Details of the Target

General Information of Target

Target ID LDTP04517
Target Name Transcription initiation factor IIA subunit 2 (GTF2A2)
Gene Name GTF2A2
Gene ID 2958
Synonyms
TF2A2; Transcription initiation factor IIA subunit 2; General transcription factor IIA subunit 2; TFIIA p12 subunit; TFIIA-12; TFIIAS; Transcription initiation factor IIA gamma chain; TFIIA-gamma
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRG
SLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE
Target Bioclass
Other
Family
TFIIA subunit 2 family
Subcellular location
Nucleus
Function TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.
Uniprot ID
P52657
Ensemble ID
ENST00000396060.7
HGNC ID
HGNC:4647

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K94(10.07)  LDD2218  [1]
IPM
 Probe Info  		C98(2.39)  LDD2229  [2]
m-APA
 Probe Info  		14.51  LDD0403  [3]
BTD
 Probe Info  		C98(1.77)  LDD1700  [4]
DBIA
 Probe Info  		C68(1.25); C98(1.50)  LDD0531  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C68(0.00); C98(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C68(0.00); C98(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C68(0.00); C98(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C68(0.00); 0.00  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C68(0.00); C98(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C68(1.25); C98(1.50)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C68(1.39); C98(1.24)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C98(1.14)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C98(1.14)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C98(1.20)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C98(0.98)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C98(1.09)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C98(1.04)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C98(1.16)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C98(1.00)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C98(1.11)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C98(0.88)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C68(1.36); C98(1.31)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C98(1.33)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C98(1.05)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C98(0.99)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C98(0.85)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C98(1.26)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C98(1.30)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C98(1.62)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C98(1.13)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C98(1.14)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C98(1.17)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C68(1.33); C98(1.16)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C98(1.28)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C98(1.00)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C98(1.21)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C98(0.92)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C98(1.04)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C98(1.10)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C98(1.26)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C98(1.16)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C68(1.31)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C68(1.14)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C68(1.20)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C68(1.26)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C68(1.07)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C68(1.34)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C68(1.36)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C68(1.47)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C68(1.54)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C68(1.31)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C68(1.29)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C68(1.14)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C68(1.44); C98(1.47)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C68(1.09)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C68(1.23)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C68(1.25)  LDD1141  [5]
 LDCM0263  AC143 HEK-293T C98(0.91)  LDD0861  [5]
 LDCM0264  AC144 HEK-293T C98(0.91)  LDD0862  [5]
 LDCM0265  AC145 HEK-293T C98(0.73)  LDD0863  [5]
 LDCM0266  AC146 HEK-293T C98(0.87)  LDD0864  [5]
 LDCM0267  AC147 HEK-293T C98(0.70)  LDD0865  [5]
 LDCM0268  AC148 HEK-293T C98(0.88)  LDD0866  [5]
 LDCM0269  AC149 HEK-293T C98(0.86)  LDD0867  [5]
 LDCM0270  AC15 HCT 116 C98(1.07); C68(1.54)  LDD0587  [5]
 LDCM0271  AC150 HEK-293T C98(0.80)  LDD0869  [5]
 LDCM0272  AC151 HEK-293T C98(0.78)  LDD0870  [5]
 LDCM0273  AC152 HEK-293T C98(0.96)  LDD0871  [5]
 LDCM0274  AC153 HEK-293T C98(0.98)  LDD0872  [5]
 LDCM0621  AC154 HEK-293T C98(1.00)  LDD2162  [5]
 LDCM0622  AC155 HEK-293T C98(0.88)  LDD2163  [5]
 LDCM0623  AC156 HEK-293T C98(0.86)  LDD2164  [5]
 LDCM0624  AC157 HEK-293T C98(0.94)  LDD2165  [5]
 LDCM0276  AC17 HCT 116 C68(0.47)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C68(0.53)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C68(0.53)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C68(1.24); C98(1.39)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C68(0.63)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C68(0.42)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C68(0.53)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C68(0.78)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C68(0.61)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C98(0.87); C68(0.95)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C98(0.95); C68(0.98)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C98(0.98); C68(0.89)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C98(0.97); C68(0.94)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C98(0.90); C68(0.94)  LDD1528  [13]
 LDCM0290  AC3 HCT 116 C68(1.18); C98(1.79)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C98(0.97); C68(0.92)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C98(0.98); C68(0.92)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C98(0.96); C68(0.93)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C98(0.90); C68(1.11)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C98(0.90); C68(0.98)  LDD1534  [13]
 LDCM0296  AC35 HCT 116 C98(1.09)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C98(0.97)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C98(1.12)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C98(1.01)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C98(1.00)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C68(1.18); C98(2.11)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C98(1.14)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C98(1.05)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C98(0.95)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C98(1.12)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C98(1.23)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C98(1.40)  LDD0624  [5]
 LDCM0308  AC46 PaTu 8988t C68(1.06)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C68(1.07)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C68(1.26)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C68(1.38)  LDD1190  [5]
 LDCM0312  AC5 HCT 116 C68(1.28); C98(2.14)  LDD0629  [5]
 LDCM0313  AC50 PaTu 8988t C68(1.26)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C68(1.02)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C68(1.24)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C68(1.35)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C68(1.45)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C68(1.04)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C68(1.41)  LDD1198  [5]
 LDCM0320  AC57 HCT 116 C98(1.41)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C98(1.41)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C98(1.47)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C98(1.02); C68(1.32)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C98(1.59)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C98(1.55)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C98(1.53)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C98(1.42)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C98(1.84)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C98(2.13)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C98(2.13)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C98(2.24)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C98(0.96)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C98(0.75)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C98(0.93); C68(1.39)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C98(0.82)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C98(1.00)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C98(0.91)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C98(0.92)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C98(0.99)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C98(0.82)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C98(0.87)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C98(0.84)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C98(0.72)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C98(0.79)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C98(0.91); C68(1.29)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C98(1.01)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C98(0.89)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C98(0.95)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C98(0.93)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C98(0.95)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C98(0.83)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C98(0.80)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C98(0.69)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C98(1.03)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C98(0.92)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C98(0.92)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C98(0.89)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C98(0.83)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C98(0.94)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C98(1.07)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C98(0.95)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C98(0.97)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C98(0.98)  LDD0962  [5]
 LDCM0365  AC98 HCT 116 C98(1.10)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C98(1.14)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C68(1.25); C98(1.31)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C98(1.27); C68(1.38)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C98(0.93); C68(1.72)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 14.51  LDD0403  [3]
 LDCM0630  CCW28-3 231MFP C68(1.20)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 PaTu 8988t C98(0.95); C68(1.01)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C98(1.10); C68(1.11)  LDD1247  [5]
 LDCM0369  CL100 HCT 116 C68(1.18); C98(1.49)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C98(0.97); C68(1.57)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C98(1.13); C68(1.78)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C68(1.09); C98(1.12)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C68(1.20); C98(1.26)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C68(0.70)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C68(0.71)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C68(0.57)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C68(0.58)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C68(0.51)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C98(1.05); C68(1.00)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C68(0.78)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C68(0.51)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C98(0.92); C68(0.90)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C98(0.88); C68(0.94)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C98(0.88); C68(1.06)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C98(0.95); C68(0.99)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C98(1.03); C68(1.04)  LDD1590  [13]
 LDCM0387  CL117 HCT 116 C98(1.04)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C98(1.05)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C98(1.02)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C98(1.17); C68(1.04)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C98(1.00)  LDD0708  [5]
 LDCM0392  CL121 PaTu 8988t C68(1.07)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C68(1.26)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C68(1.28)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C68(1.31)  LDD1274  [5]
 LDCM0396  CL125 HCT 116 C98(1.04)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C98(1.16)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C98(1.14)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C98(1.64)  LDD0716  [5]
 LDCM0400  CL13 PaTu 8988t C98(1.37); C68(1.43)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C98(1.23); C68(1.50)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C98(1.10); C68(1.07)  LDD1281  [5]
 LDCM0403  CL16 HCT 116 C98(1.05)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C98(1.06)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C98(1.35)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C98(1.40)  LDD0723  [5]
 LDCM0407  CL2 PaTu 8988t C98(1.04); C68(1.04)  LDD1286  [5]
 LDCM0408  CL20 HCT 116 C98(1.20)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C98(1.39)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C98(2.00)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C98(1.26)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C98(1.57)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C98(1.38)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C98(1.31)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C98(1.09)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C98(1.25)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C98(1.50)  LDD0734  [5]
 LDCM0418  CL3 PaTu 8988t C98(1.20); C68(1.33)  LDD1297  [5]
 LDCM0419  CL30 HCT 116 C98(1.15)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C68(0.93); C98(1.51)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C68(0.82); C98(1.95)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C68(0.82); C98(1.35)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C68(1.08); C98(1.90)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C68(1.12); C98(1.75)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C68(1.49); C98(1.85)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C68(1.38); C98(1.64)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C68(1.06); C98(2.25)  LDD0745  [5]
 LDCM0429  CL4 PaTu 8988t C98(1.08); C68(1.15)  LDD1308  [5]
 LDCM0430  CL40 HCT 116 C68(1.25); C98(1.92)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C68(1.06); C98(1.90)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C68(1.22); C98(2.69)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C68(1.66); C98(1.92)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C68(1.07); C98(2.83)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C68(1.12); C98(2.43)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C98(0.88)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C98(0.87)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C98(0.83)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C98(1.03)  LDD0756  [5]
 LDCM0440  CL5 PaTu 8988t C98(1.26); C68(1.42)  LDD1319  [5]
 LDCM0441  CL50 HCT 116 C98(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C98(0.87)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C98(0.79)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C98(0.84)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C98(0.89)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C98(0.99)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C98(0.91)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C98(0.90)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C98(0.89)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C98(0.97)  LDD0767  [5]
 LDCM0451  CL6 PaTu 8988t C98(1.08); C68(1.24)  LDD1330  [5]
 LDCM0452  CL60 HCT 116 C98(0.93)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C98(1.20)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C98(1.37)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C98(1.57)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C98(1.39)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C98(1.38)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C98(1.75)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C98(1.52)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C98(1.57)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C98(1.29)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C98(1.30); C68(1.23)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C98(1.51)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C98(1.50)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C98(1.38)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C98(1.46)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C98(1.59)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C68(1.10); C98(0.96)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C68(1.23); C98(0.88)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C68(1.17); C98(0.83)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C68(1.37); C98(1.12)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C98(1.09); C68(1.13)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C68(1.31); C98(0.82)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C68(1.27); C98(0.92)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C68(1.61); C98(0.89)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C68(1.52); C98(0.84)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C68(1.69); C98(0.92)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C68(1.08); C98(0.94)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C68(1.05); C98(1.09)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C68(1.28); C98(1.60)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C68(1.45); C98(1.03)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C68(1.72); C98(0.91)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C98(1.03); C68(1.42)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C68(0.94); C98(0.71)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C68(1.13); C98(1.15)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C68(1.10); C98(0.94)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C68(1.08); C98(0.87)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C68(1.06); C98(1.37)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C68(1.13); C98(0.95)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C68(1.14); C98(1.00)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C68(1.11); C98(1.24)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C68(1.24); C98(1.35)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C68(1.13); C98(1.66)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C98(0.86); C68(0.99)  LDD1698  [13]
 LDCM0625  F8 Ramos C98(1.19)  LDD2187  [15]
 LDCM0572  Fragment10 MDA-MB-231 C68(1.12)  LDD1389  [16]
 LDCM0573  Fragment11 MDA-MB-231 C68(1.13)  LDD1391  [16]
 LDCM0574  Fragment12 MDA-MB-231 C68(1.22)  LDD1393  [16]
 LDCM0575  Fragment13 MDA-MB-231 C68(0.87)  LDD1395  [16]
 LDCM0576  Fragment14 MDA-MB-231 C68(1.04)  LDD1397  [16]
 LDCM0577  Fragment15 MDA-MB-231 C68(0.84)  LDD1399  [16]
 LDCM0579  Fragment20 Ramos C98(0.62)  LDD2194  [15]
 LDCM0580  Fragment21 MDA-MB-231 C68(0.79)  LDD1404  [16]
 LDCM0582  Fragment23 MDA-MB-231 C68(1.05)  LDD1408  [16]
 LDCM0585  Fragment26 Ramos C68(0.74)  LDD1412  [16]
 LDCM0578  Fragment27 MDA-MB-231 C68(1.52)  LDD1401  [16]
 LDCM0586  Fragment28 MDA-MB-231 C68(0.78)  LDD1415  [16]
 LDCM0587  Fragment29 Ramos C68(1.11)  LDD1418  [16]
 LDCM0588  Fragment30 MDA-MB-231 C68(0.76)  LDD1419  [16]
 LDCM0589  Fragment31 MDA-MB-231 C68(1.10)  LDD1421  [16]
 LDCM0590  Fragment32 MDA-MB-231 C68(1.29)  LDD1423  [16]
 LDCM0468  Fragment33 HCT 116 C98(1.46)  LDD0785  [5]
 LDCM0594  Fragment36 MDA-MB-231 C68(2.14)  LDD1431  [16]
 LDCM0595  Fragment37 Ramos C68(1.14)  LDD1432  [16]
 LDCM0596  Fragment38 MDA-MB-231 C68(0.99)  LDD1433  [16]
 LDCM0566  Fragment4 MDA-MB-231 C68(1.10)  LDD1378  [16]
 LDCM0598  Fragment40 MDA-MB-231 C68(0.80)  LDD1436  [16]
 LDCM0599  Fragment41 Ramos C68(1.21)  LDD1439  [16]
 LDCM0600  Fragment42 Ramos C68(0.86)  LDD1440  [16]
 LDCM0604  Fragment46 MDA-MB-231 C68(0.81)  LDD1445  [16]
 LDCM0605  Fragment47 MDA-MB-231 C68(1.03)  LDD1446  [16]
 LDCM0606  Fragment48 MDA-MB-231 C68(1.43)  LDD1447  [16]
 LDCM0607  Fragment49 MDA-MB-231 C68(1.29)  LDD1448  [16]
 LDCM0427  Fragment51 HCT 116 C68(1.30); C98(2.39)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C68(1.38)  LDD1453  [16]
 LDCM0611  Fragment53 MDA-MB-231 C68(0.91)  LDD1454  [16]
 LDCM0614  Fragment56 MDA-MB-231 C68(0.86)  LDD1458  [16]
 LDCM0568  Fragment6 MDA-MB-231 C68(1.78)  LDD1382  [16]
 LDCM0569  Fragment7 Ramos C98(0.82)  LDD2186  [15]
 LDCM0570  Fragment8 Ramos C68(1.02)  LDD1386  [16]
 LDCM0571  Fragment9 MDA-MB-231 C68(1.00)  LDD1387  [16]
 LDCM0022  KB02 MDA-MB-231 C68(1.12)  LDD1374  [16]
 LDCM0023  KB03 HEK-293T C98(1.02); C68(0.98)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C98(2.64)  LDD3310  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C98(1.09)  LDD2099  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C98(1.00)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C98(1.03)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C98(0.71)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C98(1.38)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C98(0.49)  LDD2115  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C98(1.05)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C98(0.85)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C98(0.98)  LDD2127  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C98(0.73)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C98(0.45)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C98(1.27)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C98(0.96)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C98(1.77)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C98(0.87)  LDD2140  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C98(0.38)  LDD2148  [4]
 LDCM0131  RA190 MM1.R C68(1.27)  LDD0304  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM7 (TRIM7) TRIM/RBCC family Q9C029
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TATA-box-binding protein (TBP) TBP family P20226
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription initiation factor IIA subunit 1 (GTF2A1) TFIIA subunit 1 family P52655

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.