Details of the Target

General Information of Target

Target ID LDTP09821
Target Name Stalled ribosome sensor GCN1 (GCN1)
Gene Name GCN1
Gene ID 10985
Synonyms
GCN1L1; KIAA0219; Stalled ribosome sensor GCN1; GCN1 eIF-2-alpha kinase activator homolog; GCN1-like protein 1; General control of amino-acid synthesis 1-like protein 1; Translational activator GCN1; HsGCN1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTSDQDAKVVAEPQTQRVQEGKDSAHLMNGPISQTTSQTSSIPPLSQVPATKVSELNPNA
EVWGAPVLHLEASSAADGVSAAWEEVAGHHADRGPQGSDANGDGDQGHENAALPDPQESD
PADMNALALGPSEYDSLPENSETGGNESQPDSQEDPREVLKKTLEFCLSRENLASDMYLI
SQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVIL
REISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQ
GKPIKARIKAKAIAINTFLPKNGFRPLDVSLYAQQRYATSFYFPPMYSPQQQFPLYSLIT
PQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSHLRH
AIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAGPGRV
EPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFPPLPGA
AGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSP
SPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATELRKPSYAEICQRTSKE
PPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGAPRDQRRPAGGRPSPS
AMGKRLSREQSTPPKSPQ
Target Bioclass
Other
Family
GCN1 family
Subcellular location
Cytoplasm
Function
Ribosome collision sensor that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes. Directly binds to the ribosome and acts as a sentinel for colliding ribosomes: activated following ribosome stalling and promotes recruitment of RNF14, which directly ubiquitinates EEF1A1/eEF1A, leading to its degradation. In addition to EEF1A1/eEF1A, the RNF14-RNF25 translation quality control pathway mediates degradation of ETF1/eRF1 and ubiquitination of ribosomal protein. GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation. Interaction with EIF2AK4/GCN2 on translating ribosomes stimulates EIF2AK4/GCN2 kinase activity, leading to phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1). EIF2S1/eIF-2-alpha phosphorylation converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to a reduced overall utilization of amino acids, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Uniprot ID
Q92616
Ensemble ID
ENST00000300648.7
HGNC ID
HGNC:4199
ChEMBL ID
CHEMBL3706558

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.69  LDD0402  [1]
A-EBA
 Probe Info  		3.80  LDD0215  [2]
11RK72
 Probe Info  		7.77  LDD0327  [3]
11RK73
 Probe Info  		7.42  LDD0328  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
TH211
 Probe Info  		Y1399(20.00); Y2079(20.00); Y2186(20.00); Y565(16.68)  LDD0257  [5]
TH214
 Probe Info  		Y252(20.00); Y2186(14.17)  LDD0258  [5]
TH216
 Probe Info  		Y1210(20.00); Y1399(20.00); Y1654(20.00); Y2079(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [7]
ONAyne
 Probe Info  		K2012(1.92)  LDD0274  [8]
BTD
 Probe Info  		C2015(4.25)  LDD1699  [9]
Probe 1
 Probe Info  		Y774(17.18); Y1205(17.00); Y1210(15.49); Y1312(21.78)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C1362(0.00); C1482(0.00); C2015(0.00); C1527(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C1482(1.08)  LDD0460  [11]
DA-P3
 Probe Info  		19.36  LDD0183  [12]
AHL-Pu-1
 Probe Info  		C1482(4.18); C648(2.55)  LDD0168  [13]
HPAP
 Probe Info  		3.33  LDD0064  [14]
EA-probe
 Probe Info  		N.A.  LDD0440  [15]
HHS-475
 Probe Info  		Y2611(0.74); Y2001(0.99)  LDD0264  [16]
HHS-465
 Probe Info  		Y2001(7.47); Y2611(3.34)  LDD2237  [17]
DBIA
 Probe Info  		C939(0.99); C55(0.98); C1275(0.93); C907(0.85)  LDD0078  [18]
ATP probe
 Probe Info  		K1553(0.00); K788(0.00); K789(0.00); K1556(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1527(0.00); C1235(0.00); C2558(0.00); C1595(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		C907(0.00); C246(0.00); C2015(0.00); C2558(0.00)  LDD0032  [21]
Lodoacetamide azide
 Probe Info  		C1527(0.00); C2015(0.00); C1235(0.00); C2558(0.00)  LDD0037  [20]
JW-RF-010
 Probe Info  		C36(0.00); C2558(0.00)  LDD0026  [22]
NAIA_4
 Probe Info  		C36(0.00); C1235(0.00); C1275(0.00); C1362(0.00)  LDD2226  [23]
TFBX
 Probe Info  		C1595(0.00); C1527(0.00); C1535(0.00); C36(0.00)  LDD0027  [22]
WYneN
 Probe Info  		C932(0.00); C1235(0.00); C1984(0.00); C2558(0.00)  LDD0021  [24]
WYneO
 Probe Info  		C329(0.00); C1595(0.00); C2255(0.00); C932(0.00)  LDD0022  [24]
1d-yne
 Probe Info  		N.A.  LDD0356  [25]
Compound 10
 Probe Info  		N.A.  LDD2216  [26]
Compound 11
 Probe Info  		N.A.  LDD2213  [26]
ENE
 Probe Info  		C932(0.00); C329(0.00); C1535(0.00); C2558(0.00)  LDD0006  [24]
IPM
 Probe Info  		C2558(0.00); C1527(0.00); C1235(0.00); C1781(0.00)  LDD0005  [24]
NHS
 Probe Info  		K12(0.00); K2418(0.00); K268(0.00); K821(0.00)  LDD0010  [24]
NPM
 Probe Info  		C1595(0.00); C2558(0.00); C1235(0.00)  LDD0016  [24]
PF-06672131
 Probe Info  		C246(0.00); C648(0.00); C1235(0.00)  LDD0017  [27]
STPyne
 Probe Info  		K2222(0.00); K2591(0.00); K2259(0.00); K436(0.00)  LDD0009  [24]
VSF
 Probe Info  		C1535(0.00); C1362(0.00); C648(0.00); C1595(0.00)  LDD0007  [24]
1c-yne
 Probe Info  		K695(0.00); K1208(0.00); K776(0.00); K2354(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		H2538(0.00); C648(0.00); H1551(0.00); H2539(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [28]
Methacrolein
 Probe Info  		C55(0.00); C246(0.00); C2015(0.00); C932(0.00)  LDD0218  [28]
W1
 Probe Info  		C1362(0.00); C2015(0.00); C1781(0.00); C2255(0.00)  LDD0236  [29]
AOyne
 Probe Info  		4.90  LDD0443  [30]
NAIA_5
 Probe Info  		C1527(0.00); C2015(0.00); C1235(0.00); C2558(0.00)  LDD2223  [23]
HHS-482
 Probe Info  		Y1391(0.71); Y1399(1.67); Y1526(0.84); Y1643(0.75)  LDD2239  [17]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.77  LDD0475  [31]
FFF probe14
 Probe Info  		12.03  LDD0477  [31]
FFF probe3
 Probe Info  		5.73  LDD0465  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
DA-2
 Probe Info  		N.A.  LDD0071  [34]
STS-1
 Probe Info  		N.A.  LDD0068  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C932(0.74); C2015(1.39)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C932(0.71); C2015(1.34)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C932(0.63)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1275(0.78)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C932(1.03); C2015(1.36); C2255(1.11); C1535(0.90)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C932(1.03); C2255(1.16)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C932(1.05)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C932(0.67); C2015(0.56); C2255(0.44); C648(0.64)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C932(0.71); C2015(1.07); C1275(0.88)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C1482(4.18); C648(2.55)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C932(2.07); C540(2.82); C2015(2.25); C1482(2.27)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C449(0.90); C121(1.03); C1235(1.08); C1275(1.02)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C1527(1.62); C449(1.01); C1235(0.89); C1275(0.91)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C1527(0.86); C449(0.81); C1235(1.06); C1275(0.83)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C1527(1.37); C449(0.88); C1235(1.01); C1275(0.88)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C1527(1.24); C449(0.85); C1235(1.05); C1275(0.80)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C1527(1.17); C449(0.83); C1235(0.99); C1275(0.94)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C1527(1.34); C449(0.92); C1235(0.99); C1275(0.86)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C1527(0.99); C449(0.85); C1235(1.11); C1275(0.87)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C1527(1.01); C449(0.77); C1235(1.12); C1275(0.93)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C1527(1.07); C449(0.80); C1235(1.11); C1275(1.07)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C1527(0.76); C449(0.72); C1235(0.98); C1275(0.85)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C1527(1.16); C449(0.79); C1235(1.17); C1275(0.87)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C1527(1.58); C449(1.03); C1235(0.83); C1275(0.86)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C1527(1.03); C449(0.86); C1235(0.97); C1275(0.87)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C1527(1.16); C449(0.90); C1235(1.03); C1275(0.97)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C1527(0.97); C449(0.78); C1235(0.99); C1275(0.94)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C1527(1.09); C449(0.99); C1235(1.03); C1275(1.03)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C1527(1.01); C449(1.02); C1235(1.02); C1275(1.05)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C1527(0.97); C449(1.04); C1235(1.00); C1275(1.10)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C1527(0.95); C449(0.88); C1235(0.93); C1275(1.08)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C1527(0.82); C449(0.78); C1235(0.91); C1275(1.07)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C1527(0.71); C449(0.76); C1235(0.95); C1275(0.94)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C1527(0.84); C449(0.70); C1235(0.88); C1275(0.94)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C1527(0.93); C449(0.87); C1235(0.90); C1275(0.89)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C1527(0.88); C449(1.18); C1235(1.22); C1275(0.97)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C1527(1.09); C449(0.82); C1235(0.99); C1275(1.04)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C1527(0.94); C449(0.69); C1235(1.03); C1275(0.96)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C1527(0.95); C449(1.11); C1235(1.11); C1275(1.01)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C1527(0.82); C449(1.10); C1235(0.99); C1275(1.03)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C1527(0.96); C449(0.71); C1235(1.06); C1275(0.99)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C1527(1.02); C449(0.78); C1235(1.05); C1275(1.06)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C1527(0.80); C449(0.70); C1235(1.03); C1275(1.04)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C1527(1.46); C449(1.48); C1235(1.56); C1275(1.27)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C1527(0.99); C449(1.31); C1235(1.67); C1275(1.22)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C1527(0.79); C449(1.12); C1235(1.52); C1275(1.16)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C1527(1.49); C449(2.00); C1235(1.75); C1275(1.28)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C1527(0.78); C449(0.79); C1235(1.21); C1275(1.07)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C1527(1.01); C449(1.07); C1235(1.26); C1275(1.06)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C1527(1.63); C449(1.41); C1235(1.36); C1275(1.23)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C1527(0.92); C449(1.06); C1235(1.27); C1275(1.16)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C1527(1.01); C449(1.18); C1235(1.20); C1275(1.13)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C1527(0.97); C449(1.24); C1235(1.15); C1275(1.09)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C1527(1.86); C449(1.95); C1235(1.40); C1275(1.21)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C1527(1.03); C449(0.95); C1235(1.23); C1275(1.13)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C1527(5.29); C449(1.32); C1235(0.94); C1275(0.89)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C1527(1.45); C449(1.20); C1235(1.38); C1275(1.23)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C1527(1.30); C449(1.32); C1235(1.34); C1275(1.18)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C1527(0.99); C449(0.99); C1235(1.18); C1275(1.05)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C449(0.91); C1235(0.98); C1275(0.95); C1482(0.99)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C51(0.77); C246(0.82); C2255(0.86); C1595(0.92)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C51(0.58); C2015(0.81); C2255(0.83); C932(0.89)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C2015(0.77); C246(0.83); C51(0.86); C1535(0.88)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C1984(0.75); C2015(0.86); C51(0.88); C246(0.88)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C2015(0.76); C939(0.90); C246(0.94); C329(1.03)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C2015(0.73); C246(0.78); C1535(0.90); C932(0.91)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C907(0.74); C246(0.94); C1275(0.95); C2558(0.96)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C51(0.48); C1984(0.73); C2015(0.74); C246(0.86)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C51(0.49); C1984(0.64); C1595(0.84); C55(0.86)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C1984(0.64); C2015(0.70); C246(0.87); C907(0.94)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C246(0.90); C1984(0.90); C939(0.90); C2015(0.97)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C449(1.10); C1235(1.14); C1275(1.05); C1482(1.16)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C449(0.90); C1235(1.28); C1275(1.07); C1482(1.39)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C449(0.89); C1235(1.18); C1275(1.07); C1482(1.22)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C449(1.27); C1235(1.45); C1275(1.16); C1482(1.28)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C1527(0.59); C1595(0.82); C2015(0.86); C1535(0.86)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C907(0.72); C121(0.80); C1595(0.86); C449(0.92)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C1595(0.78); C121(0.79); C1781(0.85); C1527(0.87)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C907(0.88); C329(0.92); C1362(0.97); C1275(0.97)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C121(0.79); C2558(0.83); C329(0.85); C2015(0.85)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C329(0.87); C2015(0.88); C1535(0.90); C246(0.91)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C1527(0.80); C1595(0.86); C1781(0.87); C2015(0.87)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C1595(0.69); C1781(0.81); C2015(0.89); C121(0.89)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C1595(0.76); C1781(0.80); C329(0.85); C2015(0.85)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C1527(0.63); C121(0.63); C449(0.75); C246(0.81)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C1527(0.47); C121(0.68); C246(0.75); C449(0.81)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C246(0.71); C1527(0.73); C2136(0.79); C1984(0.80)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C1527(0.49); C121(0.66); C449(0.74); C246(0.74)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C246(0.70); C121(0.76); C449(0.80); C1984(0.80)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C907(0.85); C1362(0.94); C2179(0.95); C2255(1.00)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C121(0.60); C246(0.71); C1527(0.77); C449(0.82)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C1527(0.70); C246(0.73); C449(0.83); C2179(0.84)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C246(0.66); C121(0.66); C1527(0.69); C1535(0.85)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C246(0.66); C121(0.66); C1984(0.80); C1595(0.84)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C246(0.66); C121(0.76); C2558(0.84); C1984(0.87)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C1527(0.46); C907(0.71); C2136(0.77); C449(0.78)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C1527(0.47); C329(0.77); C2136(0.77); C1984(0.79)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C1527(0.45); C1984(0.77); C1781(0.80); C2136(0.84)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C907(0.85); C2558(0.87); C329(0.87); C449(0.88)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C1527(0.43); C449(0.65); C907(0.68); C2179(0.85)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C907(0.81); C1362(0.95); C2179(1.02); C329(1.03)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C1527(0.65); C907(0.84); C449(0.90); C329(0.91)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C907(0.74); C932(0.78); C2136(0.78); C329(0.82)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C907(0.80); C932(0.86); C939(0.87); C329(0.92)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C1235(0.79); C932(0.83); C907(0.84); C329(0.87)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C2136(0.75); C907(0.78); C932(0.80); C939(0.83)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C329(0.77); C932(0.87); C939(0.88); C1781(0.89)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C1527(0.69); C2136(0.79); C329(0.83); C2255(0.85)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C1781(0.79); C2179(0.81); C329(0.88); C2136(0.88)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C1781(0.77); C2136(0.78); C2179(0.85); C449(0.87)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C1781(0.72); C1527(0.76); C2255(0.85); C329(0.88)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C907(0.69); C1362(0.88); C449(0.93); C329(0.99)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C1781(0.63); C2255(0.92); C1595(0.97); C246(0.97)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C2136(0.73); C329(0.75); C1781(0.80); C1984(0.83)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C329(0.79); C1781(0.81); C2179(0.85); C932(0.89)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C1781(0.69); C2136(0.74); C2255(0.86); C329(0.93)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C1781(0.70); C1595(0.82); C2136(0.86); C329(0.92)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C1781(0.68); C2136(0.92); C2255(0.92); C329(1.03)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C1781(0.79); C1595(0.88); C2255(0.97); C329(1.16)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C1781(0.73); C449(0.82); C246(0.90); C907(0.95)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C1781(0.73); C246(0.89); C1535(0.95); C1595(0.96)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C1781(0.75); C51(0.92); C246(0.92); C1235(0.94)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C246(0.81); C907(0.85); C1235(0.89); C2136(0.89)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C907(0.88); C1235(0.88); C246(0.88); C1781(0.88)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C1781(0.84); C449(0.87); C907(0.88); C1235(0.91)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C1781(0.67); C449(0.70); C246(0.92); C1595(1.01)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C51(0.62); C449(0.76); C246(0.89); C1781(0.91)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C1781(0.74); C449(0.74); C51(0.87); C907(0.95)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C449(0.81); C51(0.87); C1595(0.91); C1781(0.94)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C907(0.90); C449(0.94); C1235(0.97); C1595(0.99)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C51(0.71); C1781(0.71); C449(0.87); C1595(0.90)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C939(0.87); C907(0.90); C2015(0.92); C246(0.92)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C246(0.86); C939(0.91); C329(0.98); C907(1.01)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C907(0.63); C2255(0.82); C246(0.86); C1235(0.87)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C449(0.81); C246(0.89); C939(0.96); C907(0.99)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C939(0.87); C907(0.91); C246(0.91); C1984(1.05)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C939(0.92); C449(0.93); C246(0.96); C932(0.97)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C449(0.81); C1527(0.95); C939(0.97); C329(1.02)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C939(0.98); C246(1.02); C907(1.03); C449(1.13)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C449(0.88); C939(0.93); C1527(0.94); C246(1.11)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C939(0.90); C329(1.00); C246(1.02); C449(1.04)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C246(0.89); C329(0.95); C939(0.95); C2015(1.06)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C932(0.87); C329(0.90); C939(0.92); C246(0.92)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C939(0.89); C907(0.93); C246(0.97); C2255(0.98)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C907(0.59); C246(0.86); C1275(0.89); C1235(0.94)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C939(0.92); C246(1.00); C449(1.00); C907(1.02)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C907(0.63); C939(0.84); C1235(0.91); C329(0.99)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C939(0.94); C449(1.01); C246(1.02); C907(1.11)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C1527(0.23); C1595(0.72); C246(0.84); C329(0.89)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C1527(0.45); C1595(0.77); C246(0.89); C329(0.92)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C1527(0.27); C1595(0.73); C907(0.76); C2558(0.80)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C1527(0.23); C1595(0.81); C246(0.85); C2558(0.87)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C1527(0.33); C121(0.87); C449(0.91); C246(0.93)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C1527(0.31); C246(0.86); C121(0.92); C932(0.93)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C1527(0.21); C246(0.82); C2558(0.87); C2015(0.90)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C1527(0.22); C329(0.86); C2179(0.86); C449(0.89)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C1527(0.26); C1595(0.72); C246(0.92); C932(0.95)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C1527(0.23); C1595(0.76); C329(0.84); C246(0.85)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C1527(0.51); C1362(0.77); C1595(0.78); C2558(0.84)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C1527(0.50); C1595(0.68); C2558(0.89); C449(0.89)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C1527(0.31); C1595(0.77); C246(0.82); C1362(0.83)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C1527(0.79); C1595(0.84); C246(0.89); C2015(0.94)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C1527(0.24); C1595(0.68); C246(0.79); C2558(0.82)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C246(0.56); C1781(0.64); C329(0.67); C449(0.80)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C329(0.61); C246(0.66); C1482(0.66); C1781(0.71)  LDD0683  [18]
 LDCM0520  AKOS000195272 MDA-MB-231 C2015(1.01)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C1527(1.29); C449(0.97); C1235(0.83); C1275(0.88)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C907(0.69); C246(0.84); C1235(0.85); C449(0.92)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C246(0.86); C907(0.92); C2255(1.02); C932(1.05)  LDD0592  [18]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C939(0.99); C55(0.98); C1275(0.93); C907(0.85)  LDD0078  [18]
 LDCM0102  BDHI 8 Jurkat C1467(16.94); C1984(10.51)  LDD0204  [36]
 LDCM0498  BS-3668 MDA-MB-231 C2015(0.75); C2255(0.90); C1984(0.76)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa H602(0.00); C907(0.00); C2136(0.00); H705(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C246(20.00); C1535(20.00); C1527(2.51); C1362(2.41)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C1482(0.76); C2179(0.81); C648(0.82); C1984(0.82)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C648(0.80); C2136(0.84); C1482(0.94); C1984(1.00)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C907(0.85); C329(0.86); C1362(0.87); C449(0.94)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C907(0.74); C246(0.81); C2255(0.84); C1235(0.89)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C907(0.67); C2255(0.75); C1781(0.85); C246(0.86)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C2255(0.62); C907(0.77); C1781(0.82); C1275(0.87)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C907(0.79); C246(0.84); C2255(0.87); C1781(0.88)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C121(0.79); C1527(0.82); C246(0.88); C329(0.88)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C121(0.81); C907(0.94); C1527(1.02); C246(1.09)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C121(0.75); C1527(0.87); C907(0.89); C246(0.94)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C1527(0.76); C907(0.86); C449(0.87); C1595(0.90)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C1595(0.71); C1527(0.74); C2015(0.82); C246(0.85)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C1482(0.77); C648(0.90); C2136(0.93); C2015(1.09)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C1595(0.82); C121(0.88); C1535(0.91); C1781(0.94)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C121(0.79); C329(0.87); C1595(0.88); C2015(0.90)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C121(0.72); C449(0.77); C907(0.80); C2136(0.81)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C121(0.61); C246(0.70); C1535(0.89); C2255(0.92)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C246(0.71); C121(0.74); C2558(0.77); C1984(0.80)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C121(0.59); C246(0.67); C907(0.77); C2179(0.79)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C121(0.50); C246(0.72); C2179(0.76); C907(0.80)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C907(0.86); C939(0.92); C329(1.05); C2015(1.06)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C1527(0.59); C907(0.79); C449(0.88); C2136(0.89)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C1527(0.50); C2558(0.84); C932(0.87); C1781(0.87)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C2136(0.89); C1482(1.01); C246(1.07); C2179(1.15)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C1527(0.61); C2136(0.69); C449(0.72); C2179(0.80)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C1781(0.56); C2136(0.68); C1235(0.73); C1275(0.74)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C1595(0.82); C2136(0.87); C329(0.89); C1781(0.93)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C1781(0.67); C1595(0.73); C2136(0.79); C449(0.86)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C1781(0.71); C1527(0.72); C2255(0.89); C329(0.90)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C907(0.78); C449(0.82); C2179(0.85); C939(0.88)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C907(0.62); C939(0.81); C2558(0.83); C1781(0.86)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C1781(0.83); C1595(0.88); C907(0.90); C1535(0.91)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C1781(0.87); C1235(0.89); C246(0.90); C329(0.98)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C1482(0.64); C648(0.90); C2136(0.93); C1527(1.00)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C1482(0.69); C1535(0.88); C1984(0.88); C246(0.91)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C1482(0.56); C1527(0.69); C449(0.85); C1984(0.93)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C121(0.79); C449(0.81); C1984(0.84); C2558(0.84)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C1527(0.51); C1781(0.83); C449(0.88); C1275(0.93)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C1527(0.61); C246(0.86); C449(0.88); C1275(0.91)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C1527(0.69); C1781(0.84); C1275(0.94); C2255(0.95)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C1482(0.71); C449(0.76); C2136(0.78); C1527(0.84)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C1527(0.62); C2015(0.73); C246(0.83); C1482(0.88)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C1527(0.55); C2015(0.80); C121(0.85); C246(0.86)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C2015(0.81); C939(0.83); C1482(0.90); C246(0.94)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C1781(0.78); C246(0.89); C2255(0.96); C1595(0.96)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C449(0.85); C939(0.89); C246(0.94); C1362(0.97)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C1527(0.72); C449(0.96); C121(1.57); C1235(1.01)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C1527(0.80); C449(1.03); C121(1.36); C1235(1.03)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C1527(1.00); C449(0.92); C121(1.14); C1235(0.97)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C1527(0.52); C449(0.81); C121(1.31); C1235(0.96)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C1527(1.37); C449(1.01); C121(1.26); C1235(1.04)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C1527(1.46); C449(1.60); C1235(1.07); C1275(0.98)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C1527(0.70); C449(1.01); C121(1.21); C1235(0.89)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C1527(0.95); C449(1.21); C121(1.27); C1235(1.17)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C1527(0.74); C449(1.21); C121(1.74); C1235(1.14)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C1527(0.51); C449(1.44); C121(1.33); C1235(1.23)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C1527(0.56); C449(1.15); C121(1.13); C1235(1.19)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C1527(1.51); C449(1.66); C121(1.04); C1235(1.32)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C1527(1.21); C449(2.16); C121(1.21); C1235(1.42)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C1527(1.65); C449(1.57); C121(1.23); C1235(1.53)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C1527(0.86); C449(1.44); C121(1.03); C1235(1.29)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C1527(1.17); C449(1.09); C1235(0.95); C1275(0.95)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C1527(0.89); C449(1.48); C121(1.32); C1235(1.30)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C1527(1.30); C449(1.56); C121(1.22); C1235(1.35)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C1527(1.83); C449(2.13); C121(1.77); C1235(1.89)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C1527(0.63); C449(1.57); C121(0.88); C1235(1.62)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C1527(0.68); C449(1.55); C121(1.27); C1235(1.23)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C1527(0.63); C449(1.21); C121(1.40); C1235(1.30)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C1527(0.89); C449(0.58); C1235(1.14); C1275(1.00)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C1527(1.37); C449(0.80); C1235(1.08); C1275(1.06)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C1527(1.39); C449(0.78); C1235(1.27); C1275(1.08)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C1527(0.84); C449(1.00); C1235(1.47); C1275(1.08)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C1527(0.71); C449(0.84); C1235(1.13); C1275(1.03)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C1527(1.87); C449(0.94); C1235(1.20); C1275(1.04)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C1527(1.08); C449(0.69); C1235(1.19); C1275(1.03)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C1527(1.36); C449(0.76); C1235(1.07); C1275(0.90)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C1527(2.41); C449(6.45); C1235(1.41); C1275(1.10)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C1527(1.76); C449(0.85); C1235(1.18); C1275(1.04)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C1527(1.43); C449(0.85); C1235(1.42); C1275(1.08)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C1527(1.68); C449(1.06); C1235(1.08); C1275(0.97)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C1527(1.50); C449(1.20); C1235(1.09); C1275(0.99)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C1527(1.09); C449(0.80); C1235(1.17); C1275(0.93)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C1527(1.07); C449(0.86); C1235(1.11); C1275(1.01)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C1527(0.58); C449(0.66); C1235(0.99); C1275(1.00)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C1527(1.30); C449(0.75); C1235(1.16); C1275(1.05)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C1527(0.73); C449(0.78); C121(0.83); C1235(1.02)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C1527(0.64); C449(0.74); C121(0.82); C1235(0.99)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C1527(0.98); C449(0.95); C121(0.73); C1235(0.92)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C1527(0.64); C449(0.74); C121(0.80); C1235(0.95)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C1527(1.09); C449(1.20); C121(0.75); C1235(1.00)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C1527(0.82); C449(0.70); C121(0.86); C1235(1.04)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C1527(1.54); C449(1.09); C121(0.83); C1235(1.02)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C1527(4.21); C449(3.31); C121(0.74); C1235(1.02)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C1527(0.81); C449(0.69); C121(0.75); C1235(1.03)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C1527(0.52); C449(0.71); C1235(1.05); C1275(1.07)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C1527(1.15); C449(1.13); C121(0.73); C1235(0.99)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C1527(1.03); C449(0.97); C121(0.68); C1235(1.08)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C1527(1.10); C449(1.03); C121(0.68); C1235(0.86)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C1527(1.34); C449(1.16); C121(0.77); C1235(0.97)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C1527(1.37); C449(1.15); C121(0.86); C1235(1.04)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C1527(1.55); C449(1.41); C1235(1.02); C1275(1.05)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C1527(1.47); C449(1.23); C1235(1.17); C1275(1.12)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C1527(0.97); C449(1.10); C1235(1.06); C1275(1.04)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C1527(1.49); C449(1.17); C1235(1.19); C1275(1.21)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C1527(0.82); C449(0.94); C1235(1.47); C1275(1.22)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C1527(0.89); C449(1.08); C1235(1.19); C1275(1.10)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C1527(1.10); C449(1.11); C1235(1.11); C1275(1.10)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C1527(0.95); C449(1.19); C1235(1.30); C1275(1.37)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C1527(1.33); C449(0.97); C1235(1.27); C1275(1.30)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C1527(1.27); C449(1.01); C1235(1.39); C1275(1.50)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C1527(1.35); C449(1.19); C1235(1.20); C1275(1.12)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C1527(1.15); C449(1.16); C1235(1.14); C1275(1.05)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C1527(0.84); C449(1.16); C1235(1.08); C1275(1.10)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C1527(0.88); C449(1.05); C1235(1.20); C1275(1.16)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C1527(1.23); C449(1.12); C1235(1.31); C1275(1.56)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C1527(0.50); C449(0.53); C1235(1.26); C1275(1.15)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C1527(0.91); C449(1.16); C1235(1.24); C1275(1.07)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C449(1.16); C121(1.30); C1235(1.00); C1275(0.98)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C449(0.98); C121(1.26); C1235(1.07); C1275(1.02)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C449(0.90); C121(1.14); C1235(1.10); C1275(1.01)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C449(1.04); C121(1.00); C1235(1.05); C1275(0.97)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C449(0.93); C121(1.08); C1235(1.05); C1275(0.93)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C449(1.01); C121(1.08); C1235(0.99); C1275(0.95)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C449(0.97); C121(1.04); C1235(0.99); C1275(0.96)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C449(1.05); C121(1.20); C1235(1.01); C1275(1.13)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C449(0.95); C121(1.25); C1235(1.02); C1275(1.02)  LDD0811  [18]
 LDCM0634  CY-0357 Hep-G2 C648(0.93); C2255(0.92); C932(0.85); C2015(0.71)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C1482(0.93); C2558(0.97); C329(0.96); C449(0.90)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1235(82.95); C932(21.92); C2255(19.02); C648(5.23)  LDD1702  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 19.36  LDD0183  [12]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [15]
 LDCM0625  F8 Ramos C2558(1.41); C1482(1.26); C55(0.55); C1595(1.21)  LDD2187  [38]
 LDCM0572  Fragment10 MDA-MB-231 C1692(1.90)  LDD1389  [39]
 LDCM0573  Fragment11 MDA-MB-231 C1692(1.00)  LDD1391  [39]
 LDCM0574  Fragment12 Ramos C2558(6.83); C1482(2.52); C55(7.17); C1595(11.32)  LDD2191  [38]
 LDCM0575  Fragment13 MDA-MB-231 C1692(1.11)  LDD1395  [39]
 LDCM0576  Fragment14 MDA-MB-231 C1692(17.22)  LDD1397  [39]
 LDCM0577  Fragment15 Ramos C1692(1.84)  LDD1400  [39]
 LDCM0579  Fragment20 MDA-MB-231 C1692(1.67)  LDD1402  [39]
 LDCM0580  Fragment21 Ramos C1692(1.34)  LDD1405  [39]
 LDCM0581  Fragment22 MDA-MB-231 C1692(0.97)  LDD1406  [39]
 LDCM0582  Fragment23 MDA-MB-231 C1692(20.00)  LDD1408  [39]
 LDCM0583  Fragment24 Ramos C1692(5.99)  LDD1410  [39]
 LDCM0584  Fragment25 MDA-MB-231 C1692(0.60)  LDD1411  [39]
 LDCM0585  Fragment26 Ramos C1692(1.01)  LDD1412  [39]
 LDCM0578  Fragment27 MDA-MB-231 C1692(0.93)  LDD1401  [39]
 LDCM0586  Fragment28 Ramos C1692(1.19)  LDD1416  [39]
 LDCM0587  Fragment29 MDA-MB-231 C1692(1.22)  LDD1417  [39]
 LDCM0588  Fragment30 Ramos C2558(1.83); C1482(1.28); C55(1.05); C1595(2.05)  LDD2199  [38]
 LDCM0589  Fragment31 MDA-MB-231 C1692(4.36)  LDD1421  [39]
 LDCM0590  Fragment32 MDA-MB-231 C1692(1.49)  LDD1423  [39]
 LDCM0468  Fragment33 HCT 116 C1527(0.96); C449(0.87); C121(0.95); C1235(0.92)  LDD0785  [18]
 LDCM0594  Fragment36 MDA-MB-231 C1692(0.99)  LDD1431  [39]
 LDCM0595  Fragment37 Ramos C1692(0.91)  LDD1432  [39]
 LDCM0596  Fragment38 Ramos C1692(1.38)  LDD1434  [39]
 LDCM0566  Fragment4 MDA-MB-231 C1692(1.12)  LDD1378  [39]
 LDCM0598  Fragment40 Ramos C1692(0.90)  LDD1437  [39]
 LDCM0599  Fragment41 MDA-MB-231 C1692(0.68)  LDD1481  [39]
 LDCM0600  Fragment42 Ramos C1692(1.27)  LDD1440  [39]
 LDCM0601  Fragment43 MDA-MB-231 C1692(1.50)  LDD1441  [39]
 LDCM0604  Fragment46 MDA-MB-231 C1692(0.81)  LDD1445  [39]
 LDCM0427  Fragment51 HCT 116 C1527(1.29); C449(1.79); C121(1.21); C1235(1.68)  LDD0744  [18]
 LDCM0610  Fragment52 Ramos C1692(1.25)  LDD1453  [39]
 LDCM0611  Fragment53 MDA-MB-231 C1692(0.94)  LDD1454  [39]
 LDCM0612  Fragment54 MDA-MB-231 C1692(1.28)  LDD1456  [39]
 LDCM0614  Fragment56 MDA-MB-231 C1692(1.05)  LDD1458  [39]
 LDCM0569  Fragment7 MDA-MB-231 C1692(1.33)  LDD1383  [39]
 LDCM0570  Fragment8 MDA-MB-231 C1692(1.34)  LDD1385  [39]
 LDCM0571  Fragment9 MDA-MB-231 C1692(1.67)  LDD1387  [39]
 LDCM0116  HHS-0101 DM93 Y2611(0.74); Y2001(0.99)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y2001(0.82); Y2611(0.88)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y2001(0.98); Y2611(1.11)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y2611(0.77); Y2001(0.94)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y2001(1.11); Y2611(1.14)  LDD0268  [16]
 LDCM0015  HNE MDA-MB-231 C1482(1.16)  LDD0346  [38]
 LDCM0107  IAA HeLa H2538(0.00); H2236(0.00); H922(0.00); H705(0.00)  LDD0221  [28]
 LDCM0179  JZ128 PC-3 C1362(0.00); C1482(0.00); C2015(0.00); C1527(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C55(1.85); C1275(2.28); C939(1.75); C1235(3.97)  LDD0080  [18]
 LDCM0023  KB03 HCT 116 C55(5.14); C1275(8.30); C939(6.18); C1235(7.44)  LDD0081  [18]
 LDCM0024  KB05 HCT 116 C55(13.93); C1275(3.73); C939(3.65); C1235(2.95)  LDD0082  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C932(1.02); C2255(0.98)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C932(0.68); C2255(0.86)  LDD2121  [9]
 LDCM0109  NEM HeLa H922(0.00); H91(0.00); H2236(0.00); H2538(0.00)  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C932(0.72); C2255(0.57)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C932(1.03); C2015(1.06); C2255(1.52)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C932(0.80); C2255(1.01)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C932(0.99); C2255(1.24)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C2255(1.06); C55(0.63)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C932(0.49); C2255(0.68); C36(0.19); C1595(0.77)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C932(0.96); C2255(0.93)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C932(1.21); C2255(0.75)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C932(1.02); C2015(1.19); C2255(0.97); C1275(1.15)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C2255(0.67)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C2255(0.97); C36(0.63)  LDD2101  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C932(1.07); C2255(1.37)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C932(0.95)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C932(0.96); C2255(0.87); C1275(0.82); C1535(0.89)  LDD2107  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C932(0.96); C2015(1.26); C2255(1.17); C1535(0.98)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C2015(1.29); C2255(1.08)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C932(1.08); C2015(0.72)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C2255(0.77)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C932(0.53); C2255(0.69); C1595(0.35)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C932(1.03); C2255(1.14); C36(0.53)  LDD2118  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C932(0.81); C2015(0.89); C2255(1.04)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C932(1.17); C2015(0.90); C2255(0.86); C1595(0.66)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C932(0.93); C2015(0.91); C1275(0.88); C1535(0.72)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C2255(0.87); C36(0.40)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C932(0.95); C2015(0.89); C2255(0.89); C1275(0.86)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C932(2.32)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C932(1.19); C2015(1.24); C36(0.87); C1984(0.86)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C932(1.21); C2015(0.69); C2255(1.05)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C2015(1.14); C2255(1.12)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C2015(0.56); C2255(0.45)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C932(0.56); C2015(0.59); C2255(0.53); C55(0.33)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C2015(1.22); C2255(1.12); C36(0.98)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C932(1.30); C2015(1.09); C1275(1.24); C36(1.25)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C932(0.94); C2255(1.03); C1275(0.81); C1535(0.71)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C932(1.69)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C932(0.82); C2015(0.99); C2255(0.84); C1535(0.80)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C932(0.91); C2255(0.42)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C932(0.99); C2255(0.95)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C2015(1.56); C2255(1.56)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C932(1.01); C2015(0.77); C2255(1.13)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C932(2.48); C2255(2.95)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C2015(0.49); C2255(0.92)  LDD2148  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C932(0.58); C2015(0.71); C2255(0.70)  LDD2150  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C932(1.73); C2255(2.44); C1595(1.01)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C2558(0.76); C36(0.74); C1595(0.63); C2179(0.28)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C1595(1.53); C36(1.46); C1527(1.18); C329(1.11)  LDD2207  [40]
 LDCM0014  Panhematin hPBMC 3.33  LDD0064  [14]
 LDCM0021  THZ1 HeLa S3 C1482(1.08)  LDD0460  [11]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
15 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
35 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
36 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.