Details of the Target

General Information of Target

Target ID LDTP03695
Target Name Heat shock 70 kDa protein 4 (HSPA4)
Gene Name HSPA4
Gene ID 3308
Synonyms
APG2; Heat shock 70 kDa protein 4; HSP70RY; Heat shock 70-related protein APG-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNA
KNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAM
LLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALA
YGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVL
VNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGT
MNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGK
ELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVF
SKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKV
KVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPA
ENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDREMLNLYIEN
EGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLY
EDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKE
DQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCS
PIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID
Target Bioclass
Other
Family
Heat shock protein 70 family
Subcellular location
Cytoplasm
Uniprot ID
P34932
Ensemble ID
ENST00000304858.7
HGNC ID
HGNC:5237
ChEMBL ID
CHEMBL5169130

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.L284F DBIA    Probe Info 
HCC1395 SNV: p.L751P DBIA    Probe Info 
HT3 SNV: p.P43L DBIA    Probe Info 
NCIH1703 SNV: p.P189L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 52 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.94  LDD0402  [1]
A-EBA
 Probe Info  		3.36  LDD0215  [2]
CHEMBL5175495
 Probe Info  		5.96  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y30(11.70); Y435(10.38); Y400(9.63)  LDD0257  [5]
TH214
 Probe Info  		Y435(7.78)  LDD0258  [5]
TH216
 Probe Info  		Y723(20.00); Y435(9.04)  LDD0259  [5]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [6]
ONAyne
 Probe Info  		K477(0.53); K686(1.29)  LDD0274  [7]
BTD
 Probe Info  		C270(2.09)  LDD1699  [8]
AZ-9
 Probe Info  		E622(0.48)  LDD2208  [9]
OPA-S-S-alkyne
 Probe Info  		K686(8.32)  LDD3494  [10]
Probe 1
 Probe Info  		Y30(78.14); Y336(19.37); Y435(22.78); Y597(21.62)  LDD3495  [11]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [12]
THZ1-DTB
 Probe Info  		C380(1.06); C290(1.05); C417(1.03)  LDD0460  [12]
AHL-Pu-1
 Probe Info  		C140(5.11)  LDD0168  [13]
HHS-482
 Probe Info  		Y181(1.18); Y184(1.12); Y336(0.84); Y400(0.66)  LDD0285  [14]
HHS-475
 Probe Info  		Y30(0.81); Y184(0.83); Y723(0.87); Y336(0.90)  LDD0264  [15]
HHS-465
 Probe Info  		Y184(8.12); Y30(10.00); Y336(10.00); Y435(10.00)  LDD2237  [16]
DBIA
 Probe Info  		C34(0.89); C38(0.88)  LDD0078  [17]
AMP probe
 Probe Info  		K477(0.00); K479(0.00)  LDD0200  [18]
ATP probe
 Probe Info  		K477(0.00); K479(0.00); K686(0.00); K422(0.00)  LDD0199  [18]
1d-yne
 Probe Info  		N.A.  LDD0358  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C779(0.00); C245(0.00); C310(0.00); C376(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		C290(0.00); C270(0.00); C417(0.00); C140(0.00)  LDD0032  [21]
IPIAA_H
 Probe Info  		C779(0.00); C270(0.00); C245(0.00); C140(0.00)  LDD0030  [22]
IPIAA_L
 Probe Info  		C290(0.00); C140(0.00); C270(0.00); C779(0.00)  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		C779(0.00); C245(0.00); C310(0.00); C376(0.00)  LDD0037  [20]
ATP probe
 Probe Info  		K773(0.00); K53(0.00); K573(0.00); K329(0.00)  LDD0035  [23]
JW-RF-010
 Probe Info  		C376(0.00); C290(0.00); C417(0.00); C34(0.00)  LDD0026  [24]
TFBX
 Probe Info  		C376(0.00); C34(0.00); C380(0.00); C167(0.00)  LDD0027  [24]
WYneN
 Probe Info  		C167(0.00); C34(0.00)  LDD0021  [25]
Compound 10
 Probe Info  		C140(0.00); C146(0.00); C167(0.00); C245(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C146(0.00); C167(0.00)  LDD2213  [26]
ENE
 Probe Info  		C270(0.00); C380(0.00)  LDD0006  [25]
IPM
 Probe Info  		N.A.  LDD0005  [25]
NHS
 Probe Info  		K53(0.00); K477(0.00); K679(0.00); K194(0.00)  LDD0010  [25]
NPM
 Probe Info  		N.A.  LDD0016  [25]
PF-06672131
 Probe Info  		C376(0.00); C380(0.00)  LDD0017  [27]
SF
 Probe Info  		K356(0.00); Y30(0.00); K477(0.00); K430(0.00)  LDD0028  [28]
STPyne
 Probe Info  		K477(0.00); K272(0.00); K53(0.00); K674(0.00)  LDD0009  [25]
VSF
 Probe Info  		C34(0.00); C417(0.00)  LDD0007  [25]
Phosphinate-6
 Probe Info  		C417(0.00); C34(0.00)  LDD0018  [29]
Ox-W18
 Probe Info  		N.A.  LDD2175  [30]
1c-yne
 Probe Info  		K521(0.00); K543(0.00); K717(0.00); K422(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C245(0.00); C417(0.00); C310(0.00); C779(0.00)  LDD0217  [31]
Crotonaldehyde
 Probe Info  		C417(0.00); C270(0.00); C380(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C417(0.00); C245(0.00); C167(0.00); C270(0.00)  LDD0218  [31]
W1
 Probe Info  		C417(0.00); C270(0.00)  LDD0236  [32]
NAIA_5
 Probe Info  		C34(0.00); C245(0.00); C310(0.00); C290(0.00)  LDD2223  [33]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.92  LDD1868  [34]
STS-2
 Probe Info  		8.83  LDD0138  [35]
VE-P
 Probe Info  		N.A.  LDD0396  [36]
STS-1
 Probe Info  		N.A.  LDD0068  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C167(0.45); C38(0.49); C146(0.59); C34(0.65)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C167(0.57); C779(0.44); C38(0.56); C146(0.79)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C270(0.82); C167(0.56); C779(0.51)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C270(1.25); C167(1.14); C779(0.82); C38(0.98)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C270(1.26); C167(1.19); C779(1.02); C38(1.02)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C270(1.82); C779(1.38)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C38(0.89)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C779(0.36); C146(0.65); C140(0.62)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C270(0.92); C167(1.01); C779(0.67)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C140(5.11)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C380(2.18); C38(4.66); C140(6.72); C417(2.97)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C38(1.00); C140(1.31); C146(1.37); C167(1.20)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C38(0.64); C140(0.83); C146(0.88); C167(1.00)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C38(2.26); C140(1.37); C146(1.14); C167(0.62)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C38(0.62); C140(0.62); C146(0.66); C167(0.51)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C38(0.70); C140(0.68); C146(0.68); C167(0.52)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C38(0.44); C140(0.44); C146(0.48); C167(0.35)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C38(0.70); C140(0.62); C146(0.64); C167(0.47)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C38(0.58); C140(0.53); C146(0.57); C167(0.43)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C38(0.58); C140(0.50); C146(0.51); C167(0.44)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C38(1.01); C140(0.51); C146(0.49); C167(0.43)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C38(0.72); C140(0.51); C146(0.68); C167(0.60)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C38(0.78); C140(0.65); C146(0.73); C167(0.44)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C38(0.58); C140(0.91); C146(0.90); C167(1.07)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C38(0.69); C140(0.69); C146(0.72); C167(0.39)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C38(0.76); C140(0.54); C146(0.57); C167(0.39)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C38(0.86); C140(0.55); C146(0.50); C167(0.43)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C38(1.18); C140(1.08); C146(1.11); C167(1.07)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C38(1.11); C140(0.90); C146(0.81); C167(0.86)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C38(0.90); C140(0.83); C146(0.77); C167(0.82)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C38(0.78); C140(0.77); C146(0.77); C167(0.72)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C38(0.88); C140(0.88); C146(0.88); C167(0.87)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C38(0.75); C140(0.92); C146(0.92); C167(0.89)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C38(0.76); C140(0.85); C146(0.85); C167(0.88)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C38(0.84); C140(1.02); C146(0.97); C167(1.26)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C38(0.82); C140(1.00); C146(0.99); C167(0.76)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C38(0.71); C140(1.03); C146(1.07); C167(0.89)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C38(0.68); C140(1.22); C146(1.29); C167(0.99)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C38(0.76); C140(1.18); C146(1.35); C167(1.30)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C38(0.91); C140(0.81); C146(0.84); C167(0.86)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C38(0.67); C140(1.76); C146(1.81); C167(0.81)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C38(0.84); C140(0.78); C146(0.78); C167(0.80)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C38(0.78); C140(0.97); C146(0.97); C167(0.76)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C38(0.55); C140(0.23); C146(0.85); C167(0.32)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C38(1.33); C140(0.97); C146(1.13); C167(1.04)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C38(0.94); C140(0.77); C146(1.13); C167(0.97)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C38(1.48); C140(1.29); C146(1.48); C167(1.26)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C38(0.64); C140(1.01); C146(1.06); C167(1.26)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C38(0.63); C140(0.82); C146(1.02); C167(1.13)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C38(0.63); C140(0.58); C146(0.77); C167(0.84)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C38(0.51); C140(0.68); C146(0.97); C167(0.82)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C38(0.62); C140(0.72); C146(0.91); C167(1.07)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C38(0.60); C140(0.93); C146(1.01); C167(1.13)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C38(0.51); C140(0.75); C146(0.92); C167(0.98)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C38(0.53); C140(0.83); C146(0.83); C167(1.04)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C38(0.67); C140(1.11); C146(1.28); C167(1.20)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C38(0.42); C140(0.68); C146(0.68); C167(0.87)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C38(0.50); C140(0.88); C146(0.84); C167(1.07)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C38(0.73); C140(1.25); C146(1.20); C167(1.65)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C38(0.95); C140(1.52); C146(1.24); C167(0.74)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C167(0.50); C146(1.02); C38(1.04); C245(1.08)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C167(0.76); C34(0.91); C38(0.92); C245(1.00)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C167(0.69); C34(0.84); C245(0.99); C140(0.99)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C167(0.47); C146(0.85); C245(0.88); C34(0.90)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C167(0.12); C140(0.20); C245(0.32); C146(0.40)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C167(0.44); C146(0.81); C140(0.83); C245(0.88)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C38(0.59); C34(0.80); C290(0.86); C140(0.86)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C34(0.88); C38(0.99); C146(1.08); C245(1.15)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C167(0.90); C34(1.01); C146(1.01); C38(1.03)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C167(0.39); C140(0.60); C146(0.68); C245(0.74)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C167(0.11); C140(0.21); C245(0.31); C146(0.42)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C38(1.02); C140(1.37); C146(1.03); C167(0.55)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C38(1.07); C140(1.29); C146(1.00); C167(0.72)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C38(1.06); C140(1.43); C146(1.09); C167(0.70)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C38(1.05); C140(1.59); C146(1.22); C167(0.83)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C38(0.83); C34(0.92); C140(0.99); C167(1.03)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C38(0.34); C34(0.76); C140(0.81); C167(0.93)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C38(0.83); C140(0.94); C34(0.95); C167(0.96)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C38(0.75); C34(0.80); C245(0.85); C140(0.96)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C38(0.89); C34(0.92); C167(0.93); C417(1.07)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C140(0.92); C38(0.95); C34(0.96); C245(1.03)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C38(0.80); C34(0.86); C290(0.93); C140(1.05)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C38(0.56); C34(0.78); C167(1.01); C140(1.02)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C38(0.89); C417(1.01); C167(1.01); C245(1.07)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C146(0.84); C167(0.93); C34(0.93); C417(1.01)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C146(0.74); C34(0.75); C38(0.79); C167(0.93)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C34(0.72); C38(0.82); C417(1.01); C167(1.01)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C34(0.72); C38(0.81); C146(0.86); C167(0.87)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C38(0.69); C34(0.77); C146(0.89); C167(0.91)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C34(0.71); C38(0.83); C245(0.95); C140(0.97)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C38(0.55); C34(0.66); C167(0.90); C146(0.95)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C34(0.72); C38(0.77); C146(1.00); C167(1.08)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C38(0.52); C34(0.77); C146(0.78); C167(0.79)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C38(0.75); C34(0.86); C167(0.90); C146(0.91)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C38(0.76); C34(0.79); C167(0.83); C417(0.98)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C417(0.98); C245(0.98); C34(1.12); C167(1.17)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C290(0.96); C417(1.01); C245(1.24); C34(1.26)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C290(1.03); C417(1.07); C167(1.13); C245(1.30)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C417(0.88); C290(0.99); C38(1.01); C34(1.02)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C34(0.86); C38(0.97); C417(1.02); C245(1.03)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C34(0.60); C38(0.70); C140(0.81); C146(0.91)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C140(0.60); C310(0.75); C34(0.76); C245(0.78)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C290(0.97); C245(1.06); C417(1.14); C167(1.14)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C140(0.88); C417(0.89); C167(0.93); C34(0.95)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C38(1.02); C417(1.05); C34(1.06); C245(1.17)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C140(0.86); C245(0.95); C417(1.01); C34(1.02)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C140(0.50); C245(0.67); C310(0.71); C146(0.72)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C310(0.89); C167(0.98); C38(1.01); C34(1.02)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C146(0.94); C140(0.94); C310(0.97); C167(0.98)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C310(0.79); C290(1.03); C245(1.23); C34(1.34)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C140(0.21); C167(0.49); C245(0.58); C38(0.71)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C34(0.53); C38(0.62); C140(0.82); C146(0.98)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C140(0.25); C146(0.53); C167(0.54); C245(0.65)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C245(1.03); C38(1.06); C310(1.06); C417(1.18)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C140(0.86); C245(0.92); C146(0.94); C310(0.95)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C140(0.51); C167(0.70); C146(0.74); C417(0.88)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C140(0.46); C146(0.68); C167(0.69); C245(0.73)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C140(0.20); C146(0.46); C167(0.57); C245(0.74)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C140(0.17); C167(0.51); C146(0.61); C245(0.61)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C140(0.75); C146(0.77); C34(0.79); C38(0.83)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C38(0.70); C34(0.79); C140(0.85); C167(0.85)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C140(0.54); C146(0.57); C38(0.58); C34(0.59)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C38(0.71); C34(0.81); C140(0.82); C146(0.91)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C140(0.92); C38(0.93); C34(0.94); C146(0.98)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C34(1.03); C38(1.06); C417(1.14); C146(1.28)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C146(0.52); C140(0.52); C38(0.56); C34(0.56)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C140(0.89); C146(0.96); C417(0.97); C34(1.01)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C34(0.62); C146(0.62); C140(0.65); C38(0.67)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C34(0.59); C38(0.60); C140(0.67); C146(0.71)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C38(0.68); C34(0.71); C140(0.88); C146(0.95)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C34(0.45); C38(0.46); C146(0.46); C140(0.46)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C417(0.87); C146(0.89); C290(0.94); C140(0.97)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C167(0.67); C146(0.78); C140(0.88); C34(0.95)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C38(0.74); C34(0.78); C290(0.87); C146(0.96)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C167(0.18); C146(0.34); C140(0.41); C34(0.47)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C417(0.74); C140(0.94); C34(0.96); C146(0.97)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C167(0.60); C140(0.62); C146(0.63); C417(0.67)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C167(0.16); C146(0.30); C140(0.34); C34(0.43)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C167(0.19); C146(0.33); C140(0.34); C34(0.44)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C167(0.17); C146(0.33); C140(0.39); C34(0.47)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C167(0.32); C140(0.41); C146(0.42); C34(0.63)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C167(0.26); C146(0.46); C140(0.56); C245(0.70)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C417(0.88); C167(1.02); C290(1.02); C146(1.07)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C417(0.85); C146(0.86); C167(0.86); C34(0.86)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C38(0.62); C34(0.79); C146(0.90); C290(0.92)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C167(0.45); C146(0.61); C140(0.61); C417(0.72)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C290(0.34); C167(0.78); C417(0.81); C34(0.85)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C167(0.17); C146(0.37); C140(0.41); C34(0.43)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C140(0.15); C146(0.18); C310(0.32); C38(0.47)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C140(0.26); C146(0.28); C38(0.48); C310(0.53)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C167(0.80); C38(0.80); C146(0.81); C140(0.82)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C140(0.42); C146(0.53); C38(0.70); C167(0.89)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C140(0.69); C146(0.81); C290(0.82); C167(0.84)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C140(0.42); C146(0.44); C38(0.73); C167(0.79)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C140(0.42); C146(0.44); C310(0.69); C167(0.72)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C140(0.10); C290(0.76); C146(0.87); C34(0.92)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C146(0.17); C140(0.17); C310(0.27); C167(0.45)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C140(0.19); C146(0.22); C310(0.35); C38(0.50)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C167(0.79); C146(0.84); C140(0.88); C34(0.95)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C140(0.91); C245(0.93); C417(0.98); C290(1.00)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C290(0.96); C417(1.05); C310(1.13); C245(1.20)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C140(0.59); C146(0.68); C167(0.72); C417(0.83)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C140(0.24); C146(0.33); C310(0.51); C167(0.53)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C167(0.21); C140(0.29); C38(0.29); C146(0.30)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C167(0.64); C38(0.66); C140(0.70); C146(0.72)  LDD0683  [17]
 LDCM0545  Acetamide MDA-MB-231 C167(0.98); C779(0.68)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C270(0.70); C167(0.65); C779(0.80); C38(0.79)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C38(0.83); C140(1.05); C146(0.94); C167(1.23)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C34(0.76); C38(0.76); C290(0.92); C245(0.94)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C38(0.24); C140(0.28); C34(0.54); C167(0.61)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 C34(0.00); C290(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C34(0.89); C38(0.88)  LDD0078  [17]
 LDCM0498  BS-3668 MDA-MB-231 C167(0.99); C779(0.78); C38(1.10)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C34(1.41)  LDD2214  [38]
 LDCM0108  Chloroacetamide HeLa C245(0.00); C167(0.00); C779(0.00); C417(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C245(0.97)  LDD2227  [33]
 LDCM0367  CL1 HCT 116 C417(0.89); C245(0.95); C140(1.06); C146(1.06)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C310(0.72); C38(0.79); C245(0.80); C140(0.86)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C34(0.71); C38(0.81); C140(0.86); C245(0.93)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C38(0.58); C140(0.79); C146(0.94); C167(1.02)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C38(0.79); C146(0.81); C140(0.89); C290(0.95)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C140(0.85); C146(0.87); C417(0.92); C38(0.93)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C140(0.91); C146(0.96); C38(0.99); C290(1.00)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C38(0.60); C34(0.69); C140(0.79); C146(0.90)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C38(0.46); C34(0.61); C140(0.97); C167(1.03)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C38(0.39); C34(0.62); C140(0.68); C146(0.91)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C38(0.34); C140(0.46); C34(0.57); C146(0.78)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C34(0.74); C38(0.77); C140(0.82); C167(0.96)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C38(0.32); C245(0.48); C310(0.62); C167(0.69)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C38(0.62); C140(0.68); C146(0.75); C167(0.76)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C38(0.58); C140(0.85); C167(0.89); C146(0.90)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C38(0.63); C34(0.81); C146(0.85); C167(0.86)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C38(0.63); C167(0.81); C146(0.84); C34(0.85)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C38(0.61); C146(0.64); C167(0.77); C34(0.82)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C38(0.68); C167(0.76); C34(0.78); C146(0.80)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C34(0.74); C38(0.79); C167(0.94); C146(0.96)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C140(0.20); C245(0.33); C310(0.35); C38(0.43)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C34(0.94); C417(0.96); C140(0.97); C146(1.04)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C140(0.82); C245(0.88); C146(0.93); C34(0.95)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C38(0.25); C310(0.42); C245(0.42); C167(0.70)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C38(1.03); C34(1.08); C167(1.11); C140(1.13)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C290(0.89); C34(0.99); C245(0.99); C310(1.02)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C310(1.00); C245(1.02); C167(1.09); C146(1.12)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C140(0.47); C146(0.52); C167(0.56); C310(0.65)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C140(0.26); C146(0.50); C167(0.55); C245(0.77)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C140(0.84); C38(0.86); C34(0.86); C146(0.88)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C140(0.80); C38(0.80); C146(0.83); C34(0.88)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C140(0.89); C38(0.93); C146(0.96); C34(0.99)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C140(0.62); C146(0.63); C34(0.68); C38(0.69)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C38(0.96); C245(0.99); C34(1.04); C140(1.08)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C310(0.82); C245(0.86); C417(0.94); C290(0.98)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C310(0.73); C167(0.82); C140(0.91); C146(0.91)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C38(0.82); C146(0.85); C140(0.96); C310(1.02)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C417(0.84); C146(0.88); C38(0.90); C140(1.15)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C417(1.05); C290(1.62); C146(1.73); C310(2.28)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C417(0.87); C146(0.94); C140(1.07); C310(1.09)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C290(0.82); C34(1.02); C245(1.04); C417(1.09)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C38(0.56); C167(0.63); C310(0.67); C140(0.69)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C167(0.39); C38(0.43); C140(0.47); C146(0.51)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C38(0.11); C167(0.20); C140(0.22); C310(0.31)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C167(0.64); C38(0.79); C310(1.08); C146(1.10)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C167(0.31); C140(0.36); C38(0.38); C146(0.48)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C38(0.48); C140(0.56); C146(0.51); C167(0.50)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C38(1.21); C140(0.95); C146(0.81); C167(0.77)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C38(0.97); C140(1.05); C146(0.86); C167(0.86)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C38(0.76); C140(0.97); C146(0.79); C167(0.81)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C38(0.62); C140(0.83); C146(0.96); C167(0.71)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C38(1.22); C140(1.05); C146(1.05); C167(1.11)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C38(1.25); C140(1.22); C146(1.12); C167(1.06)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C38(1.07); C140(0.77); C146(0.79); C167(0.82)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C38(1.31); C140(1.83); C146(1.44); C167(1.17)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C38(1.23); C140(1.02); C146(0.99); C167(0.90)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C38(0.98); C140(0.34); C146(0.54); C167(0.65)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C38(1.42); C140(0.32); C146(0.58); C167(0.65)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C38(1.12); C140(0.45); C146(0.57); C167(0.84)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C38(1.23); C140(0.22); C146(0.46); C167(0.51)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C38(0.92); C140(0.38); C146(0.57); C167(0.73)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C38(1.18); C140(1.08); C146(1.08); C167(0.98)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C38(1.42); C140(0.49); C146(0.61); C167(0.79)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C38(1.19); C140(0.56); C146(0.74); C167(1.06)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C38(0.75); C140(0.14); C146(0.51); C167(0.48)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C38(1.29); C140(0.20); C146(0.49); C167(0.55)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C38(1.20); C140(0.78); C146(0.85); C167(0.92)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C38(0.95); C140(0.55); C146(0.61); C167(0.73)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C38(0.87); C140(1.30); C146(1.29); C167(1.12)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C38(0.79); C140(1.06); C146(1.06); C167(1.12)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C38(0.97); C140(1.40); C146(1.36); C167(1.15)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C38(0.96); C140(1.11); C146(1.11); C167(1.05)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C38(1.17); C140(1.09); C146(1.09); C167(1.17)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C38(0.90); C140(0.97); C146(1.00); C167(1.11)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C38(0.66); C140(0.99); C146(0.97); C167(1.14)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C38(0.74); C140(1.05); C146(1.01); C167(1.07)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C38(0.81); C140(1.12); C146(1.12); C167(1.08)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C38(0.82); C140(1.24); C146(1.17); C167(0.85)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C38(0.98); C140(1.19); C146(1.23); C167(1.20)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C38(1.04); C140(1.19); C146(1.11); C167(0.97)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C38(0.80); C140(1.01); C146(0.95); C167(0.97)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C38(0.91); C140(1.20); C146(1.16); C167(1.24)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C38(1.13); C140(1.09); C146(1.06); C167(1.26)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C38(1.38); C140(1.15); C146(1.15); C167(1.18)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C38(1.02); C140(0.96); C146(0.99); C167(0.98)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C38(0.86); C140(1.13); C146(1.11); C167(1.41)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C38(0.77); C140(1.12); C146(1.06); C167(1.05)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C38(0.68); C140(0.87); C146(0.86); C167(1.03)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C38(0.49); C140(0.91); C146(0.87); C167(0.96)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C38(0.65); C140(1.03); C146(1.04); C167(1.12)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C38(0.32); C140(0.72); C146(0.68); C167(0.90)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C38(0.52); C140(1.16); C146(1.10); C167(1.08)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C38(0.75); C140(1.34); C146(1.39); C167(1.24)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C38(1.51); C140(1.64); C146(1.54); C167(1.32)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C38(0.50); C140(0.83); C146(0.83); C167(0.98)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C38(0.90); C140(1.26); C146(1.22); C167(1.33)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C38(0.48); C140(0.93); C146(1.00); C167(1.05)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C38(0.77); C140(1.16); C146(1.18); C167(1.07)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C38(0.57); C140(2.47); C146(2.52); C167(1.03)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C38(0.55); C140(1.29); C146(1.29); C167(1.12)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C38(1.03); C140(1.09); C146(1.06); C167(0.88)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C38(0.83); C140(3.50); C146(3.30); C167(0.74)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C38(0.69); C140(0.72); C146(0.72); C167(0.90)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C38(0.55); C140(0.60); C146(0.61); C167(0.67)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C38(0.23); C140(0.66); C146(0.66); C167(0.55)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C38(1.31); C140(1.06); C146(1.10); C167(1.18)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C38(0.71); C140(0.72); C146(0.71); C167(0.76)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C38(0.42); C140(0.48); C146(0.49); C167(0.51)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C38(0.45); C140(0.45); C146(0.49); C167(0.56)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C38(0.29); C140(0.39); C146(0.40); C167(0.48)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C38(0.81); C140(0.84); C146(0.83); C167(0.80)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C38(0.92); C140(0.99); C146(1.05); C167(1.57)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C38(0.73); C140(0.79); C146(0.87); C167(0.91)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C38(0.51); C140(0.77); C146(0.77); C167(0.62)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C38(0.36); C140(0.48); C146(0.48); C167(0.46)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C38(0.98); C140(0.79); C146(0.79); C167(0.94)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C38(0.81); C140(0.69); C146(0.72); C167(0.67)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C38(0.86); C140(0.80); C146(1.12); C167(0.77)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C38(0.77); C140(0.79); C146(0.94); C167(0.90)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C38(0.80); C140(1.06); C146(1.08); C167(0.94)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C38(0.76); C140(0.78); C146(0.98); C167(0.99)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C38(0.71); C140(0.73); C146(0.81); C167(0.85)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C38(0.76); C140(0.82); C146(0.86); C167(0.93)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C38(0.73); C140(0.86); C146(1.00); C167(1.29)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C38(0.67); C140(0.72); C146(0.87); C167(1.08)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C38(0.75); C140(0.85); C146(1.00); C167(1.04)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C779(0.86); C167(1.08); C310(0.96); C245(0.84)  LDD1698  [39]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C38(1.44); C245(1.02); C34(0.70)  LDD1702  [8]
 LDCM0625  F8 Ramos C270(1.06); C417(1.52); C167(0.56); C290(0.68)  LDD2187  [40]
 LDCM0572  Fragment10 MDA-MB-231 C34(1.43)  LDD1389  [41]
 LDCM0573  Fragment11 MDA-MB-231 C34(1.06)  LDD1391  [41]
 LDCM0574  Fragment12 MDA-MB-231 C34(1.06)  LDD1393  [41]
 LDCM0575  Fragment13 MDA-MB-231 C34(1.09)  LDD1395  [41]
 LDCM0576  Fragment14 MDA-MB-231 C34(0.75)  LDD1397  [41]
 LDCM0577  Fragment15 Ramos C34(0.78)  LDD1400  [41]
 LDCM0579  Fragment20 MDA-MB-231 C34(0.92)  LDD1402  [41]
 LDCM0580  Fragment21 MDA-MB-231 C34(1.01)  LDD1404  [41]
 LDCM0581  Fragment22 MDA-MB-231 C34(1.38)  LDD1406  [41]
 LDCM0582  Fragment23 MDA-MB-231 C34(20.00)  LDD1408  [41]
 LDCM0583  Fragment24 Ramos C34(1.22)  LDD1410  [41]
 LDCM0584  Fragment25 MDA-MB-231 C34(1.13)  LDD1411  [41]
 LDCM0578  Fragment27 MDA-MB-231 C34(1.00)  LDD1401  [41]
 LDCM0586  Fragment28 Ramos C270(0.75); C417(0.78); C167(1.21); C290(0.53)  LDD2198  [40]
 LDCM0587  Fragment29 MDA-MB-231 C34(1.20)  LDD1417  [41]
 LDCM0588  Fragment30 Ramos C270(1.34); C417(1.39); C167(1.11)  LDD2199  [40]
 LDCM0589  Fragment31 MDA-MB-231 C34(0.96)  LDD1421  [41]
 LDCM0590  Fragment32 MDA-MB-231 C34(0.89)  LDD1423  [41]
 LDCM0468  Fragment33 HCT 116 C38(0.51); C140(1.03); C146(1.01); C167(1.19)  LDD0785  [17]
 LDCM0593  Fragment35 Ramos C34(1.02)  LDD1430  [41]
 LDCM0596  Fragment38 MDA-MB-231 C34(0.76)  LDD1433  [41]
 LDCM0566  Fragment4 MDA-MB-231 C34(1.40)  LDD1378  [41]
 LDCM0598  Fragment40 Ramos C34(0.95)  LDD1437  [41]
 LDCM0599  Fragment41 MDA-MB-231 C34(0.91)  LDD1438  [41]
 LDCM0601  Fragment43 MDA-MB-231 C34(0.84)  LDD1441  [41]
 LDCM0605  Fragment47 MDA-MB-231 C34(1.31)  LDD1446  [41]
 LDCM0607  Fragment49 MDA-MB-231 C34(6.39)  LDD1448  [41]
 LDCM0608  Fragment50 MDA-MB-231 C34(1.99)  LDD1449  [41]
 LDCM0427  Fragment51 HCT 116 C38(0.78); C140(0.17); C146(0.30); C167(0.43)  LDD0744  [17]
 LDCM0610  Fragment52 MDA-MB-231 C34(1.14)  LDD1452  [41]
 LDCM0611  Fragment53 Ramos C34(0.83)  LDD1455  [41]
 LDCM0612  Fragment54 MDA-MB-231 C34(2.12)  LDD1456  [41]
 LDCM0614  Fragment56 Ramos C270(1.65); C417(0.91); C167(0.93)  LDD2205  [40]
 LDCM0569  Fragment7 MDA-MB-231 C34(0.86)  LDD1383  [41]
 LDCM0570  Fragment8 MDA-MB-231 C34(0.81)  LDD1385  [41]
 LDCM0571  Fragment9 MDA-MB-231 C34(0.86)  LDD1387  [41]
 LDCM0116  HHS-0101 DM93 Y30(0.81); Y184(0.83); Y723(0.87); Y336(0.90)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y30(0.51); Y336(0.69); Y184(0.74); Y723(0.75)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y336(0.71); Y181(0.74); Y723(0.78); Y184(0.83)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y184(0.72); Y723(0.81); Y30(0.89); Y336(0.89)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y184(0.69); Y336(0.76); Y435(0.79); Y723(0.85)  LDD0268  [15]
 LDCM0107  IAA HeLa C417(0.00); C167(0.00); C245(0.00); C310(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y181(1.18); Y184(1.12); Y336(0.84); Y400(0.66)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y181(0.63); Y184(0.76); Y30(2.06); Y336(0.83)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y181(0.79); Y184(0.91); Y336(0.78); Y400(0.87)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y181(2.14); Y184(1.73); Y30(0.99); Y336(4.77)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y181(1.68); Y184(1.77); Y30(0.87); Y336(1.34)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y181(1.04); Y184(0.93); Y336(3.03); Y400(0.20)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y181(0.35); Y184(0.54); Y336(0.58); Y400(0.72)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y181(0.75); Y184(0.86); Y336(1.09); Y400(0.48)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [12]
 LDCM0022  KB02 HCT 116 C140(4.70); C146(2.11); C417(1.27); C290(1.00)  LDD0080  [17]
 LDCM0023  KB03 HCT 116 C140(11.87); C146(3.17); C417(1.23); C290(1.28)  LDD0081  [17]
 LDCM0024  KB05 HCT 116 C140(5.49); C146(2.04); C417(1.23); C290(1.03)  LDD0082  [17]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C270(1.31); C779(0.95); C140(0.99)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C270(0.70); C167(1.07)  LDD2121  [8]
 LDCM0109  NEM HeLa C167(0.00); C310(0.00); H530(0.00); H424(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C270(0.76); C167(1.06); C779(0.87)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C270(0.91); C38(1.48); C146(0.72)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C270(1.75); C38(0.92); C146(0.95)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C270(0.68); C167(1.73); C779(1.01); C245(2.03)  LDD2093  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C270(0.14); C779(0.22); C146(0.62); C140(0.63)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C270(0.64); C38(0.88)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C270(1.30); C146(1.01); C140(1.04); C34(0.99)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C270(1.51); C167(0.96); C779(0.97); C38(0.93)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C167(0.40); C38(0.62)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C270(0.93); C167(0.87); C779(1.03); C38(1.00)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C270(1.00); C167(0.81); C245(0.75); C38(0.71)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C270(1.16); C167(1.23); C34(1.43)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C270(0.54); C38(0.77); C146(0.47); C140(0.64)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C270(1.08); C167(1.01); C146(0.98); C140(1.07)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C270(0.52); C140(0.86)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C270(0.76); C167(0.88); C779(0.60); C140(0.84)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C270(1.65); C38(0.97); C140(0.84); C34(0.82)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C270(1.41); C167(1.57); C779(1.02)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C270(1.04); C167(1.23); C779(0.39); C146(0.76)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C270(0.46); C167(0.46); C779(0.60); C38(0.65)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C779(0.39); C38(2.06); C140(0.80)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C779(0.35); C38(1.60); C140(0.93); C34(1.52)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C270(2.25); C167(2.73); C779(2.06); C146(0.92)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C270(1.16); C779(0.91); C38(0.74); C146(0.82)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C270(0.16); C779(0.37); C38(2.12); C146(0.65)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C270(0.85); C167(1.00); C779(0.87); C245(0.99)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C270(0.10); C167(0.30); C779(0.27); C38(1.96)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C270(1.05); C167(0.99); C779(0.86); C38(0.90)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C270(0.11); C167(0.41); C779(0.32); C38(1.50)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C270(1.10); C167(1.30); C38(0.91); C146(1.01)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C779(0.64); C38(1.07)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C270(0.90); C779(0.97); C245(1.37)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C270(0.48); C779(0.52); C38(0.94)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C270(0.29); C779(0.50); C38(0.64); C146(0.84)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C270(0.81); C779(1.25); C38(1.14); C146(1.04)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C270(1.15); C167(1.34); C779(1.11); C38(1.25)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C270(1.11); C167(1.04); C779(1.10); C245(1.04)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C779(2.57); C167(1.51)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C270(0.95); C167(0.95); C779(0.96); C38(0.75)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C270(0.99); C779(0.44); C38(0.38); C146(0.70)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C270(1.71); C779(0.76); C38(0.81); C146(0.86)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C270(3.62); C167(2.44); C779(2.05)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C167(0.20); C245(0.24); C38(1.21); C140(0.56)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C270(1.06); C779(0.63); C146(1.00); C140(0.87)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C270(0.36); C167(0.47); C779(0.61); C38(0.76)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C270(0.32); C779(0.41); C38(3.23); C146(0.84)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C270(0.77); C167(0.65); C38(1.42)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C270(0.28); C779(0.35); C140(0.70); C34(1.07)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C270(1.10)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C34(0.71)  LDD2206  [42]
 LDCM0628  OTUB2-COV-1 HEK-293T C34(1.49); C34(0.96)  LDD2207  [42]
 LDCM0021  THZ1 HeLa S3 C380(1.06); C290(1.05); C417(1.03)  LDD0460  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid protein-binding protein 2 (APPBP2) . Q92624
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
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