Details of the Target

General Information of Target

Target ID LDTP08573
Target Name Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)
Gene Name ANKHD1
Gene ID 404734
Synonyms
KIAA1085; MASK; VBARP; Ankyrin repeat and KH domain-containing protein 1; HIV-1 Vpr-binding ankyrin repeat protein; Multiple ankyrin repeats single KH domain; hMASK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG
GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD
PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT
HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE
ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK
VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD
TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI
VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC
LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK
IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL
LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN
GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP
LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV
RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE
VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS
REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ
EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI
LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV
NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP
KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE
RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA
ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA
AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV
LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT
STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN
LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS
EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF
VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS
QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST
SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS
NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI
WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA
SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD
AQQIWPGTWAPHIGNMHLKYVN
Target Bioclass
Other
Family
Mask family
Subcellular location
Cytoplasm
Function
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.
Uniprot ID
Q8IWZ3
Ensemble ID
ENST00000360839.7
HGNC ID
HGNC:24714

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.D295Y DBIA    Probe Info 
CAL27 SNV: p.H360Y .
CHL1 SNV: p.G784S .
COLO679 SNV: p.S1938F DBIA    Probe Info 
FUOV1 SNV: p.Q398P DBIA    Probe Info 
HCC1806 SNV: p.E1496K .
HEC1 Deletion: p.R1532GfsTer5
SNV: p.R480W;p.A1347V;p.L2250R		 DBIA    Probe Info 
HEC1B SNV: p.R480W .
HT115 SNV: p.E776K .
KATOIII SNV: p.A82T DBIA    Probe Info 
KMRC1 SNV: p.V1694I .
KYSE150 SNV: p.A499T .
MEWO SNV: p.P1385L; p.P1808S DBIA    Probe Info 
MFE280 SNV: p.Q203R .
MFE296 SNV: p.R717H DBIA    Probe Info 
NCIH2286 SNV: p.N2535K .
SNGM SNV: p.L533P; p.A2130T .
THP1 SNV: p.E1505D .
TOV21G Deletion: p.R1532GfsTer5
SNV: p.S2416L		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K194(8.33)  LDD0277  [2]
Probe 1
 Probe Info  		Y472(9.76); Y1661(11.30)  LDD3495  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
BTD
 Probe Info  		C1130(0.64)  LDD2100  [5]
Sulforaphane-probe2
 Probe Info  		2.28  LDD0042  [6]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [7]
DA-P3
 Probe Info  		75.61  LDD0182  [8]
AHL-Pu-1
 Probe Info  		C777(10.41)  LDD0168  [9]
DBIA
 Probe Info  		C873(24.56)  LDD0204  [10]
Acrolein
 Probe Info  		N.A.  LDD0221  [11]
5E-2FA
 Probe Info  		H199(0.00); H294(0.00)  LDD2235  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C615(0.00); C873(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C615(0.00); C213(0.00); C1716(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C535(0.00); C213(0.00); C1308(0.00); C873(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
TFBX
 Probe Info  		C1130(0.00); C213(0.00)  LDD0027  [14]
Compound 10
 Probe Info  		C1965(0.00); C615(0.00); C873(0.00)  LDD2216  [15]
IPM
 Probe Info  		C1716(0.00); C181(0.00); C873(0.00)  LDD0005  [16]
VSF
 Probe Info  		C1716(0.00); C181(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		C615(0.00); C181(0.00); C873(0.00)  LDD0018  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		C213(0.00); C873(0.00)  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		10.10  LDD0443  [19]
NAIA_5
 Probe Info  		C213(0.00); C380(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.46  LDD1725  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1130(0.77)  LDD2112  [5]
 LDCM0025  4SU-RNA HEK-293T C777(10.41)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C777(13.37); C181(2.25)  LDD0169  [9]
 LDCM0562  Abegg_cp(-)-11 HeLa C213(2.21)  LDD0313  [14]
 LDCM0214  AC1 HEK-293T C1716(0.99); C535(0.84); C777(1.05); C873(1.08)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C1716(1.04); C535(1.11); C777(0.85); C873(1.03)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C1716(1.01); C873(0.97); C615(1.03)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C1716(1.03); C535(1.03); C777(0.95); C873(0.98)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C1716(0.95); C535(1.01); C873(1.10); C615(1.12)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C1716(0.99); C535(1.01); C873(1.03); C615(0.97)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C1716(0.94); C535(1.17); C777(1.13); C873(1.19)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C1716(1.07); C535(0.95); C777(0.95); C873(0.94)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C1716(0.87); C873(1.24); C615(1.10)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C1716(1.06); C535(0.93); C777(0.94); C873(1.02)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C1716(1.01); C535(0.94); C777(0.75); C873(0.99)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C1716(0.99); C535(0.92); C873(0.99); C1965(1.04)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C1716(0.98); C535(0.94); C873(1.04); C615(0.99)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C1716(1.06); C535(1.12); C873(0.99); C615(0.86)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C1716(0.96); C535(1.03); C615(0.86); C1965(0.99)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C1716(1.01); C535(0.96); C777(1.01); C873(1.11)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C1716(0.96); C535(0.90); C777(0.94); C873(0.94)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C1716(0.97); C873(1.04); C615(1.05)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C1716(1.04); C535(0.92); C777(0.81); C873(1.01)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C1716(1.02); C535(0.97); C873(1.07); C1965(1.06)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C1716(1.11); C873(0.87); C615(1.06)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C1716(0.99); C535(1.03); C873(1.04); C615(1.10)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C1716(1.06); C535(1.06); C873(1.17); C615(1.11)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C1716(0.98); C535(0.95); C615(0.97); C1965(0.99)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C1716(0.83); C535(0.94); C777(1.03); C873(1.05)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C1716(1.02); C535(1.05); C777(0.91); C873(0.99)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C1716(0.98); C873(0.99); C615(0.96)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C1716(1.09); C535(1.01); C777(1.23); C873(0.98)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C1716(1.05); C535(1.09); C873(1.04); C1965(0.99)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C1716(0.98); C535(1.03); C873(1.04); C615(1.13)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C1716(1.01); C535(1.08); C873(1.09); C615(1.06)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C1716(1.03); C535(1.03); C777(0.86); C873(0.92)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C1716(1.01); C535(1.04); C615(0.93); C1965(0.98)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C1716(0.90); C535(1.12); C777(1.12); C873(1.00)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C1716(0.99); C535(0.99); C777(0.92); C873(1.05)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C1716(0.91); C873(1.01); C615(0.92)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C1716(1.11); C535(1.05); C777(0.80); C873(0.94)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C1716(0.99); C535(1.03); C873(1.03); C1965(1.08)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C1716(0.98); C535(1.09); C873(1.16); C615(1.22)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C1716(0.94); C535(0.94); C873(0.99); C615(1.05)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C1716(0.99); C535(1.02); C615(0.91); C1965(0.97)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C1716(0.86); C535(1.03); C777(0.98); C873(1.06)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C1716(1.06); C535(1.06); C873(0.94); C1965(1.04)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C1716(1.02); C535(0.99); C777(0.99); C873(0.93)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C1716(0.98); C873(0.99); C615(0.99)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C1716(0.96); C535(0.95); C777(0.83); C873(0.93)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C1716(1.01); C535(0.99); C873(0.97); C1965(1.03)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C1716(1.02); C535(1.10); C873(1.05); C615(1.17)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C1716(0.99); C535(1.00); C873(1.02); C615(0.97)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C1716(0.93); C535(0.98); C615(0.96); C1965(0.99)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C1716(0.92); C535(0.95); C777(1.03); C873(0.88)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C1716(1.07); C535(0.89); C777(0.99); C873(0.85)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C1716(1.09); C873(0.88); C615(1.05)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C1716(1.07); C535(0.92); C873(1.06); C615(1.14)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C1716(1.03); C535(1.11); C777(0.84); C873(0.96)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C1716(0.99); C535(0.98); C873(0.91); C1965(1.12)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C1716(0.98); C535(1.07); C873(0.95); C615(1.10)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C1716(0.99); C535(1.11); C873(0.91); C615(1.12)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C1716(0.99); C535(0.93); C615(0.96); C1965(0.96)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C1716(0.97); C535(0.97); C873(1.10); C615(1.03)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C1716(0.99); C535(0.99); C615(0.92); C1965(0.89)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C1716(0.98); C535(0.98); C873(0.97); C1965(1.04)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C1716(0.99); C535(1.16); C777(1.05); C873(0.98)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C1716(0.93); C535(1.02); C615(0.98); C1965(0.93)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 11.84  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C873(24.56)  LDD0204  [10]
 LDCM0087  Capsaicin HEK-293T 11.04  LDD0185  [8]
 LDCM0108  Chloroacetamide HeLa C873(0.00); C213(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C1232(20.00); C213(20.00); C873(2.62); C1716(1.32)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C1716(0.98); C535(0.96)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C1716(0.98); C535(1.10); C873(1.21); C615(1.31)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C1716(0.99); C535(1.00); C873(1.06); C615(1.12)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C1716(0.96); C535(0.98)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C1716(0.94); C777(0.93); C873(1.02); C2518(1.15)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C1716(1.04); C873(0.98); C615(0.91)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C1716(1.03); C535(1.07); C873(0.90); C615(1.11)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C1716(0.93); C535(0.86)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C1716(0.93); C777(1.05); C873(0.89); C2518(1.23)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C1716(0.98); C873(0.99); C615(0.92)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C1716(1.04); C535(1.06); C873(1.01); C615(0.98)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C1716(0.95); C535(0.89)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C1716(0.97); C535(1.19); C873(1.16); C615(1.05)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C1716(0.92); C777(1.11); C873(0.93); C2518(1.09)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C1716(0.93); C873(0.92); C615(1.04)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C1716(1.04); C535(1.19); C873(1.14); C615(1.09)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C1716(0.96); C535(1.06)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C1716(0.92); C777(0.98); C873(1.11); C2518(1.38)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C1716(0.90); C873(0.93); C615(1.03)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C1716(1.09); C535(1.11); C873(1.07); C615(1.16)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C1716(1.01); C535(1.08)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C1716(0.93); C777(1.11); C873(1.07); C2518(0.89)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C1716(0.99); C873(0.85); C615(0.98)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C1716(0.94); C535(1.24); C615(0.96); C1965(0.83)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C1716(1.11); C535(1.08); C873(0.98); C615(1.09)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C1716(0.99); C535(0.91)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C1716(0.94); C777(1.07); C873(0.77); C2518(1.22)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C1716(0.77); C873(0.91); C615(1.03)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C1716(0.99); C535(0.96); C873(0.89); C615(1.04)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C1716(0.92); C535(0.78)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C1716(0.91); C777(1.01); C873(0.77); C2518(1.52)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C1716(0.88); C873(0.74); C615(1.10)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C1716(0.95); C535(0.90); C873(0.86); C615(1.06)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C1716(0.94); C535(0.87)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C1716(0.91); C777(1.14); C873(0.96); C2518(0.93)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C1716(0.92); C873(0.93); C615(0.90)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C1716(1.03); C535(1.15); C873(0.96); C615(1.10)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C1716(0.99); C535(0.77); C777(0.94); C873(1.00)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C1716(1.05); C535(0.97); C777(1.00); C873(0.90)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C1716(0.95); C873(0.80); C615(1.13)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C1716(1.00); C777(0.97); C873(0.88); C2518(0.98)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C1716(1.08); C535(0.98); C777(0.78); C873(0.95)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C1716(0.94); C535(0.94); C873(1.02); C1965(0.92)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C1716(1.01); C535(1.09); C873(1.08); C615(1.29)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C1716(0.99); C535(1.11); C873(1.08); C615(1.00)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C1716(0.94); C535(1.26); C615(0.90); C1965(0.78)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C1716(0.91); C535(0.79)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C1716(0.99); C777(1.26); C873(0.97); C2518(0.90)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C1716(0.91); C873(0.87); C615(0.99)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C1716(1.00); C535(1.00); C873(1.01); C615(1.03)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C1716(0.97); C535(0.88); C777(1.12); C873(1.02)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C1716(0.95); C873(0.81); C615(1.06)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C1716(1.04); C535(1.02); C777(0.88); C873(0.95)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C1716(0.97); C873(0.84); C615(1.03)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C1716(1.02); C535(0.92); C777(0.90); C873(0.85)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C1716(0.81); C535(0.84); C873(0.93); C1965(0.97)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C1716(1.03); C535(1.18); C873(1.05); C615(1.03)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C1716(0.98); C535(1.04); C873(1.03); C615(1.06)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C1716(0.88); C535(1.13); C615(0.98); C1965(0.81)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C1716(0.93); C535(0.83)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C1716(0.95); C873(0.78); C615(0.92)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C1716(1.03); C535(1.05); C873(0.82); C615(1.05)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C1716(1.13); C535(1.19); C873(1.03); C615(1.00)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C1716(0.87); C535(0.94); C777(0.99); C873(1.07)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C1716(1.04); C535(0.85); C777(0.90); C873(0.85)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C1716(1.00); C873(0.88); C615(1.01)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C1716(0.99); C535(0.96); C777(0.90); C873(1.05)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C1716(0.97); C535(0.92); C873(1.00); C1965(1.02)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C1716(1.13); C535(1.15); C873(1.11); C615(1.13)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C1716(0.89); C535(1.33); C873(1.16); C615(1.09)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C1716(0.84); C535(1.11); C615(1.07); C1965(0.87)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C1716(0.96); C535(0.95)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C1716(0.99); C535(0.87); C777(1.04); C873(0.85)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C1716(0.94); C777(1.14); C873(0.95); C2518(1.06)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C1716(1.02); C535(1.02); C873(1.02); C615(0.99)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C1716(0.91); C535(0.87); C777(1.04); C873(1.10)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C1716(0.88); C535(0.84); C777(0.90); C873(0.83)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C1716(0.96); C873(1.08); C615(1.09)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C1716(1.01); C535(0.95); C777(0.74); C873(1.04)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C1716(0.90); C535(0.94); C873(1.03); C1965(1.12)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C1716(1.07); C535(1.01); C873(1.03); C615(1.13)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C1716(0.96); C535(1.15); C873(1.15); C615(1.11)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C1716(0.94); C535(0.85); C777(0.90); C873(0.75)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C1716(0.95); C535(1.09); C615(0.98); C1965(0.82)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C1716(0.98); C535(0.94)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C1716(0.99); C777(1.28); C873(1.07); C2518(0.91)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C1716(0.92); C873(0.94); C615(0.85)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C1716(1.04); C535(0.92); C873(0.97); C615(0.96)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C1716(0.98); C535(1.07); C777(1.12); C873(1.01)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C1716(1.03); C535(1.01); C777(0.99); C873(0.93)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C1716(0.94); C873(0.95); C615(1.12)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C1716(0.98); C535(0.88); C777(1.21); C873(0.88)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C1716(0.95); C535(0.95); C873(0.88); C1965(0.97)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C1716(0.92); C873(0.86); C615(1.12)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C1716(1.12); C535(1.31); C873(1.12); C615(1.19)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C1716(0.94); C535(1.15); C873(0.99); C615(1.09)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C1716(1.05); C535(1.12); C615(0.98); C1965(0.83)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C1716(0.91); C535(0.88)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C1716(0.96); C777(1.10); C873(0.78); C2518(0.95)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C1716(1.03); C535(0.96); C873(0.87); C615(1.06)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C1716(0.88); C535(0.84); C777(1.02); C873(0.99)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C1716(1.08); C535(0.97); C777(0.85); C873(0.95)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C1716(1.04); C873(0.89); C615(1.08)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C1716(0.76); C535(0.80); C777(0.80); C873(0.70)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C1716(1.00); C535(0.96); C777(0.98); C873(0.88)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C1716(1.01); C535(0.96); C873(0.87); C1965(0.94)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C1716(1.01); C535(1.21); C873(1.02); C615(1.13)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C1716(0.92); C535(1.07); C873(0.91); C615(1.10)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C1716(0.93); C535(0.97); C615(0.92); C1965(0.80)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C1716(1.00); C535(0.85)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C1716(0.95); C777(1.06); C873(0.71); C2518(0.85)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C1716(0.95); C873(0.70); C615(1.13)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C1716(1.05); C535(0.83); C873(0.77); C615(1.10)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C1716(0.92); C535(1.08); C777(1.01); C873(0.78)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C1716(1.03); C535(0.93); C873(0.96); C1965(0.96)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C1716(0.88); C535(0.74); C777(1.00); C873(0.75)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C1716(0.95); C873(0.60); C615(1.00)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C1716(0.94); C535(0.89); C777(0.76); C873(0.75)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C1716(0.95); C535(0.97); C873(0.88); C1965(1.00)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C1716(0.93); C535(1.32); C873(1.06); C615(1.23)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C1716(0.88); C535(1.04); C873(1.09); C615(1.22)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C1716(0.88); C535(0.93); C615(0.95); C1965(0.89)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C1716(0.93); C535(0.93)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C1716(1.01); C777(1.19); C873(0.99); C2518(0.93)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C1716(0.92); C873(0.90); C615(1.24)  LDD1697  [22]
 LDCM0634  CY-0357 Hep-G2 C213(1.14)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C1716(1.05); C873(0.97); C615(0.98)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1308(1.68); C1965(1.42); C873(1.29)  LDD1702  [5]
 LDCM0031  Epigallocatechin gallate HEK-293T 46.59  LDD0183  [8]
 LDCM0625  F8 Ramos C615(1.34); C181(0.24); C2518(5.13)  LDD2187  [23]
 LDCM0573  Fragment11 Ramos C181(5.97)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C181(0.92)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C615(0.68)  LDD1396  [7]
 LDCM0576  Fragment14 MDA-MB-231 C615(1.92)  LDD1397  [7]
 LDCM0579  Fragment20 Ramos C615(3.85)  LDD1403  [7]
 LDCM0580  Fragment21 Ramos C181(0.33)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C615(2.16)  LDD1409  [7]
 LDCM0583  Fragment24 Ramos C615(1.23)  LDD1410  [7]
 LDCM0584  Fragment25 MDA-MB-231 C615(0.85)  LDD1411  [7]
 LDCM0585  Fragment26 Ramos C615(1.16)  LDD1412  [7]
 LDCM0578  Fragment27 MDA-MB-231 C615(0.57)  LDD1401  [7]
 LDCM0586  Fragment28 Ramos C615(1.73); C181(0.55); C2518(0.65)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C181(0.64)  LDD2199  [23]
 LDCM0589  Fragment31 MDA-MB-231 C615(1.52)  LDD1421  [7]
 LDCM0468  Fragment33 HEK-293T C1716(0.99); C873(0.88); C615(1.00)  LDD1671  [22]
 LDCM0596  Fragment38 MDA-MB-231 C615(1.64)  LDD1433  [7]
 LDCM0566  Fragment4 Ramos C615(1.73); C181(0.61)  LDD2184  [23]
 LDCM0598  Fragment40 Ramos C615(1.65)  LDD1437  [7]
 LDCM0601  Fragment43 MDA-MB-231 C615(20.00)  LDD1441  [7]
 LDCM0604  Fragment46 MDA-MB-231 C615(0.96)  LDD1445  [7]
 LDCM0427  Fragment51 Ramos C615(1.25)  LDD1451  [7]
 LDCM0610  Fragment52 Ramos C181(0.47)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C181(0.48)  LDD2205  [23]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [7]
 LDCM0570  Fragment8 MDA-MB-231 C615(20.00)  LDD1385  [7]
 LDCM0571  Fragment9 MDA-MB-231 C615(1.17)  LDD1387  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 MDA-MB-231 C615(20.00)  LDD1374  [7]
 LDCM0023  KB03 Jurkat C1716(30.55)  LDD0209  [10]
 LDCM0024  KB05 IGR37 C1308(2.62)  LDD3314  [24]
 LDCM0030  Luteolin HEK-293T 75.61  LDD0182  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1130(0.64)  LDD2100  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C380(0.97)  LDD2125  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1130(0.80)  LDD2141  [5]
 LDCM0003  Sulforaphane MCF-7 2.28  LDD0042  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome c1, heme protein, mitochondrial (CYC1) Cytochrome c family P08574
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor epsilon (NFKBIE) NF-kappa-B inhibitor family O00221
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840