Details of the Target

General Information of Target

Target ID LDTP09912
Target Name DNA repair protein RAD50 (RAD50)
Gene Name RAD50
Gene ID 10111
Synonyms
DNA repair protein RAD50; hRAD50; EC 3.6.-.-
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTA
AHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSE
LIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNM
LCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKT
IQAK
Target Bioclass
Enzyme
Family
SMC family, RAD50 subfamily
Subcellular location
Nucleus
Function
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Uniprot ID
Q92878
Ensemble ID
ENST00000378823.8
HGNC ID
HGNC:9816

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T532I .
CAL148 SNV: p.D1238N DBIA    Probe Info 
CHL1 SNV: p.D324N DBIA    Probe Info 
DU145 SNV: p.N509K DBIA    Probe Info 
HCT116 Deletion: p.K722RfsTer14 .
HEC1 SNV: p.P780T DBIA    Probe Info 
HGC27 SNV: p.T1127I DBIA    Probe Info 
HT115 SNV: p.E526D DBIA    Probe Info 
IGROV1 Deletion: p.K722RfsTer14 DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.K722RfsTer14 DBIA    Probe Info 
JURKAT Deletion: p.G124VfsTer6
SNV: p.N1066S		 .
LNCaP clone FGC Deletion: p.K722RfsTer14 DBIA    Probe Info 
MFE296 Insertion: p.N459KfsTer5 DBIA    Probe Info 
MFE319 Deletion: p.K722RfsTer14 DBIA    Probe Info 
MOLT4 SNV: p.R656Ter; p.Q882Ter IA-alkyne    Probe Info 
RL952 Deletion: p.K722RfsTer14 DBIA    Probe Info 
SNU1 SNV: p.I611V DBIA    Probe Info 
SW403 SNV: p.Q104H DBIA    Probe Info 
WM793 SNV: p.E1037K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.09  LDD0402  [1]
TH211
 Probe Info  		Y957(18.08); Y1125(7.62); Y1282(6.05)  LDD0257  [2]
Probe 1
 Probe Info  		Y244(24.93); Y462(18.73); Y625(26.66); Y902(8.85)  LDD3495  [3]
BTD
 Probe Info  		C221(0.68)  LDD2089  [4]
AHL-Pu-1
 Probe Info  		C633(2.97)  LDD0168  [5]
DBIA
 Probe Info  		C48(14.18); C1296(4.60); C102(12.38); C53(7.12)  LDD0209  [6]
HHS-475
 Probe Info  		Y902(0.33); Y244(0.35); Y957(0.57)  LDD0264  [7]
5E-2FA
 Probe Info  		H530(0.00); H993(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K264(0.00); K267(0.00); K126(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C102(0.00); C48(0.00); C788(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C1302(0.00); C1296(0.00); C157(0.00)  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C133(0.00); C1296(0.00); C102(0.00); C48(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		C1302(0.00); C48(0.00)  LDD0026  [12]
TFBX
 Probe Info  		C1296(0.00); C1302(0.00); C53(0.00); C48(0.00)  LDD0027  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
1d-yne
 Probe Info  		N.A.  LDD0356  [14]
ENE
 Probe Info  		C133(0.00); C1296(0.00)  LDD0006  [13]
IPM
 Probe Info  		C1296(0.00); C102(0.00); C48(0.00); C1302(0.00)  LDD0005  [13]
NHS
 Probe Info  		K252(0.00); K343(0.00); K815(0.00); K493(0.00)  LDD0010  [13]
SF
 Probe Info  		Y462(0.00); Y902(0.00)  LDD0028  [15]
STPyne
 Probe Info  		K230(0.00); K343(0.00); K446(0.00)  LDD0009  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		K815(0.00); K22(0.00); K343(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		C633(0.00); C990(0.00); C48(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C48(0.00); C788(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C48(0.00); C990(0.00)  LDD0218  [17]
W1
 Probe Info  		C48(0.00); C102(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C1296(0.00); C788(0.00); C990(0.00)  LDD2223  [20]
HHS-482
 Probe Info  		Y1282(1.35); Y625(1.18)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		5.41  LDD0465  [22]
STS-1
 Probe Info  		N.A.  LDD0137  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C221(0.71); C1201(0.67); C990(0.47)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C48(1.01); C990(1.11)  LDD2117  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C221(0.89)  LDD2103  [4]
 LDCM0025  4SU-RNA HEK-293T C633(2.97)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C633(2.74)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C102(0.98); C1296(1.04); C1302(0.97); C990(1.04)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C102(0.94); C1296(0.95); C1302(1.03); C990(0.98)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C102(0.90); C1296(0.96); C1302(1.14); C990(1.12)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C102(0.91); C1296(1.02); C1302(1.09); C990(1.07)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C102(0.94); C1296(0.98); C1302(1.05); C990(1.00)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C102(0.93); C1296(1.02); C1302(0.92); C990(1.07)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C102(1.02); C1296(1.01); C1302(1.14); C990(0.97)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C102(1.02); C1296(0.92); C1302(0.99); C990(1.01)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C102(1.29); C1296(1.23); C1302(1.54); C990(0.91)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C102(0.91); C1296(0.91); C1302(1.01); C990(1.02)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C102(0.97); C1296(0.97); C1302(1.01); C990(1.06)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C102(1.00); C1296(0.98); C1302(0.94); C990(1.03)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C102(0.97); C1296(0.99); C1302(1.05); C990(1.09)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C102(0.97); C1296(0.96); C1302(0.86); C990(1.05)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C102(0.96); C1296(0.99); C1302(0.99); C990(1.07)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C102(1.00); C1296(1.01); C1302(1.14); C990(0.95)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C102(1.02); C1296(0.94); C1302(0.96); C990(0.98)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C102(1.00); C1296(0.99); C1302(1.16); C990(0.89)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C102(0.98); C1296(0.96); C1302(1.05); C990(1.08)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C102(1.00); C1296(0.94); C1302(0.97); C990(1.02)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C102(0.89); C1296(1.00); C1302(1.22); C990(0.86)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C102(1.00); C1296(1.01); C1302(0.94); C990(0.95)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C102(0.98); C1296(0.95); C1302(0.93); C990(1.16)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C102(0.96); C1296(0.95); C1302(1.11); C990(0.99)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C102(0.95); C1296(0.97); C1302(1.17); C990(1.06)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C102(0.92); C1296(0.88); C1302(0.96); C990(1.04)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C102(0.89); C1296(0.98); C1302(1.16); C990(1.07)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C102(0.87); C1296(0.90); C1302(1.03); C990(1.07)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C102(0.86); C1296(0.89); C1302(0.96); C990(0.98)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C102(0.91); C1296(1.01); C1302(1.10); C990(1.06)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C102(0.88); C1296(0.92); C1302(0.99); C990(1.04)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C102(0.93); C1296(0.97); C1302(0.99); C990(1.05)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C102(0.89); C1296(0.88); C1302(1.05); C990(0.97)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C102(0.93); C1296(1.01); C1302(1.08); C990(1.09)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C102(0.94); C1296(0.93); C1302(1.10); C990(0.98)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C102(0.90); C1296(0.94); C1302(1.17); C990(0.89)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C102(0.90); C1296(0.95); C1302(1.03); C990(1.05)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C102(0.89); C1296(0.91); C1302(0.99); C990(0.94)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C102(0.94); C1296(1.03); C1302(1.05); C990(1.10)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C102(0.92); C1296(0.95); C1302(0.93); C990(1.03)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C102(0.88); C1296(0.90); C1302(1.05); C990(1.08)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C102(0.94); C1296(1.06); C1302(1.11); C990(1.01)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C102(0.89); C1296(0.92); C1302(0.99); C990(0.92)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C102(0.89); C1296(0.90); C1302(0.96); C990(0.89)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C102(0.96); C1296(0.99); C1302(1.14); C990(1.02)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C102(0.90); C1296(1.02); C1302(1.04); C990(1.01)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C102(0.90); C1296(0.96); C1302(0.93); C990(1.00)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C102(0.89); C1296(1.07); C1302(1.09); C990(1.04)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C102(0.92); C1296(0.93); C1302(0.87); C990(1.06)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C102(0.92); C1296(0.91); C1302(1.02); C990(1.10)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C102(0.97); C1296(1.03); C1302(1.00); C990(1.08)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C102(0.91); C1296(0.97); C1302(0.93); C990(1.05)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C102(0.94); C1296(0.99); C1302(0.95); C990(0.87)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C102(0.90); C1296(1.02); C1302(1.01); C990(0.94)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C102(0.95); C1296(1.00); C1302(1.04); C990(1.05)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C102(0.93); C1296(0.94); C1302(0.96); C990(0.91)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C102(0.90); C1296(1.01); C1302(0.95); C990(1.10)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C102(0.94); C1296(0.99); C1302(1.06); C990(1.00)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C102(0.91); C1296(0.98); C1302(1.01); C990(1.01)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C102(0.93); C1296(0.99); C1302(0.97); C990(1.00)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C102(0.93); C1296(0.94); C1302(1.09); C990(0.94)  LDD1569  [24]
 LDCM0545  Acetamide MDA-MB-231 C221(0.26); C1201(0.21)  LDD2138  [4]
 LDCM0248  AKOS034007472 HEK-293T C102(0.94); C1296(0.98); C1302(0.94); C990(0.96)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C102(0.98); C1296(1.04); C1302(1.07); C990(1.11)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C102(0.92); C1296(0.94); C1302(1.05); C990(0.98)  LDD1514  [24]
 LDCM0498  BS-3668 MDA-MB-231 C221(0.32); C102(0.40)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C990(0.00); C48(0.00); C788(0.00); C325(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C1296(0.59)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C102(0.98); C1296(0.86); C1302(1.00); C990(1.12)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C102(1.12); C1296(1.37); C1302(1.33); C990(0.82)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C102(0.93); C1296(0.92); C1302(1.12); C990(0.99)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C102(1.00); C1296(0.92); C1302(1.02); C990(1.08)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C102(0.90); C1296(1.02); C1302(1.08); C990(0.94)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C102(0.99); C1296(1.06); C1302(1.05); C53(0.99)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C102(0.92); C1296(0.97); C1302(1.06); C990(1.03)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C102(0.97); C1296(0.90); C1302(1.01); C990(1.06)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C102(0.99); C1296(1.01); C1302(1.06); C990(0.99)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C102(0.95); C1296(1.03); C1302(0.97); C53(0.96)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C102(0.91); C1296(0.92); C1302(0.92); C990(0.94)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C102(0.95); C1296(0.93); C1302(1.03); C990(1.10)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C102(1.02); C1296(1.15); C1302(1.13); C990(0.94)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C102(0.98); C1296(1.07); C1302(1.10); C990(0.89)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C102(1.04); C1296(1.01); C1302(0.95); C53(0.95)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C102(0.96); C1296(0.97); C1302(1.07); C990(0.99)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C102(0.97); C1296(0.82); C1302(1.06); C990(1.07)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C102(0.88); C1296(1.11); C1302(1.06); C990(0.97)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C102(0.89); C1296(0.91); C1302(1.01); C53(0.96)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C102(0.90); C1296(0.90); C1302(1.02); C990(1.02)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C102(0.95); C1296(0.89); C1302(0.99); C990(1.12)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C102(0.92); C1296(1.06); C1302(1.10); C990(1.07)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C102(0.92); C1296(1.01); C1302(1.07); C53(0.97)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C102(0.98); C1296(1.01); C1302(1.06); C990(1.03)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C102(0.95); C1296(0.97); C1302(1.02); C990(1.00)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C102(0.97); C1296(0.87); C1302(1.03); C990(1.04)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C102(0.93); C1296(1.05); C1302(1.09); C990(0.94)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C102(0.98); C1296(1.09); C1302(1.03); C53(1.04)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C102(0.92); C1296(0.98); C1302(1.00); C990(0.99)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C102(0.92); C1296(0.88); C1302(0.91); C990(1.07)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C102(0.90); C1296(1.00); C1302(0.91); C990(1.05)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C102(0.94); C1296(1.00); C1302(0.95); C53(0.99)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C102(0.90); C1296(0.94); C1302(0.96); C990(1.01)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C102(1.02); C1296(0.89); C1302(1.08); C990(0.96)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C102(0.93); C1296(0.97); C1302(0.94); C990(0.95)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C102(1.05); C1296(1.07); C1302(1.07); C53(0.99)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C102(0.93); C1296(1.07); C1302(1.02); C990(0.91)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C102(0.99); C1296(1.19); C1302(1.29); C990(0.80)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C102(0.93); C1296(1.01); C1302(1.09); C990(0.99)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C102(0.92); C1296(0.99); C1302(1.22); C990(1.11)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C102(0.91); C1296(0.97); C1302(0.89); C990(1.04)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C102(1.00); C1296(1.07); C1302(0.99); C990(0.98)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C102(1.11); C1296(1.12); C1302(1.06); C990(0.94)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C102(1.03); C1296(1.38); C1302(0.98); C990(0.99)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C102(1.08); C1296(1.15); C1302(1.04); C990(1.03)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C102(0.95); C1296(1.06); C1302(1.10); C990(1.08)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C102(1.00); C1296(1.02); C1302(1.06); C990(0.90)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C102(0.99); C1296(0.98); C1302(1.04); C990(1.02)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C102(0.95); C1296(0.93); C1302(1.05); C53(0.94)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C102(0.96); C1296(0.97); C1302(1.03); C990(0.99)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C102(1.02); C1296(0.98); C1302(1.06); C990(1.02)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C102(0.94); C1296(1.04); C1302(0.96); C53(1.05)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C102(1.01); C1296(0.97); C1302(1.04); C990(1.05)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C102(1.00); C1296(0.96); C1302(1.16); C990(1.06)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C102(0.99); C1296(1.04); C1302(1.04); C990(1.10)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C102(1.13); C1296(1.10); C1302(1.11); C990(0.88)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C102(1.13); C1296(1.29); C1302(1.01); C990(1.02)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C102(1.12); C1296(1.06); C1302(1.00); C990(1.02)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C102(1.11); C1296(1.06); C1302(1.20); C990(0.98)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C102(0.96); C1296(0.90); C1302(1.04); C990(1.08)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C102(0.93); C1296(0.88); C1302(0.88); C53(0.94)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C102(0.90); C1296(1.05); C1302(1.02); C990(1.05)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C102(0.97); C1296(0.91); C1302(0.95); C990(1.04)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C102(1.01); C1296(1.03); C1302(1.13); C990(1.00)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C102(0.99); C1296(0.94); C1302(0.87); C990(0.98)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C102(1.05); C1296(0.91); C1302(1.12); C990(0.87)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C102(1.05); C1296(1.04); C1302(1.06); C990(1.03)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C102(1.08); C1296(1.08); C1302(0.99); C990(0.96)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C102(1.10); C1296(1.11); C1302(0.93); C990(0.92)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C102(1.10); C1296(1.13); C1302(1.05); C990(0.97)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C102(1.05); C1296(1.10); C1302(1.03); C990(0.99)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C102(0.92); C1296(0.86); C1302(0.92); C990(1.06)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C102(0.97); C1296(1.07); C1302(1.04); C990(0.99)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C102(0.88); C1296(0.95); C1302(1.05); C990(1.07)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C102(0.90); C1296(0.98); C1302(0.99); C990(0.98)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C102(0.99); C1296(1.05); C1302(1.29); C990(0.99)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C102(0.97); C1296(0.98); C1302(1.14); C990(1.00)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C102(0.92); C1296(0.92); C1302(1.26); C990(0.91)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C102(0.91); C1296(0.97); C1302(1.00); C990(1.01)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C102(1.04); C1296(1.12); C1302(1.12); C990(1.01)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C102(1.06); C1296(1.21); C1302(1.08); C990(0.92)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C102(1.02); C1296(1.06); C1302(0.99); C990(0.97)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C102(0.99); C1296(1.04); C1302(1.09); C990(1.01)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C102(0.96); C1296(0.97); C1302(0.99); C990(1.02)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C102(0.93); C1296(0.88); C1302(0.94); C990(1.08)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C102(0.94); C1296(0.92); C1302(1.00); C990(1.09)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C102(0.94); C1296(0.93); C1302(0.97); C53(1.05)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C102(0.98); C1296(0.99); C1302(1.19); C990(0.98)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C102(0.96); C1296(1.01); C1302(1.08); C990(1.09)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C102(0.93); C1296(0.95); C1302(0.91); C990(1.10)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C102(0.94); C1296(0.90); C1302(1.13); C990(0.82)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C102(0.96); C1296(1.11); C1302(1.02); C990(1.10)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C102(1.02); C1296(1.09); C1302(0.99); C990(1.06)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C102(0.97); C1296(0.95); C1302(1.06); C990(1.01)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C102(1.06); C1296(1.15); C1302(1.02); C990(1.01)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C102(1.02); C1296(1.08); C1302(0.92); C990(1.01)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C102(0.97); C1296(1.01); C1302(1.13); C990(1.05)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C102(1.01); C1296(0.86); C1302(0.98); C990(0.95)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C102(0.90); C1296(0.93); C1302(1.00); C990(1.13)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C102(0.92); C1296(0.95); C1302(0.96); C990(1.03)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C102(1.06); C1296(1.08); C1302(1.23); C990(1.06)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C102(0.93); C1296(0.91); C1302(1.00); C990(0.99)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C102(0.94); C1296(0.90); C1302(1.01); C990(0.90)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C102(1.32); C1296(1.20); C1302(1.13); C990(0.75)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C102(0.93); C1296(0.98); C1302(0.98); C990(1.12)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C102(1.00); C1296(1.10); C1302(0.95); C990(1.07)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C102(1.01); C1296(1.19); C1302(0.97); C990(0.92)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C102(1.04); C1296(1.04); C1302(0.99); C990(0.96)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C102(0.98); C1296(1.05); C1302(1.11); C990(1.04)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C102(0.94); C1296(0.84); C1302(0.92); C990(1.10)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C102(0.84); C1296(0.91); C1302(0.85); C990(0.94)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C102(0.90); C1296(0.97); C1302(0.89); C53(1.03)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C102(0.89); C1296(0.95); C1302(0.95); C990(0.93)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C102(0.93); C1296(0.96); C1302(0.97); C990(1.01)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C102(0.98); C1296(1.13); C1302(0.99); C990(0.94)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C102(1.11); C1296(1.06); C1302(1.23); C990(0.86)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C102(0.87); C1296(0.94); C1302(1.01); C990(1.06)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C102(0.94); C1296(0.98); C1302(0.99); C990(1.03)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C102(0.98); C1296(0.94); C1302(0.95); C990(0.92)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C102(0.96); C1296(1.06); C1302(0.92); C990(0.99)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C102(1.26); C1296(1.24); C1302(1.18); C990(0.87)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C102(0.96); C1296(1.04); C1302(1.10); C990(1.05)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C102(1.02); C1296(0.98); C1302(1.14); C990(1.04)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C102(0.96); C1296(0.98); C1302(1.04); C990(0.98)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C102(0.91); C1296(0.93); C1302(0.87); C53(0.98)  LDD1697  [24]
 LDCM0634  CY-0357 Hep-G2 C1296(0.90); C1302(0.59)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C102(0.89); C1296(0.88); C1302(0.94); C53(0.98)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C157(3.02)  LDD1702  [4]
 LDCM0625  F8 Ramos C1296(1.11); C102(0.97); C48(1.02); C1302(1.34)  LDD2187  [25]
 LDCM0572  Fragment10 MDA-MB-231 C1302(2.16); C1296(4.93)  LDD1389  [26]
 LDCM0573  Fragment11 MDA-MB-231 C1302(1.30); C1296(1.55)  LDD1391  [26]
 LDCM0574  Fragment12 Ramos C1296(1.06); C102(2.32); C48(1.04); C1302(1.64)  LDD2191  [25]
 LDCM0575  Fragment13 MDA-MB-231 C1296(1.54)  LDD1395  [26]
 LDCM0576  Fragment14 MDA-MB-231 C1302(2.50)  LDD1397  [26]
 LDCM0577  Fragment15 Ramos C1302(1.61)  LDD1400  [26]
 LDCM0579  Fragment20 MDA-MB-231 C1302(4.98)  LDD1402  [26]
 LDCM0580  Fragment21 MDA-MB-231 C1302(1.06); C1296(1.43); C102(1.80)  LDD1404  [26]
 LDCM0581  Fragment22 MDA-MB-231 C1296(1.73)  LDD1406  [26]
 LDCM0582  Fragment23 MDA-MB-231 C1296(2.76)  LDD1408  [26]
 LDCM0583  Fragment24 Ramos C1302(2.16); C1296(10.51)  LDD1410  [26]
 LDCM0584  Fragment25 MDA-MB-231 C1302(0.94); C1296(0.90); C102(0.98)  LDD1411  [26]
 LDCM0578  Fragment27 MDA-MB-231 C1302(0.62); C1296(0.82); C102(0.60)  LDD1401  [26]
 LDCM0586  Fragment28 MDA-MB-231 C1302(0.90); C1296(1.17)  LDD1415  [26]
 LDCM0587  Fragment29 MDA-MB-231 C1302(1.24)  LDD1417  [26]
 LDCM0588  Fragment30 Ramos C1296(0.99); C102(2.06); C48(0.88); C1302(1.75)  LDD2199  [25]
 LDCM0589  Fragment31 MDA-MB-231 C1302(2.71); C1296(7.87); C102(12.99)  LDD1421  [26]
 LDCM0590  Fragment32 MDA-MB-231 C1302(2.08); C1296(2.43)  LDD1423  [26]
 LDCM0468  Fragment33 HEK-293T C102(0.93); C1296(0.99); C1302(0.97); C53(1.00)  LDD1671  [24]
 LDCM0593  Fragment35 Ramos C1302(1.05)  LDD1430  [26]
 LDCM0594  Fragment36 MDA-MB-231 C1302(1.68)  LDD1431  [26]
 LDCM0596  Fragment38 MDA-MB-231 C1302(1.40); C1296(20.00)  LDD1433  [26]
 LDCM0566  Fragment4 MDA-MB-231 C1302(2.33); C1296(3.71)  LDD1378  [26]
 LDCM0598  Fragment40 Ramos C1302(1.09)  LDD1437  [26]
 LDCM0599  Fragment41 MDA-MB-231 C102(3.23)  LDD1438  [26]
 LDCM0600  Fragment42 Ramos C1296(1.49)  LDD1440  [26]
 LDCM0601  Fragment43 MDA-MB-231 C1302(1.66); C102(3.20)  LDD1441  [26]
 LDCM0602  Fragment44 MDA-MB-231 C1296(0.79)  LDD1443  [26]
 LDCM0605  Fragment47 MDA-MB-231 C1302(1.18)  LDD1446  [26]
 LDCM0606  Fragment48 MDA-MB-231 C1302(1.14)  LDD1447  [26]
 LDCM0608  Fragment50 MDA-MB-231 C1296(3.23)  LDD1449  [26]
 LDCM0427  Fragment51 Ramos C102(0.67)  LDD1451  [26]
 LDCM0610  Fragment52 MDA-MB-231 C1302(0.93)  LDD1452  [26]
 LDCM0612  Fragment54 MDA-MB-231 C1296(1.64)  LDD1456  [26]
 LDCM0613  Fragment55 MDA-MB-231 C1296(1.21)  LDD1457  [26]
 LDCM0614  Fragment56 MDA-MB-231 C1302(0.99); C1296(1.05); C102(1.01)  LDD1458  [26]
 LDCM0569  Fragment7 MDA-MB-231 C1302(1.90)  LDD1383  [26]
 LDCM0570  Fragment8 MDA-MB-231 C1302(2.72); C1296(3.35); C102(4.53)  LDD1385  [26]
 LDCM0571  Fragment9 MDA-MB-231 C1302(1.78); C1296(1.26)  LDD1387  [26]
 LDCM0116  HHS-0101 DM93 Y902(0.33); Y244(0.35); Y957(0.57)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y902(1.44); Y957(2.05); Y244(8.08)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y957(0.45); Y902(0.76); Y244(20.00)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y957(1.16); Y244(1.42)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y902(0.29); Y957(0.66); Y244(2.19)  LDD0268  [7]
 LDCM0107  IAA HeLa C633(0.00); C990(0.00); C48(0.00); H610(0.00)  LDD0221  [17]
 LDCM0022  KB02 MDA-MB-231 C1302(3.98); C1296(8.71); C102(20.00)  LDD1374  [26]
 LDCM0023  KB03 Jurkat C48(14.18); C1296(4.60); C102(12.38); C53(7.12)  LDD0209  [6]
 LDCM0024  KB05 G361 C1207(6.22); C59(2.68)  LDD3311  [27]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C221(1.12)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C221(0.74)  LDD2121  [4]
 LDCM0109  NEM HeLa H1071(0.00); H68(0.00)  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C221(0.68)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C48(1.20); C221(1.19)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C48(1.04)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C221(1.16)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C221(0.41)  LDD2096  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C221(0.81)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C48(0.89)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C221(0.51); C788(0.62)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C990(0.63)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C221(0.51)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C221(0.64); C990(0.28)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C48(1.04); C221(1.21); C990(1.24)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C221(0.65); C990(0.40)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C48(0.65); C221(0.70); C990(0.52); C788(0.81)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C990(0.46)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C48(0.94); C990(1.17)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C221(0.82); C788(0.38)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C990(0.41)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C48(0.67); C221(0.47); C102(0.93)  LDD2118  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C102(1.23)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C221(0.55)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C48(1.00); C990(0.91)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C48(0.36); C221(0.40)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C48(1.06); C990(0.79); C1296(1.12)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C48(0.76); C221(0.38)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C48(0.88); C990(1.19); C788(0.71)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C221(1.01)  LDD2128  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C990(0.38)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C48(0.73); C990(1.04)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C48(1.10); C990(1.62)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C48(0.80); C788(1.08)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C221(0.91); C990(0.88)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C221(0.37); C788(0.82)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C48(0.44); C221(0.96); C102(1.12)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C48(1.04)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C990(0.61); C788(0.20)  LDD2145  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C221(3.75)  LDD2147  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C48(0.71); C221(0.50)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C221(0.30); C1201(0.17)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C221(0.60)  LDD2151  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C133(1.04); C1302(1.03); C1296(0.88)  LDD2206  [28]
 LDCM0628  OTUB2-COV-1 HEK-293T C1296(0.74); C1302(0.39)  LDD2207  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA repair protein RAD50 (RAD50) SMC family Q92878
Transcriptional regulator ATRX (ATRX) SNF2/RAD54 helicase family P46100
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell cycle checkpoint protein RAD17 (RAD17) Rad17/RAD24 family O75943

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
27 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.