Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment21  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 80 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 18.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 4.3
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 3.9
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 3.1
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.8
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 2.6
 LDTP05859  Integrin-linked protein kinase (ILK) C346 2.6
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 2.6
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 2.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 2.4
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 2.3
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 2.2
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 2.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 2.0
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 2.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.9
 LDTP06211  Caspase-8 (CASP8) C360 1.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.9
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.8
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.8
 LDTP02502  Thioredoxin (TXN) C32 1.8
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 1.7
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.7
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.7
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.7
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.6
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 1.6
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.5
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 1.5
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.5
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.5
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.5
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 1.5
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.5
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.5
 LDTP04374  Dynamin-2 (DNM2) C27 1.5
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.5
 LDTP04689  Adenosine kinase (ADK) C353 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.4
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.4
 LDTP04424  Galactokinase (GALK1) C182 1.3
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 1.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.3
 LDTP02672  Elongation factor 2 (EEF2) C41 1.3
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.3
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 1.3
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.3
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.3
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.3
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.3
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.3
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.2
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.2
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 1.2
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.2
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 1.2
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.1
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.1
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.0
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.8
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 0.7
Transporter and channel
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11855  Pinin (PNN) C249 8.6
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 7.7
 LDTP04801  Gasdermin-D (GSDMD) C268 3.4
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 3.2
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.8
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.7
 LDTP04662  Exportin-2 (CSE1L) C842 1.5
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.4
 LDTP01574  Importin-7 (IPO7) C757 1.4
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.2
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.1
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.0
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
 LDTP00501  Exportin-1 (XPO1) C528 0.8
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03393  Aryl hydrocarbon receptor nuclear translocator (ARNT) C119 2.1
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 2.0
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.3
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 69 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 4.7
 LDTP07755  Dynamin-binding protein (DNMBP) C691 3.9
 LDTP12412  Reticulon-4 (RTN4) C1101 3.9
 LDTP04902  Actin-related protein 3 (ACTR3) C235 3.7
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 3.6
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 3.3
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 3.1
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) C513 2.7
 LDTP01532  ZW10 interactor (ZWINT) C54 2.6
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 2.5
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 2.4
 LDTP04092  Crk-like protein (CRKL) C249 2.3
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 2.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.1
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C1117 2.1
 LDTP02205  Tubulin beta chain (TUBB) C239 2.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 2.0
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.9
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.9
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.8
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.8
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.8
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.8
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.8
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 1.7
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.7
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) C211 1.6
 LDTP13580  Coronin-1C (CORO1C) C420 1.6
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.6
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.6
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.6
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.6
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.6
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.5
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.5
 LDTP02205  Tubulin beta chain (TUBB) C354 1.5
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.4
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.4
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.4
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.4
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.4
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.4
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.4
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.3
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC) C500 1.3
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.3
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 1.3
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.3
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.3
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 1.3
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.3
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.3
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.3
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.2
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.2
 LDTP10864  Calponin-2 (CNN2) C215 1.2
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.2
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.1
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 1.0
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.8
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.8
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.