Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment38					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	20.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	20.0
LDTP05992	Bleomycin hydrolase (BLMH)				C73	15.2
LDTP02502	Thioredoxin (TXN)				C32	13.8
LDTP05289	AMP deaminase 2 (AMPD2)				C107	5.0
LDTP03400	Deoxycytidine kinase (DCK)				C9	4.7
LDTP06211	Caspase-8 (CASP8)				C360	4.1
LDTP02672	Elongation factor 2 (EEF2)				C41	3.3
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	3.2
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	3.0
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	2.7
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	2.6
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	2.6
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	2.5
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	2.5
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	2.4
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	2.4
LDTP03786	Glutaredoxin-1 (GLRX)				C23	2.4
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	2.3
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	2.1
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	2.0
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	2.0
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.9
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	1.9
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	1.8
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.7
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.7
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	1.7
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.6
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.6
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	1.6
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.6
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.5
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.5
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.5
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.5
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.5
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.5
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.4
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.4
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.4
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.4
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.4
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.4
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.4
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.4
LDTP10801	ATPase WRNIP1 (WRNIP1)				C272	1.4
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.4
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	1.4
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.3
LDTP04689	Adenosine kinase (ADK)				C353	1.3
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.3
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.3
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.3
LDTP02672	Elongation factor 2 (EEF2)				C136	1.3
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.3
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.2
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.2
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.2
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.2
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.1
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.1
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	1.1
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.1
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.1
LDTP04374	Dynamin-2 (DNM2)				C27	1.0
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	1.0
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.0
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.0
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C170	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04801	Gasdermin-D (GSDMD)				C268	1.4
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.3
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.3
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.3
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.1
LDTP13661	Sorting nexin-6 (SNX6)				C264	1.0
LDTP00501	Exportin-1 (XPO1)				C34	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.9
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	1.7
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.3
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	1.2
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.2

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	5.8
LDTP18494	Tropomodulin-3 (TMOD3)				C132	5.5
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	3.7
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	3.7
LDTP10864	Calponin-2 (CNN2)				C215	3.7
LDTP05867	Treacle protein (TCOF1)				C1298	3.5
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	2.7
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	2.7
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	2.7
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	2.6
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	2.5
LDTP02205	Tubulin beta chain (TUBB)				C354	2.4
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	2.3
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	2.3
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	2.2
LDTP04092	Crk-like protein (CRKL)				C249	2.2
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	2.1
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	2.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	2.1
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	2.0
LDTP07755	Dynamin-binding protein (DNMBP)				C691	2.0
LDTP01532	ZW10 interactor (ZWINT)				C54	2.0
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.9
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.9
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.8
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.8
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.8
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.7
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	1.6
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	1.5
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.5
LDTP00202	AH receptor-interacting protein (AIP)				C122	1.5
LDTP02205	Tubulin beta chain (TUBB)				C239	1.5
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	1.5
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	1.4
LDTP02511	cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)				C18	1.4
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.4
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	1.4
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	1.4
LDTP13591	A-kinase anchor protein 8-like (AKAP8L)				C211	1.4
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	1.4
LDTP09549	Conserved oligomeric Golgi complex subunit 1 (COG1)				C513	1.4
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.3
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	1.3
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	1.3
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.3
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.3
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.3
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.3
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.2
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	1.2
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.2
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	1.1
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.1
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.1
LDTP14337	Protein strawberry notch homolog 1 (SBNO1)				C445	1.1
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	1.0
LDTP00430	Transcription elongation regulator 1 (TCERG1)				C1062	0.9

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.