Details of the Target

General Information of Target

Target ID LDTP09549
Target Name Conserved oligomeric Golgi complex subunit 1 (COG1)
Gene Name COG1
Gene ID 9382
Synonyms
KIAA1381; LDLB; Conserved oligomeric Golgi complex subunit 1; COG complex subunit 1; Component of oligomeric Golgi complex 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAATSPALKRLDLRDPAALFETHGAEEIRGLERQVRAEIEHKKEELRQMVGERYRDLI
EAADTIGQMRRCAVGLVDAVKATDQYCARLRQAGSAAPRPPRAQQPQQPSQEKFYSMAAQ
IKLLLEIPEKIWSSMEASQCLHATQLYLLCCHLHSLLQLDSSSSRYSPVLSRFPILIRQV
AAASHFRSTILHESKMLLKCQGVSDQAVAEALCSIMLLEESSPRQALTDFLLARKATIQK
LLNQPHHGAGIKAQICSLVELLATTLKQAHALFYTLPEGLLPDPALPCGLLFSTLETITG
QHPAGKGTGVLQEEMKLCSWFKHLPASIVEFQPTLRTLAHPISQEYLKDTLQKWIHMCNE
DIKNGITNLLMYVKSMKGLAGIRDAMWELLTNESTNHSWDVLCRRLLEKPLLFWEDMMQQ
LFLDRLQTLTKEGFDSISSSSKELLVSALQELESSTSNSPSNKHIHFEYNMSLFLWSESP
NDLPSDAAWVSVANRGQFASSGLSMKAQAISPCVQNFCSALDSKLKVKLDDLLAYLPSDD
SSLPKDVSPTQAKSSAFDRYADAGTVQEMLRTQSVACIKHIVDCIRAELQSIEEGVQGQQ
DALNSAKLHSVLFMARLCQSLGELCPHLKQCILGKSESSEKPAREFRALRKQGKVKTQEI
IPTQAKWQEVKEVLLQQSVMGYQVWSSAVVKVLIHGFTQSLLLDDAGSVLATATSWDELE
IQEEAESGSSVTSKIRLPAQPSWYVQSFLFSLCQEINRVGGHALPKVTLQEMLKSCMVQV
VAAYEKLSEEKQIKKEGAFPVTQNRALQLLYDLRYLNIVLTAKGDEVKSGRSKPDSRIEK
VTDHLEALIDPFDLDVFTPHLNSNLHRLVQRTSVLFGLVTGTENQLAPRSSTFNSQEPHN
ILPLASSQIRFGLLPLSMTSTRKAKSTRNIETKAQVVPPARSTAGDPTVPGSLFRQLVSE
EDNTSAPSLFKLGWLSSMTK
Target Bioclass
Other
Family
COG1 family
Subcellular location
Golgi apparatus membrane
Function Required for normal Golgi function.
Uniprot ID
Q8WTW3
Ensemble ID
ENST00000299886.9
HGNC ID
HGNC:6545
ChEMBL ID
CHEMBL4105805

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TG42
 Probe Info  		4.74  LDD0326  [2]
STPyne
 Probe Info  		K528(5.41)  LDD0277  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C72(2.12)  LDD1700  [5]
Johansson_61
 Probe Info  		_(4.51)  LDD1485  [6]
AHL-Pu-1
 Probe Info  		C200(9.75)  LDD0170  [7]
HHS-465
 Probe Info  		Y56(6.64)  LDD2237  [8]
DBIA
 Probe Info  		C87(1.10); C72(1.07); C618(0.92); C625(0.92)  LDD0078  [9]
CY4
 Probe Info  		N.A.  LDD0247  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C256(0.00); C87(0.00); C584(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C256(0.00); C87(0.00); C72(0.00); C584(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C256(0.00); C87(0.00); C288(0.00); C72(0.00)  LDD0037  [11]
TFBX
 Probe Info  		C577(0.00); C513(0.00); C72(0.00)  LDD0027  [12]
IPM
 Probe Info  		C87(0.00); C318(0.00)  LDD0005  [13]
NPM
 Probe Info  		N.A.  LDD0016  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		C87(0.00); C513(0.00)  LDD0236  [15]
AOyne
 Probe Info  		11.00  LDD0443  [16]
NAIA_5
 Probe Info  		C256(0.00); C87(0.00); C72(0.00); C776(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		20.97  LDD1799  [18]
Alk-rapa
 Probe Info  		4.92  LDD0213  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C72(0.85); C584(0.95)  LDD2117  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C72(0.30)  LDD2132  [5]
 LDCM0025  4SU-RNA DM93 C200(9.75)  LDD0170  [7]
 LDCM0214  AC1 HCT 116 C518(0.92); C513(0.85); C584(1.12); C200(1.00)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C518(1.12); C513(1.12); C584(2.59); C200(1.20)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C518(0.78); C513(0.70); C584(1.05); C577(0.61)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C518(0.75); C513(0.77); C584(1.01); C577(0.65)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C518(0.82); C513(0.78); C584(1.04); C577(0.67)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C518(0.83); C513(0.86); C584(0.80); C577(0.75)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C518(0.79); C513(0.76); C584(1.01); C577(0.70)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C518(0.78); C513(0.77); C584(0.72); C577(0.79)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C518(0.82); C513(0.79); C584(0.84); C577(0.74)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C518(0.89); C513(0.86); C584(1.09); C577(0.73)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C518(0.83); C513(0.81); C584(0.87); C577(0.61)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C518(0.82); C513(0.77); C584(0.74); C577(0.62)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C518(1.06); C513(1.06); C584(1.55); C200(1.38)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C518(0.73); C513(0.73); C584(0.98); C577(0.66)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C518(0.69); C513(0.70); C584(0.85); C577(0.62)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C518(0.72); C513(0.76); C584(0.90); C577(0.71)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C518(0.98); C513(0.98); C577(0.80); C618(0.95)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C518(0.97); C513(0.97); C577(0.90); C618(1.04)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C518(1.05); C513(1.05); C577(0.97); C618(0.98)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C518(0.95); C513(0.95); C577(1.13); C618(0.91)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C518(1.00); C513(1.00); C577(1.02); C618(0.94)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C518(0.98); C513(0.98); C577(1.03); C618(1.03)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C518(1.00); C513(1.00); C577(1.07); C618(1.04)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C518(1.00); C513(1.00); C584(1.14); C200(1.07)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C518(0.97); C513(0.97); C577(1.17); C618(0.91)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C518(1.10); C513(1.10); C577(1.00); C618(0.94)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C518(1.03); C513(1.03); C577(0.90); C618(0.96)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C518(1.04); C513(1.04); C577(0.92); C618(1.22)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C518(1.02); C513(1.02); C577(0.86); C618(1.00)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C518(0.95); C513(0.95); C577(0.95); C618(0.96)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C518(1.04); C513(1.04); C577(0.98); C618(1.05)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C518(1.09); C513(1.09); C577(1.05); C618(1.05)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C518(1.33); C513(1.32); C584(1.32); C200(1.56)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C518(1.03); C513(1.06); C584(0.84); C200(1.39)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C518(1.10); C513(1.19); C584(1.09); C200(2.44)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C518(1.01); C513(1.04); C584(0.88); C200(2.29)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C518(1.04); C513(1.06); C584(1.12); C200(1.62)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C518(1.07); C513(1.10); C584(1.20); C200(1.55)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C518(1.16); C513(1.17); C584(1.12); C200(2.03)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C518(1.12); C513(1.14); C584(1.24); C200(2.32)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C518(1.15); C513(1.22); C584(1.11); C200(1.50)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C518(1.09); C513(1.07); C584(1.07); C200(1.14)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C518(1.28); C513(1.29); C584(1.17); C200(1.29)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C518(1.09); C513(1.12); C584(1.25); C200(1.29)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C518(1.02); C513(1.02); C584(0.93); C200(1.31)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C518(1.24); C513(1.24); C584(1.12); C200(2.07)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C518(1.15); C513(1.20); C584(1.15); C200(1.44)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C518(1.02); C513(1.08); C584(1.16); C200(1.52)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C518(0.91); C513(0.94); C584(1.18); C577(0.81)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C625(0.91); C584(0.96); C513(0.96); C518(0.97)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C584(0.73); C618(0.96); C625(0.99); C518(0.99)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C584(0.64); C618(1.03); C513(1.04); C72(1.07)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C584(0.85); C72(0.89); C618(0.92); C577(0.95)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C72(1.05); C577(1.08); C513(1.23); C618(1.26)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C625(1.07); C513(1.07); C72(1.08); C87(1.14)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C584(0.91); C87(0.93); C72(1.02); C518(1.04)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C625(0.92); C618(0.93); C513(0.97); C518(0.99)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C513(0.90); C584(0.95); C518(0.97); C87(0.98)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C584(0.87); C513(1.01); C87(1.06); C518(1.08)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C513(1.27); C577(1.28); C618(1.29); C518(1.38)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C518(1.09); C513(1.05); C584(1.20); C577(1.05)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C518(1.02); C513(0.94); C584(0.87); C577(1.04)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C518(0.97); C513(0.94); C584(0.73); C577(1.11)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C518(0.94); C513(0.88); C584(0.68); C577(1.15)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C72(0.83); C87(0.86); C513(0.96); C618(0.98)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C72(0.86); C87(0.91); C513(0.93); C518(1.00)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C72(0.85); C87(0.85); C618(0.90); C625(0.90)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C87(0.87); C72(0.94); C518(0.94); C513(0.98)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C72(0.87); C618(1.02); C625(1.02); C513(1.03)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C72(0.94); C618(0.97); C625(0.97); C87(0.99)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C618(0.87); C625(0.87); C72(0.98); C513(1.01)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C72(0.79); C618(0.96); C625(0.96); C87(0.99)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C72(0.80); C87(0.80); C618(0.91); C625(0.91)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C518(0.82); C513(0.92); C618(0.92); C625(0.92)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C518(0.74); C513(0.89); C618(0.98); C625(0.98)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C518(0.79); C513(0.90); C618(0.94); C625(0.94)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C518(0.82); C513(0.87); C87(1.10); C72(1.13)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C518(0.88); C513(1.02); C618(1.07); C625(1.07)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C72(0.85); C87(0.90); C513(0.92); C518(0.92)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C518(0.99); C618(1.07); C625(1.07); C87(1.07)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C518(0.86); C87(0.90); C513(0.92); C618(1.04)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C518(0.79); C513(1.02); C618(1.03); C625(1.03)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C518(0.79); C618(0.95); C625(0.95); C87(0.96)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C518(0.92); C72(1.10); C87(1.10); C513(1.10)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C72(0.94); C513(0.96); C518(1.02); C618(1.05)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C518(0.95); C513(1.00); C618(1.03); C625(1.03)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C518(0.93); C513(0.96); C618(1.01); C625(1.01)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C518(0.88); C513(0.99); C618(1.03); C625(1.03)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C513(1.01); C518(1.03); C618(1.05); C625(1.05)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C72(0.79); C513(0.88); C518(0.94); C87(1.03)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C518(0.93); C513(0.98); C618(1.13); C625(1.13)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C518(0.82); C513(0.97); C618(1.00); C625(1.00)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C518(1.01); C87(1.04); C618(1.05); C625(1.05)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C518(0.88); C87(0.96); C513(1.05); C618(1.13)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C513(0.93); C518(0.95); C87(0.95); C618(1.13)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C513(0.98); C518(1.05); C87(1.05); C618(1.17)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C200(0.89); C213(0.89); C618(0.90); C625(0.90)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C618(0.95); C625(0.95); C200(0.98); C213(0.98)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C618(0.85); C625(0.85); C518(1.01); C513(1.01)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C618(0.98); C625(0.98); C518(1.13); C513(1.13)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C72(0.78); C87(0.82); C513(0.92); C518(0.96)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C618(0.92); C625(0.92); C518(1.04); C513(1.04)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C618(0.84); C625(0.84); C518(0.95); C513(0.95)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C200(0.86); C213(0.86); C618(0.92); C625(0.92)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C618(1.00); C625(1.00); C87(1.07); C518(1.34)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C200(0.90); C213(0.90); C518(1.06); C513(1.06)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C618(1.04); C625(1.04); C518(1.05); C513(1.05)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C618(1.13); C625(1.13); C518(1.18); C513(1.18)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C87(0.90); C618(0.98); C625(0.98); C518(0.98)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C72(0.98); C618(1.00); C625(1.00); C518(1.01)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C87(0.89); C518(0.99); C513(0.99); C72(1.05)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C87(0.97); C618(1.01); C625(1.01); C584(1.10)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C618(0.95); C625(0.95); C87(0.96); C518(0.98)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C87(0.86); C72(0.87); C518(0.93); C513(0.93)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C87(0.92); C518(1.08); C513(1.08); C72(1.10)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C618(0.94); C625(0.94); C518(0.96); C513(0.96)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C87(0.88); C518(1.10); C513(1.10); C618(1.14)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C87(0.79); C72(1.05); C618(1.10); C625(1.10)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C72(1.03); C518(1.03); C513(1.03); C87(1.03)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C87(0.87); C72(1.11); C518(1.14); C513(1.14)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C72(0.89); C513(1.07); C577(1.08); C618(1.10)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C72(0.75); C577(1.00); C618(1.10); C625(1.10)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C577(0.93); C87(0.95); C618(1.01); C625(1.01)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C72(0.77); C577(1.01); C584(1.06); C513(1.09)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C618(0.98); C625(0.98); C513(0.98); C584(1.02)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C618(0.98); C625(0.98); C577(1.00); C72(1.05)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C584(0.79); C577(0.94); C72(1.10); C618(1.36)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C72(1.13); C577(1.24); C513(1.29); C518(1.32)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C72(0.83); C577(0.89); C584(1.11); C618(1.50)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C72(1.00); C577(1.10); C618(1.12); C625(1.12)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C72(0.80); C577(0.96); C584(1.03); C618(1.07)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C584(0.79); C618(0.96); C625(0.96); C72(1.02)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C72(0.70); C584(0.92); C618(0.99); C625(0.99)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C87(0.85); C577(1.00); C200(1.03); C213(1.03)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C72(0.95); C584(1.01); C577(1.08); C618(1.09)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C577(1.04); C72(1.06); C513(1.07); C618(1.10)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C72(1.02); C577(1.05); C513(1.62); C518(1.63)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C577(1.02); C584(1.03); C618(1.14); C625(1.14)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C584(0.85); C577(0.97); C618(1.21); C625(1.21)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C584(0.82); C577(1.02); C618(1.06); C625(1.06)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C584(0.87); C577(0.90); C518(1.07); C513(1.07)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C584(0.90); C577(0.98); C518(1.07); C513(1.07)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C584(0.81); C577(0.91); C518(1.07); C513(1.07)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C584(0.92); C577(1.04); C518(1.13); C513(1.13)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C518(1.02); C513(1.02); C618(1.04); C625(1.04)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C584(1.04); C577(1.09); C72(1.14); C618(1.22)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C577(1.17); C584(1.17); C618(1.19); C625(1.19)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C577(0.99); C584(1.01); C518(1.06); C513(1.06)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C72(0.86); C577(0.98); C584(1.06); C87(1.10)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C584(0.84); C577(0.87); C518(0.95); C513(0.95)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C72(0.88); C577(1.07); C584(1.16); C518(1.16)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C577(1.00); C584(1.04); C618(1.20); C625(1.20)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C584(0.85); C577(0.88); C618(0.97); C625(0.97)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C577(0.66); C513(0.77); C518(0.82); C87(0.84)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C518(1.00); C513(1.00); C584(1.20); C200(1.55)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C518(0.96); C513(0.96); C618(0.98); C625(0.98)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C87(1.00); C72(1.09); C584(1.11); C518(1.20)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.98  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C87(1.10); C72(1.07); C618(0.92); C625(0.92)  LDD0078  [9]
 LDCM0632  CL-Sc Hep-G2 C72(1.35)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C200(0.90); C213(0.90); C618(0.93); C625(0.93)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C200(0.74); C213(0.74); C72(0.97); C87(0.99)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C72(0.91); C87(0.96); C518(0.99); C513(1.03)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C87(0.82); C72(0.97); C518(0.98); C513(0.98)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C87(0.86); C72(0.97); C518(1.00); C513(1.00)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C618(0.92); C625(0.92); C72(0.97); C87(1.02)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C87(0.96); C577(0.96); C618(1.01); C625(1.01)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C87(0.78); C72(0.83); C577(1.03); C618(1.04)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C72(0.88); C87(0.93); C618(1.19); C625(1.19)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C72(0.92); C87(0.94); C577(1.00); C513(1.02)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C87(0.87); C72(0.91); C618(1.15); C625(1.15)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C87(0.84); C618(0.90); C625(0.90); C72(0.92)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C72(0.81); C200(1.13); C213(1.13); C87(1.16)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C72(0.80); C87(0.91); C618(1.10); C625(1.10)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C87(0.85); C72(0.86); C513(0.95); C518(1.00)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C518(0.91); C513(0.98); C72(1.00); C618(1.01)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C518(0.77); C513(1.00); C72(1.06); C87(1.06)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C72(0.90); C618(1.10); C625(1.10); C87(1.17)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C518(0.85); C618(0.99); C625(0.99); C87(1.08)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C518(0.70); C513(0.89); C618(1.05); C625(1.05)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C513(1.10); C72(1.11); C518(1.18); C87(1.31)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C72(0.88); C518(0.95); C87(0.97); C618(1.00)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C518(0.92); C513(0.99); C87(1.00); C72(1.05)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C72(1.03); C87(1.17); C200(1.18); C213(1.18)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C518(0.87); C618(1.03); C625(1.03); C513(1.03)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C87(0.88); C518(1.14); C513(1.14); C618(1.16)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C87(0.95); C200(0.95); C213(0.95); C618(1.00)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C618(0.98); C625(0.98); C87(1.23); C200(1.28)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C618(1.01); C625(1.01); C87(1.20); C200(1.27)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C87(0.87); C577(0.88); C518(0.89); C513(0.89)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C577(0.87); C518(0.91); C513(0.91); C618(0.96)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C518(0.88); C513(0.88); C584(0.89); C87(0.90)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C87(0.86); C72(0.98); C518(1.01); C513(1.01)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C72(0.93); C518(0.96); C584(1.03); C87(1.06)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C518(0.80); C200(0.86); C213(0.86); C618(0.88)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C72(0.78); C518(0.88); C618(1.05); C625(1.05)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C87(0.91); C518(1.03); C513(1.03); C618(1.06)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C72(0.87); C87(0.95); C577(1.02); C518(1.02)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C87(0.84); C518(0.85); C513(0.85); C577(1.02)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C87(0.86); C72(0.99); C518(0.99); C513(0.99)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C200(0.66); C213(0.66); C518(0.77); C618(0.89)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C87(0.92); C72(0.99); C518(1.00); C513(1.00)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C72(0.86); C87(0.87); C618(1.25); C625(1.25)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C72(0.88); C87(1.05); C618(1.32); C625(1.32)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C584(0.83); C87(0.93); C518(0.98); C513(0.98)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C87(1.02); C584(1.11); C72(1.14); C618(1.15)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C518(2.99); C513(2.99); C584(1.64); C577(1.46)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C518(1.09); C513(1.09); C584(0.99); C577(1.27)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C518(4.30); C513(4.30); C584(0.95); C577(1.15)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C518(2.25); C513(2.25); C584(1.44); C577(1.33)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C518(1.04); C513(1.04); C584(0.87); C577(1.24)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C518(0.90); C513(1.01); C584(0.98); C200(0.59)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C518(0.97); C513(0.97); C584(1.06); C577(1.02)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C518(1.15); C513(1.16); C584(1.25); C200(1.01)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C518(1.89); C513(1.71); C584(0.80); C200(0.96)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C518(1.21); C513(1.23); C584(0.88); C200(1.35)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C518(1.75); C513(1.77); C584(0.81); C200(1.81)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C518(1.11); C513(1.16); C584(0.84); C200(1.76)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C518(1.37); C513(1.85); C584(0.82); C200(1.41)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C518(1.66); C513(1.67); C584(0.72); C200(2.12)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C518(2.31); C513(2.20); C584(0.56); C200(1.25)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C518(1.20); C513(1.23); C584(1.61); C200(0.82)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C518(1.44); C513(1.32); C584(0.58); C200(1.74)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C518(1.03); C513(1.11); C584(0.83); C200(1.26)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C518(1.67); C513(1.75); C584(0.58); C200(2.27)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C518(1.23); C513(1.26); C584(0.54); C200(1.97)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C518(1.13); C513(1.14); C584(0.69); C200(1.35)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C518(1.34); C513(1.36); C584(0.85); C200(1.47)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C518(0.99); C513(1.04); C577(0.62); C618(0.78)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C518(0.87); C513(0.93); C577(0.70); C618(0.81)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C518(0.97); C513(1.09); C577(0.97); C618(0.77)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C518(1.09); C513(1.11); C577(0.90); C618(0.83)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C518(0.82); C513(0.89); C584(0.98); C200(0.88)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C518(0.92); C513(0.94); C577(0.67); C618(0.79)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C518(0.85); C513(1.23); C577(0.60); C618(0.78)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C518(1.55); C513(1.29); C577(0.81); C618(0.80)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C518(1.06); C513(1.23); C577(0.84); C618(0.83)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C518(0.99); C513(0.98); C577(0.62); C618(0.76)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C518(0.87); C513(0.85); C577(0.69); C618(0.78)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C518(0.94); C513(0.97); C577(0.77); C618(0.90)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C518(0.97); C513(1.03); C577(0.68); C618(0.85)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C518(0.86); C513(0.89); C577(0.96); C618(0.81)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C518(0.94); C513(0.96); C577(0.72); C618(0.91)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C518(2.76); C513(2.63); C584(1.32); C200(0.70)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C518(0.99); C513(1.07); C577(0.76); C618(0.87)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C518(1.10); C513(1.26); C584(0.98); C200(1.30)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C518(1.14); C513(1.18); C584(1.02); C200(1.22)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C518(1.12); C513(1.43); C584(1.13); C200(1.23)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C518(2.39); C513(2.10); C584(2.93); C200(1.87)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C518(1.10); C513(1.14); C584(1.31); C200(1.35)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C518(1.54); C513(1.54); C584(1.30); C200(1.71)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C518(1.27); C513(1.28); C584(1.48); C200(0.91)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C518(1.31); C513(1.39); C584(1.54); C200(1.38)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C518(1.07); C513(1.41); C584(1.11); C200(0.95)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C518(0.86); C513(1.02); C584(2.35); C200(0.85)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C518(1.18); C513(1.17); C584(1.55); C200(1.54)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C518(1.38); C513(1.36); C584(1.30); C200(1.21)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C518(1.04); C513(1.15); C584(1.26); C200(1.16)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C518(1.14); C513(1.23); C584(1.34); C200(2.02)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C518(1.20); C513(1.22); C584(1.29); C200(1.50)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C518(0.98); C513(0.98); C584(1.04); C200(1.35)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C518(1.06); C513(1.06); C584(1.07); C200(1.21)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C518(1.06); C513(1.06); C584(1.00); C200(1.22)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C518(1.17); C513(1.17); C584(1.04); C200(1.89)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C518(2.05); C513(1.90); C584(5.70); C200(1.12)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C518(0.98); C513(0.98); C584(1.20); C200(1.12)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C518(1.15); C513(1.15); C584(1.53); C200(1.36)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C518(1.36); C513(1.36); C584(1.37); C200(1.96)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C518(1.82); C513(1.82); C584(1.53); C200(1.85)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C518(3.02); C513(3.02); C584(1.63); C200(2.89)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C518(1.11); C513(1.11); C584(1.12); C200(1.75)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C518(1.68); C513(1.68); C584(1.36); C200(1.22)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C518(2.15); C513(2.15); C584(1.06); C200(1.63)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C518(1.24); C513(1.24); C584(1.29); C200(1.75)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C518(1.48); C513(1.48); C584(2.27); C200(2.24)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C518(1.60); C513(1.83); C584(2.49); C200(1.00)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C518(1.13); C513(1.13); C584(0.97); C200(0.94)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C518(0.94); C513(0.96); C584(1.09); C200(1.14)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C518(1.26); C513(1.30); C584(0.94); C200(0.79)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C518(1.12); C513(1.04); C584(0.87); C200(1.05)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C518(1.12); C513(1.11); C584(0.92); C200(1.16)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C518(3.31); C513(2.86); C584(1.29); C200(1.10)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C518(1.34); C513(1.32); C584(1.16); C200(1.05)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C518(1.65); C513(1.66); C584(1.26); C200(1.16)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C518(1.06); C513(1.14); C584(1.15); C200(1.13)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C518(0.88); C513(0.90); C584(1.18); C200(1.11)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C87(1.08); C584(0.94); C577(0.99); C358(1.06)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C584(1.56); C72(1.12); C318(0.89)  LDD1702  [5]
 LDCM0625  F8 Ramos C87(1.29); C72(0.97)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C513(0.93)  LDD1390  [6]
 LDCM0573  Fragment11 Ramos C87(15.50); C72(20.00)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C87(1.62); C72(0.97)  LDD2191  [21]
 LDCM0575  Fragment13 MDA-MB-231 C513(1.02)  LDD1395  [6]
 LDCM0576  Fragment14 Ramos C513(1.52)  LDD1398  [6]
 LDCM0579  Fragment20 MDA-MB-231 C513(1.46)  LDD1402  [6]
 LDCM0580  Fragment21 Ramos C513(2.68)  LDD1405  [6]
 LDCM0582  Fragment23 Ramos C87(0.96); C72(1.12)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C87(0.84); C72(1.10)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C87(0.76); C72(0.73)  LDD2198  [21]
 LDCM0587  Fragment29 MDA-MB-231 C513(1.16)  LDD1417  [6]
 LDCM0588  Fragment30 Ramos C87(1.09); C72(2.11)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C87(0.93); C72(1.04)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C87(1.75); C72(0.67)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C518(1.25); C513(1.34); C584(1.25); C200(1.21)  LDD0785  [9]
 LDCM0593  Fragment35 Ramos C513(1.31)  LDD1430  [6]
 LDCM0595  Fragment37 Ramos C513(0.91)  LDD1432  [6]
 LDCM0596  Fragment38 Ramos C513(1.35)  LDD1434  [6]
 LDCM0566  Fragment4 MDA-MB-231 C513(20.00)  LDD1378  [6]
 LDCM0427  Fragment51 HCT 116 C518(3.02); C513(3.30); C584(0.52); C200(2.48)  LDD0744  [9]
 LDCM0610  Fragment52 MDA-MB-231 C513(1.80)  LDD1452  [6]
 LDCM0614  Fragment56 Ramos C87(1.55); C72(1.33)  LDD2205  [21]
 LDCM0615  Fragment63-R Jurkat _(4.36)  LDD1487  [6]
 LDCM0569  Fragment7 Jurkat _(4.51)  LDD1485  [6]
 LDCM0571  Fragment9 Ramos C87(2.21)  LDD2188  [21]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C513(19.15); C518(19.15); C72(1.59)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C513(20.00); C518(20.00); C72(1.58)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C513(14.20); C518(14.20); C72(1.54)  LDD0082  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C72(0.92)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C72(0.96); C577(0.68)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C72(1.04); C577(0.56)  LDD2101  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C72(0.99); C577(0.67)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C72(0.89); C584(0.58)  LDD2109  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C72(1.74); C584(2.12)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C72(1.05)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C72(0.74); C577(0.49); C584(1.26)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C72(1.15)  LDD2127  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C72(0.51)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C72(0.78); C577(0.82)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C72(1.18); C87(0.81)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C577(1.00)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C577(0.82)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C72(2.12)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C72(0.90); C577(0.53)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C72(1.56)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C72(0.99)  LDD2146  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C513(0.80); C87(0.67); C72(0.20)  LDD2207  [22]
 LDCM0090  Rapamycin JHH-7 4.92  LDD0213  [19]
 LDCM0021  THZ1 HCT 116 C87(1.12)  LDD2173  [9]
 LDCM0112  W16 Hep-G2 C513(0.74)  LDD0239  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 4 (COG4) COG4 family Q9H9E3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.