Details of the Target

General Information of Target

Target ID LDTP19851
Target Name Isochorismatase domain-containing protein 1 (ISOC1)
Gene Name ISOC1
Gene ID 51015
Synonyms
Isochorismatase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSRPPCGATSSARRACQFPAPMAAAREPELPQEAPATEPAPPPACRFFLEGRCRFGARC
RQPHPGAPAPPGREAQPEAGAKKPPLRTAADVIQRIRWDPRLDPADFSVGYVDRFLGVRE
EPFSAFCWDQPLAALGPGVLAVPQHRVRFFRFHGRLVWDRASRTDLVFGSGSAAGRGPTI
LDAPNTEGAHGAEGAEWTLAGTGQEAQAAPKRGSTRPLCTGHQEPGVEEPGELEAAQERA
LGTAADLGTLAPRGRLAGVTEEALKPTAATRTTLLGGKEAQALGVPGGSAETTEAEWGPA
AWPEDKRARLSVAAPCQPRPTHFVALMVTEPGLQAEVTKAQEYLVHVAPHCANFLVPSQN
LHLTLALLRLAGAGEEAAAIGALRRALLAPGLNAPPRLSFRKLVLLGPHVLCAPPSPTLE
SMAQVLSQRLEAEGLSTLQSPGQLHPHLTVAKVPHGSQVHLPKLEFTLSQEVGCQPLQTL
WLCRIGRTGGPFQPLAEIRLE
Target Bioclass
Enzyme
Family
Isochorismatase family
Uniprot ID
Q96CN7
Ensemble ID
ENST00000173527.6
HGNC ID
HGNC:24254

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
11RK72
 Probe Info  		6.09  LDD0327  [1]
11RK73
 Probe Info  		6.53  LDD0328  [1]
TH211
 Probe Info  		Y132(20.00)  LDD0257  [2]
Probe 1
 Probe Info  		Y132(36.92); Y160(30.29)  LDD3495  [3]
DBIA
 Probe Info  		C215(1.16)  LDD3340  [4]
THZ1-DTB
 Probe Info  		C120(1.02)  LDD0460  [5]
BTD
 Probe Info  		C93(2.49)  LDD1700  [6]
HHS-475
 Probe Info  		Y160(0.76)  LDD0264  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
IA-alkyne
 Probe Info  		C119(0.00); C120(0.00)  LDD2241  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
SF
 Probe Info  		Y160(0.00); K279(0.00)  LDD0028  [10]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
AOyne
 Probe Info  		4.30  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
HHS-465
 Probe Info  		K162(0.00); Y160(0.00)  LDD2240  [15]
PAL-AfBPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.68  LDD1728  [16]
C055
 Probe Info  		12.21  LDD1752  [16]
C063
 Probe Info  		11.16  LDD1760  [16]
C064
 Probe Info  		7.31  LDD1761  [16]
C070
 Probe Info  		9.25  LDD1766  [16]
C092
 Probe Info  		17.63  LDD1783  [16]
C112
 Probe Info  		24.25  LDD1799  [16]
C134
 Probe Info  		27.47  LDD1816  [16]
C143
 Probe Info  		19.29  LDD1825  [16]
C153
 Probe Info  		15.56  LDD1834  [16]
C160
 Probe Info  		7.26  LDD1840  [16]
C161
 Probe Info  		10.41  LDD1841  [16]
C173
 Probe Info  		9.58  LDD1853  [16]
C191
 Probe Info  		11.39  LDD1868  [16]
C238
 Probe Info  		10.85  LDD1911  [16]
C240
 Probe Info  		9.25  LDD1913  [16]
C246
 Probe Info  		13.93  LDD1919  [16]
C273
 Probe Info  		7.67  LDD1943  [16]
C275
 Probe Info  		16.11  LDD1945  [16]
C289
 Probe Info  		27.47  LDD1959  [16]
C290
 Probe Info  		8.51  LDD1960  [16]
C313
 Probe Info  		29.45  LDD1980  [16]
C350
 Probe Info  		40.50  LDD2011  [16]
C354
 Probe Info  		7.16  LDD2015  [16]
C362
 Probe Info  		35.26  LDD2023  [16]
C366
 Probe Info  		5.78  LDD2027  [16]
C367
 Probe Info  		18.77  LDD2028  [16]
C413
 Probe Info  		14.12  LDD2069  [16]
C419
 Probe Info  		46.85  LDD2074  [16]
FFF probe11
 Probe Info  		17.23  LDD0471  [17]
FFF probe13
 Probe Info  		13.43  LDD0475  [17]
FFF probe14
 Probe Info  		15.25  LDD0477  [17]
FFF probe2
 Probe Info  		18.08  LDD0463  [17]
FFF probe3
 Probe Info  		5.73  LDD0464  [17]
JN0003
 Probe Info  		12.19  LDD0469  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C93(1.01)  LDD2117  [6]
 LDCM0214  AC1 HEK-293T C215(0.85)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C215(1.02); C119(1.18)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C215(0.98); C119(0.91)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C215(0.93); C119(0.83)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C215(0.90)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C215(1.09); C119(0.73)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C215(0.89)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C215(1.00); C119(0.62)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C215(0.84); C119(0.85)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C215(1.02); C119(0.95)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C215(1.12); C119(0.73)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C215(1.08)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C215(1.01)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C215(0.91); C119(0.74)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C215(0.97); C119(0.78)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C215(0.83)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C215(1.02); C119(1.09)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C215(1.01); C119(0.93)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C215(0.86); C119(0.76)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C215(1.04)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C215(0.95); C119(0.81)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C215(0.91)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C215(1.02); C119(0.80)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C215(1.11); C119(0.88)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C215(0.83)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C215(1.10); C119(0.76)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C215(0.91); C119(0.98)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C215(1.02); C119(0.76)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C215(0.92)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C215(0.98)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C215(1.04); C119(0.77)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C215(1.13); C119(0.75)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C215(0.99); C119(0.81)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C215(1.07)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C215(0.97); C119(0.81)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C215(1.03); C119(0.86)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C215(0.80); C119(0.56)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C215(0.91)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C215(0.96)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C215(1.15); C119(1.00)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C215(1.02); C119(1.01)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C215(0.91)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C215(0.95)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C215(1.08); C119(0.82)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C215(0.99); C119(0.94)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C215(0.99); C119(0.77)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C215(0.95)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C215(0.97)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C215(1.09); C119(0.71)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C215(0.95); C119(0.75)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C215(1.24)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C215(1.09); C119(1.07)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C215(1.11); C119(0.97)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C215(1.01)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C215(0.94); C119(0.72)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C215(1.04)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C215(0.94)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C215(1.08); C119(0.80)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C215(1.05); C119(0.99)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C215(1.11); C119(0.73)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C215(0.93); C119(0.69)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C215(0.92)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C215(0.86)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C215(0.98); C119(0.75)  LDD1514  [18]
 LDCM0498  BS-3668 MDA-MB-231 C93(1.23)  LDD2091  [6]
 LDCM0367  CL1 HEK-293T C215(1.15)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C215(1.06)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C215(1.00)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C215(1.07)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C215(0.85)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C215(1.13); C119(0.96)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C215(0.93)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C215(0.93)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C215(0.94)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C215(1.00); C119(0.87)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C215(1.01)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C215(0.92)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C215(1.41); C119(1.09)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C215(0.84)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C215(1.14); C119(0.80)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C215(0.84)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C215(0.87)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C215(0.82)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C215(1.05); C119(1.33)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C215(1.25)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C215(0.96)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C215(0.91)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C215(1.10); C119(0.69)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C215(1.31); C119(0.83)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C215(0.98)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C215(1.10)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C215(0.90)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C215(0.86); C119(0.71)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C215(0.93)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C215(1.50)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C215(0.97)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C215(1.09); C119(0.92)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C215(1.05)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C215(1.15)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C215(0.92)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C215(1.16); C119(0.98)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C215(0.97)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C215(0.93)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C215(1.18); C119(0.75)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C215(1.06); C119(0.96)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C215(1.01)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C215(1.01); C119(0.97)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C215(0.96)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C215(1.18)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C215(1.27); C119(0.89)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C215(1.32); C119(1.08)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C215(1.00)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C215(0.99)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C215(1.12); C119(0.84)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C215(0.83)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C215(0.91)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C215(1.14); C119(1.11)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C215(1.13); C119(0.88)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C215(1.18); C119(0.86)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C215(1.09); C119(0.77)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C215(0.93)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C215(1.22)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C215(1.19); C119(0.95)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C215(1.30); C119(1.25)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C215(1.13)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C215(0.99); C119(0.87)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C215(0.98)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C215(0.93)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C215(0.74)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C215(1.11); C119(1.23)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C215(1.15); C119(0.99)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C215(0.95); C119(0.80)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C215(1.14)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C215(1.18)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C215(1.19); C119(1.28)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C215(1.13); C119(0.75)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C215(1.07)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C215(1.46)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C215(0.76)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C215(1.07)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C215(0.93)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C215(1.08); C119(0.93)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C215(1.03); C119(0.82)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C215(1.09); C119(0.63)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C215(1.01)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C215(1.02)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C215(1.29); C119(0.92)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C215(1.22); C119(0.99)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C215(1.14); C119(0.87)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C215(1.24)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C215(0.87)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C215(1.01); C119(0.67)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C215(0.87)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C215(0.86)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C215(1.09); C119(1.01)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C215(1.01); C119(0.97)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C215(0.93); C119(1.03)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C215(1.21)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C215(1.06); C119(1.00)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C215(1.09)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C215(1.16); C119(0.98)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C215(1.18); C119(1.24)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C215(1.14)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C215(0.93)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C215(0.95)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C215(1.15)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C215(1.06); C119(0.78)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C215(1.04); C119(0.90)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C215(1.02); C119(0.69)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C215(0.99); C119(1.35)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C215(1.06)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C215(1.23)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C215(1.18); C119(0.99)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C215(1.00); C119(0.90)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C215(1.59)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C215(1.21)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C215(1.06); C119(1.56)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C215(1.01)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C215(0.90)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C215(1.08)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C215(0.92); C119(0.76)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C215(1.31); C119(0.97)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C215(0.97); C119(1.29)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C215(0.93)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C215(1.27)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C215(0.65); C119(0.58)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C215(1.27); C119(0.88)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C215(0.97)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C215(0.84)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C215(1.08); C119(0.75)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C215(1.07); C119(1.06)  LDD1698  [18]
 LDCM0468  Fragment33 HEK-293T C215(1.05); C119(0.88)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C215(1.06)  LDD1631  [18]
 LDCM0116  HHS-0101 DM93 Y160(0.76)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y160(0.75)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y160(0.73)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y160(1.04)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y160(1.05)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C215(1.07)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C215(0.99)  LDD1497  [18]
 LDCM0024  KB05 NB1 C215(1.16)  LDD3340  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C93(0.87)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C93(0.64)  LDD2109  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C93(0.41)  LDD2118  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C93(0.25)  LDD2122  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C93(0.29)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C93(0.85)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C93(0.39)  LDD2126  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C93(2.01)  LDD2129  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C93(0.81)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C93(2.49)  LDD1700  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C93(0.58)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C93(0.76)  LDD2146  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C93(0.48)  LDD2149  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C93(0.30)  LDD2151  [6]
 LDCM0021  THZ1 HeLa S3 C120(1.02)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) CALCOCO family Q9P1Z2

References

1 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402