Details of the Target

General Information of Target

Target ID LDTP05867
Target Name Treacle protein (TCOF1)
Gene Name TCOF1
Gene ID 6949
Synonyms
Treacle protein; Treacher Collins syndrome protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS
MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP
AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP
APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI
FVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTN
VVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVL
AQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAP
ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQ
SLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKT
GGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLT
ELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPE
KTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKK
EKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQTV
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus
Function
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Uniprot ID
Q13428
Ensemble ID
ENST00000323668.11
HGNC ID
HGNC:11654

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		8.35  LDD0215  [2]
AZ-9
 Probe Info  		10.00  LDD0393  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
W1
 Probe Info  		30.35  LDD0235  [5]
C-Sul
 Probe Info  		2.03  LDD0066  [6]
ONAyne
 Probe Info  		K31(0.96)  LDD0274  [7]
DBIA
 Probe Info  		C38(2.85); C1334(2.38)  LDD3331  [8]
BTD
 Probe Info  		C1012(0.70)  LDD2095  [9]
AHL-Pu-1
 Probe Info  		C1298(2.75)  LDD0168  [10]
Alkyne-RA190
 Probe Info  		2.10  LDD0299  [11]
EA-probe
 Probe Info  		C38(1.34); C38(2.88)  LDD2210  [12]
HHS-475
 Probe Info  		Y15(0.12)  LDD0264  [13]
Acrolein
 Probe Info  		N.A.  LDD0223  [14]
5E-2FA
 Probe Info  		H141(0.00); H1028(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K637(0.00); K732(0.00); K642(0.00); K820(0.00)  LDD0199  [16]
1d-yne
 Probe Info  		N.A.  LDD0358  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C38(0.00); C1298(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
Lodoacetamide azide
 Probe Info  		C38(0.00); C1298(0.00)  LDD0037  [18]
IPM
 Probe Info  		N.A.  LDD0025  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		N.A.  LDD2226  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		C1298(0.00); C38(0.00)  LDD2213  [22]
NHS
 Probe Info  		K904(0.00); K379(0.00); K244(0.00); K1044(0.00)  LDD0010  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [23]
VSF
 Probe Info  		C1012(0.00); C1298(0.00)  LDD0007  [23]
Phosphinate-6
 Probe Info  		C1012(0.00); C38(0.00); C644(0.00); C1298(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K1263(0.00); K732(0.00); K1065(0.00); K37(0.00)  LDD0228  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
HHS-465
 Probe Info  		K1273(0.00); K31(0.00)  LDD2240  [25]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		16.22  LDD1865  [26]
C191
 Probe Info  		12.55  LDD1868  [26]
C193
 Probe Info  		7.67  LDD1869  [26]
FFF probe13
 Probe Info  		5.63  LDD0475  [27]
JN0003
 Probe Info  		20.00  LDD0469  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1012(1.16)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1012(0.70)  LDD2095  [9]
 LDCM0025  4SU-RNA HEK-293T C1298(2.75)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1298(3.14)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C1012(0.87); C1298(0.98); C38(1.05)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C1012(0.99); C1298(1.03); C38(0.99)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C1012(0.95); C1298(1.01); C38(0.98)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C1012(1.11); C1298(1.05); C38(1.05)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C1012(1.02); C1298(1.06); C38(1.05)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C1012(1.08); C1298(0.96); C38(1.02)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C1012(1.20); C1298(1.00); C38(1.01)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C1012(1.02); C1298(1.04); C38(0.99)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C1012(0.93); C1298(1.08); C38(0.98)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C1012(1.09); C1298(0.99); C38(1.04)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C1012(0.86); C1298(1.06); C38(0.96)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C1012(1.09); C1298(0.99); C38(0.94)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C1012(0.94); C1298(1.06); C38(1.05)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C1012(1.16); C1298(0.96); C38(0.99)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C1012(1.03); C1298(0.97); C38(0.99)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C1012(0.90); C1298(1.00); C38(1.02)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C1012(1.08); C1298(0.99); C38(1.00)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C1012(0.91); C1298(1.11); C38(0.98)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C1012(1.02); C1298(1.13); C38(0.97)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C1012(1.07); C1298(1.08); C38(0.94)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C1012(1.25); C1298(1.03); C38(0.96)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C1012(1.01); C1298(1.01); C38(1.04)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C1012(1.07); C1298(0.96); C38(1.00)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C1012(0.87); C1298(1.05); C38(0.99)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C1012(1.24); C1298(1.06); C38(1.03)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C1012(1.20); C1298(0.95); C38(1.01)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C1012(1.08); C1298(0.95); C38(0.96)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C1012(1.00); C1298(1.06); C38(1.00)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C1012(1.07); C1298(0.99); C38(1.02)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C1012(1.04); C1298(1.01); C38(1.05)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C1012(1.04); C1298(0.97); C38(0.97)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C1012(1.20); C1298(1.10); C38(1.07)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C1012(1.05); C1298(1.04); C38(1.12)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C1012(1.07); C1298(1.05); C38(0.99)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C1012(1.26); C1298(1.02); C38(0.93)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C1012(1.15); C1298(1.00); C38(0.95)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C1012(1.00); C1298(1.03); C38(1.03)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C1012(1.05); C1298(1.01); C38(1.03)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C1012(1.01); C1298(1.04); C38(1.04)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C1012(1.15); C1298(1.08); C38(0.97)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C1012(0.99); C1298(1.05); C38(1.03)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C1012(1.06); C1298(1.00); C38(1.00)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C1012(0.93); C1298(1.10); C38(0.97)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C1012(0.94); C1298(0.92); C38(1.00)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C1012(0.93); C1298(0.93); C38(0.97)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C1012(1.04); C1298(0.93); C38(1.04)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C1012(1.03); C1298(1.02); C38(1.00)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C1012(0.99); C1298(1.12); C38(1.05)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C1012(1.22); C1298(1.05); C38(0.98)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C1012(1.08); C1298(1.04); C38(0.99)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C1012(0.97); C1298(1.07); C38(1.04)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C1012(0.95); C1298(0.96); C38(1.02)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C1012(0.95); C1298(0.96); C38(1.01)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C1012(1.09); C1298(1.04); C38(1.02)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C1012(1.00); C1298(1.03); C38(1.05)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C1012(1.15); C1298(1.09); C38(1.00)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C1012(1.02); C1298(0.99); C38(1.10)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C1012(1.07); C1298(1.00); C38(0.99)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C1012(0.95); C1298(1.01); C38(1.03)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C1012(1.20); C1298(0.99); C38(1.00)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C1012(1.00); C1298(1.02); C38(1.04)  LDD1569  [28]
 LDCM0248  AKOS034007472 HEK-293T C1012(1.10); C1298(1.03); C38(1.04)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C1012(1.16); C1298(0.99); C38(1.00)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C1012(0.94); C1298(1.02); C38(0.99)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C1298(1.60)  LDD2214  [29]
 LDCM0367  CL1 HEK-293T C1012(0.98); C1298(1.08); C38(1.02)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C1012(0.93); C1298(1.38); C38(1.03)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C1012(0.98); C1298(1.16); C38(1.13)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C1012(1.05); C1298(1.05); C38(1.01)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C1012(0.95); C1298(1.15); C38(1.10)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C1012(1.06); C1298(1.08); C38(1.07)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C1012(0.93); C1298(1.12); C38(1.08)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C1012(0.96); C1298(1.03); C38(1.02)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C1012(0.93); C1298(1.02); C38(1.07)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C1012(0.91); C1298(1.05); C38(1.04)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C1012(0.99); C1298(0.99); C38(1.05)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C1012(0.93); C1298(1.06); C38(1.03)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C1012(1.11); C1298(1.01); C38(1.04)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C1012(0.94); C1298(1.18); C38(1.06)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C1012(0.99); C1298(1.08); C38(1.05)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C1012(0.99); C1298(1.16); C38(1.02)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C1012(1.00); C1298(1.00); C38(1.01)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C1012(0.97); C1298(1.18); C38(1.02)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C1012(1.00); C1298(1.07); C38(1.06)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C1012(1.02); C1298(1.04); C38(0.98)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C1012(0.99); C1298(1.03); C38(1.02)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C1012(1.06); C1298(1.05); C38(1.02)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C1012(0.97); C1298(1.04); C38(1.06)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C1012(0.99); C1298(1.03); C38(1.02)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C1012(0.99); C1298(1.04); C38(1.07)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C1012(1.00); C1298(1.03); C38(1.04)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C1012(0.95); C1298(1.03); C38(1.00)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C1012(0.89); C1298(1.33); C38(1.13)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C1012(0.99); C1298(1.07); C38(1.08)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C1012(0.90); C1298(1.02); C38(1.02)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C1012(1.10); C1298(1.11); C38(1.01)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C1012(1.11); C1298(1.09); C38(1.06)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C1012(0.98); C1298(1.06); C38(1.02)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C1012(1.26); C1298(1.14); C38(0.95)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C1012(0.97); C1298(1.09); C38(1.02)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C1012(0.81); C1298(1.27); C38(1.16)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C1012(0.93); C1298(1.03); C38(1.05)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C1012(1.11); C1298(1.36); C38(1.12)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C1012(1.14); C1298(1.01); C38(1.00)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C1012(1.00); C1298(0.97); C38(1.04)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C1012(1.04); C1298(1.00); C38(1.04)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C1012(1.18); C1298(1.00); C38(1.09)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C1012(1.41); C1298(1.19); C38(1.03)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C1012(1.13); C1298(1.04); C38(1.08)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C1012(1.22); C1298(1.02); C38(1.04)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C1012(1.03); C1298(1.04); C38(1.13)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C1012(0.86); C1298(1.09); C38(1.11)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C1012(0.96); C1298(1.05); C38(1.04)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C1012(1.01); C1298(1.11); C38(1.07)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C1012(0.94); C1298(1.03); C38(1.06)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C1012(0.91); C1298(1.01); C38(1.04)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C1012(1.10); C1298(1.10); C38(1.06)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C1012(0.95); C1298(0.99); C38(1.00)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C1012(1.09); C1298(1.08); C38(0.93)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C1012(1.14); C1298(0.94); C38(1.00)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C1012(0.93); C1298(1.15); C38(1.03)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C1012(0.94); C1298(0.99); C38(1.09)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C1012(1.26); C1298(0.96); C38(1.04)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C1012(1.13); C1298(1.11); C38(1.09)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C1012(0.90); C1298(1.02); C38(1.10)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C1012(0.92); C1298(1.06); C38(0.99)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C1012(0.96); C1298(1.10); C38(1.08)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C1012(0.93); C1298(1.04); C38(1.00)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C1012(1.13); C1298(1.09); C38(1.05)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C1012(0.98); C1298(0.94); C38(1.03)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C1012(0.99); C1298(1.04); C38(0.96)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C1012(1.09); C1298(0.99); C38(0.99)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C1012(1.02); C1298(1.11); C38(1.00)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C1012(1.06); C1298(0.94); C38(1.04)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C1012(1.26); C1298(1.05); C38(1.01)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C1012(1.17); C1298(1.06); C38(1.05)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C1012(0.96); C1298(1.02); C38(1.01)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C1012(1.08); C1298(1.03); C38(1.04)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C1012(0.92); C1298(1.03); C38(1.11)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C1012(1.09); C1298(1.04); C38(1.03)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C1012(1.06); C1298(1.10); C38(1.10)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C1012(0.89); C1298(1.33); C38(1.01)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C1012(1.01); C1298(1.07); C38(1.01)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C1012(1.11); C1298(0.88); C38(1.05)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C1012(1.09); C1298(1.10); C38(0.98)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C1012(1.12); C1298(1.11); C38(1.10)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C1012(1.01); C1298(0.97); C38(1.03)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C1012(1.14); C1298(1.02); C38(1.15)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C1012(1.04); C1298(1.10); C38(1.12)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C1012(0.90); C1298(0.98); C38(1.03)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C1012(0.93); C1298(1.04); C38(0.98)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C1012(0.91); C1298(1.07); C38(1.06)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C1012(0.79); C1298(1.20); C38(1.02)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C1012(1.11); C1298(1.02); C38(0.97)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C1012(0.96); C1298(1.04); C38(0.92)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C1012(1.17); C1298(0.95); C38(0.98)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C1012(0.95); C1298(0.92); C38(1.10)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C1012(1.11); C1298(1.05); C38(1.09)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C1012(1.16); C1298(0.96); C38(1.06)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C1012(1.04); C1298(1.06); C38(1.09)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C1012(1.22); C1298(1.02); C38(1.01)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C1012(0.98); C1298(1.07); C38(1.11)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C1012(0.89); C1298(0.99); C38(1.03)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C1012(1.01); C1298(1.01); C38(1.02)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C1012(0.90); C1298(1.03); C38(1.07)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C1012(0.96); C1298(1.10); C38(1.09)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C1012(1.13); C1298(0.97); C38(1.02)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C1012(0.96); C1298(1.00); C38(0.95)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C1012(0.81); C1298(1.90); C38(0.91)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C1012(0.94); C1298(0.95); C38(1.03)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C1012(1.18); C1298(0.98); C38(0.99)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C1012(0.99); C1298(1.05); C38(1.04)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C1012(1.15); C1298(1.01); C38(0.92)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C1012(1.03); C1298(1.07); C38(1.10)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C1012(0.87); C1298(1.04); C38(1.03)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C1012(1.07); C1298(1.10); C38(1.01)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C1012(1.08); C1298(1.18); C38(1.03)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C1012(0.99); C1298(1.13); C38(1.01)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C1012(1.18); C1298(1.09); C38(1.06)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C1012(1.19); C1298(1.00); C38(1.02)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C1012(0.87); C1298(1.59); C38(0.98)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C1012(1.32); C1298(1.01); C38(1.00)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C1012(1.06); C1298(1.30); C38(1.07)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C1012(1.15); C1298(1.07); C38(0.96)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C1012(0.97); C1298(1.01); C38(1.05)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C1012(0.95); C1298(1.26); C38(0.97)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C1012(1.00); C1298(1.20); C38(1.06)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C1012(1.13); C1298(1.12); C38(1.07)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C1012(1.00); C1298(1.13); C38(0.97)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C1012(0.91); C1298(1.07); C38(1.06)  LDD1697  [28]
 LDCM0495  E2913 HEK-293T C1012(0.97); C1298(1.17); C38(1.02)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1012(0.95)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa C38(1.34); C38(2.88)  LDD2210  [12]
 LDCM0625  F8 Ramos C1012(1.35)  LDD2187  [30]
 LDCM0572  Fragment10 MDA-MB-231 C38(2.04); C1298(2.04)  LDD1389  [31]
 LDCM0573  Fragment11 MDA-MB-231 C38(2.46); C1298(3.05)  LDD1391  [31]
 LDCM0574  Fragment12 MDA-MB-231 C38(2.88); C1298(12.52)  LDD1393  [31]
 LDCM0575  Fragment13 Ramos C38(0.86); C1298(0.82)  LDD1396  [31]
 LDCM0576  Fragment14 MDA-MB-231 C38(5.96); C1298(2.07)  LDD1397  [31]
 LDCM0577  Fragment15 MDA-MB-231 C38(1.58)  LDD1399  [31]
 LDCM0579  Fragment20 MDA-MB-231 C38(3.42); C1298(3.72)  LDD1402  [31]
 LDCM0580  Fragment21 MDA-MB-231 C38(1.27); C1298(1.47)  LDD1404  [31]
 LDCM0581  Fragment22 Ramos C38(0.91)  LDD1407  [31]
 LDCM0582  Fragment23 MDA-MB-231 C38(1.21); C1298(2.35)  LDD1408  [31]
 LDCM0583  Fragment24 Ramos C1298(1.81)  LDD1410  [31]
 LDCM0584  Fragment25 MDA-MB-231 C38(0.80); C1298(1.01)  LDD1411  [31]
 LDCM0585  Fragment26 Ramos C38(0.79); C1298(0.80)  LDD1412  [31]
 LDCM0578  Fragment27 MDA-MB-231 C38(0.85); C1298(0.92)  LDD1401  [31]
 LDCM0586  Fragment28 MDA-MB-231 C38(1.15); C1298(0.88)  LDD1415  [31]
 LDCM0587  Fragment29 MDA-MB-231 C38(1.33); C1298(1.63)  LDD1417  [31]
 LDCM0588  Fragment30 MDA-MB-231 C38(1.07); C1298(0.91)  LDD1419  [31]
 LDCM0589  Fragment31 MDA-MB-231 C38(1.73)  LDD1421  [31]
 LDCM0590  Fragment32 MDA-MB-231 C38(2.88); C1298(4.81)  LDD1423  [31]
 LDCM0468  Fragment33 HEK-293T C1012(1.00); C1298(1.07); C38(1.05)  LDD1671  [28]
 LDCM0592  Fragment34 MDA-MB-231 C1298(0.91)  LDD1427  [31]
 LDCM0593  Fragment35 MDA-MB-231 C38(1.06)  LDD1429  [31]
 LDCM0594  Fragment36 MDA-MB-231 C38(1.72)  LDD1431  [31]
 LDCM0596  Fragment38 MDA-MB-231 C38(1.58); C1298(1.27)  LDD1433  [31]
 LDCM0597  Fragment39 MDA-MB-231 C38(4.82)  LDD1435  [31]
 LDCM0566  Fragment4 MDA-MB-231 C38(2.29); C1298(2.06)  LDD1378  [31]
 LDCM0598  Fragment40 MDA-MB-231 C38(1.02)  LDD1436  [31]
 LDCM0599  Fragment41 MDA-MB-231 C38(1.57); C1298(1.54)  LDD1438  [31]
 LDCM0601  Fragment43 MDA-MB-231 C38(2.55); C1298(4.04)  LDD1441  [31]
 LDCM0603  Fragment45 MDA-MB-231 C38(13.31)  LDD1444  [31]
 LDCM0604  Fragment46 MDA-MB-231 C38(1.11); C1298(0.92)  LDD1445  [31]
 LDCM0605  Fragment47 MDA-MB-231 C38(1.34)  LDD1446  [31]
 LDCM0606  Fragment48 MDA-MB-231 C38(1.38)  LDD1447  [31]
 LDCM0608  Fragment50 MDA-MB-231 C38(3.79)  LDD1449  [31]
 LDCM0427  Fragment51 Ramos C38(0.95); C1298(1.06)  LDD1451  [31]
 LDCM0610  Fragment52 MDA-MB-231 C38(1.94); C1298(1.41)  LDD1452  [31]
 LDCM0611  Fragment53 Ramos C38(1.18)  LDD1455  [31]
 LDCM0614  Fragment56 MDA-MB-231 C38(0.89); C1298(1.02)  LDD1458  [31]
 LDCM0568  Fragment6 MDA-MB-231 C38(1.29); C1298(1.02)  LDD1382  [31]
 LDCM0569  Fragment7 MDA-MB-231 C38(2.51); C1298(2.12)  LDD1383  [31]
 LDCM0570  Fragment8 MDA-MB-231 C38(1.99); C1298(2.52)  LDD1385  [31]
 LDCM0571  Fragment9 MDA-MB-231 C38(1.94); C1298(1.56)  LDD1387  [31]
 LDCM0116  HHS-0101 DM93 Y15(0.12)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y15(0.09)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y15(0.12)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y15(20.00)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y15(0.08)  LDD0268  [13]
 LDCM0022  KB02 MDA-MB-231 C38(5.40); C1298(11.27)  LDD1374  [31]
 LDCM0023  KB03 MDA-MB-231 C38(5.22); C1298(20.00)  LDD1376  [31]
 LDCM0024  KB05 MKN-1 C38(2.85); C1334(2.38)  LDD3331  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0627  NUDT7-COV-1 HEK-293T C38(1.33); C38(0.75)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C38(1.00); C38(0.45); C1298(0.34); C38(0.07)  LDD2207  [32]
 LDCM0131  RA190 MM1.R 2.10  LDD0299  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
TGF-beta receptor type-2 (TGFBR2) TKL Ser/Thr protein kinase family P37173
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-arrestin-1 (ARRB1) Arrestin family P49407
Beta-arrestin-2 (ARRB2) Arrestin family P32121
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
Nibrin (NBN) . O60934

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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