Details of the Target

General Information of Target

Target ID LDTP04662
Target Name Exportin-2 (CSE1L)
Gene Name CSE1L
Gene ID 1434
Synonyms
CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKV
CASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGR
EDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAF
ALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMN
NFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNL
LVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEE
AFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNP
SVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVL
KADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATL
FTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQ
KLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFI
PYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIA
SAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQN
SKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK
ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQ
TAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQ
GYLQAASVTLL
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
XPO2/CSE1 family
Subcellular location
Cytoplasm
Function
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
TTD ID
T05324
Uniprot ID
P55060
DrugMap ID
TTTRULD
Ensemble ID
ENST00000262982.3
HGNC ID
HGNC:2431

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.T303P DBIA    Probe Info 
HT115 SNV: p.N186D DBIA    Probe Info 
HUH1 SNV: p.I379T DBIA    Probe Info 
ICC106 SNV: p.L557F DBIA    Probe Info 
MFE319 SNV: p.I591V DBIA    Probe Info 
NB1 SNV: p.E51G DBIA    Probe Info 
TE1 SNV: p.L218V DBIA    Probe Info 
YSCCC SNV: p.E551D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 56 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.06  LDD0402  [1]
A-EBA
 Probe Info  		4.21  LDD0215  [2]
CHEMBL5175495
 Probe Info  		8.94  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y369(20.00); Y408(11.24); Y42(8.88)  LDD0257  [5]
TH214
 Probe Info  		Y278(20.00)  LDD0258  [5]
TH216
 Probe Info  		Y369(20.00); Y278(12.62); Y861(9.02)  LDD0259  [5]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [6]
AZ-9
 Probe Info  		E353(1.10)  LDD2208  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K17(1.76); K158(3.34)  LDD3494  [9]
Probe 1
 Probe Info  		Y282(69.31); Y369(38.11)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C344(0.00); C842(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C85(1.09); C842(1.06); C344(1.05)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C272(2.36)  LDD0168  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
HHS-482
 Probe Info  		Y369(0.39)  LDD0286  [14]
HHS-475
 Probe Info  		Y571(2.43)  LDD0264  [15]
DBIA
 Probe Info  		C387(0.90); C939(0.87); C842(0.87)  LDD0078  [16]
5E-2FA
 Probe Info  		H98(0.00); H198(0.00); H144(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K158(0.00); K346(0.00); K574(0.00); K165(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C387(0.00); C195(0.00); C842(0.00); C85(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C387(0.00); C344(0.00); C272(0.00); C939(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [21]
IPIAA_L
 Probe Info  		C344(0.00); C85(0.00); C272(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C387(0.00); C195(0.00); C842(0.00); C85(0.00)  LDD0037  [19]
BTD
 Probe Info  		N.A.  LDD0004  [22]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [23]
NAIA_4
 Probe Info  		C85(0.00); C344(0.00); 0.00  LDD2226  [24]
TFBX
 Probe Info  		C344(0.00); C853(0.00); C939(0.00); C272(0.00)  LDD0027  [23]
WYneN
 Probe Info  		C842(0.00); C195(0.00); C272(0.00); C387(0.00)  LDD0021  [22]
WYneO
 Probe Info  		C387(0.00); C272(0.00); C842(0.00); C939(0.00)  LDD0022  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [25]
Compound 10
 Probe Info  		C272(0.00); C344(0.00); C387(0.00); C842(0.00)  LDD2216  [26]
ENE
 Probe Info  		C344(0.00); C842(0.00); C939(0.00); C272(0.00)  LDD0006  [22]
IPM
 Probe Info  		C272(0.00); C939(0.00); C387(0.00); C195(0.00)  LDD0005  [22]
NHS
 Probe Info  		K912(0.00); K481(0.00)  LDD0010  [22]
PF-06672131
 Probe Info  		C272(0.00); C842(0.00)  LDD0017  [27]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
SF
 Probe Info  		N.A.  LDD0028  [28]
STPyne
 Probe Info  		K440(0.00); K481(0.00); K281(0.00); K427(0.00)  LDD0009  [22]
VSF
 Probe Info  		C85(0.00); C842(0.00); C939(0.00); C272(0.00)  LDD0007  [22]
YN-1
 Probe Info  		N.A.  LDD0447  [29]
Phosphinate-6
 Probe Info  		C387(0.00); C842(0.00); C85(0.00)  LDD0018  [30]
Ox-W18
 Probe Info  		N.A.  LDD2175  [31]
1c-yne
 Probe Info  		K126(0.00); K346(0.00); K824(0.00); K109(0.00)  LDD0228  [25]
Acrolein
 Probe Info  		C195(0.00); C85(0.00); C344(0.00); H914(0.00)  LDD0217  [32]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [32]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [32]
Methacrolein
 Probe Info  		C344(0.00); C85(0.00); C195(0.00); C853(0.00)  LDD0218  [32]
W1
 Probe Info  		C344(0.00); C272(0.00); C939(0.00); C853(0.00)  LDD0236  [33]
AOyne
 Probe Info  		11.50  LDD0443  [34]
NAIA_5
 Probe Info  		C387(0.00); C842(0.00); C939(0.00); C85(0.00)  LDD2223  [24]
HHS-465
 Probe Info  		K574(0.00); Y571(0.00); Y408(0.00)  LDD2240  [35]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		7.48  LDD0471  [36]
FFF probe13
 Probe Info  		9.12  LDD0475  [36]
FFF probe14
 Probe Info  		12.22  LDD0477  [36]
FFF probe3
 Probe Info  		5.93  LDD0464  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
LD-F
 Probe Info  		E34(0.00); S35(0.00)  LDD0015  [39]
DA-2
 Probe Info  		N.A.  LDD0070  [40]
STS-1
 Probe Info  		N.A.  LDD0068  [41]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C85(0.93); C387(0.96); C272(0.91); C939(0.65)  LDD2142  [42]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C387(1.14); C272(0.91); C842(0.93); C61(1.45)  LDD2112  [42]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C85(0.82); C387(0.71); C272(0.64); C939(0.64)  LDD2095  [42]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C85(0.91); C387(0.87); C272(1.00); C939(0.87)  LDD2130  [42]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C85(1.24); C387(1.09); C272(1.20); C939(0.82)  LDD2117  [42]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C85(1.51); C387(1.32); C272(1.27); C939(1.04)  LDD2152  [42]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C85(1.05); C387(1.03); C272(1.06); C939(1.01)  LDD2103  [42]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C85(0.78); C387(0.62); C272(0.56); C939(0.63)  LDD2132  [42]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C85(0.75); C387(0.62); C272(0.72); C939(0.65)  LDD2131  [42]
 LDCM0025  4SU-RNA HEK-293T C272(2.36)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C272(2.40); C939(2.47)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C272(0.89); C344(1.04); C387(1.36); C61(1.13)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C272(0.81); C344(1.07); C387(1.22); C61(0.82)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C272(0.62); C344(0.91); C387(1.26); C61(0.58)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C272(0.57); C344(0.80); C387(1.09); C61(0.58)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C272(0.63); C344(0.81); C387(1.08); C61(0.58)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C272(0.61); C344(0.85); C387(1.11); C61(0.43)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C272(0.62); C344(0.85); C387(1.21); C61(0.63)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C272(0.58); C344(0.79); C387(1.15); C61(0.46)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C272(0.61); C344(0.88); C387(1.11); C61(0.46)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C272(0.67); C344(0.95); C387(1.14); C61(0.52)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C272(0.63); C344(0.88); C387(1.22); C61(0.84)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C272(0.69); C344(0.87); C387(1.03); C61(0.89)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C272(0.77); C344(1.02); C387(1.12); C61(0.85)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C272(0.63); C344(0.88); C387(1.08); C61(0.63)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C272(0.64); C344(0.85); C387(0.98); C61(0.66)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C272(0.57); C344(0.81); C387(1.12); C61(0.50)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C272(0.87); C344(0.89); C387(1.03); C61(0.97)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C272(0.72); C344(0.83); C387(1.05); C61(0.77)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C272(0.83); C344(0.83); C387(1.14); C61(0.67)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C272(0.85); C344(0.78); C387(0.97); C61(0.64)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C272(0.88); C344(0.86); C387(1.07); C61(0.79)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C272(0.81); C344(0.90); C387(0.98); C61(0.76)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C272(0.86); C344(0.83); C387(1.09); C61(0.74)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C272(0.92); C344(1.20); C387(1.32); C61(0.98)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C272(0.83); C344(0.81); C387(1.00); C61(0.75)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C272(0.91); C344(1.02); C387(1.28); C61(0.90)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C272(0.92); C344(0.89); C387(1.05); C61(0.80)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C272(0.95); C344(0.84); C387(1.61); C61(0.87)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C272(0.93); C344(0.87); C387(1.20); C61(0.89)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C272(1.12); C344(0.86); C387(0.89); C61(0.80)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C272(0.82); C344(0.88); C387(0.85); C61(0.68)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C272(0.87); C344(0.93); C387(0.96); C61(0.69)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C272(1.14); C344(1.34); C387(1.19); C61(0.99)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C272(0.99); C344(1.15); C387(1.02); C61(1.27)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C272(0.99); C344(1.14); C387(1.16); C61(0.94)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C272(1.15); C344(1.17); C387(1.05); C61(1.15)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C272(1.02); C344(1.27); C387(1.15); C61(1.26)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C272(0.97); C344(1.27); C387(0.99); C61(0.96)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C272(0.93); C344(1.10); C387(1.11); C61(0.89)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C272(1.02); C344(1.22); C387(1.05); C61(0.94)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C272(1.02); C344(1.15); C387(1.26); C61(0.98)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C272(0.92); C344(1.23); C387(1.25); C61(1.08)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C272(1.03); C344(1.29); C387(1.28); C61(0.80)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C272(0.98); C344(1.11); C387(1.14); C61(0.97)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C272(0.85); C344(0.94); C387(1.09); C61(1.02)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C272(0.96); C344(1.24); C387(1.31); C61(0.79)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C272(1.02); C344(1.21); C387(1.23); C61(0.81)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C272(0.95); C344(1.14); C387(1.30); C61(1.60)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C272(0.90); C344(0.69); C387(1.04); C61(0.81)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C61(0.59); C272(0.67); C344(0.76); C853(0.96)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C344(0.64); C61(0.80); C272(0.81); C853(0.99)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C272(0.64); C344(0.69); C61(0.73); C853(0.96)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C344(0.66); C61(0.67); C272(0.80); C853(0.95)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C61(0.72); C272(0.90); C344(0.99); C387(1.10)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C272(0.65); C344(0.73); C61(0.77); C853(0.95)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C61(0.82); C939(0.92); C272(0.98); C344(1.00)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C272(0.75); C61(0.78); C853(0.94); C344(0.99)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C272(0.79); C61(0.87); C853(0.91); C842(0.99)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C61(0.69); C272(0.70); C344(0.92); C853(1.01)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C344(0.76); C61(0.83); C272(1.01); C853(1.26)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C272(0.68); C344(0.82); C387(1.24); C61(0.74)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C272(0.71); C344(0.84); C387(1.19); C61(0.76)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C272(0.89); C344(0.97); C387(1.16); C61(1.01)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C272(0.82); C344(0.74); C387(1.47); C61(0.91)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C61(0.84); C853(0.93); C344(0.96); C272(0.96)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C61(0.75); C939(0.92); C853(0.98); C272(1.00)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C61(0.74); C853(0.94); C344(0.94); C842(0.95)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C272(0.85); C853(0.99); C61(0.99); C344(0.99)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C61(0.75); C853(0.95); C387(0.96); C272(0.97)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C61(0.66); C344(0.98); C853(0.99); C272(1.01)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C61(0.92); C939(0.94); C853(0.97); C272(1.02)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C61(0.86); C853(0.98); C272(0.99); C344(1.09)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C61(0.86); C853(0.94); C272(0.97); C387(1.00)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C272(0.75); C939(0.84); C853(0.87); C344(0.95)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C272(0.64); C61(0.88); C939(0.92); C853(0.95)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C272(0.62); C939(0.75); C853(0.80); C344(0.82)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C272(0.63); C939(0.89); C853(0.91); C798(0.91)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C272(0.68); C939(0.86); C344(0.89); C853(0.89)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C272(0.80); C939(1.00); C853(1.02); C344(1.07)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C272(0.70); C344(0.83); C853(0.89); C939(0.90)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C272(0.65); C939(0.77); C853(0.90); C344(0.95)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C272(0.60); C939(0.89); C344(0.92); C853(0.93)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C272(0.64); C853(0.77); C344(0.91); C939(0.93)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C272(0.75); C853(0.91); C61(0.92); C344(0.93)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C939(0.93); C842(0.95); C387(0.98); C853(1.02)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C344(0.92); C853(0.93); C842(0.95); C272(0.98)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C842(0.89); C853(0.90); C344(0.94); C387(0.98)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C344(0.90); C939(0.92); C272(0.96); C853(0.98)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C387(0.92); C344(0.99); C272(1.03); C61(1.05)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C272(0.75); C61(0.97); C853(1.01); C939(1.03)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C387(0.87); C61(0.94); C344(1.00); C853(1.02)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C853(0.95); C344(0.98); C842(0.99); C272(1.00)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C387(0.92); C344(0.93); C61(0.96); C272(0.99)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C272(0.94); C387(0.96); C344(0.98); C853(0.99)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C344(0.94); C853(0.98); C61(1.01); C272(1.03)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C61(1.00); C344(1.00); C853(1.09); C272(1.12)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C387(1.01); C842(1.02); C853(1.08); C61(1.12)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C344(0.89); C272(0.98); C61(1.04); C853(1.05)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C344(0.93); C842(1.11); C853(1.13); C272(1.16)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C61(0.92); C387(1.00); C344(1.14); C939(1.19)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C272(0.82); C853(1.00); C798(1.02); C61(1.07)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C61(0.90); C387(1.08); C272(1.13); C344(1.14)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C842(0.94); C344(1.00); C853(1.03); C387(1.10)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C344(0.90); C61(0.98); C853(1.06); C272(1.07)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C61(0.90); C344(1.07); C272(1.07); C939(1.08)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C61(0.95); C272(1.08); C939(1.09); C344(1.09)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C61(0.91); C272(1.08); C344(1.12); C853(1.20)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C61(1.04); C387(1.15); C272(1.33); C939(1.39)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C61(0.63); C387(0.79); C272(0.91); C798(0.91)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C61(0.72); C798(0.91); C939(1.00); C853(1.02)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C61(0.60); C272(0.87); C387(0.88); C939(0.99)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C61(0.76); C272(0.82); C344(0.99); C939(1.01)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C61(0.67); C272(0.80); C387(0.85); C939(0.88)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C61(0.82); C939(0.87); C272(0.91); C344(0.93)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C61(0.68); C387(0.92); C272(0.94); C798(0.97)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C61(0.66); C798(0.82); C272(0.91); C344(0.95)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C61(0.69); C272(0.88); C387(0.96); C939(1.02)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C61(0.65); C387(0.86); C272(0.94); C939(0.97)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C61(0.74); C387(0.94); C939(0.95); C272(0.98)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C61(0.73); C272(0.88); C798(0.96); C387(0.99)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C61(0.92); C344(0.93); C272(0.94); C853(1.03)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C61(0.85); C272(1.02); C939(1.08); C853(1.10)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C939(0.89); C61(0.92); C853(0.95); C344(0.95)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C61(0.81); C272(0.89); C344(0.92); C853(1.01)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C344(0.98); C853(1.02); C272(1.05); C61(1.06)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C61(0.88); C272(0.96); C853(1.02); C344(1.13)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C61(0.85); C272(1.14); C853(1.30); C939(1.32)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C61(0.87); C272(1.24); C853(1.31); C939(1.45)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C61(0.97); C272(1.22); C939(1.33); C853(1.45)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C61(0.88); C272(1.05); C853(1.13); C939(1.16)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C61(0.87); C272(0.98); C853(1.07); C344(1.13)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C272(1.02); C853(1.02); C842(1.11); C61(1.11)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C272(0.93); C853(1.00); C61(1.06); C842(1.16)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C61(0.79); C939(0.80); C272(0.93); C344(1.00)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C61(0.87); C272(1.04); C853(1.08); C939(1.09)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C272(1.01); C853(1.02); C344(1.02); C61(1.13)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C61(1.02); C344(1.26); C272(1.27); C939(1.41)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C61(0.63); C272(0.76); C344(0.80); C853(1.04)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C61(0.58); C272(0.71); C344(0.83); C853(1.03)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C272(0.65); C61(0.68); C344(0.78); C853(0.93)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C272(0.63); C344(0.71); C61(0.74); C853(0.95)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C272(0.73); C344(0.78); C61(0.91); C853(0.98)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C272(0.69); C61(0.74); C853(0.90); C344(0.95)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C272(0.66); C61(0.71); C344(0.83); C853(1.04)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C344(0.93); C853(1.00); C272(1.02); C939(1.09)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C61(0.67); C272(0.74); C344(0.80); C853(1.00)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C61(0.60); C272(0.68); C344(0.80); C853(0.97)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C61(0.59); C272(0.68); C344(0.79); C853(0.93)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C272(0.72); C61(0.78); C344(0.92); C853(0.98)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C272(0.59); C344(0.84); C61(0.85); C853(0.89)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C61(0.65); C272(0.69); C344(0.88); C853(0.88)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C61(0.64); C272(0.69); C344(0.71); C853(0.92)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C61(0.46); C272(0.53); C939(0.94); C853(0.96)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C272(0.65); C61(0.77); C939(0.81); C853(0.83)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C387(0.40); C272(0.50); C939(0.35); C842(0.34)  LDD2138  [42]
 LDCM0520  AKOS000195272 MDA-MB-231 C85(0.72); C272(0.85); C939(0.86); C842(1.03)  LDD2113  [42]
 LDCM0248  AKOS034007472 HCT 116 C272(0.87); C344(1.08); C387(1.06); C61(1.32)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C272(0.80); C853(0.87); C939(0.95); C344(1.00)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C61(0.83); C939(0.94); C272(0.95); C344(0.99)  LDD0592  [16]
 LDCM0020  ARS-1620 HCC44 C387(0.90); C939(0.87); C842(0.87)  LDD0078  [16]
 LDCM0498  BS-3668 MDA-MB-231 C85(0.68); C387(0.46); C272(0.66); C939(0.36)  LDD2091  [42]
 LDCM0108  Chloroacetamide HeLa C195(0.00); C344(0.00); H914(0.00); H98(0.00)  LDD0222  [32]
 LDCM0632  CL-Sc Hep-G2 C272(20.00); C842(1.62); C85(1.38); C85(0.89)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C387(0.84); C798(0.85); C842(0.93); C853(0.94)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C61(0.85); C798(0.87); C853(0.88); C387(1.02)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C272(0.88); C61(0.97); C798(0.98); C853(1.00)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C61(0.79); C272(0.81); C939(0.83); C344(0.89)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C939(0.78); C272(0.80); C344(0.90); C61(0.97)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C939(0.79); C853(0.83); C272(0.87); C344(0.95)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C939(0.90); C272(0.90); C344(0.91); C61(1.00)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C61(0.85); C272(0.94); C853(0.98); C387(1.03)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C61(0.70); C272(1.06); C387(1.16); C344(1.18)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C61(0.66); C272(1.00); C853(1.09); C344(1.13)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C61(0.68); C939(0.92); C387(1.00); C344(1.06)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C61(0.67); C272(0.91); C853(0.92); C344(0.93)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C798(0.81); C61(0.87); C853(0.88); C387(1.03)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C61(0.68); C272(0.90); C853(0.98); C939(0.99)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C61(0.74); C272(0.92); C853(0.98); C344(1.00)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C939(0.73); C272(0.81); C853(0.89); C798(0.91)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C272(0.63); C344(0.91); C853(0.91); C939(0.91)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C272(0.76); C939(0.87); C853(0.89); C344(0.89)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C272(0.59); C344(0.83); C939(0.85); C853(0.87)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C272(0.63); C939(0.89); C853(0.90); C344(0.96)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C61(1.00); C387(1.13); C344(1.21); C272(1.24)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C272(0.90); C344(0.99); C853(1.01); C842(1.01)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C61(0.95); C344(1.01); C272(1.03); C853(1.08)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C61(0.86); C387(0.96); C798(1.00); C272(1.16)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C272(0.99); C842(0.99); C344(1.01); C853(1.07)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C939(0.80); C387(0.90); C61(0.91); C842(0.93)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C61(1.01); C939(1.04); C272(1.06); C387(1.08)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C344(0.84); C61(0.95); C939(1.04); C853(1.07)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C61(0.90); C344(0.99); C387(1.15); C272(1.17)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C387(0.75); C798(0.84); C939(0.89); C853(0.97)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C939(0.76); C61(0.79); C387(0.82); C344(0.83)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C939(0.83); C61(0.84); C344(0.88); C853(0.90)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C61(0.64); C272(0.89); C387(0.91); C939(0.97)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C798(0.88); C387(0.90); C61(0.92); C853(0.98)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C853(0.78); C798(0.89); C387(0.92); C272(0.93)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C798(0.71); C61(0.96); C272(1.03); C387(1.05)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C344(0.75); C939(0.81); C798(0.90); C842(0.91)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C344(0.90); C939(0.92); C853(0.94); C842(0.95)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C344(0.83); C842(0.92); C939(0.93); C853(0.93)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C61(0.72); C344(0.79); C842(0.97); C939(1.03)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C853(0.75); C798(0.84); C387(0.94); C842(0.95)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C344(0.85); C939(0.95); C853(0.96); C842(1.01)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C344(0.84); C61(0.88); C939(1.00); C853(1.03)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C61(0.67); C939(1.07); C344(1.13); C853(1.35)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C61(0.82); C344(0.89); C853(0.93); C842(0.94)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C61(0.82); C344(0.84); C853(1.08); C939(1.14)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C344(0.93); C61(0.79); C798(1.23); C842(1.11)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C344(0.71); C61(0.81); C798(1.18); C842(1.09)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C344(0.67); C61(0.93); C798(1.10); C842(0.94)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C344(0.84); C61(0.81); C798(1.06); C842(0.99)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C344(0.91); C61(0.97); C798(1.17); C842(1.05)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C272(1.06); C344(1.05); C387(1.14); C61(1.07)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C344(0.82); C61(0.96); C798(1.08); C842(1.01)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C272(0.86); C344(0.91); C387(1.02); C61(0.72)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C272(0.82); C344(1.06); C387(1.03); C61(0.81)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C272(0.81); C344(1.05); C387(1.08); C61(0.69)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C272(0.89); C344(0.91); C387(1.10); C61(0.73)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C272(0.99); C344(0.97); C387(1.10); C61(0.74)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C272(0.90); C344(1.02); C387(1.09); C61(0.66)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C272(0.92); C344(1.02); C387(1.12); C61(0.74)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C272(0.92); C344(1.22); C387(1.05); C61(0.69)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C272(0.92); C344(0.92); C387(0.99); C61(0.96)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C272(0.92); C344(1.07); C387(0.95); C61(0.66)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C272(0.74); C344(0.85); C387(1.06); C61(0.70)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C272(1.19); C344(1.18); C387(0.92); C61(0.61)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C272(0.99); C344(1.05); C387(1.06); C61(0.69)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C272(0.86); C344(0.95); C387(1.16); C61(0.83)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C272(1.03); C344(1.01); C387(1.14); C61(0.71)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C272(1.12); C344(1.12); C387(0.87); C61(1.67)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C272(0.98); C344(0.91); C387(1.03); C61(1.72)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C272(1.15); C344(0.92); C387(1.01); C61(1.60)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C272(0.97); C344(1.00); C387(1.08); C61(1.22)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C272(0.99); C344(1.14); C387(0.85); C61(0.95)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C272(0.97); C344(1.01); C387(1.07); C61(1.33)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C272(1.02); C344(1.12); C387(1.10); C61(1.39)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C272(1.01); C344(1.16); C387(0.99); C61(1.37)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C272(0.95); C344(0.96); C387(0.98); C61(1.26)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C272(1.09); C344(1.08); C387(0.96); C61(1.44)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C272(1.06); C344(1.18); C387(1.01); C61(1.39)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C272(0.88); C344(1.01); C387(0.98); C61(1.29)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C272(0.94); C344(0.94); C387(0.88); C61(1.31)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C272(0.99); C344(1.05); C387(0.96); C61(1.58)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C272(0.84); C344(1.02); C387(1.01); C61(1.18)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C272(0.97); C344(1.14); C387(0.93); C61(1.08)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C272(0.93); C344(0.89); C387(1.01); C61(1.30)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C272(0.91); C344(0.83); C387(1.02); C61(0.91)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C272(0.89); C344(0.91); C387(0.85); C61(0.96)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C272(0.79); C344(0.74); C387(1.06); C61(0.66)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C272(0.82); C344(0.79); C387(1.12); C61(0.48)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C272(0.80); C344(0.92); C387(0.93); C61(0.81)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C272(0.82); C344(0.82); C387(0.99); C61(0.50)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C272(0.88); C344(0.83); C387(1.15); C61(0.49)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C272(1.00); C344(0.82); C387(1.11); C61(0.62)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C272(0.84); C344(0.79); C387(0.99); C61(1.15)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C272(1.19); C344(1.23); C387(0.83); C61(0.87)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C272(0.85); C344(0.92); C387(1.02); C61(0.71)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C272(0.87); C344(0.92); C387(1.19); C61(0.62)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C272(0.90); C344(0.81); C387(0.94); C61(0.97)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C272(1.73); C344(0.88); C387(0.96); C61(0.60)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C272(0.98); C344(0.88); C387(0.89); C61(0.55)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C272(0.94); C344(0.97); C387(0.86); C61(0.79)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C272(4.11); C344(0.98); C387(0.96); C61(0.64)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C272(0.96); C344(1.04); C387(1.05); C61(0.69)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C272(0.89); C344(1.00); C387(1.05); C61(0.59)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C272(1.15); C344(1.10); C387(0.92); C61(0.71)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C272(0.95); C344(1.03); C387(1.14); C61(0.88)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C272(0.84); C344(1.06); C387(1.02); C61(0.63)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C272(1.04); C344(1.20); C387(1.15); C61(0.66)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C272(1.12); C344(1.15); C387(1.03); C61(0.63)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C272(1.40); C344(1.17); C387(1.17); C61(0.68)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C272(0.88); C344(0.98); C387(1.03); C61(0.66)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C272(0.93); C344(1.05); C387(0.93); C61(0.80)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C272(0.88); C344(1.08); C387(1.02); C61(0.67)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C272(1.11); C344(1.17); C387(1.01); C61(0.65)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C272(1.19); C344(1.27); C387(1.16); C61(0.75)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C272(1.12); C344(1.05); C387(1.01); C61(0.95)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C272(0.99); C344(1.08); C387(0.98); C61(1.11)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C272(0.86); C344(0.98); C387(1.00); C61(0.82)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C272(0.97); C344(1.02); C387(1.05); C61(0.82)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C272(1.05); C344(1.13); C387(1.12); C61(0.96)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C272(0.81); C344(0.96); C387(0.95); C61(0.77)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C272(0.82); C344(0.92); C387(1.08); C61(0.74)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C272(0.80); C344(0.96); C387(1.00); C61(0.86)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C272(0.84); C344(0.99); C387(1.13); C61(0.90)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C272(0.75); C344(1.02); C387(1.20); C61(0.80)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C272(0.79); C344(1.02); C387(1.17); C61(0.88)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C195(1.35); C272(1.31); C344(0.87)  LDD2228  [24]
 LDCM0495  E2913 HEK-293T C939(1.02); C387(0.95); C272(0.84); C842(0.99)  LDD1698  [43]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C842(60.37); C387(34.71); C939(28.71); C195(13.26)  LDD1702  [42]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C939(1.36); C61(1.07); C85(1.48); C853(1.17)  LDD2187  [44]
 LDCM0572  Fragment10 MDA-MB-231 C842(1.52)  LDD1389  [45]
 LDCM0573  Fragment11 MDA-MB-231 C842(1.33)  LDD1391  [45]
 LDCM0574  Fragment12 Ramos C939(20.00); C61(0.87); C85(1.08); C853(4.14)  LDD2191  [44]
 LDCM0575  Fragment13 MDA-MB-231 C842(1.59)  LDD1395  [45]
 LDCM0576  Fragment14 MDA-MB-231 C842(1.76)  LDD1397  [45]
 LDCM0577  Fragment15 Ramos C842(0.88)  LDD1400  [45]
 LDCM0579  Fragment20 Ramos C842(0.67)  LDD1403  [45]
 LDCM0580  Fragment21 Ramos C842(1.50)  LDD1405  [45]
 LDCM0581  Fragment22 MDA-MB-231 C842(1.27)  LDD1406  [45]
 LDCM0582  Fragment23 Ramos C842(0.17)  LDD1409  [45]
 LDCM0583  Fragment24 Ramos C842(1.11)  LDD1410  [45]
 LDCM0584  Fragment25 MDA-MB-231 C842(0.93)  LDD1411  [45]
 LDCM0585  Fragment26 Ramos C842(0.80)  LDD1412  [45]
 LDCM0578  Fragment27 MDA-MB-231 C842(1.36)  LDD1401  [45]
 LDCM0586  Fragment28 MDA-MB-231 C842(1.04)  LDD1415  [45]
 LDCM0587  Fragment29 MDA-MB-231 C842(0.90)  LDD1417  [45]
 LDCM0588  Fragment30 MDA-MB-231 C842(1.16)  LDD1419  [45]
 LDCM0589  Fragment31 MDA-MB-231 C842(3.06)  LDD1421  [45]
 LDCM0590  Fragment32 MDA-MB-231 C842(6.31)  LDD1423  [45]
 LDCM0468  Fragment33 HCT 116 C272(0.88); C344(0.78); C387(1.12); C61(0.64)  LDD0785  [16]
 LDCM0593  Fragment35 Ramos C842(1.05)  LDD1430  [45]
 LDCM0595  Fragment37 Ramos C842(1.00)  LDD1432  [45]
 LDCM0596  Fragment38 MDA-MB-231 C842(2.14)  LDD1433  [45]
 LDCM0566  Fragment4 MDA-MB-231 C842(1.32)  LDD1378  [45]
 LDCM0598  Fragment40 MDA-MB-231 C842(0.98)  LDD1436  [45]
 LDCM0599  Fragment41 MDA-MB-231 C842(1.60)  LDD1438  [45]
 LDCM0601  Fragment43 MDA-MB-231 C842(1.29)  LDD1441  [45]
 LDCM0602  Fragment44 MDA-MB-231 C842(0.67)  LDD1443  [45]
 LDCM0603  Fragment45 MDA-MB-231 C842(1.71)  LDD1444  [45]
 LDCM0604  Fragment46 MDA-MB-231 C842(0.97)  LDD1445  [45]
 LDCM0605  Fragment47 MDA-MB-231 C842(0.92)  LDD1446  [45]
 LDCM0606  Fragment48 MDA-MB-231 C842(1.11)  LDD1447  [45]
 LDCM0608  Fragment50 MDA-MB-231 C842(3.89)  LDD1449  [45]
 LDCM0427  Fragment51 HCT 116 C272(1.13); C344(0.97); C387(0.87); C61(0.77)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C939(2.40); C61(1.11); C85(1.13); C853(1.73)  LDD2204  [44]
 LDCM0611  Fragment53 MDA-MB-231 C842(1.09)  LDD1454  [45]
 LDCM0612  Fragment54 MDA-MB-231 C842(1.03)  LDD1456  [45]
 LDCM0614  Fragment56 MDA-MB-231 C842(0.89)  LDD1458  [45]
 LDCM0568  Fragment6 MDA-MB-231 C842(1.78)  LDD1382  [45]
 LDCM0569  Fragment7 Ramos C939(13.24); C61(0.83); C85(1.03); C853(2.73)  LDD2186  [44]
 LDCM0570  Fragment8 MDA-MB-231 C842(1.21)  LDD1385  [45]
 LDCM0571  Fragment9 MDA-MB-231 C842(1.27)  LDD1387  [45]
 LDCM0116  HHS-0101 DM93 Y571(2.43)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y571(2.50)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y571(0.64)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y571(2.09)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y571(3.41)  LDD0268  [15]
 LDCM0015  HNE MDA-MB-231 C272(1.20); C842(1.11); C853(1.17); C939(1.05)  LDD0346  [44]
 LDCM0107  IAA HeLa C195(0.00); C344(0.00); H914(0.00); H98(0.00)  LDD0221  [32]
 LDCM0124  JWB142 DM93 Y369(0.39)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y369(1.34)  LDD0287  [14]
 LDCM0127  JWB152 DM93 Y369(2.94)  LDD0289  [14]
 LDCM0129  JWB202 DM93 Y369(0.37)  LDD0291  [14]
 LDCM0179  JZ128 PC-3 C344(0.00); C842(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C272(2.30); C344(1.56); C387(2.41); C939(1.89)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C272(2.47); C344(1.28); C387(2.38); C939(2.12)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C272(4.82); C344(3.80); C387(3.13); C939(1.82)  LDD0082  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C85(0.97); C387(2.30); C272(1.43); C939(2.00)  LDD2102  [42]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C85(1.06); C387(0.49); C272(0.62); C939(0.40)  LDD2121  [42]
 LDCM0109  NEM HeLa H98(0.00); H144(0.00); H914(0.00); C344(0.00)  LDD0223  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C85(1.09); C387(0.57); C272(0.68); C939(0.45)  LDD2089  [42]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C85(1.00); C387(1.51); C272(1.57); C939(1.69)  LDD2090  [42]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C85(0.97); C387(1.21); C272(1.08); C939(1.38)  LDD2092  [42]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C85(1.00); C387(1.03); C272(1.13); C939(0.89)  LDD2093  [42]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C85(1.01); C387(1.38); C272(1.22); C939(1.63)  LDD2094  [42]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C85(1.19); C842(0.34); C195(0.43); C61(1.28)  LDD2096  [42]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C85(0.81); C272(0.95); C939(0.92); C842(1.46)  LDD2097  [42]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C85(0.94); C387(3.01); C272(1.38); C939(0.94)  LDD2098  [42]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C85(1.11); C387(0.88); C272(1.04); C939(0.61)  LDD2099  [42]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C85(1.19); C387(1.78); C272(0.85); C939(0.56)  LDD2100  [42]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C85(0.70); C272(0.87); C939(1.10); C842(1.11)  LDD2101  [42]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C85(0.92); C387(0.94); C272(0.88); C939(1.05)  LDD2104  [42]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C85(0.97); C387(1.22); C272(1.43); C939(1.43)  LDD2105  [42]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C85(1.00); C272(1.25); C939(1.43); C842(0.72)  LDD2106  [42]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C85(1.34); C387(0.92); C272(1.09); C939(0.68)  LDD2107  [42]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C85(0.94); C387(1.05); C272(0.87); C939(0.81)  LDD2108  [42]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C85(0.78); C387(0.81); C272(0.80); C939(0.65)  LDD2109  [42]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C85(1.69); C842(2.06); C195(1.33); C344(0.94)  LDD2110  [42]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C85(1.14); C387(1.10); C939(0.69); C842(0.84)  LDD2111  [42]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C85(0.89); C387(1.11); C272(0.77); C842(0.67)  LDD2114  [42]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C85(0.43); C387(1.26); C272(0.49); C939(0.81)  LDD2115  [42]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C272(0.54); C842(0.63); C195(0.63); C61(2.13)  LDD2116  [42]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C85(1.28); C842(0.71); C195(1.01); C61(1.66)  LDD2118  [42]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C85(2.66); C387(2.18); C272(2.32); C939(3.26)  LDD2119  [42]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C85(0.92); C387(0.87); C272(1.11); C939(0.95)  LDD2120  [42]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C85(1.16); C272(0.62); C939(0.19); C842(0.45)  LDD2122  [42]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C85(1.03); C387(0.78); C272(0.95); C939(0.71)  LDD2123  [42]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C85(1.32); C939(0.12); C842(0.46); C195(0.45)  LDD2124  [42]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C85(0.96); C387(0.78); C272(0.83); C939(0.63)  LDD2125  [42]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C85(1.42); C939(0.27); C842(0.43); C195(0.53)  LDD2126  [42]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C85(1.30); C387(1.23); C272(1.39); C939(0.92)  LDD2127  [42]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C85(1.09); C387(0.87); C939(1.17); C842(0.92)  LDD2128  [42]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C85(1.24); C387(0.89); C272(0.92); C939(0.76)  LDD2129  [42]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C85(0.56); C387(0.56); C272(0.59); C939(1.02)  LDD2133  [42]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C85(0.48); C272(0.46); C939(0.56); C842(0.54)  LDD2134  [42]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C85(1.22); C387(1.11); C272(1.14); C939(0.84)  LDD2135  [42]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C85(1.54); C387(1.70); C272(1.39); C939(0.93)  LDD2136  [42]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C85(1.09); C387(0.81); C272(0.88); C939(0.76)  LDD2137  [42]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C195(3.29); C61(2.73); C85(2.13); C842(1.96)  LDD1700  [42]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C85(0.94); C387(0.77); C272(0.80); C939(0.51)  LDD2140  [42]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C85(1.48); C387(0.72); C272(0.69); C939(0.68)  LDD2141  [42]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C85(1.09); C387(0.97); C939(1.19); C842(1.03)  LDD2143  [42]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C85(2.31); C387(2.52); C272(2.41); C939(3.28)  LDD2144  [42]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C85(6.56); C272(8.26); C939(2.74); C842(2.71)  LDD2145  [42]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C85(1.06); C387(0.83); C272(0.84); C939(0.67)  LDD2146  [42]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C85(2.53); C387(2.98); C939(3.63); C842(3.10)  LDD2147  [42]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C85(0.47); C387(0.63); C272(0.46); C939(0.85)  LDD2148  [42]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C85(1.29); C387(0.69); C272(0.56); C939(0.17)  LDD2149  [42]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C85(0.78); C387(0.48); C272(0.55); C939(0.31)  LDD2150  [42]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C85(1.03); C842(0.59); C195(0.74); C61(1.58)  LDD2151  [42]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C85(1.55); C272(2.19); C939(2.35); C842(3.81)  LDD2153  [42]
 LDCM0627  NUDT7-COV-1 HEK-293T C939(1.14); C939(0.99); C842(0.96); C842(0.62)  LDD2206  [46]
 LDCM0628  OTUB2-COV-1 HEK-293T C272(1.68); C387(0.82); C344(0.82); C272(0.76)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C272(2.00); C853(1.70)  LDD0304  [47]
 LDCM0021  THZ1 HeLa S3 C85(1.09); C842(1.06); C344(1.05)  LDD0460  [11]
 LDCM0113  W17 Hep-G2 C939(1.70)  LDD0240  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) MS4A family Q96JQ5
Cellular tumor antigen p53 (TP53) P53 family P04637
Protein unc-93 homolog B1 (UNC93B1) Unc-93 family Q9H1C4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
P2Y purinoceptor 6 (P2RY6) G-protein coupled receptor 1 family Q15077
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 13B (TNFSF13B) Tumor necrosis factor family Q9Y275
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Ubiquitin-related modifier 1 (URM1) URM1 family Q9BTM9

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
14 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
27 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
28 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
29 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
30 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
31 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
32 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
33 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
34 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
35 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
36 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
38 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
39 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
40 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
41 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
42 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
44 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
45 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
46 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
47 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.