)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C17(1.06); C306(1.14); C603(1.01); C574(0.95)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C17(1.00); C306(1.09); C603(0.91); C574(0.84)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C17(1.02); C306(1.00); C603(1.12); C574(0.80)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C17(0.98); C306(1.13); C603(0.93); C574(0.95)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C17(0.99); C306(1.00); C603(0.89); C574(1.11)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C17(0.99); C306(1.00); C603(0.86); C574(1.09)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C17(0.94); C306(0.96); C603(1.03); C574(1.02)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C17(0.94); C306(0.94); C603(0.76); C574(0.91)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C17(1.07); C306(1.11); C603(1.07); C574(1.12)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C17(0.98); C306(1.09); C603(0.94); C574(1.03)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C17(0.87); C306(0.91); C603(0.69); C574(0.69)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C17(1.04); C306(1.02); C603(1.20); C574(1.13)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C17(1.03); C306(1.09); C603(1.03); C574(0.91)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C17(1.06); C306(1.10); C603(0.98); C574(0.97)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C17(1.05); C306(1.17); C603(1.04); C574(0.74)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C17(1.01); C306(0.98); C603(1.03); C574(0.95)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C17(1.04); C306(0.89); C603(1.04); C574(0.97)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C17(0.97); C306(0.95); C603(1.06); C574(0.91)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C17(1.01); C306(0.85); C603(0.99); C574(0.99)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C17(0.77); C306(0.93); C603(0.91); C574(0.93)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C17(0.94); C306(0.95); C603(1.08); C574(0.84)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C17(1.04); C306(1.08); C603(0.99); C574(0.84)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C17(0.74); C306(0.99); C603(0.68); C574(0.82)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C17(1.07); C306(1.06); C603(1.02); C574(1.07)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C17(0.91); C306(0.97); C603(0.90); C574(0.88)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C17(1.01); C306(1.00); C603(0.91); C574(0.87)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C17(1.06); C306(1.03); C603(0.88); C574(0.88)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C17(0.87); C306(0.87); C603(0.92); C574(0.65)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C17(0.98); C306(0.90); C603(0.91); C574(0.87)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C17(0.99); C306(0.98); C603(0.91); C574(0.83)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C17(0.99); C306(0.94); C603(0.92); C574(0.94)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C17(0.94); C306(0.94); C603(0.90); C574(0.93)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C17(0.98); C306(0.98); C603(0.99); C574(1.04)  LDD1698  [24]
 LDCM0468  Fragment33 HEK-293T C17(1.02); C306(0.96); C603(0.96); C574(1.05)  LDD1671  [24]
 LDCM0427  Fragment51 HEK-293T C17(0.96); C306(0.96); C603(0.84); C574(1.05)  LDD1631  [24]
 LDCM0116  HHS-0101 DM93 Y545(0.74); Y15(0.82); Y431(0.87); Y525(0.90)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y545(0.45); Y137(0.63); Y15(0.64); Y525(0.69)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y545(0.55); Y525(0.71); Y15(0.80); Y431(0.81)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y15(0.67); Y525(0.75); Y41(0.75); Y545(0.78)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y41(0.48); Y525(0.59); Y115(0.63); Y107(0.71)  LDD0268  [10]
 LDCM0107  IAA HeLa C603(0.00); H227(0.00); H332(0.00); H89(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C17(1.06); C306(0.92); C603(1.30); C574(1.04)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C17(1.03); C306(1.00); C603(1.20); C574(1.02)  LDD1497  [24]
 LDCM0024  KB05 G361 C17(1.65)  LDD3311  [9]
 LDCM0109  NEM HeLa H332(0.00); H227(0.00); H240(0.00); C306(0.00)  LDD0223  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteinase-activated receptor 2 (F2RL1) G-protein coupled receptor 1 family P55085

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402