Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment51					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	20.0
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	20.0
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	20.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	20.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	14.9
LDTP05992	Bleomycin hydrolase (BLMH)				C73	9.8
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	9.5
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	7.0
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	3.7
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	3.2
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	2.8
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	2.8
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	2.7
LDTP03786	Glutaredoxin-1 (GLRX)				C23	2.5
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	2.4
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	2.2
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	2.1
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	2.1
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C453	1.8
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.7
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.6
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.6
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	1.4
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	1.4
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.3
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.3
LDTP01245	Enoyl-CoA delta isomerase 2 (ECI2)				C380	1.3
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.3
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	1.2
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	1.2
LDTP02502	Thioredoxin (TXN)				C32	1.2
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.2
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.2
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	1.2
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.2
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.2
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.2
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.2
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	1.2
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	1.1
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	1.1
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C641	1.1
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.1
LDTP08135	E3 ubiquitin-protein ligase HUWE1 (HUWE1)				C4367	1.1
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.1
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	1.1
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.0
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.0
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.0
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.0
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.0
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.9
LDTP04424	Galactokinase (GALK1)				C182	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	0.9
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	0.9
LDTP02672	Elongation factor 2 (EEF2)				C136	0.9
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.9
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	0.9
LDTP04374	Dynamin-2 (DNM2)				C27	0.9
LDTP02672	Elongation factor 2 (EEF2)				C41	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.9
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.9
LDTP04689	Adenosine kinase (ADK)				C353	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.9
LDTP14888	Pre-rRNA-processing protein TSR1 homolog (TSR1)				C126	0.9
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.8
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	0.8
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	0.8
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	0.8
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	0.8
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	0.8
LDTP02733	Pyruvate kinase PKM (PKM)				C423	0.8
LDTP03806	ADP-ribosylation factor-like protein 3 (ARL3)				C174	0.8
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.8
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	0.7
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	0.7
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C179	0.7
LDTP09912	DNA repair protein RAD50 (RAD50)				C102	0.7
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	0.6
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	2.6
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	2.5
LDTP04801	Gasdermin-D (GSDMD)				C268	1.4
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.3
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	1.3
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.1
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.1
LDTP00501	Exportin-1 (XPO1)				C34	1.0
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	0.9
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.9
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.9
LDTP00501	Exportin-1 (XPO1)				C528	0.9
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	0.8
LDTP01574	Importin-7 (IPO7)				C757	0.7
LDTP04662	Exportin-2 (CSE1L)				C842	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	20.0
LDTP05284	Transcription factor RelB (RELB)				C109	1.6
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	1.4
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.1
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.9
LDTP05485	Recombining binding protein suppressor of hairless (RBPJ)				C313	0.8
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	0.7

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	6.1
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	4.1
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	4.0
LDTP07755	Dynamin-binding protein (DNMBP)				C691	3.6
LDTP04092	Crk-like protein (CRKL)				C249	2.4
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	2.3
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	2.1
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	1.7
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.7
LDTP13583	Targeting protein for Xklp2 (TPX2)				C536	1.7
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.6
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	1.5
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.5
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.4
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.3
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	1.3
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	1.3
LDTP08573	Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)				C615	1.3
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	1.2
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.2
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	1.2
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	1.2
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.2
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	1.2
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	1.2
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.2
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	1.1
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.1
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.1
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1059	1.1
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.1
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	1.1
LDTP05867	Treacle protein (TCOF1)				C1298	1.1
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	1.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.0
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	1.0
LDTP10864	Calponin-2 (CNN2)				C215	1.0
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	1.0
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.0
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	1.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.0
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	1.0
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.0
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.0
LDTP05867	Treacle protein (TCOF1)				C38	1.0
LDTP02205	Tubulin beta chain (TUBB)				C239	0.9
LDTP10864	Calponin-2 (CNN2)				C164	0.9
LDTP13964	MOB-like protein phocein (MOB4)				C134	0.9
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	0.9
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.9
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	0.9
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.9
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	0.9
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	0.9
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	0.9
LDTP02205	Tubulin beta chain (TUBB)				C354	0.9
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	0.8
LDTP14195	FH1/FH2 domain-containing protein 1 (FHOD1)				C502	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.8
LDTP13580	Coronin-1C (CORO1C)				C456	0.8
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C280	0.8
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	0.8
LDTP18494	Tropomodulin-3 (TMOD3)				C132	0.8
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	0.8
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	0.8
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	0.8
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	0.7
LDTP01532	ZW10 interactor (ZWINT)				C54	0.6
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	0.6
LDTP03244	Cofilin-1 (CFL1)				C80	0.6
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	0.6

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.