Details of the Target

General Information of Target

Target ID LDTP04374
Target Name Dynamin-2 (DNM2)
Gene Name DNM2
Gene ID 1785
Synonyms
DYN2; Dynamin-2; EC 3.6.5.5; Dynamin 2; Dynamin II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKL
QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL
KEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLID
IEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDL
RQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLV
DSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRD
DMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGR
PPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPP
GIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
Subcellular location
Cytoplasm
Function
Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton. Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis. During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission. Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes. During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers. Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles. Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton. The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1. Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18, by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction. Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane. Also plays a role in cytokinesis. May participate in centrosome cohesion through its interaction with TUBG1. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Involved in membrane tubulation.
TTD ID
T10592
Uniprot ID
P50570
DrugMap ID
TTVRA5G
Ensemble ID
ENST00000355667.11
HGNC ID
HGNC:2974
ChEMBL ID
CHEMBL5812

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		2.85  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y265(20.00); Y726(20.00); Y125(18.46); Y626(5.13)  LDD0257  [4]
TH214
 Probe Info  		Y265(6.42)  LDD0258  [4]
TH216
 Probe Info  		Y726(20.00); Y231(8.60); Y125(6.33); Y265(5.05)  LDD0259  [4]
ONAyne
 Probe Info  		K299(5.88)  LDD0274  [5]
STPyne
 Probe Info  		K299(9.09); K393(10.00); K508(9.10); K577(1.49)  LDD0277  [5]
Probe 1
 Probe Info  		Y154(7.14); Y231(27.98); Y314(85.46); Y463(13.83)  LDD3495  [6]
DBIA
 Probe Info  		C86(2.50)  LDD3310  [7]
BTD
 Probe Info  		C86(0.83)  LDD2089  [8]
AHL-Pu-1
 Probe Info  		C27(2.38)  LDD0171  [9]
HHS-475
 Probe Info  		Y626(0.80); Y597(0.82); Y390(0.82); Y726(0.87)  LDD0264  [10]
HHS-465
 Probe Info  		Y125(1.16); Y265(1.26); Y390(9.87); Y597(3.85)  LDD2237  [11]
W1
 Probe Info  		C27(0.68)  LDD0239  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C427(0.00); C27(0.00); C607(0.00); C86(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C427(0.00); C27(0.00)  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		C427(0.00); C424(0.00); C27(0.00); C607(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C27(0.00); C86(0.00)  LDD2226  [19]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
IPM
 Probe Info  		N.A.  LDD0005  [21]
NHS
 Probe Info  		N.A.  LDD0010  [21]
Acrolein
 Probe Info  		C86(0.00); H85(0.00)  LDD0217  [22]
AOyne
 Probe Info  		6.60  LDD0443  [23]
NAIA_5
 Probe Info  		C427(0.00); C27(0.00); C424(0.00); C607(0.00)  LDD2223  [19]
HHS-482
 Probe Info  		Y390(1.47)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C112
 Probe Info  		28.64  LDD1799  [24]
C174
 Probe Info  		6.11  LDD1854  [24]
C244
 Probe Info  		16.45  LDD1917  [24]
C264
 Probe Info  		18.38  LDD1935  [24]
FFF probe11
 Probe Info  		10.88  LDD0471  [25]
FFF probe13
 Probe Info  		18.23  LDD0475  [25]
FFF probe14
 Probe Info  		13.50  LDD0477  [25]
FFF probe2
 Probe Info  		7.59  LDD0463  [25]
FFF probe3
 Probe Info  		17.02  LDD0464  [25]
FFF probe6
 Probe Info  		10.78  LDD0467  [25]
JN0003
 Probe Info  		12.21  LDD0469  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
SAHA-CA-8PAP
 Probe Info  		6.50  LDD0362  [27]
DA-2
 Probe Info  		N.A.  LDD0073  [28]
OEA-DA
 Probe Info  		3.03  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C424(0.98); C86(1.32)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C424(1.02)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C424(0.80)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C424(0.95)  LDD2132  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C27(2.38)  LDD0171  [9]
 LDCM0214  AC1 PaTu 8988t C427(0.32)  LDD1093  [30]
 LDCM0215  AC10 PaTu 8988t C427(0.95)  LDD1094  [30]
 LDCM0216  AC100 HEK-293T C427(1.05)  LDD0814  [30]
 LDCM0217  AC101 HEK-293T C427(1.33)  LDD0815  [30]
 LDCM0218  AC102 HEK-293T C427(1.35)  LDD0816  [30]
 LDCM0219  AC103 HEK-293T C427(1.40)  LDD0817  [30]
 LDCM0220  AC104 HEK-293T C427(1.45)  LDD0818  [30]
 LDCM0221  AC105 HEK-293T C427(0.76)  LDD0819  [30]
 LDCM0222  AC106 HEK-293T C427(0.85)  LDD0820  [30]
 LDCM0223  AC107 HEK-293T C427(1.07)  LDD0821  [30]
 LDCM0224  AC108 HEK-293T C427(0.92)  LDD0822  [30]
 LDCM0225  AC109 HEK-293T C427(1.20)  LDD0823  [30]
 LDCM0226  AC11 PaTu 8988t C427(0.95)  LDD1105  [30]
 LDCM0227  AC110 HEK-293T C427(2.26)  LDD0825  [30]
 LDCM0228  AC111 HEK-293T C427(3.06)  LDD0826  [30]
 LDCM0229  AC112 HEK-293T C427(2.33)  LDD0827  [30]
 LDCM0230  AC113 PaTu 8988t C427(1.35)  LDD1109  [30]
 LDCM0231  AC114 PaTu 8988t C427(1.38)  LDD1110  [30]
 LDCM0232  AC115 PaTu 8988t C427(1.08)  LDD1111  [30]
 LDCM0233  AC116 PaTu 8988t C427(1.32)  LDD1112  [30]
 LDCM0234  AC117 PaTu 8988t C427(1.39)  LDD1113  [30]
 LDCM0235  AC118 PaTu 8988t C427(1.01)  LDD1114  [30]
 LDCM0236  AC119 PaTu 8988t C427(0.93)  LDD1115  [30]
 LDCM0237  AC12 PaTu 8988t C427(0.82)  LDD1116  [30]
 LDCM0238  AC120 PaTu 8988t C427(1.38)  LDD1117  [30]
 LDCM0239  AC121 PaTu 8988t C427(1.36)  LDD1118  [30]
 LDCM0240  AC122 PaTu 8988t C427(1.15)  LDD1119  [30]
 LDCM0241  AC123 PaTu 8988t C427(1.12)  LDD1120  [30]
 LDCM0242  AC124 PaTu 8988t C427(1.09)  LDD1121  [30]
 LDCM0243  AC125 PaTu 8988t C427(0.86)  LDD1122  [30]
 LDCM0244  AC126 PaTu 8988t C427(1.11)  LDD1123  [30]
 LDCM0245  AC127 PaTu 8988t C427(0.95)  LDD1124  [30]
 LDCM0259  AC14 PaTu 8988t C427(0.92)  LDD1138  [30]
 LDCM0270  AC15 PaTu 8988t C427(0.95)  LDD1149  [30]
 LDCM0276  AC17 HEK-293T C424(1.21); C27(1.04); C427(0.93); C86(1.04)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C424(1.08); C27(0.94); C427(1.14); C86(0.99)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C424(1.24); C27(0.87); C427(0.94); C86(1.02)  LDD1517  [31]
 LDCM0279  AC2 PaTu 8988t C427(0.33)  LDD1158  [30]
 LDCM0280  AC20 HEK-293T C424(1.16); C27(1.00); C427(1.06); C86(0.93)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C424(1.04); C27(1.07); C427(0.93); C86(0.94)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C424(1.22); C27(1.12); C427(1.02); C86(0.93)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C424(1.10); C27(1.09); C427(0.95); C86(1.07)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C424(1.01); C27(1.11); C427(0.82); C86(1.08)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C427(0.99)  LDD0883  [30]
 LDCM0286  AC26 HEK-293T C427(0.89)  LDD0884  [30]
 LDCM0287  AC27 HEK-293T C427(0.93)  LDD0885  [30]
 LDCM0288  AC28 HEK-293T C427(1.27)  LDD0886  [30]
 LDCM0289  AC29 HEK-293T C427(0.96)  LDD0887  [30]
 LDCM0290  AC3 PaTu 8988t C427(0.31)  LDD1169  [30]
 LDCM0291  AC30 HEK-293T C427(1.15)  LDD0889  [30]
 LDCM0292  AC31 HEK-293T C427(1.07)  LDD0890  [30]
 LDCM0293  AC32 HEK-293T C427(0.80)  LDD0891  [30]
 LDCM0294  AC33 HEK-293T C427(1.06)  LDD0892  [30]
 LDCM0295  AC34 HEK-293T C427(0.80)  LDD0893  [30]
 LDCM0296  AC35 HEK-293T C424(1.08); C27(1.16); C427(1.00); C86(0.91)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C424(1.10); C27(0.99); C427(1.09); C86(0.91)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C424(0.93); C27(1.04); C427(0.92); C86(0.96)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C424(1.11); C27(0.97); C427(1.10); C86(1.02)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C424(1.05); C27(1.13); C427(1.02); C86(1.01)  LDD1539  [31]
 LDCM0301  AC4 PaTu 8988t C427(0.28)  LDD1180  [30]
 LDCM0302  AC40 HEK-293T C424(1.27); C27(1.06); C427(0.85); C86(1.00)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C424(1.05); C27(1.05); C427(0.80); C86(0.96)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C424(1.02); C27(0.90); C427(1.09); C86(0.90)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C424(0.95); C27(0.96); C427(0.99); C86(0.91)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C424(1.00); C27(0.90); C427(1.02); C86(1.01)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C424(0.98); C27(1.06); C427(1.03); C86(0.90)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C427(1.10)  LDD0906  [30]
 LDCM0309  AC47 HEK-293T C427(1.29)  LDD0907  [30]
 LDCM0310  AC48 HEK-293T C427(1.18)  LDD0908  [30]
 LDCM0311  AC49 HEK-293T C427(1.23)  LDD0909  [30]
 LDCM0312  AC5 PaTu 8988t C427(0.22)  LDD1191  [30]
 LDCM0313  AC50 HEK-293T C427(1.24)  LDD0911  [30]
 LDCM0314  AC51 HEK-293T C427(1.48)  LDD0912  [30]
 LDCM0315  AC52 HEK-293T C427(1.39)  LDD0913  [30]
 LDCM0316  AC53 HEK-293T C427(1.24)  LDD0914  [30]
 LDCM0317  AC54 HEK-293T C427(1.41)  LDD0915  [30]
 LDCM0318  AC55 HEK-293T C427(1.33)  LDD0916  [30]
 LDCM0319  AC56 HEK-293T C427(1.11)  LDD0917  [30]
 LDCM0320  AC57 HEK-293T C427(0.81)  LDD0918  [30]
 LDCM0321  AC58 HEK-293T C427(0.71)  LDD0919  [30]
 LDCM0322  AC59 HEK-293T C427(0.91)  LDD0920  [30]
 LDCM0323  AC6 PaTu 8988t C427(0.87)  LDD1202  [30]
 LDCM0324  AC60 HEK-293T C427(1.36)  LDD0922  [30]
 LDCM0325  AC61 HEK-293T C427(1.56)  LDD0923  [30]
 LDCM0326  AC62 HEK-293T C427(0.90)  LDD0924  [30]
 LDCM0327  AC63 HEK-293T C427(0.95)  LDD0925  [30]
 LDCM0328  AC64 HEK-293T C427(0.78)  LDD0926  [30]
 LDCM0329  AC65 HEK-293T C427(1.19)  LDD0927  [30]
 LDCM0330  AC66 HEK-293T C427(0.82)  LDD0928  [30]
 LDCM0331  AC67 HEK-293T C427(1.06)  LDD0929  [30]
 LDCM0334  AC7 PaTu 8988t C427(0.89)  LDD1213  [30]
 LDCM0345  AC8 PaTu 8988t C427(0.85)  LDD1224  [30]
 LDCM0349  AC83 HEK-293T C427(0.86)  LDD0947  [30]
 LDCM0350  AC84 HEK-293T C427(1.20)  LDD0948  [30]
 LDCM0351  AC85 HEK-293T C427(0.90)  LDD0949  [30]
 LDCM0352  AC86 HEK-293T C427(1.06)  LDD0950  [30]
 LDCM0353  AC87 HEK-293T C427(1.17)  LDD0951  [30]
 LDCM0354  AC88 HEK-293T C427(1.27)  LDD0952  [30]
 LDCM0355  AC89 HEK-293T C427(1.42)  LDD0953  [30]
 LDCM0357  AC90 HEK-293T C427(1.34)  LDD0955  [30]
 LDCM0358  AC91 HEK-293T C427(1.17)  LDD0956  [30]
 LDCM0359  AC92 HEK-293T C427(1.08)  LDD0957  [30]
 LDCM0360  AC93 HEK-293T C427(1.13)  LDD0958  [30]
 LDCM0361  AC94 HEK-293T C427(1.35)  LDD0959  [30]
 LDCM0362  AC95 HEK-293T C427(1.23)  LDD0960  [30]
 LDCM0363  AC96 HEK-293T C427(1.26)  LDD0961  [30]
 LDCM0364  AC97 HEK-293T C427(2.80)  LDD0962  [30]
 LDCM0365  AC98 HEK-293T C427(0.93)  LDD0963  [30]
 LDCM0366  AC99 HEK-293T C427(0.80)  LDD0964  [30]
 LDCM0248  AKOS034007472 PaTu 8988t C427(0.92)  LDD1127  [30]
 LDCM0356  AKOS034007680 PaTu 8988t C427(1.01)  LDD1235  [30]
 LDCM0275  AKOS034007705 PaTu 8988t C427(1.04)  LDD1154  [30]
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C424(0.42)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C27(1.44)  LDD2214  [32]
 LDCM0108  Chloroacetamide HeLa C86(0.00); H85(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C424(20.00); C86(0.94)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C424(1.15); C27(0.95); C427(0.88); C86(0.88)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C424(0.90); C27(1.23); C427(1.17); C86(1.07)  LDD1572  [31]
 LDCM0369  CL100 PaTu 8988t C427(0.22)  LDD1248  [30]
 LDCM0370  CL101 PaTu 8988t C427(0.95)  LDD1249  [30]
 LDCM0371  CL102 PaTu 8988t C427(0.81)  LDD1250  [30]
 LDCM0372  CL103 PaTu 8988t C427(1.00)  LDD1251  [30]
 LDCM0373  CL104 PaTu 8988t C427(0.88)  LDD1252  [30]
 LDCM0374  CL105 HEK-293T C424(1.12); C27(1.03); C427(1.01); C86(0.83)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C424(1.13); C27(0.99); C427(1.05); C86(0.99)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C424(1.14); C27(1.03); C427(0.99); C86(1.00)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C424(1.17); C27(0.97); C427(1.00); C86(1.04)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C424(1.13); C27(0.95); C427(0.94); C86(0.94)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C424(0.79); C27(1.08); C427(1.26); C86(1.12)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C424(1.16); C27(1.16); C427(1.02); C86(0.94)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C424(1.19); C27(1.10); C427(1.04); C86(0.99)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C427(1.53)  LDD0980  [30]
 LDCM0383  CL113 HEK-293T C427(0.95)  LDD0981  [30]
 LDCM0384  CL114 HEK-293T C427(1.91)  LDD0982  [30]
 LDCM0385  CL115 HEK-293T C427(1.36)  LDD0983  [30]
 LDCM0386  CL116 HEK-293T C427(1.04)  LDD0984  [30]
 LDCM0387  CL117 HEK-293T C424(1.06); C27(0.95); C427(0.96); C86(0.86)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C424(1.08); C27(0.92); C427(1.07); C86(0.93)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C424(1.11); C27(0.99); C427(0.97); C86(0.84)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C424(0.98); C27(1.01); C427(0.95); C86(1.06)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C424(1.03); C27(0.83); C427(0.91); C86(0.89)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C427(1.41)  LDD0990  [30]
 LDCM0393  CL122 HEK-293T C427(1.24)  LDD0991  [30]
 LDCM0394  CL123 HEK-293T C427(1.26)  LDD0992  [30]
 LDCM0395  CL124 HEK-293T C427(1.31)  LDD0993  [30]
 LDCM0396  CL125 HEK-293T C427(0.97)  LDD0994  [30]
 LDCM0397  CL126 HEK-293T C427(0.97)  LDD0995  [30]
 LDCM0398  CL127 HEK-293T C427(0.78)  LDD0996  [30]
 LDCM0399  CL128 HEK-293T C427(0.74)  LDD0997  [30]
 LDCM0400  CL13 HEK-293T C424(1.01); C27(0.88); C427(0.89); C86(0.88)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C424(1.10); C27(1.07); C427(1.03); C86(0.93)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C424(1.15); C27(0.93); C427(1.07); C86(0.87)  LDD1606  [31]
 LDCM0403  CL16 PaTu 8988t C427(1.20)  LDD1282  [30]
 LDCM0404  CL17 PaTu 8988t C427(0.95)  LDD1283  [30]
 LDCM0405  CL18 PaTu 8988t C427(1.45)  LDD1284  [30]
 LDCM0406  CL19 PaTu 8988t C427(1.24)  LDD1285  [30]
 LDCM0407  CL2 HEK-293T C424(1.10); C27(1.12); C427(1.01); C86(0.93)  LDD1611  [31]
 LDCM0408  CL20 PaTu 8988t C427(1.44)  LDD1287  [30]
 LDCM0409  CL21 PaTu 8988t C427(1.54)  LDD1288  [30]
 LDCM0410  CL22 PaTu 8988t C427(1.37)  LDD1289  [30]
 LDCM0411  CL23 PaTu 8988t C427(1.26)  LDD1290  [30]
 LDCM0412  CL24 PaTu 8988t C427(1.28)  LDD1291  [30]
 LDCM0413  CL25 PaTu 8988t C427(1.05)  LDD1292  [30]
 LDCM0414  CL26 PaTu 8988t C427(1.36)  LDD1293  [30]
 LDCM0415  CL27 PaTu 8988t C427(1.15)  LDD1294  [30]
 LDCM0416  CL28 PaTu 8988t C427(1.22)  LDD1295  [30]
 LDCM0417  CL29 PaTu 8988t C427(1.40)  LDD1296  [30]
 LDCM0418  CL3 HEK-293T C424(1.14); C27(1.00); C427(1.03); C86(0.95)  LDD1622  [31]
 LDCM0419  CL30 PaTu 8988t C427(1.15)  LDD1298  [30]
 LDCM0420  CL31 HEK-293T C424(0.95); C27(0.87); C427(0.92); C86(1.08)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C424(0.83); C27(0.94); C427(1.09); C86(1.04)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C424(0.87); C27(0.93); C427(1.11); C86(1.05)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C424(0.87); C27(0.95); C427(1.13); C86(1.20)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C424(0.79); C27(1.03); C427(0.98); C86(1.17)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C424(0.88); C27(1.05); C427(0.98); C86(1.11)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C424(1.02); C27(0.54); C427(0.86); C86(0.95)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C424(1.04); C27(1.05); C427(1.06); C86(0.89)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C424(1.10); C27(0.89); C427(1.07); C86(1.06)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C424(1.05); C27(1.08); C427(0.90); C86(1.00)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C424(0.96); C27(1.15); C427(0.82); C86(0.94)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C424(0.90); C27(0.91); C427(1.03); C86(0.99)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C424(0.84); C27(0.92); C427(1.16); C86(1.04)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C424(0.90); C27(0.93); C427(1.02); C86(0.99)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C424(0.76); C27(0.93); C427(0.99); C86(0.99)  LDD1639  [31]
 LDCM0436  CL46 PaTu 8988t C427(0.86)  LDD1315  [30]
 LDCM0437  CL47 PaTu 8988t C427(0.90)  LDD1316  [30]
 LDCM0438  CL48 PaTu 8988t C427(0.81)  LDD1317  [30]
 LDCM0439  CL49 PaTu 8988t C427(0.82)  LDD1318  [30]
 LDCM0440  CL5 HEK-293T C424(0.96); C27(0.82); C427(0.98); C86(0.98)  LDD1644  [31]
 LDCM0441  CL50 PaTu 8988t C427(0.79)  LDD1320  [30]
 LDCM0442  CL51 PaTu 8988t C427(0.87)  LDD1321  [30]
 LDCM0443  CL52 PaTu 8988t C427(0.83)  LDD1322  [30]
 LDCM0444  CL53 PaTu 8988t C427(0.78)  LDD1323  [30]
 LDCM0445  CL54 PaTu 8988t C427(0.87)  LDD1324  [30]
 LDCM0446  CL55 PaTu 8988t C427(0.80)  LDD1325  [30]
 LDCM0447  CL56 PaTu 8988t C427(0.75)  LDD1326  [30]
 LDCM0448  CL57 PaTu 8988t C427(0.75)  LDD1327  [30]
 LDCM0449  CL58 PaTu 8988t C427(0.75)  LDD1328  [30]
 LDCM0450  CL59 PaTu 8988t C427(0.84)  LDD1329  [30]
 LDCM0451  CL6 HEK-293T C424(0.96); C27(0.87); C427(0.97); C86(1.03)  LDD1654  [31]
 LDCM0452  CL60 PaTu 8988t C427(0.82)  LDD1331  [30]
 LDCM0453  CL61 HEK-293T C427(0.92)  LDD1051  [30]
 LDCM0454  CL62 HEK-293T C427(0.75)  LDD1052  [30]
 LDCM0455  CL63 HEK-293T C427(1.02)  LDD1053  [30]
 LDCM0456  CL64 HEK-293T C427(1.15)  LDD1054  [30]
 LDCM0457  CL65 HEK-293T C427(1.15)  LDD1055  [30]
 LDCM0458  CL66 HEK-293T C427(1.10)  LDD1056  [30]
 LDCM0459  CL67 HEK-293T C427(1.23)  LDD1057  [30]
 LDCM0460  CL68 HEK-293T C427(1.18)  LDD1058  [30]
 LDCM0461  CL69 HEK-293T C427(1.52)  LDD1059  [30]
 LDCM0462  CL7 HEK-293T C424(0.88); C27(0.96); C427(0.97); C86(1.08)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C427(1.50)  LDD1061  [30]
 LDCM0464  CL71 HEK-293T C427(2.38)  LDD1062  [30]
 LDCM0465  CL72 HEK-293T C427(1.34)  LDD1063  [30]
 LDCM0466  CL73 HEK-293T C427(1.42)  LDD1064  [30]
 LDCM0467  CL74 HEK-293T C427(3.07)  LDD1065  [30]
 LDCM0469  CL76 HEK-293T C427(0.92)  LDD1067  [30]
 LDCM0470  CL77 HEK-293T C427(0.77)  LDD1068  [30]
 LDCM0471  CL78 HEK-293T C427(1.45)  LDD1069  [30]
 LDCM0472  CL79 HEK-293T C427(1.16)  LDD1070  [30]
 LDCM0473  CL8 HEK-293T C424(1.13); C27(0.87); C427(1.39); C86(0.96)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C427(1.19)  LDD1072  [30]
 LDCM0475  CL81 HEK-293T C427(1.08)  LDD1073  [30]
 LDCM0476  CL82 HEK-293T C427(0.75)  LDD1074  [30]
 LDCM0477  CL83 HEK-293T C427(0.88)  LDD1075  [30]
 LDCM0478  CL84 HEK-293T C427(1.15)  LDD1076  [30]
 LDCM0479  CL85 HEK-293T C427(1.26)  LDD1077  [30]
 LDCM0480  CL86 HEK-293T C427(1.09)  LDD1078  [30]
 LDCM0481  CL87 HEK-293T C427(1.08)  LDD1079  [30]
 LDCM0482  CL88 HEK-293T C427(1.21)  LDD1080  [30]
 LDCM0483  CL89 HEK-293T C427(1.47)  LDD1081  [30]
 LDCM0484  CL9 HEK-293T C424(0.73); C27(0.99); C427(0.94); C86(1.03)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C427(1.33)  LDD1083  [30]
 LDCM0486  CL91 PaTu 8988t C427(0.25)  LDD1365  [30]
 LDCM0487  CL92 PaTu 8988t C427(0.23)  LDD1366  [30]
 LDCM0488  CL93 PaTu 8988t C427(0.26)  LDD1367  [30]
 LDCM0489  CL94 PaTu 8988t C427(0.36)  LDD1368  [30]
 LDCM0490  CL95 PaTu 8988t C427(0.23)  LDD1369  [30]
 LDCM0491  CL96 PaTu 8988t C427(0.30)  LDD1370  [30]
 LDCM0492  CL97 PaTu 8988t C427(0.62)  LDD1371  [30]
 LDCM0493  CL98 PaTu 8988t C427(0.27)  LDD1372  [30]
 LDCM0494  CL99 PaTu 8988t C427(0.24)  LDD1373  [30]
 LDCM0634  CY-0357 Hep-G2 C27(1.15)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C424(1.12); C27(0.92); C427(0.99); C86(0.90)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C27(2.73); C86(1.60)  LDD1702  [8]
 LDCM0625  F8 Ramos C27(1.08)  LDD2187  [33]
 LDCM0572  Fragment10 MDA-MB-231 C27(1.33)  LDD1389  [34]
 LDCM0573  Fragment11 MDA-MB-231 C27(1.00)  LDD1391  [34]
 LDCM0574  Fragment12 Ramos C27(0.65)  LDD1394  [34]
 LDCM0575  Fragment13 MDA-MB-231 C27(1.00)  LDD1395  [34]
 LDCM0576  Fragment14 MDA-MB-231 C27(1.55)  LDD1397  [34]
 LDCM0577  Fragment15 Ramos C27(1.09)  LDD1400  [34]
 LDCM0579  Fragment20 MDA-MB-231 C27(1.19)  LDD1402  [34]
 LDCM0580  Fragment21 MDA-MB-231 C27(0.78)  LDD1404  [34]
 LDCM0581  Fragment22 MDA-MB-231 C27(0.98)  LDD1406  [34]
 LDCM0582  Fragment23 MDA-MB-231 C27(1.66)  LDD1408  [34]
 LDCM0583  Fragment24 Ramos C27(1.64)  LDD1410  [34]
 LDCM0584  Fragment25 MDA-MB-231 C27(1.31)  LDD1411  [34]
 LDCM0585  Fragment26 Ramos C27(0.91)  LDD1412  [34]
 LDCM0578  Fragment27 MDA-MB-231 C27(1.02)  LDD1401  [34]
 LDCM0586  Fragment28 MDA-MB-231 C27(0.92)  LDD1415  [34]
 LDCM0587  Fragment29 MDA-MB-231 C27(1.27)  LDD1417  [34]
 LDCM0588  Fragment30 MDA-MB-231 C27(0.74)  LDD1419  [34]
 LDCM0589  Fragment31 MDA-MB-231 C27(2.17)  LDD1421  [34]
 LDCM0590  Fragment32 MDA-MB-231 C27(1.12)  LDD1423  [34]
 LDCM0468  Fragment33 HEK-293T C427(2.34)  LDD1066  [30]
 LDCM0592  Fragment34 MDA-MB-231 C27(0.76)  LDD1427  [34]
 LDCM0593  Fragment35 MDA-MB-231 C27(0.80)  LDD1429  [34]
 LDCM0594  Fragment36 MDA-MB-231 C27(2.02)  LDD1431  [34]
 LDCM0595  Fragment37 Ramos C27(0.92)  LDD1432  [34]
 LDCM0596  Fragment38 MDA-MB-231 C27(0.94)  LDD1433  [34]
 LDCM0566  Fragment4 MDA-MB-231 C27(1.21)  LDD1378  [34]
 LDCM0598  Fragment40 MDA-MB-231 C27(0.81)  LDD1436  [34]
 LDCM0599  Fragment41 MDA-MB-231 C27(1.31)  LDD1438  [34]
 LDCM0600  Fragment42 Ramos C27(0.97)  LDD1440  [34]
 LDCM0601  Fragment43 MDA-MB-231 C27(0.96)  LDD1441  [34]
 LDCM0602  Fragment44 MDA-MB-231 C27(0.88)  LDD1443  [34]
 LDCM0603  Fragment45 MDA-MB-231 C27(2.53)  LDD1444  [34]
 LDCM0604  Fragment46 MDA-MB-231 C27(1.04)  LDD1445  [34]
 LDCM0605  Fragment47 MDA-MB-231 C27(1.36)  LDD1446  [34]
 LDCM0607  Fragment49 MDA-MB-231 C27(1.16)  LDD1448  [34]
 LDCM0608  Fragment50 MDA-MB-231 C27(1.29)  LDD1449  [34]
 LDCM0427  Fragment51 MDA-MB-231 C27(0.96)  LDD1450  [34]
 LDCM0610  Fragment52 MDA-MB-231 C27(1.05)  LDD1452  [34]
 LDCM0611  Fragment53 MDA-MB-231 C27(1.00)  LDD1454  [34]
 LDCM0612  Fragment54 MDA-MB-231 C27(1.28)  LDD1456  [34]
 LDCM0613  Fragment55 MDA-MB-231 C27(0.89)  LDD1457  [34]
 LDCM0614  Fragment56 MDA-MB-231 C27(0.96)  LDD1458  [34]
 LDCM0568  Fragment6 MDA-MB-231 C27(1.62)  LDD1382  [34]
 LDCM0569  Fragment7 MDA-MB-231 C27(1.14)  LDD1383  [34]
 LDCM0570  Fragment8 MDA-MB-231 C27(0.98)  LDD1385  [34]
 LDCM0571  Fragment9 MDA-MB-231 C27(0.92)  LDD1387  [34]
 LDCM0116  HHS-0101 DM93 Y626(0.80); Y597(0.82); Y390(0.82); Y726(0.87)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y563(0.75); Y390(0.76); Y597(0.79); Y626(0.83)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y563(0.53); Y597(0.72); Y390(0.79); Y626(0.89)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y314(0.52); Y563(0.72); Y125(0.72); Y597(0.85)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y314(0.68); Y597(0.77); Y726(0.88); Y390(0.97)  LDD0268  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [22]
 LDCM0022  KB02 MDA-MB-231 C27(1.64)  LDD1374  [34]
 LDCM0023  KB03 MDA-MB-231 C27(2.21)  LDD1376  [34]
 LDCM0024  KB05 COLO792 C86(2.50)  LDD3310  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C424(1.19)  LDD2102  [8]
 LDCM0109  NEM HeLa H288(0.00); H396(0.00); H681(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C86(0.83)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C424(1.16)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C424(0.89); C86(0.92)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C424(1.01)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C424(1.24); C86(1.04)  LDD2094  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C424(1.01)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C424(0.91); C86(1.41)  LDD2099  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C424(1.69)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C424(1.05)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C424(0.63); C86(0.77)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C424(0.90)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C424(0.70)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C424(2.65); C86(0.96)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C424(0.84)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C424(0.77); C86(1.03)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C424(0.66)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C424(0.88)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C424(0.97)  LDD2129  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C424(0.63)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C86(1.00)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C424(1.30); C86(1.87)  LDD2136  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C424(0.57); C86(0.99)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C424(0.90)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C424(2.96); C86(1.85)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C86(1.26)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C424(2.28)  LDD2147  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C424(0.38)  LDD2150  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C424(2.06)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C27(0.69)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C27(1.26)  LDD2207  [35]
 LDCM0131  RA190 MM1.R C27(1.54)  LDD0304  [36]
 LDCM0096  SAHA K562 6.50  LDD0362  [27]
 LDCM0112  W16 Hep-G2 C27(0.68)  LDD0239  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) ABHD17 family Q6PCB6
Piwi-like protein 1 (PIWIL1) Argonaute family Q96J94
Tyrosyl-DNA phosphodiesterase 2 (TDP2) CCR4/nocturin family O95551
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Probable ATP-dependent RNA helicase DDX20 (DDX20) DEAD box helicase family Q9UHI6
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
5' exonuclease Apollo (DCLRE1B) DNA repair metallo-beta-lactamase (DRMBL) family Q9H816
Serine protease FAM111B (FAM111B) FAM111 family Q6SJ93
Eyes absent homolog 3 (EYA3) EYA family Q99504
Hexokinase-3 (HK3) Hexokinase family P52790
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Nucleoside diphosphate kinase B (NME2) NDK family P22392
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Mitogen-activated protein kinase 11 (MAPK11) CMGC Ser/Thr protein kinase family Q15759
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
RNA exonuclease 4 (REXO4) REXO4 family Q9GZR2
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Zinc-regulated GTPase metalloprotein activator 1C (ZNG1C) SIMIBI class G3E GTPase family Q5JTY5
Ras-related protein Rab-35 (RAB35) Rab family Q15286
Ras-related protein Rab-38 (RAB38) Rab family P57729
Thioredoxin (TXN) Thioredoxin family P10599
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
Unconventional myosin-Ie (MYO1E) Myosin family Q12965
Ataxin-3 (ATXN3) . P54252
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Bcl-2-related ovarian killer protein (BOK) Bcl-2 family Q9UMX3
Occludin (OCLN) ELL/occludin family Q16625
Huntingtin (HTT) Huntingtin family P42858
Solute carrier family 52, riboflavin transporter, member 3 (SLC52A3) Riboflavin transporter family Q9NQ40
Sorting nexin-2 (SNX2) Sorting nexin family O60749
Sorting nexin-33 (SNX33) Sorting nexin family Q8WV41
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Thyrotroph embryonic factor (TEF) BZIP family Q10587
Zinc finger protein 697 (ZNF697) Krueppel C2H2-type zinc-finger protein family Q5TEC3
Nuclear receptor subfamily 0 group B member 2 (NR0B2) Nuclear hormone receptor family Q15466
Paired mesoderm homeobox protein 2A (PHOX2A) Paired homeobox family O14813
Visual system homeobox 2 (VSX2) Paired homeobox family P58304
Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) . Q9H147
Forkhead box protein R1 (FOXR1) . Q6PIV2
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Zinc finger and BTB domain-containing protein 38 (ZBTB38) . Q8NAP3
Zinc finger protein 366 (ZNF366) . Q8N895
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-4 (FZD4) G-protein coupled receptor Fz/Smo family Q9ULV1
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Granulocyte-macrophage colony-stimulating factor (CSF2) GM-CSF family P04141
Other
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mth938 domain-containing protein (AAMDC) AAMDC family Q9H7C9
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Transgelin-2 (TAGLN2) Calponin family P37802
DAP3-binding cell death enhancer 1 (DELE1) DELE1 family Q14154
Endophilin-A1 (SH3GL2) Endophilin family Q99962
Ferritin light chain (FTL) Ferritin family P02792
Golgi phosphoprotein 3-like (GOLPH3L) GOLPH3/VPS74 family Q9H4A5
GRB2-related adapter protein (GRAP) GRB2/sem-5/DRK family Q13588
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Histone H2A.Z (H2AZ1) Histone H2A family P0C0S5
Histone H3.1 (H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12) Histone H3 family P68431
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Nucleosome assembly protein 1-like 3 (NAP1L3) Nucleosome assembly protein (NAP) family Q99457
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) PACSIN family Q9UNF0
Prolactin-inducible protein (PIP) PIP family P12273
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Charged multivesicular body protein 6 (CHMP6) SNF7 family Q96FZ7
Sorting nexin-9 (SNX9) Sorting nexin family Q9Y5X1
Syntaxin-11 (STX11) Syntaxin family O75558
Fasciculation and elongation protein zeta-2 (FEZ2) Zygin family Q9UHY8
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
BAG family molecular chaperone regulator 3 (BAG3) . O95817
C-type lectin domain family 2 member B (CLEC2B) . Q92478
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Chromobox protein homolog 1 (CBX1) . P83916
Cytokine-inducible SH2-containing protein (CISH) . Q9NSE2
F-box only protein 42 (FBXO42) . Q6P3S6
F-box/LRR-repeat protein 4 (FBXL4) . Q9UKA2
Galectin-9C (LGALS9C) . Q6DKI2
Intersectin-1 (ITSN1) . Q15811
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
Jouberin (AHI1) . Q8N157
Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) . Q9UI95
Nebulette (NEBL) . O76041
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein MGARP (MGARP) . Q8TDB4
SH3 domain-binding protein 4 (SH3BP4) . Q9P0V3
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Src substrate cortactin (CTTN) . Q14247
TP53-binding protein 1 (TP53BP1) . Q12888
Trefoil factor 2 (TFF2) . Q03403

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ionis-dnm2-2.5rx Antisense oligonucleotide DLCB65

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.